A long grazing season improves the profitability of pasture-based dairy production. It can entail grazing under wet soil conditions and the risk of damaging swards. Housing cows either temporarily or ...completely while soil moisture is high can avoid damaging swards. An experiment with 4 grazing systems was conducted over 3 yr (Sep. 1, 2013, to Aug. 31, 2016). The purpose was to evaluate whether soil moisture measurements are an effective decision support to assess the risk of treading damage and effects on pasture productivity and dairy cow performance during wet soil conditions. Access time to pasture between February and December of each grazing season was dependent on volumetric soil moisture content (VSMC, m3/m3) measured each morning: Control = cows were housed at VSMC >0.5 and otherwise allowed 22 h/d access to pasture; S<7 = cows were housed on days with VSMC >0.7 and otherwise allowed 22 h/d access to pasture; S7–6 = cows were housed at VSMC >0.7 and allowed 8 h/d access to pasture at VSMC between 0.7 and 0.6 and 22 h/d access at VSMC ≤0.6; S7–5 = cows were housed at VSMC >0.7 and allowed 8 h/d access to pasture at VSMC between 0.7 and 0.5 and 22 h/d access at VSMC ≤0.5. Cows with 8-h access per day received no other feeding when housed. All herds were compact spring-calving, with a mean calving date of Feb. 19. Mean stocking rate was 2.57 cows/ha. Measurements of VSMC provided an objective indicator for the risk of treading damage. Less time spent at pasture under wet soil conditions lowered treading damage but had no effect on annual pasture production (mean 14.8 t of organic matter/ha). Annual milk solids production per cow was lowest for the control herd (485 kg) and not different between the other systems (503 kg). Reducing treading damage to swards did not improve productivity or profitability of the grazing systems. Nevertheless, measuring soil moisture was a useful decision support for assessing the risk of treading damage when turning cows out to pasture.
Solving the green gap problem is a key challenge for the development of future LED-based light systems. A promising approach to achieve higher LED efficiencies in the green spectral region is the ...growth of III-nitrides in the cubic zincblende phase. However, the metastability of zincblende GaN along with the crystal growth process often lead to a phase mixture with the wurtzite phase, high mosaicity, high densities of extended defects and point defects, and strain, which can all impair the performance of light emitting devices. X-ray diffraction (XRD) is the main characterization technique to analyze these device-relevant structural properties, as it is very cheap in comparison to other techniques and enables fast feedback times. In this review, we will describe and apply various XRD techniques to identify the phase purity in predominantly zincblende GaN thin films, to analyze their mosaicity, strain state, and wafer curvature. The different techniques will be illustrated on samples grown by metalorganic vapor phase epitaxy on pieces of 4″ SiC/Si wafers. We will discuss possible issues, which may arise during experimentation, and provide a critical view on the common theories.
The number of people in the world with diabetes has nearly quadrupled in the past 40 years. Current data show that 25% of these diabetics will develop a foot ulcer in their lifetime and that the cost ...of care for a diabetic foot ulcer (DFU) is over twice that of any other chronic ulcer aetiology. Microbial biofilm has been linked to both wound chronicity and infection. Close to 1 in 2 diabetics with a DFU are predicted to go on to develop a diabetic foot infection (DFI). The majority of these DFIs have been found to evolve even before the diabetic individual has received an initial referral for expert DFU management. Of these infected DFUs, less than half have been shown to heal over the next year; many of these individuals will require costly hospitalisation, and current data show that far too many DFIs will require extremity amputation to achieve infection resolution. The development of an infection in a DFU is critical at least in part because paradigms of infection prevention and management are evolving. The effectiveness of our current practice standards is being challenged by a growing body of research related to the prevalence and recalcitrance of the microbes in biofilm to topical and systemic antimicrobials. This article will review the magnitude of current challenges related to DFI prevention and management along with what is currently considered to be standard of care. These ideas will be compared and contrasted with what is known about the biofilm phenotype; then, considerations to support progress towards the development of more cost‐effective protocols of care are highlighted.
Australia has a universal healthcare system, yet organisation and delivery of primary healthcare (PHC) services varies across local areas. Understanding the nature and extent of this variation is ...essential to improve quality of care and health equity, but this has been hampered by a lack of suitable measures across the breadth of effective PHC systems. Using a suite of measures constructed at the area-level, this study explored their application in assessing area-level variation in PHC organisation and delivery.
Routinely collected data from New South Wales, Australia were used to construct 13 small area-level measures of PHC service organisation and delivery that best approximated access (availability, affordability, accommodation) comprehensiveness and coordination. Regression analyses and pairwise Pearson's correlations were used to examine variation by area, and by remoteness and area disadvantage.
PHC service delivery varied geographically at the small-area level-within cities and more remote locations. Areas in major cities were more accessible (all measures), while in remote areas, services were more comprehensive and coordinated. In disadvantaged areas of major cities, there were fewer GPs (most disadvantaged quintile 0.9SD 0.1 vs least 1.0SD 0.2), services were more affordable (97.4%1.6 bulk-billed vs 75.711.3), a greater proportion were after-hours (10.3%3.0 vs 6.22.9) and for chronic disease care (28%3.4 vs 17.68.0) but fewer for preventive care (50.7%3.8 had cervical screening vs 62.54.9). Patterns were similar in regional locations, other than disadvantaged areas had less after-hours care (1.3%0.7 vs 6.1%3.9). Measures were positively correlated, except GP supply and affordability in major cities (-0.41, p < .01).
Application of constructed measures revealed inequity in PHC service delivery amenable to policy intervention. Initiatives should consider the maldistribution of GPs not only by remoteness but also by area disadvantage. Avenues for improvement in disadvantaged areas include preventative care across all regions and after-hours care in regional locations.
Docks are a widespread problem in grassland, necessitating novel management solutions as pesticides become increasingly regulated. The objective was to investigate the role of soil test Potassium (K) ...concentrations (Morgan's solution; Na acetate + acetic acid, pH 4.8; STK) on competitiveness of docks in grassland. The experimental site (52°21 N, 7°18 W) was reseeded with perennial ryegrass in October 2009. A plot experiment was laid down in a randomised complete block design with seven rates of fertiliser K (0, 50, 100, 150, 200, 250 and 300 kg ha−1) and eight replicates. Dock numbers were measured over 6 years (2010–2015) and herbage production over 5 years (2012–2016). There was poor alignment between fertiliser K and STK in the early years of the study, however this alignment improved over time. While fertiliser K had no effect on dock numbers, there were positive correlations between STK early in the study and dock numbers m−2 throughout the study. Dock numbers m−2 were relatively static between 2010 and 2012 and increased substantially between 2013 and 2015. Between 2013 and 2016 there were strong inverse relationships (r > −.765; p < .001) between dock and grass herbage production. Towards the end of the study the lower annual fertiliser K inputs (0 and 50 kg ha−1) resulted in lower (p < .01) dock root and herbage production with an associated increase (p < .05) in grass herbage production. It is evident there is a threshold STK for permanent grassland infested with docks at which grass is more competitive for plant‐available soil K than the docks to the detriment of the dock component of the sward.
AC photoelectrochemical imaging at electrolyte–semiconductor interfaces provides spatially resolved information such as surface potentials, ion concentrations and electrical impedance. In this work, ...thin films of InGaN/GaN were used successfully for AC photoelectrochemical imaging, and experimentally shown to generate a considerable photocurrent under illumination with a 405 nm modulated diode laser at comparatively high frequencies and low applied DC potentials, making this a promising substrate for bioimaging applications. Linear sweep voltammetry showed negligible dark currents. The imaging capabilities of the sensor substrate were demonstrated with a model system and showed a lateral resolution of 7 microns.
Patients with rheumatoid arthritis (RA)-related autoantibodies have an increased mortality rate. Different autoantibodies are frequently co-occurring and it is unclear which autoantibodies associate ...with increased mortality. In addition, association with different causes of death is thus far unexplored. Both questions were addressed in three early RA populations.
2331 patients with early RA included in Better Anti-Rheumatic Farmaco-Therapy cohort (BARFOT) (n=805), Norfolk Arthritis Register (NOAR) (n=678) and Leiden Early Arthritis Clinic cohort (EAC) (n=848) were studied. The presence of anticitrullinated protein antibodies (ACPA), rheumatoid factor (RF) and anticarbamylated protein (anti-CarP) antibodies was studied in relation to all-cause and cause-specific mortality, obtained from national death registers. Cox proportional hazards regression models (adjusted for age, sex, smoking and inclusion year) were constructed per cohort; data were combined in inverse-weighted meta-analyses.
During 26 300 person-years of observation, 29% of BARFOT patients, 30% of NOAR and 18% of EAC patients died, corresponding to mortality rates of 24.9, 21.0 and 20.8 per 1000 person-years. The HR for all-cause mortality (95% CI) was 1.48 (1.22 to 1.79) for ACPA, 1.47 (1.22 to 1.78) for RF and 1.33 (1.11 to 1.60) for anti-CarP. When including all three antibodies in one model, RF was associated with all-cause mortality independent of other autoantibodies, HR 1.30 (1.04 to 1.63). When subsequently stratifying for death cause, ACPA positivity associated with increased cardiovascular death, HR 1.52 (1.04 to 2.21), and RF with increased neoplasm-related death, HR 1.64 (1.02 to 2.62), and respiratory disease-related death, HR 1.71 (1.01 to 2.88).
The presence of RF in patients with RA associates with an increased overall mortality rate. Cause-specific mortality rates differed between autoantibodies: ACPA associates with increased cardiovascular death and RF with death related to neoplasm and respiratory disease.
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