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  • Hitting the target: fragmen... Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes
    Yin, Xingyu; Scalia, Alexander; Leroy, Ludmila ... Acta crystallographica. Section D, Biological crystallography., 20/May , Volume: 70, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Acoustic droplet ejection (ADE) is a powerful technology that supports crystallographic applications such as growing, improving and manipulating protein crystals. A fragment‐screening strategy is ...
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  • Solvent minimization induce... Solvent minimization induces preferential orientation and crystal clustering in serial micro-crystallography on micro-meshes, in situ plates and on a movable crystal conveyor belt
    Soares, Alexei S.; Mullen, Jeffrey D.; Parekh, Ruchi M. ... Journal of synchrotron radiation, November 2014, Volume: 21, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    X‐ray diffraction data were obtained at the National Synchrotron Light Source from insulin and lysozyme crystals that were densely deposited on three types of surfaces suitable for serial ...
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  • Maintaining Microclimates d... Maintaining Microclimates during Nanoliter Chemical Dispensations Using Custom-Designed Source Plate Lids
    Foley, Bryan J; Drozd, Ashley M; Bollard, Mary T ... Journal of laboratory automation 21, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    A method is described for using custom snap-on lids to protect chemicals in microtiter plates from evaporation and contamination. The lids contain apertures (diameter 1.5, 1.0, or 0.5 mm) through ...
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4.
  • Hitting the target: fragmen... Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes
    Yin, Xingyu; Stony Brook University, NY 11794-5215; Nanjing University, Nanjing, Jiangsu ... Acta crystallographica. Section D, Biological crystallography., 05/2014, Volume: 70, Issue: Pt 5
    Journal Article
    Peer reviewed

    A method is presented for screening fragment libraries using acoustic droplet ejection to co-crystallize proteins and chemicals directly on micromeshes with as little as 2.5 nl of each component. ...
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