Tin diselenide (SnSe2) nanosheets as novel 2D layered materials have excellent optical properties with many promising application prospects, such as photoelectric detectors, nonlinear optics, ...infrared photoelectric devices, and ultrafast photonics. Among them, ultrafast photonics has attracted much attention due to its enormous advantages; for instance, extremely fast pulse, strong peak power, and narrow bandwidth. In this work, SnSe2 nanosheets are fabricated by using solvothermal treatment, and the characteristics of SnSe2 are systemically investigated. In addition, the solution of SnSe2 nanosheets is successfully prepared as a fiber‐based saturable absorber by utilizing the evanescent field effect, which can bear a high pump power. 31st‐order subpicosecond harmonic mode locking is generated in an Er‐doped fiber laser, corresponding to the maximum repetition rate of 257.3 MHz and pulse duration of 887 fs. The results show that SnSe2 can be used as an excellent nonlinear photonic device in many fields, such as frequency comb, lasers, photodetectors, etc.
Tin diselenide (SnSe2) nanosheets as novel 2D layered materials have excellent optical properties. SnSe2 nanosheets fabricated by using solvothermal treatment are successfully prepared as fiber‐based saturable absorbers by utilizing the evanescent field effect, which can bear a high pump power. 31st‐order subpicosecond harmonic mode‐locking is generated, corresponding to 257.3 MHz repetition rate.
Tin diselenide (SnSe2) nanosheets as novel 2D layered materials have excellent optical properties. In article number 1902811, Xiao‐Hui Li and co‐workers characterize SnSe2 nanosheets systemically and ...successfully apply SnSe2 nanosheets in an Er‐doped fiber laser to obtain 31th order subpicosecond harmonic mode‐locking, corresponding to a 257.3‐MHz repetition rate.
Tin diselenide (SnSe
) nanosheets as novel 2D layered materials have excellent optical properties with many promising application prospects, such as photoelectric detectors, nonlinear optics, ...infrared photoelectric devices, and ultrafast photonics. Among them, ultrafast photonics has attracted much attention due to its enormous advantages; for instance, extremely fast pulse, strong peak power, and narrow bandwidth. In this work, SnSe
nanosheets are fabricated by using solvothermal treatment, and the characteristics of SnSe
are systemically investigated. In addition, the solution of SnSe
nanosheets is successfully prepared as a fiber-based saturable absorber by utilizing the evanescent field effect, which can bear a high pump power. 31st-order subpicosecond harmonic mode locking is generated in an Er-doped fiber laser, corresponding to the maximum repetition rate of 257.3 MHz and pulse duration of 887 fs. The results show that SnSe
can be used as an excellent nonlinear photonic device in many fields, such as frequency comb, lasers, photodetectors, etc.
Membranous nephropathy （MN） is the most common cause of nephrotic syndrome in adults.The renal biopsy is the gold standard for the disease diagnosis,but is invasive.M-type phospholipase A2 receptor ...（PLA2R） on human podocytes could serve as the target for podocytopathic antibodies （anti-PLA2R）.1 Patients with iMN （70%-80%） were found the circulating antibodies against PLA2R.1 And the podocyte-secreted angiopoietinlike-4 （Angptl4） could be another key role in nephrotic syndrome3.
雷帕霉素对小鼠百草枯中毒导致肺纤维化的治疗作用 Xue SHAO Meng LI Chong LUO Ying-ying WANG Ying-ying LU Shi FENG Heng LI Xia-bing LANG Yu-cheng WANG Chuan LIN Xiu-jin SHEN Qin ZHOU Hong JIANG Jiang-hua CHE
浙江大学学报：B卷英文版,
2015, Volume:
16, Issue:
1
Journal Article
► P70S6K1 regulates VEGF expression; ► P70S6K1 induces transcriptional activation through HIF-1α binding site; ► P70S6K1 regulates HIF-1α, but not HIF-1β protein expression; ► P70S6K1 mediates tumor ...growth and angiogenesis through HIF-1α and VEGF expression.
The 70
kDa ribosomal S6 kinase 1 (p70S6K1), a downstream target of phosphoinositide 3-kinase (PI3K) and ERK mitogen-activated protein kinase (MAPK), is an important regulator of cell cycle progression, and cell proliferation. Recent studies indicated an important role of p70S6K1 in PTEN-negative and AKT-overexpressing tumors. However, the mechanism of p70S6K1 in tumor angiogenesis remains to be elucidated. In this study, we specifically inhibited p70S6K1 activity in ovarian cancer cells using vector-based small interfering RNA (siRNA) against p70S6K1. We found that knockdown of p70S6K1 significantly decreased VEGF protein expression and VEGF transcriptional activation through the HIF-1α binding site at its enhancer region. The expression of p70S6K1 siRNA specifically inhibited HIF-1α, but not HIF-1β protein expression. We also found that p70S6K1 down-regulation inhibited ovarian tumor growth and angiogenesis, and decreased cell proliferation and levels of VEGF and HIF-1α expression in tumor tissues. Our results suggest that p70S6K1 is required for tumor growth and angiogenesis through HIF-1α and VEGF expression, providing a molecular mechanism of human ovarian cancer mediated by p70S6K1 signaling.
To investigate the effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine (IPV).
Sabin IPV samples containing 5 mg or 7 mg 2-phenoxyethanol each dosage respectively were ...placed separately at 4 degrees C, 37 degrees C for 2 days and 7 days. D-antigen contents were tested with ELISA method. Then neutralizing antibodies in mice and guinea pigs were detected. The safety experiment was performed according to unusual toxicity test of China requirement for biological product.
After addition of 2-phenoxyethanol, the I, II, and III D-antigen contents of Sabin IPV did not change. The antibody levels in mice and guinea pigs were not different between experimental group and control group. Animals were safe during observation period.
2-Phenoxyethanol had no effect on potency and safety of Sabin IPV. It can be used as antiseptic for Sabin IPV.
microRNA-199a (miR-199a) is a highly conserved miRNA, always deregulated in numerous human tumors. The results of microarray analysis indicated that miR-199a was frequently downregulated in ...hepatocellular carcinoma (HCC). The expression levels of miR-199a in 11 pairs of matched HCC neoplastic and adjacent non-neoplastic tissues, 5 HCC cell lines and liver cell line L02 were examined by quantitative real-time PCR analysis. We found miR-199a was significantly down-regulated in HCC tissues when compared with pair-matched adjacent non-tumor tissues. We also found the expression level of miR-199a was also substantially decreased in several human HCC cell lines including SMMC-7721, BEL-7402, BEL-7701, MHCC97H, and HepG2. To investigate the role of miR-199a in tumorigenesis, we developed a lentiviral vector for the expression of pre-miR-199a (Lenti-miR-199a). Lenti-miR-199a inhibited HCC cell proliferation in vitro and in vivo. Compared to parental cells or cells transfected with a control vector, the overexpression of microRNA-199a in the HCC cell lines HepG2 stably was showed to reduce cell proliferation in vitro and in vivo. Luciferase reporter assay revealed the regulation of miR-199a on 3’-UTR of HIF-1α. Further investigation confirmed that miR-199a significantly reduced the endogenous protein level of HIF-1α in hypoxia. MiR-199a inhibits cell proliferation in vitro and in vivo partly through down-regulation of HIF-1α in human HCC. Thus, these studies provide an important new insight into the pathogenesis of human HCC and it may open a new perspective for the development of effective gene therapy for human HCC.
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