This paper examines the effect of prior investment experience in specific industries on subsequent investment decisions. Using households’ trading records from a large discount broker between 1991 ...and 1996, I find that prior success in a given industry increases the likelihood of subsequent purchases in the same industry. The effect is stronger for more recent experiences and for less sophisticated or diversified investors, and it is not wealth enhancing. The results suggest investors categorize industries at a highly resolved level, finer than the Fama–French ten-industry classification. Similar effects are also apparent for size- and value-based categories but at smaller magnitudes.
Recent advances in shape matching have shown that jointly optimizing the maps among the shapes in a collection can lead to significant improvements when compared to estimating maps between pairs of ...shapes in isolation. These methods typically invoke a cycle‐consistency criterion — the fact that compositions of maps along a cycle of shapes should approximate the identity map. This condition regularizes the network and allows for the correction of errors and imperfections in individual maps. In particular, it encourages the estimation of maps between dissimilar shapes by compositions of maps along a path of more similar shapes.
In this paper, we introduce a novel approach for obtaining consistent shape maps in a collection that formulates the cycle‐consistency constraint as the solution to a semidefinite program (SDP). The proposed approach is based on the observation that, if the ground truth maps between the shapes are cycle‐consistent, then the matrix that stores all pair‐wise maps in blocks is low‐rank and positive semidefinite. Motivated by recent advances in techniques for low‐rank matrix recovery via semidefinite programming, we formulate the problem of estimating cycle‐consistent maps as finding the closest positive semidefinite matrix to an input matrix that stores all the initial maps. By analyzing the Karush‐Kuhn‐Tucker (KKT) optimality condition of this program, we derive theoretical guarantees for the proposed algorithm, ensuring the correctness of the recovery when the errors in the inputs maps do not exceed certain thresholds. Besides this theoretical guarantee, experimental results on benchmark datasets show that the proposed approach outperforms state‐of‐the‐art multiple shape matching methods.
Previous research was yet to establish a definite operation for transverse colon cancer (TCC); surgical procedure was often dictated by the surgeon's preference in clinical practice. The main ...surgical methods could be summarized in two main points: segmental colectomy (transverse colectomy) and right hemicolectomy.
The first patient was a 78-year-old woman, who was diagnosed with right TCC. Computed tomography revealed a right TCC and a very long transverse colon; laparoscopic exploration revealed an enlarged apical lymph node surrounding the ileocolic vessels. We performed a segmental colectomy with extensive apical lymph node dissection along the superior mesenteric vessels and its main branches for her. To distinguish it from the previous radical operations for TCC, we called this operation a segmental colectomy with extensive D3 lymph node dissection. Then, this surgical intervention was performed on 8 other TCC patients.
The total operating time was 158 min. Pathological examination confirmed 2 apical lymph node metastases; among them, one apical lymph node metastasis was in group No.203. For all 9 patients, the median operative time was 160 min (range, 140-185 min), the average number of lymph node retrieval was 30 (range, 25-39), and the average number of apical lymph node (No.203, No.213, and No.223) retrieval was 5.9 (range, 0-11). Because of the preservation of the ileocecal junction and part of the ascending colon, all patients recovered uneventfully after surgery, and long-term diarrhea, water-electrolyte imbalance, and other Clavien-Dindo grade III or greater postoperative complications did not occur.
Our procedure combined the advantages of segmental colectomy and right hemicolectomy and gave consideration to oncological and functional outcomes. It may be an optimal choice for TCC patients with a very long transverse colon and preoperative diagnosis of lymph node metastasis.
Zika virus (ZIKV) has evolved into a global health threat because of its unexpected causal link to microcephaly. Phylogenetic analysis reveals that contemporary epidemic strains have accumulated ...multiple substitutions from their Asian ancestor. Here we show that a single serine-to-asparagine substitution Ser139→Asn139 (S139N) in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. This functional adaption makes ZIKV more virulent to human NPCs, thus contributing to the increased incidence of microcephaly in recent ZIKV epidemics.
Microplastics (MPs) derived from plastic wastes have attracted wide attention throughout the world due to the wide distribution, easy transition, and potential threats to organisms. This study ...proposes efficient Mg/Zn modified magnetic biochar adsorbents for microplastic removal. For polystyrene (PS) microspheres (1 µm, 100 mg/mL) in aqueous solution, the removal efficiencies of magnetic biochar (MBC), Mg modified magnetic biochar (Mg-MBC), and Zn modified magnetic biochar (Zn-MBC) were 94.81%, 98.75%, and 99.46%, respectively. It is supposed that the adsorption process was a result of electrostatic interaction and chemical bonding interaction between microplastics and biochar. The coexisting H2PO4- and organic matters in real water significantly affected the removal efficiency of Zn-MBC due to competitive adsorption effect. Microplastic degradation and adsorbent regeneration were accomplished by thermal treatment simultaneously. The degradation of adsorbed MPs was promoted by the catalytic active sites originated from Mg and Zn, releasing adsorption sites. Thermal regeneration maintained the adsorption capability. Even after five adsorption-pyrolysis cycles, MBC (95.02%), Mg-MBC (94.60%), and Zn-MBC (95.79%) showed high microplastic removal efficiency. Therefore, the low-cost, eco-friendly, and robust Mg/Zn-MBCs have promising potential for application in microplastic removal.
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•Mg/Zn-MBCs were prepared as adsorbents for microplastic removal.•The modification by Mg and Zn-MBC enhanced removal efficiency significantly.•Zn-MBC maintained stable adsorption performance in various conditions.•MBCs promoted MPs degradation by thermal treatment for adsorbents regeneration.•Recycled Zn-MBC showed the highest removal efficiency of reported adsorbents.
There is an urgent need for vaccines against coronavirus disease 2019 (COVID-19) because of the ongoing SARS-CoV-2 pandemic. Among all approaches, a messenger RNA (mRNA)-based vaccine has emerged as ...a rapid and versatile platform to quickly respond to this challenge. Here, we developed a lipid nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (called ARCoV). Intramuscular immunization of ARCoV mRNA-LNP elicited robust neutralizing antibodies against SARS-CoV-2 as well as a Th1-biased cellular response in mice and non-human primates. Two doses of ARCoV immunization in mice conferred complete protection against the challenge of a SARS-CoV-2 mouse-adapted strain. Additionally, ARCoV is manufactured as a liquid formulation and can be stored at room temperature for at least 1 week. ARCoV is currently being evaluated in phase 1 clinical trials.
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•Development of LNP-encapsulated mRNA vaccine (ARCoV) targeting the RBD of SARS-CoV-2•ARCoV induces neutralizing antibodies and T cell immunity in mice and NHPs•ARCoV vaccination confers full protection against SARS-CoV-2 challenge in mice•ARCoV is a thermostable vaccine candidate for phase I studies
ARCoV is an LNP-encapsulated mRNA vaccine platform that is highly immunogenic and safe in mice and non-human primates, conferring protection against challenge with a SARS-CoV-2 mouse-adapted strain.
Non-small-cell lung cancer (NSCLC) is currently the leading cause of cancer-related death. Accumulating evidences suggest that overcoming the therapeutic resistance in NSCLC is a big challenge. ...Recently, the outcomes of two independent phase 3 trials regarding Alectinib versus Crizotinib in ALK-positive NSCLC are encouraging. However, given the potential relevance of HGF-MET signaling and especially autophagy to the war against ALK-positive NSCLC between Alectinib and Crizotinib, it's too early to reach a convincing conclusion. Therefore, to further improve the therapeutic efficacy of ALK-positive NSCLC, this commentary highlights the negligence in design of relevant clinical trials, emphasizes the importance of molecular characteristics investigation, and discusses the prospect of combination therapy.
Although mRNA vaccines have been effective against multiple cancers, their efficacy against pancreatic adenocarcinoma (PAAD) remains undefined. Accumulating evidence suggests that immunotyping can ...indicate the comprehensive immune status in tumors and their immune microenvironment, which is closely associated with therapeutic response and vaccination potential. The aim of this study was to identify potent antigens in PAAD for mRNA vaccine development, and further distinguish immune subtypes of PAAD to construct an immune landscape for selecting suitable patients for vaccination.
Gene expression profiles and clinical information of 239 PAAD datasets were extracted from ICGC, and RNA-Seq data of 103 samples were retrieved from TCGA. GEPIA was used to calculate differential expression levels and prognostic indices, cBioPortal program was used to compare genetic alterations, and TIMER was used to explore correlation between genes and immune infiltrating cells. Consensus cluster was used for consistency matrix construction and data clustering, DAVID was used for functional annotation, and graph learning-based dimensional reduction was used to depict immune landscape.
Six overexpressed and mutated tumor antigens associated with poor prognosis and infiltration of antigen presenting cells were identified in PAAD, including ADAM9, EFNB2, MET, TMOD3, TPX2, and WNT7A. Furthermore, five immune subtypes (IS1-IS5) and nine immune gene modules of PAAD were identified that were consistent in both patient cohorts. The immune subtypes showed distinct molecular, cellular and clinical characteristics. IS1 and IS2 exhibited immune-activated phenotypes and correlated to better survival compared to the other subtypes. IS4 and IS5 tumors were immunologically cold and associated with higher tumor mutation burden. Immunogenic cell death modulators, immune checkpoints, and CA125 and CA199, were also differentially expressed among the five immune subtypes. Finally, the immune landscape of PAAD showed a high degree of heterogeneity between individual patients.
ADAM9, EFNB2, MET, TMOD3, TPX2, and WNT7A are potent antigens for developing anti-PAAD mRNA vaccine, and patients with IS4 and IS5 tumors are suitable for vaccination.
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