•Intergenerational relationship and family social support were negatively correlated with an elderly's depression level.•Elderly who enjoyed a positive intergenerational relationship with their ...children would experience adequate family social support, which would predict few depression symptoms.
This study aimed to investigate the association among intergenerational relationship, family social support, and elderly's depression symptoms.
Data were obtained from China Longitudinal Aging Social Survey (CLASS) 2014, which is a continuous large-scale national social survey project conducted by the National Survey Research Center at Renmin University of China. Stratified multi-stage probability sampling method was used to collect the sample (N = 11,511). Structural equation modeling was adopted to analyze the association among intergenerational relationship, family social support, and elderly's depression.
Intergenerational relationship and family social support were negatively correlated with an elderly's depression level. Elderly who enjoyed positive intergenerational relationships with their children would experience adequate family social support and likely have few depression symptoms.
Intergenerational relationship directly affected the elderly's depression level. Family social support played a mediating role between intergenerational relationship and depression. Our findings could contribute to current theories and knowledge and provide implications in social policy, pension service, and social work intervention for the elderly in China.
Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular ...calcification often occurs with osteoporosis, a contradictory association called "calcification paradox". Here we show that extracellular vesicles derived from aged bone matrix (AB-EVs) during bone resorption favor BMSC adipogenesis rather than osteogenesis and augment calcification of vascular smooth muscle cells. Intravenous or intramedullary injection of AB-EVs promotes bone-fat imbalance and exacerbates Vitamin D3 (VD3)-induced vascular calcification in young or old mice. Alendronate (ALE), a bone resorption inhibitor, down-regulates AB-EVs release and attenuates aging- and ovariectomy-induced bone-fat imbalance. In the VD3-treated aged mice, ALE suppresses the ovariectomy-induced aggravation of vascular calcification. MiR-483-5p and miR-2861 are enriched in AB-EVs and essential for the AB-EVs-induced bone-fat imbalance and exacerbation of vascular calcification. Our study uncovers the role of AB-EVs as a messenger for calcification paradox by transferring miR-483-5p and miR-2861.
Previous studies have suggested that gut microbiota plays a critical role in colorectal cancer (CRC). Although preliminary comparisons of the oral and gut microbiota between CRC and healthy control ...(HC) patients have been made, the association between microbiome abundance and host clinical factors has not been fully illustrated, especially oral health conditions. Matching samples of unstimulated saliva, cancer tissues or biopsies and stools were collected from 30 CRC and 30 HC patients from Shanghai Jiao Tong University affiliated Renji Hospital for 16S rRNA sequencing analysis. The diversity in salivary and mucosal microbiome, but not stool microbiome of CRC group, was significantly different from that of HC, as demonstrated by the Principal Component Analysis. Logistic regression analysis revealed that older age and higher oral hygiene index (OHI) were independent risk factors for CRC, with odds ratios and 95% confidence intervals of 1.159 (1.045‐1.284) and 4.398 (1.328‐14.567), respectively. Salivary Firmicutes to Bacteroides ratio in CRC was significantly higher than that in the HC group (P < .001), while the mucosal ratio was slightly decreased in CRC (P < .05). Salivary Rothia and Streptococcus levels were positively correlated with OHI, while Alloprevotella, Fusobacterium, Peptostreptoccus and Prevotella genera levels were negatively associated with OHI. NetShift analysis revealed that salivary Peptococcus, Centipeda and mucosal Subdoligranulum genus might act as key drivers during the process of carcinogenesis. In conclusion, the current study provides insights into the potential influence of host clinical factors on oral and gut microbiome composition and can be a guide for future studies.
What's new?
The oral microbiota has been reported to play a critical role in the pathogenesis of colorectal cancer and may provide diagnostic biomarkers. However, oral health status, which might impact the composition of the oral microbiome, is also important to consider. Here, by integrating 16S rRNA sequencing, face‐to‐face questionnaires, and bioinformatics analysis, the authors systematically compared the oral and gut microbiota of colorectal cancer patients with healthy controls. In addition, they analysed the associations between several hosts' clinical parameters and the 50 most abundant oral and gut genera, providing potential diagnostic and therapeutic targets for colorectal cancer.
A-to-I RNA editing and m6A modification are two of the most prevalent types of RNA modifications controlling gene expression in mammals and play very important roles in tumorigenesis and tumor ...progression. However, the functional roles and correlations of these two RNA modifications remain to be further investigated in cancer. Herein, we show that ADAR1, an A-to-I RNA-editing enzyme, interacts with METTL3 and increases its protein level to promote the proliferation, migration and invasion of breast cancer cells through a mechanism connecting ADAR1, METTL3 and YTHDF1. We show that both ADAR1 and METTL3 are upregulated in breast cancer samples, and ADAR1 positively correlates with METTL3; ADAR1 edits METTL3 mRNA and changes its binding site to miR532-5p, leading to increased METTL3 protein, which further targets ARHGAP5, recognized by YTHDF1. Additionally, we show that loss of ADAR1 significantly inhibits breast cancer growth in vivo. Collectively, our findings identify the ADAR1–METTL3 axis as a novel, important pathway that connects A-to-I editing and m6A RNA modifications during breast cancer progression.
Background
Native T1 and radiomics were used for hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) differentiation previously. The current problem is that global native T1 ...remains modest discrimination performance and radiomics requires feature extraction beforehand. Deep learning (DL) is a promising technique in differential diagnosis. However, its feasibility for discriminating HCM and HHD has not been investigated.
Purpose
To examine the feasibility of DL in differentiating HCM and HHD based on T1 images and compare its diagnostic performance with other methods.
Study Type
Retrospective.
Population
128 HCM patients (men, 75; age, 50 years ± 16) and 59 HHD patients (men, 40; age, 45 years ± 17).
Field Strength/Sequence
3.0T; Balanced steady‐state free precession, phase‐sensitive inversion recovery (PSIR) and multislice native T1 mapping.
Assessment
Compare HCM and HHD patients baseline data. Myocardial T1 values were extracted from native T1 images. Radiomics was implemented through feature extraction and Extra Trees Classifier. The DL network is ResNet32. Different input including myocardial ring (DL‐myo), myocardial ring bounding box (DL‐box) and the surrounding tissue without myocardial ring (DL‐nomyo) were tested. We evaluate diagnostic performance through AUC of ROC curve.
Statistical Tests
Accuracy, sensitivity, specificity, ROC, and AUC were calculated. Independent t test, Mann–Whitney U‐test and Chi‐square test were adopted for HCM and HHD comparison. P < 0.05 was considered statistically significant.
Results
DL‐myo, DL‐box, and DL‐nomyo models showed an AUC (95% confidential interval) of 0.830 (0.702–0.959), 0.766 (0.617–0.915), 0.795 (0.654–0.936) in the testing set. AUC of native T1 and radiomics were 0.545 (0.352–0.738) and 0.800 (0.655–0.944) in the testing set.
Data Conclusion
The DL method based on T1 mapping seems capable of discriminating HCM and HHD. Considering diagnostic performance, the DL network outperformed the native T1 method. Compared with radiomics, DL won an advantage for its high specificity and automated working mode.
Level of Evidence
4
Technical Efficacy Stage
2
Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases. This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or RNA, into the ...cell. Because of their negative charge and considerable larger size, the delivery of these molecules, in general, should be mediated by gene vectors. Non-viral vectors, as promising delivery systems, have received considerable attention due to their low cytotoxicity and non-immunogenicity. As research continued, more and more functional non-viral vectors have emerged. They not only have the ability to deliver a gene into the cells but also have other functions, such as the performance of fluorescence imaging, which aids in monitoring their progress, targeted delivery, and biodegradation. Recently, many reviews related to non-viral vectors, such as polymers and cationic lipids, have been reported. However, there are few reviews regarding functional non-viral vectors. This review summarizes the common functional non-viral vectors developed in the last ten years and their potential applications in the future. The transfection efficiency and the transport mechanism of these materials were also discussed in detail. We hope that this review can help researchers design more new high-efficiency and low-toxicity multifunctional non-viral vectors, and further accelerate the progress of gene therapy.
The study of tactical missile weapon systems, particularly their operational efficiency, is increasingly important in modern warfare. These systems are crucial for accurately striking targets and ...achieving air superiority. The effectiveness evaluation of such missile systems provides a quantitative foundation for both upgrading existing weapons and setting performance benchmarks in combat exercises. This particular topic focuses on the evaluation of tactical missile weapon systems using energy big data. A comprehensive index system is utilized to conduct this evaluation, incorporating methods like fuzzy comprehensive evaluation and analytic hierarchy process. These methods enable both qualitative and quantitative analysis of the capability matrix in the ADC (Aim, Deploy, and Conclude) model. The main objective is to ensure the correctness and effectiveness of the evaluation model. An example analysis is conducted to verify the model’s validity. The results from this analysis indicate a high degree of accuracy in the model’s predictions. The disparity between the actual and expected output results is minimal, with a relative error within 4%. Furthermore, the combat effectiveness grade determined by the model aligns with the actual grade observed, confirming the model’s capability to effectively evaluate the combat effectiveness of surface-to-air missile weapon systems. This research is significant as it provides a reliable and accurate method for assessing the effectiveness of tactical missile systems. Such evaluations are vital for informed decision-making in military strategy and weapon system development. Using energy big data in this context represents a novel approach, reflecting the increasing integration of advanced data analytics in military technology assessments.
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•Unique NiCo2O4 nanofeathers Derived from Prussian Blue Analogues are fabricated.•The NF@NiCo2O4 nanofeathers//AC device exhibits an energy density of 53.9 Wh kg−1.•The ...hybrid-dimensional nanofeathers are composed of 1D nanonnedles and 2D nanosheets.•NiCo2O4 nanofeathers are consisted of ultrasmall secondary particles, implying more active sites.
Tuning the morphology and structure at nanoscale has become essential for the advancement of electrode materials. Here, the unique nanofeather arrays composing of 1D nanoneedles and 2D nanosheets are fabricated on nickle foam (NF) through a novel prussian blue analogues (PBA)-in-hydrothermal strategy with Ni-Co PBA as the precursor and template. Then the porous NiCo2O4 nanofeather arrays are formed after calcination, which are consisted of ultrasmall secondary nanoparticles with an average diameter of 3 nm, hence providing high porosity and rich active sites. Benefiting from the synergistic effect of NiCo2O4 1D nanoneedles and 2D nanosheets, the NF@NiCo2O4 nanofeathers electrode exhibits a high specific capacitance of 1797F g−1 at 1 A g−1 and superior rate capability with 85.7% capacitance retention (from 1 A g−1 to 20 A g−1). Furthermore, a high energy density of 53.9 Wh kg−1 at 801 W kg−1, a high power density of 16 kW kg−1 at 39.2 Wh kg−1 and an outstanding cycling stability of 81.5% capacitance retention at 20 A g−1 after 10,000 cycles are achieved in the assembled NF@NiCo2O4 nanofeathers//AC device. More importantly, this work provides an attractive strategy to combine PBA and classical hydrothermal process, as well as offers a new insight into the design of advanced energy materials.
An artificial while very stable solid electrolyte interphase film is formed on lithium metal using an electrochemical strategy. When this protected Li anode is first used in a Li–O2 battery, the film ...formed on the anode can effectively suppress the parasitic reactions on the Li anode/electrolyte interface and significantly enhance the cycling stability of the Li–O2 battery.
We study a single-photon band structure in a one-dimensional coupled-resonator optical waveguide that chirally couples to an array of two-level quantum emitters (QEs). The chiral interaction between ...the resonator mode and the QE can break the time-reversal symmetry without the magneto-optical effect and an external or synthetic magnetic field. As a result, nonreciprocal single-photon edge states, band gaps, and flat bands appear. By using such a chiral QE coupled-resonator optical waveguide system, including a finite number of unit cells and working in the nonreciprocal band gap, we achieve frequency-multiplexed single-photon circulators with high fidelity and low insertion loss. The chiral QE-light interaction can also protect one-way propagation of single photons against backscattering. Our work opens a new door for studying unconventional photonic band structures without electronic counterparts in condensed matter and exploring its applications in the quantum regime.
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