Abstract Vitamin B12 deficiency mainly affects the dorsal column. In this study, we investigated which part of the sensory pathway is affected in vitamin B12 deficiency using NCS and SEPs. We ...retrospectively reviewed EMG database of Teikyo University and Mitsui Memorial Hospital from 2008 to 2016, and enrolled patients who presented with sensory symptoms and/or gait disturbance, and whose serum B12 level was below 170 ng/ml. Enrolled were 17 patients. Spinal MRI demonstrated abnormalities in 4/17. NCS was abnormal in 3/15 patients for the sural nerve and in 5/12 patients for the median nerve. When NCS and peripheral segments of the SEPs were combined, conduction delay was detected in 12/15 patients for the lower limb and 8/13 patients for the upper limb. Delay of the central conduction was rarer, 3/15 patients in tibial SEPs. N9o to P13/14o segment in median SEPs was abnormal in 4/8 patients, although this is a mixture of the peripheral and central conductions. Vitamin B12 deficiency patients showed abnormalities of the peripheral nerve conduction more frequently than those of the central conduction. SEPs are useful in localizing the lesion along the sensory pathway, not only for CCT but for peripheral conduction.
J-PARC Muon Facility: MUSE (Muon Science Establishment) is responsible for the inter-university user program and the operation, maintenance, and construction of the muon beamlines, namely D-line, ...S-line, U-line, and H-line, along with the muon source at J-PARC Materials and Life Science Facility (MLF). In this paper, recent developments are briefly presented.
To date,
Veillonella tobetsuensis
has been known as an oral anaerobe and a facilitator of early-stage oral biofilm development with streptococci. Here, we report the draft genome sequences of 2 ...strains of
V. tobetsuensis
first isolated from intraoperative bronchial fluids of elderly patients with pulmonary carcinoma.
ABSTRACT
To date,
Veillonella tobetsuensis
has been known as an oral anaerobe and a facilitator of early-stage oral biofilm development with streptococci. Here, we report the draft genome sequences of 2 strains of
V. tobetsuensis
first isolated from intraoperative bronchial fluids of elderly patients with pulmonary carcinoma.
was the main causative organism for acute epiglottitis in the pre-
type b (Hib) vaccine era. However, with current widespread Hib vaccination, the causative organisms may have changed. Here, we ...report the case of a healthy infant with acute epiglottitis caused by community-acquired methicillin-resistant
(MRSA). The patient was a healthy 17-day-old male infant without a family history of immunodeficiency syndrome. He had not been started on any vaccines. On the third day of illness, he was diagnosed with acute pharyngitis with exudation on the back of the larynx. Although treatment using cefotaxime was initiated, he showed stridor, difficulty in pronunciation, and cyanosis upon crying on the fourth day. On the fifth day, he was diagnosed with acute epiglottitis by laryngoscopy, which showed a downward spread of the exudation and laryngeal edema. He was intubated and started on artificial respiration. Due to the detection of MRSA from a pharyngeal swab culture, he was treated with vancomycin. His fever disappeared on the first day after admission, and he was extubated on the eighth day after admission. MRSA genome analysis of the patient sample revealed negative Panton-Valentine leukocidin, positive toxic shock syndrome toxin 1, and type IV clone of staphylococcal cassette chromosome
. This is a first case of acute epiglottitis caused by MRSA with a Panton-Valentine leukocidin-negative and toxic shock syndrome toxin 1-positive staphylococcal cassette chromosome
type IV clone, which is known as a community-acquired MRSA in Japan. Community-acquired MRSA may be considered a causative organism for acute epiglottitis in the post-Hib vaccine era.
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