The production of beauty quarks with a \(D^{\ast\pm}\) and a muon in the final state has been measured with the ZEUS detector at HERA using an integrated luminosity of 114 pb-1. Low ...transverse-momentum thresholds for the muon and D* meson allow for a measurement of beauty production closer to the production threshold than previous measurements. The beauty signal was extracted using the charge correlations and angular distributions of the muon with respect to the D* meson. Cross sections for photoproduction and deep inelastic scattering are somewhat higher than, but compatible with, next-to-leading-order QCD predictions, and compatible with other measurements.
A search for stop production in R-parity-violating supersymmetry has been performed in e+p interactions with the ZEUS detector at HERA, using an integrated luminosity of 65 pb-1. At HERA, the ...R-parity-violating coupling λ’ allows resonant squark production, \(e^+d\to\tilde{q}\). Since the lowest-mass squark state in most supersymmetry models is the light stop, \(\tilde{t}\), this search concentrated on production of \(\tilde{t}\), followed either by a direct R-parity-violating decay, or by the gauge decay to \(b\tilde{\chi}^+_{1}\). No evidence for stop production was found and limits were set on λ’131 as a function of the stop mass in the framework of the minimal supersymmetric standard model. The results have also been interpreted in terms of constraints on the parameters of the minimal supergravity model.
The distribution of the azimuthal angle of charged and neutral hadrons relative to the lepton plane has been studied for neutral current deep inelastic ep scattering using an integrated luminosity of ...45 pb-1 taken with the ZEUS detector. The kinematic range is 100<Q2<8000 GeV2, 0.2<y<0.8 and 0.01<x<0.1 where Q2 is the virtuality of the exchanged boson, y is the inelasticity and x is the Bjorken variable. The measurements were made in the hadronic centre-of-mass system. The analysis exploits the energy-flow method, which allows the measurement to be made over a larger range of pseudorapidity compared to previous results. The dependence of the moments of the azimuthal distributions on the pseudorapidity and minimum transverse energy of the final-state hadrons are presented. Although the predictions from next-to-leading-order QCD describe the data better than do the Monte Carlo models incorporating leading-logarithm parton showers, they still fail to describe the magnitude of the asymmetries. This suggests that higher-order calculations may be necessary to describe these data.
The primary goal of this study is to determine the effects of Mn exposure via inhalation. The bioaccumulation of Mn in different organs and tissues, the alteration of biochemical parameters, and the ...locomotor activity were assessed. A group of 26 male Sprague-Dawley rats (E) were exposed to 3750 µg/m3 of Mn dust for 6 h/day, 5 days/wk for 13 consecutive weeks and compared to a control group of 12 rats (C) exposed to 4 µg/m3. After exposure, neurological evaluation was carried out for 36 h (a night-day-night cycle) using a computerized autotrack system. Rats were then sacrificed by exsanguination, and Mn content in organs and tissues was determined by neutron activation analysis. Mn concentrations in lung, putamen, and cerebellum were significantly higher in E than in C (0.30 vs. 0.17, 0.89 vs. 0.44, 0.63 vs. 0.48 ppm; p < .01), as well as in the kidney, frontal cortex, and globus pallidus (1.15 vs. 0.96, 0.84 vs. 0.47, 1.28 vs. 0.55 ppm; p < .05). Potassium concentration was significantly lower in E than in C (5.11 vs. 5.79 mmol/L; p < .05), as was alkaline phosphatase (106.9 vs. 129.6 U/L; p < .01). Locomotor activity indicated higher distance covered in the first 12-h period for E (45 383 vs. 36 098 cm; p < .05) and lower resting time in the last 12-h period for E (36 326 vs. 37 393 s; p < .05). This study is the first of several ongoing studies in our laboratory that address health concerns associated with inhalation exposure to different Mn species and to different levels of exposure.
It is unclear whether the susceptibility to myocardial depression from an accidental intravascular local anesthetic (LA) administration is associated with LA stereoselectivity or structure. By using ...direct left ventricular pressure monitoring and echocardiographic indices of contractile function in anesthetized, ventilated dogs, we compared the cardiac depressant effects of bupivacaine, ropivacaine, levobupivacaine, and lidocaine.
Open-chest dogs were randomized to receive escalating incremental infusions of the 4 local anesthetics until cardiovascular collapse. We assumed a concentration relationship for potency of 4:1 for lidocaine/bupivacaine, ropivacaine, and levobupivacaine.
All LAs produced concentration-dependent increases in left ventricular end diastolic pressure (LVEDP) and decreases in dP/dtmax, ejection fraction % (EF), fractional shortening (%) (FS), and cardiac output (CO). When comparing the long-acting agents, the effect was least for ropivacaine. The effective concentration estimates for ropivacaine that produced 35% reductions in dP/dtmax and FS were 4.0 micro g/mL (95% confidence intervals CI(95): 3.1 to 5.2 micro g/mL) and 3.0 micro g/mL (CI (95): 2.1 to 4.2 micro g/mL), respectively. The concentrations of levobupivacaine that produced these same end points of contractile dysfunction were significantly less: 2.4 micro g/mL (CI(95): 1.9 to 3.1 micro g/mL) and 1.3 micro g/mL (CI(95): 0.9 to 1.8 micro g/mL), respectively, and these were not different from bupivacaine. As expected, the concentrations of lidocaine that produced 35% reductions in dP/dtmax and FS were significantly greater than the longer acting agents; 8.0 micro g/mL (CI(95): 5.7 to 11.0 micro g/mL) and 5.5 micro g/mL (CI(95): 3.5 to 8.7 micro g/mL), respectively.
This study suggests that smaller molecular size and possibly a piperidine-free structure as opposed to stereoselectivity may be the more important factor in reducing the risk of LA-induced myocardial depression.
This paper investigates the abilities of a group of experts to produce subjective probabilities on the likelihood of their students obtaining various grades in their final-year examinations. We ...examine the calibration of these experts, and how their ability to forecast depends on experience and assessment procedures. We find that these well-motivated and statistically literate assessors, working in their field of expertise, still suffer from the types of assessment problems noted in previous studies on more naive subjects.
It is unclear whether the mechanism of death from local anesthetic (LA) intoxication is primarily a consequence of cardiac arrhythmias or myocardial contractile depression, and whether LAs might ...differ in this susceptibility to these two mechanisms. By using programmable electrical stimulation (PES) protocols in anesthetized, ventilated dogs, we compared the arrhythmogenic potential of bupivacaine (BUP), ropivacaine (ROP), levobupivacaine (LBUP), and lidocaine (LIDO). Open-chest dogs were randomized to receive escalating incremental infusions of the four local anesthetics until cardiovascular collapse. We assumed a concentration relationship of 4:1 for LIDO/BUP, LBUP, and ROP. The effective refractory period did not change significantly until the dose increment corresponding to target concentrations of 8 and 32 microg/mL for BUP, LBUP, ROP, and LIDO, respectively. Thirty percent to 50% increases in effective refractory period occurred in surviving dogs at this dose. The incidence of spontaneous or PES-induced ventricular tachycardia and ventricular fibrillation did not differ among groups. Compared with LIDO, the incidence of PES-induced extrasystoles was more frequent for BUP- and LBUP-treated dogs (P: < 0.05). ROP-treated dogs did not differ from LIDO-treated dogs with respect to PES-induced extrasystoles. At the dose increment preceding cardiovascular collapse, all LAs produced significant increases in heart rate and reductions in blood pressure compared with their respective baseline values. The incidence of programmable electrical stimulation-induced ventricular tachycardia and fibrillation with BUP does not differ from the incidence that occurs with the single S:(-) enantiomers LBUP and ROP, providing further evidence against stereoselective arrhythmogenesis as a primary component of local anesthetic-induced cardiotoxicity.
Progressive bupivacaine intoxication in anesthetized, ventilated dogs does not produce early arrhythmogenic events. The incidence of programmable electrical stimulation-induced ventricular tachycardia and fibrillation with bupivacaine does not differ from the incidence that occurs with the single S:(-) enantiomers levobupivacaine and ropivacaine, providing further evidence against stereoselective arrhythmogenesis as a primary component of local anesthetic-induced cardiotoxicity.
PDF
