The proton pump inhibitors (PPIs) as a class are remarkably safe and effective for persons with peptic ulcer disorders. Serious adverse events are extremely rare for PPIs, with case reports of ...interstitial nephritis with omeprazole, hepatitis with omeprazole and lansoprazole, and disputed visual disturbances with pantoprazole and omeprazole. PPI use is associated with the development of fundic gland polyps (FGP); stopping PPIs is associated with regression of FGP. In the absence of Helicobacter pylori infec...
In a series of 3 experiments on rats, 2 hypotheses were tested: (a) that damage to the orbital frontal cortex (OFC) would alter the socially relevant context for executing defensive responses but not ...their performance and (b) that damage done to the OFC in early infancy would produce more deficits in social behavior than similar damage occurring in adulthood. Bilateral or unilateral OFC damage in adult males did not impair their ability to defend themselves during play fighting and when protecting their food but did impair their ability to modify the pattern of defense in response to different partners. Rats that sustained bilateral damage at 3 days of age not only had deficits in partner-related modulation of defense but also exhibited hyperactivity in their play. The findings thus supported the proposed hypotheses.
Infant rats treated with basic fibroblast growth factor‐2 (FGF‐2) after postnatal day (P)10 motor cortical injury, show functional improvement in adulthood relative to those that do not receive ...FGF‐2. In this study we used a combination of behavioural, immunohistochemical, electrophysiological, electron microscopic and teratological approaches to investigate possible mechanisms by which FGF‐2 may influence functional recovery. We show that subcutaneous injections of FGF‐2 following bilateral lesions to the motor cortex at P10 in the rat leads to filling of the lesion area with migrating neuroblasts and cycling cells. We assessed the functionality of this tissue in adulthood, and show that cells from the filled region spontaneously fire and form synapses. Behavioural analysis shows enhanced motor performance in the FGF‐2‐treated lesion rats in comparison to vehicle‐treated lesion rats, and this improvement is reversed by removal of the tissue from the previously lesioned area or by blocking cortical regeneration by embryonic treatment with bromodeoxyuridine (BrdU). The results show that FGF‐2 stimulates filling of the lesion cavity with cells after neonatal motor cortex lesions, that the new tissue has anatomical and physiological properties similar to control tissue, and that the filled region supports motor behaviour.
The Modulation of Play Fighting in Rats Kamitakahara, Holly; Monfils, Marie-H; Forgie, Margaret L ...
Behavioral neuroscience,
02/2007, Volume:
121, Issue:
1
Journal Article
Peer reviewed
The cortex is not necessary for rats to engage in play fighting, but it is necessary for them to modify their pattern of play fighting in different contexts. Two experiments were conducted to ...determine the role of the motor cortex (MC). Rats with bilateral ablations of the MC performed on Postnatal Day 10 failed to show the normally present age-related modulation in defense but were able to modulate defense with different social partners. This latter finding was confirmed in rats given ablations as adults, in which responses to social status could be monitored before and after brain damage. It appears that different forms of cortical modulation of play fighting involve different cortical circuits.
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