We analyse the main physical parameters and the circumstellar environment of the young Herbig Be star HD 98922. We present AMBER/VLTI high spectral resolution (R =12000) interferometric observations ...across the Br\(\gamma\) line, accompanied by UVES high-resolution spectroscopy and SINFONI-AO assisted near-infrared integral field spectroscopic data. To interpret our observations, we develop a magneto-centrifugally driven disc-wind model. Our analysis of the UVES spectrum shows that HD 98922 is a young (~5x10^5 yr) Herbig Be star (SpT=B9V), located at a distance of 440(+60-50) pc, with a mass accretion rate of ~9+/-3x10^(-7) M_sun yr^(-1). SINFONI K-band AO-assisted imaging shows a spatially resolved circumstellar disc-like region (~140 AU in diameter) with asymmetric brightness distribution. Our AMBER/VLTI UT observations indicate that the Br\(\gamma\) emitting region (radius ~0.31+/-0.04 AU) is smaller than the continuum emitting region (inner dust radius ~0.7+/-0.2 AU), showing significant non-zero V-shaped differential phases (i.e. non S-shaped, as expected for a rotating disc). The value of the continuum-corrected pure Br\(\gamma\) line visibility at the longest baseline (89 m) is ~0.8+/-0.1, i.e. the Br\(\gamma\) emitting region is partially resolved. Our modelling suggests that the observed Br\(\gamma\) line-emitting region mainly originates from a disc wind with a half opening angle of 30deg, and with a mass-loss rate of ~2x10(-7) M_sun yr^(-1). The observed V-shaped differential phases are reliably reproduced by combining a simple asymmetric continuum disc model with our Br\(\gamma\) disc-wind model. The Br\(\gamma\) emission of HD 98922 can be modelled with a disc wind that is able to approximately reproduce all interferometric observations if we assume that the intensity distribution of the dust continuum disc is asymmetric.
Cell-free extracts of the obligate methanol-utilizing bacterium Pseudomonas W6 catalyze the oxydation of isocitrate to alpha-ketoglutarate in the presence of NAD+ and NADP+. After electro-focusing of ...the crude extract of Pseudomonas W6 actually two distinct bands each of NAD+-linked isocitrate dehydrogenase (NAD+-IDH) and of NADP+-linked isocitrate dehydrogenase (NADP+-IDH) could be observed. The NAD+-IDH was completely separated from the NADP+-IDH by employing DEAE ion exchange chromatography and further purified by affinity chromatography using Cibacron blue F 3G-A. The NAD+-IDH was inhibited by a high energy charge, whereas the NADP+-IDH was found to be independent of energy charge. Consequently the NAD+-IDH showed the control behaviour of an enzyme of an energy-generating sequence which, however, equally fulfils a catabolic and an anabolic function. With respect to the inhibition by reduced pyridine nucleotides and alpha-ketoglutarate differences between NAD+-IDH and NADP+-IDH were also found. Only the NADP+-linked enzyme exhibited a feedback inhibition by its reaction products alpha-ketoglutarate and NADPH. This control behaviour gives evidence for the biosynthetic function of the NADP+-IDH. These results confer an amphibolic character to the sequence from citrate to alpha-ketoglutarate in the incomplete citric-acid cycle of Pseudomonas W6.
Since prostaglandin (PG) F2 alpha had been shown to act anti-arrhythmically in various animal models and also in preliminary investigations in man, further evaluation of this effect was made in 30 ...patients with cardiac extrasystoles and in 2 patients with tachycardias. PGF2 alpha was infused intravenously at individually adapted consecutive rates from 5 to 100 micrograms/min each for at least 5 min. In the incidence of extrasystoles a mean maximum decrease of 41% (P less than 0.001) was obtained. One patient showed repeated short interruptions of a ventricular tachycardia. A dose-dependent significant rise in blood pressure and no significant influences on heart rate, PQ interval and QRS interval of the ECG were found. It is concluded that PGF2 alpha has probably no practical importance for the therapy of cardiac arrhythmias.
The effects on cerebral function of premedication with the benzodiazepine flunitrazepam and with morphine were studied on the evening of the preoperative day (2 mg flunitrazepam p.o.) and 90 minutes ...before induction of anaesthesia (2 mg flunitrazepam plus 15 mg morphine i.m.).
The EEG was analysed topographically (17 electrodes) and quantitatively.
As a typical effect of benzodiazepines, increases in electrical activity in the frequency band beta-1 of the power spectrum were observed, and could be demonstrated 10 minutes after oral application, mainly in the frontal and central parts of the cortex. Increases in the powerbands delta and theta indicated induction of sleep approximately 15-20 minutes after application and were not looked upon as an effect of the benzodiazepine exclusively. These increases were noticed first in the central, occipital and temporal areas and after 30 minutes in the frontal parts of the cortex. Flunitrazepam plus morphine showed qualitatively similar but quantitatively less pronounced results. Topographical differences were similar to the results of an application of flunitrazepam alone.
The results demonstrate the importance of a topographical as well as quantitative evaluation in studies on complex interactions of sedative or narcotic drugs and their clinical effects on cerebral function.
In this article, we analyze the impacts of climate change on Antarctic marine ecosystems. Observations demonstrate large-scale changes in the physical variables and circulation of the Southern Ocean ...driven by warming, stratospheric ozone depletion, and a positive Southern Annular Mode. Alterations in the physical environment are driving change through all levels of Antarctic marine food webs, which differ regionally. The distributions of key species, such as Antarctic krill, are also changing. Differential responses among predators reflect differences in species ecology. The impacts of climate change on Antarctic biodiversity will likely vary for different communities and depend on species range. Coastal communities and those of sub-Antarctic islands, especially range-restricted endemic communities, will likely suffer the greatest negative consequences of climate change. Simultaneously, ecosystem services in the Southern Ocean will likely increase. Such decoupling of ecosystem services and endemic species will require consideration in the management of human activities such as fishing in Antarctic marine ecosystems.
We investigate the single-mode operation of a quantum optical nonlinear {pi} phase-shift gate implemented by a single two-level atom in one-dimensional free space. Since the single-mode property of ...the input photons at the atom is not preserved in the interaction at the atom, we analyze the efficiency of single-mode operation that can still be achieved. We show how the input pulse shape can be optimized to obtain high efficiencies for the nonlinear single-mode operation. With this analysis, we obtain an optimal single-mode transmittance per photon of 78% for the successful nonlinear {pi} phase-shift operation.
A double-blind controlled trial was carried out to compare the efficacy of sisomicin and tobramycin in the treatment of 55 hospitalized patients with serious systemic infections, mostly ...intra-abdominal or soft-tissue infections. Each drug was administered intramuscularly or intravenously at a dosage of 2.5 to 4.0 mg/kg per day for between 5 and 21 days. At the end of treatment, 22 (79%) of 28 sisomicin-treated patients and 15 (72%) of 21 tobramycin-treated patients were assessed, on the basis of clinical and bacteriological response, as cured or partially cured. Sisomicin was superior in the treatment of Escherichia coli infections. Local tolerance to both drugs was good. The incidence of systemic adverse reactions was low, fewer cases occurring in the sisomicin treatment group than in the tobramycin treatment group.
PDF
