With the rapid development of optoelectronic fields, electrochromic (EC) materials and devices have received remarkable attention and have shown attractive potential for use in emerging wearable and ...portable electronics, electronic papers/billboards, see-through displays, and other new-generation displays, due to the advantages of low power consumption, easy viewing, flexibility, stretchability, etc. Despite continuous progress in related fields, determining how to make electrochromics truly meet the requirements of mature displays (e.g., ideal overall performance) has been a long-term problem. Therefore, the commercialization of relevant high-quality products is still in its infancy. In this review, we will focus on the progress in emerging EC materials and devices for potential displays, including two mainstream EC display prototypes (segmented displays and pixel displays) and their commercial applications. Among these topics, the related materials/devices, EC performance, construction approaches, and processing techniques are comprehensively disscussed and reviewed. We also outline the current barriers with possible solutions and discuss the future of this field.
This study developed a method for analysis of nineteen quinolone and fluoroquinolone antibiotics (FQs) in sludge samples, and investigated the occurrence and fate of the FQs in a municipal sewage ...treatment plant (STP) with anaerobic, anoxic, and aerobic treatment processes. Eleven compounds, including pipemidic acid, fleroxacin, ofloxacin, norfloxacin, ciprofloxacin, enrofloxacin, lomefloxacin, sparfloxacin, gatifloxacin, moxifloxacin, and sarafloxacin (only in sludge), were detected in the STP. The predominance of ofloxacin and norfloxacin, followed by lomefloxacin, ciprofloxacin, gatifloxacin, and moxifloxacin, were found in wastewater, suspended solids, and sludge. The total concentrations of FQs were 2573 ± 241 ng/L, 1013 ± 218 ng/L, and 18.4 ± 0.9 mg/kg in raw sewage, secondary effluent, and sludge, respectively. Extremely low mass change percentages were observed for FQs in anaerobic, anoxic, and aerobic treatment units, suggesting biodegradation to be of minor importance in the removal of FQs in STPs. 50–87% of the initial FQs loadings (except for pipemidic acid (36%)) were ultimately found in the dewatered sludge. Mean removal efficiencies of FQs in the STP were 56–75%, except for new generation drugs such as moxifloxacin (40 ± 5%) and gatifloxacin (43 ± 13%). A significant positive correlation was found between removal efficiencies and
K
d of FQs. The major factor in the removal of FQs in the STP was sorption to sludge, which was not governed by hydrophobic interactions. The long-term cycling and persistence of FQs in the STP has made activated sludge as a huge reservoir of FQ antibiotics.
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► Simultaneous analytical method was developed for nineteen FQs in sludge. ► 50–87% of the initial FQs loadings were ultimately found in the dewatered sludge. ► Significant positive correlation was found between removal efficiencies and
K
d. ► Sorption to sludge was the major factor for FQs removal.
The present study investigated the anti-virulence and anti-biofilm effects of 1,2,6-tri-O-galloyl-β-ᴅ-glucose (TGG), isolated from Camellia nitidissima Chi flowers, on Proteus penneri ALK 1200.
TGG ...was isolated from C. nitidissima Chi flowers using various chromatographic techniques. The milk plate assay, azocasein assay, and exopolysaccharides (EPS) inhibition assay revealed that TGG effectively inhibited the production of crucial virulence factors, including protease and EPS, in P. penneri ALK 1200. Furthermore, fourier transform infrared spectroscopic (FT-IR) analysis indicated that TGG interfered with the composition of P. penneri ALK 1200's cellular component, potentially reducing the bacteria's pathogenicity. In addition, crystal violet assay, scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM) analysis indicated a significant reduction in biofilm formation following TGG treatment. The swimming and swarming assays also showed that TGG reduced the motility of P. penneri ALK 1200. Furthermore, the qRT-PCR assay demonstrated that TGG down-regulated the expression of positive regulatory genes (hfq and flhD) responsible for motility and biofilm formation, while up-regulating the expression of the negative regulator of the quorum sensing system, bssS, in P. penneri ALK 1200.
TGG displayed potent anti-QS and anti-biofilm activity towards P. penneri ALK 1200.
•A double flow controlled discrete-time two-lane traffic system with vehicle-to-infrastructure communication is proposed.•A stable condition of the traffic system is derived with lyapunov stability ...theorem and given by linear matrix inequality.•The double flow control scheme can suppress traffic congestion efficiently.•The relative flow is more effective than the delayed flow in stabilizing traffic flow.•The control scheme can lower energy consumption of the traffic system.
Through vehicle-to-infrastructure communication, the road-side units could collect traffic information of a selected road section and send the refined traffic information to the vehicles on the road after information processing with edge computing servers. To study the impact of traffic information in different road sections on traffic flow, a double flow controlled two-lane traffic system considering vehicle-to-infrastructure communication is introduced in this paper. The new traffic system is analyzed with Lyapunov stability theorem and a sufficient stable condition is provided in linear matrix inequality. Through simulation, the traffic flow evolution properties and energy consumption rules under different control gains and lane changing parameters are exhibited. The results show that traffic congestion and energy consumption of the two-lane traffic system can be suppressed by taking the delayed flow control information, the relative flow control information, and lane changing effect into account. Also, the role of the control strategy on traffic flow is revealed microscopically through a two-lane car-following model by transforming the macroscopic traffic flow to vehicle's velocity. It further proved the stabilization effect of the control information on traffic flow. This research can provide some theoretical guidance for traffic control through vehicle-to-infrastructure information interaction.
The Pt catalysts supported on hexagonal BN (Pt/BN) are highly active and stable for propane combustion, with the highest specific reaction rate of 92.3 μmol gPt –1 s–1 and turnover frequency of 0.037 ...s–1 obtained on a 0.2Pt/BN catalyst at 220 °C. The Pt oxide in the catalyst could be partially reduced to the metallic state by propane during the reaction, which is beneficial for the improvement of activity, indicating that metallic Pt might be the active sites. The highly dispersed Pt particles stabilized at the grain boundary of BN could be more easily reduced in the reaction than those on the surface and thus are more active. Moreover, kinetic investigation reveals that the apparent activation energy of the Pt species at the grain boundary (111.6 ± 8.0 kJ mol–1) is much lower than that on the surface (172.4 ± 16.5 kJ mol–1), suggesting different reaction pathways on these catalysts and the possible participation of the grain boundary of the BN support in the reaction.
From Camellia nitidissima Chi flowers four undescribed flavonoids, nitidissimol A, nitidissimol B, sexangularetin 3-O-(6''-trans-p-coumarolyglucopyranoside) and sexangularetin ...3-O-(2''-trans-p-coumarolyglucopyranoside) (1-4), and two previously unreported phenolics, nitidissimol C, D (9, 10), were isolated first time along with ten known compounds, kaempferol 3-O-(6''-O-trans-p-coumaroyl)-β-D- glucopyranoside (5), kaempferol-3-O-rhamnoside (6), Quercetin-3'-O-β-D-glucoside (7), kaempferol-7-O-β-D-glucoside (8), erythro-guaiacylglycerol-O-4'-coniferyl ether (11), threo-guaiacylglycerol-O-4'-coniferyl ether (12), protocatechuic acid (13), 1,2-Diethoxybenzene (14), ethyl shikimate (15), 2,4,6-trihydroxybenzoic acid 4-O-allopyranoside (16). The structures of the isolated compounds were elucidated by spectroscopic analysis of 1 D- and 2 D-NMR and MS data. Moreover, all isolated compounds (1-16) were tested for the antibacterial activity against Xanthomonas oryzae pv. oryzae and their quorum sensing inhibitory activity in Pseudomonas aeruginosa PAO1. However, no one showed signifcant inhibition of X. oryzae pv. oryzae (MIC
90
> 0.1 mg/mL), nor did they significantly inhibit the pyocyanin synthesis, which is controlled by quorum sensing in PAO1.
Aeromonas hydrophila, a Gram-negative zoonotic bacterium, causes high mortality in fish farming and immunocompromised patients. This study aimed to extract methyl gallate (MG) from the flowers of ...Camellia nitidissima Chi and evaluate its potential as a quorum sensing inhibitor (QSI) against Aeromonas hydrophila SHAe 115. MG reduced QS-associated virulence factors, including hemolysis, protease, and lipase, while impairing swimming motility and biofilm formation. Additionally, MG down-regulated positive regulatory genes (ahyR, fleQ) and up-regulated negative regulators (litR, fleN). This highlights MG's promise as a potent QSI for A. hydrophila SHAe 115, advancing strategies against infections in aquaculture and human health.
Chromobacterium violaceum
, one free-living Gram-negative bacterium, is abundantly presented in tropics and sub-tropics soil and aquatic environment; it is also an opportunistic human pathogen. Here, ...two cinnamic acid derivatives, i.e., 4-dimethylaminocinnamic acid (DCA) and 4-methoxycinnamic acid (MCA), were identified as potential quorum sensing (QS) and biofilm inhibitors in
C. violaceum
ATCC12472. Both DCA (100 μg/mL) and MCA (200 μg/mL) inhibited the levels of
N-
decanoyl-homoserine lactone (C10-HSL) and reduced the production of certain virulence factors in
C. violaceum
, including violacein, hemolysin, and chitinase. Metabolomics analysis indicated that QS-related metabolites, such as ethanolamine and L-methionine, were down-regulated after treatment with DCA and MCA. Quantitative real-time polymerase chain reaction (qRT-PCR) demonstrated that DCA and MCA markedly suppressed the expression of two QS-related genes (
cviI
and
cviR
). In addition, DCA and MCA also inhibited biofilm formation and enhanced the susceptibility of biofilms to tobramycin, which was evidenced by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Our results indicated that DCA and MCA can serve as QS-based agent for controlling pathogens.
Key Points
•
DCA and MCA inhibited QS and biofilm formation in C. violaceum.
• The combination of DCA or MCA and tobramycin removed the preformed biofilm of C. violaceum.
•
DCA or MCA inhibited virulence factors and expressions of cviI and cviR of C. violaceum.
•
DCA or MCA are potential antibiotic accelerants for treating C. violaceum infection.
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Macrophages, which have various phenotypes and diverse functions, are becoming the target cells in inflammatory diseases. In this study, we evaluated the effects of the natural ...product smiglaside A, a phenylpropanoid glycoside isolated from the traditional Chinese medicinal herb Smilax riparia, on macrophage polarization and investigated the underlying mechanisms. We found that smiglaside A promoted M2 polarization and reduced M1 polarization in LPS-stimulated RAW264.7 cells and primary mouse peritoneal macrophages. Further mechanistic studies showed that the promoting effect of smiglaside A on M2 polarization was attenuated by pharmacological inhibition or gene silencing of AMP-activated protein kinase (AMPK) or peroxisome proliferator-activated receptor γ (PPARγ). Moreover, smiglaside A-enhanced PPARγ activity was prevented by the AMPK inhibitor compound C and by an siRNA. These findings indicate that the AMPK-PPARγ pathway is involved in promotion of M2 macrophages by smiglaside A. In a mouse model of LPS-induced acute lung injury, smiglaside A significantly increased the survival rate of LPS-injected mice and ameliorated the LPS-induced inflammatory response and lung damage. In addition, smiglaside A enhanced the protein expression levels of phosphorylated AMPK and PPARγ in the lung and promoted alveolar macrophages to the M2 phenotype in this mouse model. Taken together, our results indicate that smiglaside A can promote macrophage polarization to an anti-inflammatory M2 phenotype via stimulating the AMPK-PPARγ signaling pathway. Our study may provide novel approaches and/or targets for drug development to treat inflammatory diseases such as acute lung injury and sepsis.
•Food fraud prevention is vital for consumer safety and overall wellness.•Qualitative and quantitative data analysis approaches impact process effectiveness.•FTIR, PCR, and GCMS combined chemometrics ...are the best tools to detect food fraud.•Patents of several countries revealed cutting-edge food fraud detecting systems.•Systematic review will help food scientists develop food fraud abatement systems.
Modern food chain supply management necessitates the dire need for mitigating food fraud and adulterations. This holistic review addresses different advanced detection technologies coupled with chemometrics to identify various types of adulterated foods. The data on research, patent and systematic review analyses (2018–2023) revealed both destructive and non-destructive methods to demarcate a rational approach for food fraud detection in various countries. These intricate hygiene standards and AI-based technology are also summarized for further prospective research. Chemometrics or AI-based techniques for extensive food fraud detection are demanded. A systematic assessment reveals that various methods to detect food fraud involving multiple substances need to be simple, expeditious, precise, cost-effective, eco-friendly and non-intrusive. The scrutiny resulted in 39 relevant experimental data sets answering key questions. However, additional research is necessitated for an affirmative conclusion in food fraud detection system with modern AI and machine learning approaches.
