Efficient building energy management is essential for energy saving and green society. This paper investigates sustainable energy management for an energy building cluster with distributed ...transaction. The building cluster consists of several types of energy buildings, e.g., office, industrial, and commercial buildings. We first formulate utility functions for the buildings of consuming energy based on the characteristics of their controllable loads. Then a two-stage energy sharing strategy is presented. In the first stage, the total social energy cost is minimized through finding the optimal energy sharing profiles in a distributed way. In the second stage, the clearing for mutual energy sharing is modeled as a non-cooperative game, and the existence of the equilibrium of the game is illustrated and a relaxation-based algorithm is introduced to search for the equilibrium. Moreover, a real-time model for each building to overcome real-time uncertainties, such as renewable energy generation and base loads is provided. The simulation results show that the proposed energy sharing strategy is economically beneficial for the energy buildings, computationally efficient, and is promising to facilitate a sustainable regional building cluster.
ConspectusHydrogen is an ideal energy carrier and plays a critical role in the future energy transition. Distinct from steam reforming, electrochemical water splitting, especially powered by ...renewables, has been considered as a promising technique for scalable production of high-purity hydrogen with no carbon emission. Its commercialization relies on the reduction of electricity consumption and thus hydrogen cost, calling for highly efficient and cost-effective electrocatalysts with the capability of steadily working at high hydrogen output. This requires the electrocatalysts to feature (1) highly active intrinsic sites, (2) abundant accessible active sites, (3) effective electron and mass transfer, (4) high chemical and structural durability, and (5) low-cost and scalable synthesis. It should be noted that all these requirements should be fulfilled together for a practicable electrocatalyst. Much effort has been devoted to addressing one or a few aspects, especially improving the electrocatalytic activity by electronic modulation of active sites, while few reviews have focused on the synergistic modulation of these aspects together although it is essential for advanced electrochemical water splitting.In this Account, we will present recent innovative strategies with an emphasis on our solutions for synergistically modulating intrinsic active sites, electron transportation, mass transfer, and gas evolution, as well as mechanical and chemical durability, of non-precious-metal electrocatalysts, aiming for cost-effective and highly efficient water splitting. The following approaches for coupling these aspects are summarized for both cathodic hydrogen evolution reaction (HER) and anodic oxygen evolution reaction (OER). (1)
. The electronic structure of a catalytic site determines the adsorption/desorption of reactive intermediates and thus intrinsic activity. It can be tuned by heterogeneous doping, strain effect, spin polarization, etc. Coupling these effects to optimize the reaction pathways or target simultaneously the activity and stability would advance electrocatalytic performance. (2)
. The crystallinity, crystalline phase, crystalline facets, crystalline defects, etc. affect both activity and stability. Coupling these effects with electronic modulation would enhance the activity together with stability. (3)
. It will focus on concurrently modulating electronic structure for improving the intrinsic activity and morphology for increasing accessible active sites, especially through single action or processing. The mass transfer and gas evolution properties can also be enhanced by morphological modulation to enable water splitting at large output. (4)
. Electrocatalytic reaction generally consists of a couple of elementary reactions. Each one may need a specific active site. Designing and combining various components targeting every elementary step on a space-limited catalyst surface will balance the intermediates and these steps for accelerating the overall reaction. (5)
Taking all these strategies together into account is necessary to integrate all above essential features into one electrocatalyst for enabling high-output water electrolysis. Beyond the progress made to date, the remaining challenges and opportunities is also discussed. With these insights, hopefully, this Account will shed light on the rational design of practical water-splitting electrocatalysts for the cost-effective and scalable production of hydrogen.
Background
Molecular subtyping of triple‐negative breast cancers (TNBCs) via gene expression profiling is essential for understanding the molecular essence of this heterogeneous disease and for ...guiding individualized treatment. We aim to devise a clinically practical method based on immunohistochemistry (IHC) for the molecular subtyping of TNBCs.
Materials and Methods
By analyzing the RNA sequencing data on TNBCs from Fudan University Shanghai Cancer Center (FUSCC) (n = 360) and The Cancer Genome Atlas data set (n = 158), we determined markers that can identify specific molecular subtypes. We performed immunohistochemical staining on tumor sections of 210 TNBCs from FUSCC, established an IHC‐based classifier, and applied it to another two cohorts (n = 183 and 214).
Results
We selected androgen receptor (AR), CD8, FOXC1, and DCLK1 as immunohistochemical markers and classified TNBCs into five subtypes based on the staining results: (a) IHC‐based luminal androgen receptor (IHC‐LAR; AR‐positive +), (b) IHC‐based immunomodulatory (IHC‐IM; AR‐negative −, CD8+), (c) IHC‐based basal‐like immune‐suppressed (IHC‐BLIS; AR−, CD8−, FOXC1+), (d) IHC‐based mesenchymal (IHC‐MES; AR−, CD8−, FOXC1−, DCLK1+), and (e) IHC‐based unclassifiable (AR−, CD8−, FOXC1−, DCLK1−). The κ statistic indicated substantial agreement between the IHC‐based classification and mRNA‐based classification. Multivariate survival analysis suggested that our IHC‐based classification was an independent prognostic factor for relapse‐free survival. Transcriptomic data and pathological observations implied potential treatment strategies for different subtypes. The IHC‐LAR subtype showed relative activation of HER2 pathway. The IHC‐IM subtype tended to exhibit an immune‐inflamed phenotype characterized by the infiltration of CD8+ T cells into tumor parenchyma. The IHC‐BLIS subtype showed high expression of a VEGF signature. The IHC‐MES subtype displayed activation of JAK/STAT3 signaling pathway.
Conclusion
We developed an IHC‐based approach to classify TNBCs into molecular subtypes. This IHC‐based classification can provide additional information for prognostic evaluation. It allows for subgrouping of TNBC patients in clinical trials and evaluating the efficacy of targeted therapies within certain subtypes.
Implications for Practice
An immunohistochemistry (IHC)‐based classification approach was developed for triple‐negative breast cancer (TNBC), which exhibited substantial agreement with the mRNA expression‐based classification. This IHC‐based classification (a) allows for subgrouping of TNBC patients in large clinical trials and evaluating the efficacy of targeted therapies within certain subtypes, (b) will contribute to the practical application of subtype‐specific treatment for patients with TNBC, and (c) can provide additional information beyond traditional prognostic factors in relapse prediction.
This article describes an immunohistochemistry‐based approach to classification of triple‐negative breast cancers into molecular subtypes for purposes of the translation of TNBC molecular classification into clinical practice.
With the rapid development of energy buildings, advanced energy management is urgently demanded for a green society. In this paper, focusing on the coordinated energy management for a building ...community, we present a new and fair peer-to-peer energy sharing framework to realize an economic and sustainable building community. Specifically, in the building-centric peer-to-peer mode, buildings directly share their energy supplies/demands and offer the related payments within the community under the constraints of community energy and payment balance. We propose a non-cooperative energy sharing game for the selfish buildings, and we further show that a generalized Nash equilibrium of the game is independent of the energy sharing payments. Consequently, we firstly derive the energy sharing profiles by seeking the equilibrium. Since the buildings' energy sharing payments are mutually coupled and influenced, we propose a cost reduction ratio distribution model to determine the payments to ensure the fairness in the sense that buildings can get as large cost reductions and similar cost reduction ratios as possible. Simulation results show that all buildings can reduce their energy costs and have smoother and smaller net demand profiles on the main grid, thus making the proposed schemes and algorithms promising in real applications.
Practical electrochemical water splitting requires cost‐effective electrodes capable of steadily working at high output, leading to the challenges for efficient and stable electrodes for the oxygen ...evolution reaction (OER). Herein, by simply using conductive FeS microsheet arrays vertically pre‐grown on iron foam (FeS/IF) as both substrate and source to in situ form vertically aligned NiFe(OH)x nanosheets arrays, a hierarchical electrode with a nano/micro sheet‐on‐sheet structure (NiFe(OH)x/FeS/IF) can be readily achieved to meet the requirements. Such hierarchical electrode architecture with a superhydrophilic surface also allows for prompt gas release even at high output. As a result, NiFe(OH)x/FeS/IF exhibits superior OER activity with an overpotential of 245 mV at 50 mA cm−2 and can steadily output 1000 mA cm−2 at a low overpotential of 332 mV. The water‐alkali electrolyzer using NiFe(OH)x/FeS/IF as the anode can deliver 10 mA cm−2 at 1.50 V and steadily operate at 300 mA cm−2 with a small cell voltage for 70 h. Furthermore, a solar‐driven electrolyzer using the developed electrode demonstrates an exceptionally high solar‐to‐hydrogen efficiency of 18.6%. Such performance together with low‐cost Fe‐based materials and facile mass production suggest the present strategy may open up opportunities for rationally designing hierarchical electrocatalysts for practical water splitting or diverse applications.
A 3D hierarchical NiFe(OH)x/FeS/IF electrode with a nano/micro sheet‐on‐sheet structure exhibits superior oxygen evolution reaction activity and durability with a low overpotential of 261 mV at 100 mA cm−2 and 332 mV at 1000 mA cm−2. The water‐alkali electrolyzer, using it as an anode, achieves stable overall water splitting at 300 mA cm−2 with a small cell voltage.
Single‐atom catalysts (SACs) have been at the frontier of research field in catalysis owing to the maximized atomic utilization, unique structures and properties. The atomically dispersed and ...catalytically active metal atoms are necessarily anchored by surrounding atoms. As such, the structure and composition of anchoring sites significantly influence the catalytic performance of SACs even with the same metal element. Significant progress has been made to understand structure–activity relationships at an atomic level, but in‐depth understanding in precisely designing highly efficient SACs for the targeted reactions is still required. In this review, various anchoring sites in SACs are summarized and classified into five different types (doped heteroatoms, defect sites, surface atoms, metal sites, and cavity sites). Then, their impacts on catalytic performance are elucidated for electrochemical reactions based on their distance from the metal center (first coordination shell and beyond). Further, SACs anchored on two typical types of hosts, carbon‐ and metal‐based materials, are highlighted, and the effects of anchoring points on achieving the desirable atomic structure, catalytic performance, and reaction pathways are elaborated. At last, insights and outlook to the SAC field based on current achievements and challenges are presented.
Single‐atom catalysts (SACs) with isolated metal atoms stabilized on various supports by surrounding atoms have emerged as a new frontier. The atomic structure and composition of anchoring sites significantly influence the catalytic performance of SACs. An overview of the correlation between the property of anchoring points and catalytic performance to guide the design of SACs is provided.
This paper studies the synchronization problem of coupled delayed multistable neural networks (NNs) with directed topology. To begin with, several sufficient conditions are developed in terms of ...algebraic inequalities such that every subnetwork has multiple locally exponentially stable periodic orbits or equilibrium points. Then two new concepts named dynamical multisynchronization (DMS) and static multisynchronization (SMS) are introduced to describe the two novel kinds of synchronization manifolds. Using the impulsive control strategy and the Razumikhin-type technique, some sufficient conditions for both the DMS and the SMS of the controlled coupled delayed multistable NNs with fixed and switching topologies are derived, respectively. Simulation examples are presented to illustrate the effectiveness of the proposed results.
Photothermal therapy (PTT) usually requires hyperthermia >50 °C for effective tumor ablation, which inevitably induces heating damage to the surrounding normal tissues/organs. Moreover, low tumor ...retention and high liver accumulation are the two main obstacles that significantly limit the efficacy and safety of many nanomedicines. To solve these problems, a smart albumin‐based tumor microenvironment‐responsive nanoagent is designed via the self‐assembly of human serum albumin (HSA), dc‐IR825 (a cyanine dye and a photothermal agent), and gambogic acid (GA, a heat shock protein 90 (HSP90) inhibitor and an anticancer agent) to realize molecular targeting‐mediated mild‐temperature PTT. The formed HSA/dc‐IR825/GA nanoparticles (NPs) can escape from mitochondria to the cytosol through mitochondrial disruption under near‐infrared (NIR) laser irradiation. Moreover, the GA molecules block the hyperthermia‐induced overexpression of HSP90, achieving the reduced thermoresistance of tumor cells and effective PTT at a mild temperature (<45 °C). Furthermore, HSA/dc‐IR825/GA NPs show pH‐responsive charge reversal, effective tumor accumulation, and negligible liver deposition, ultimately facilitating synergistic mild‐temperature PTT and chemotherapy. Taken together, the NIR‐activated NPs allow the release of molecular drugs more precisely, ablate tumors more effectively, and inhibit cancer metastasis more persistently, which will advance the development of novel mild‐temperature PTT‐based combination strategies.
A smart albumin‐based theranostic nanoagent composed of human serum albumin, dc‐IR825 (a cyanine dye and a photothermal agent), and gambogic acid (an HSP90 inhibitor and an effective anticancer drug) is fabricated, which can achieve the synergistic molecular targeting‐mediated mild‐temperature photothermal therapy and chemotherapy of cancer.
Developing low‐cost, highly efficient, and durable electrocatalysts for oxygen evolution reaction (OER) is essential for the practical application of electrochemical water splitting. Herein, it is ...discovered that organic small molecule (hexabromobenzene, HBB) can activate commercial transition metal (Ni, Fe, and NiFe) foam by directly evolving metal nanomeshes embedded in graphene‐like films (M‐NM@G) through a facile Br‐induced solid‐phase migration process. Systematic investigations indicate that HBB can conformally generate graphene‐like network on bulk metal foam substrate via the cleavage of CBr bonds and the formation of CC linkage. Simultaneously, the cleaved CBr fragments can efficiently extract metal atoms from bulk substrate, in situ producing transition metal nanomeshes embedded in the graphene‐like films. As a result, such functional nanostructure can serve as an efficient OER electrocatalyst with a low overpotential and excellent long‐term stability. Specifically, the overpotential at 100 mA cm−2 is only 208 mV for NiFe‐NM@G, ranking the top‐tier OER electrocatalysts. This work demonstrates an intriguing general strategy for directly transforming bulk transition metals into nanostructured functional electrocatalysts via the interaction with organic small molecules, opening up opportunities for bridging the application of organic small molecules in energy technologies.
Transition metal nanomeshes embedded in graphene‐like film (M‐NM@G) are achieved via a newly developed Br‐induced solid‐phase migration method enabled by directly treating commercial transition metal foam with organic small molecules. NiFe‐NM@G exhibits excellent oxygen evolution reaction performance with a low overpotential of 208 mV at a current density of 100 mA cm−2, as well as excellent long‐term stability.
Highly efficient and stable bifunctional electrocatalysts for oxygen reduction and evolution are essential for aqueous rechargeable Zn–air batteries, which require highly active sites as well as ...delicate structural design for increasing effective active sites and facilitating mass/electron transfer. Herein, a scalable and facile self‐catalyzed growth strategy is developed to integrate highly active Co–N–C sites with 3D brush‐like nanostructure, achieving Co–N–C nanobrushes with Co,N‐codoped carbon nanotube branches grown on Co,N‐codoped nanoparticle assembled nanowire backbones. Systematic investigations suggest that nanobrushes deliver significantly improved electrocatalytic activity compared with nanowire or nanotube counterparts and the longer nanotube branches give the better performance. Benefiting from the increase of accessible highly active sites and enhanced mass transfer and electron transportation, the present Co–N–C nanobrush exhibits superior electrocatalytic activity and durability when used as a bifunctional oxygen catalyst. It enables a rechargeable Zn–air battery with a high peak power density of 246 mW cm−2 and excellent cycling stability. These results suggest that the reported synthetic strategy may open up possibilities for exploring efficient electrocatalysts for diverse applications.
3D hierarchical Co–N–C brush‐like nanostructure is fabricated through a self‐catalyzed chemical vapor deposition, which enables a rechargeable Zn–air batteries a high peak power density of 246 mW cm−2 and excellent cycling stability. The strategy can also be easily extended to prepare Fe‐based M–N–C nanobrush analogs.
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