In natural environment, stresses, when animals happen to be exposed to them, influence the functional activity of adrenal cortex. It can be expected that in animals, living under unfavorable ...conditions, basal concentration of glucocorticoid hormones would be increased while adrenocortical response to acute stress would be weakened. Since the main function of stress-reaction is resources mobilization meant to compensate an environmental impact, its weakening should lead to reduction of reserve metabolic capacities. To test this hypothesis, we compared energy metabolism, body temperature, and corticosterone concentration in blood plasma measured in northern red-back voles (Myodes rutilus) before and after acute cooling in helium-oxygen mixture. Voles belonged to two populations that deffered in relative abundance. It is found out that voles from a population of low relative abundance inhabiting the recreational forest of Novosibirsk Scientific Center, despite their being more stress-prone and having weakened stress-reaction, have higher maximum metabolic rate than voles from the mountain taiga polulation with high relative abundance. The results obtained suggest that living under unfavorable conditions leads to physiological adaptations which enhance resistance to acute stress, yet increase the risk of chronic stresses that have negative effect on fitness.
The animal models used in biomedical research cover virtually every human disease. RatDEGdb, a knowledge base of the differentially expressed genes (DEGs) of the rat as a model object in biomedical ...research is a collection of published data on gene expression in rat strains simulating arterial hypertension, age-related diseases, psychopathological conditions and other human afflictions. The current release contains information on 25,101 DEGs representing 14,320 unique rat genes that change transcription levels in 21 tissues of 10 genetic rat strains used as models of 11 human diseases based on 45 original scientific papers. RatDEGdb is novel in that, unlike any other biomedical database, it offers the manually curated annotations of DEGs in model rats with the use of independent clinical data on equal changes in the expression of homologous genes revealed in people with pathologies. The rat DEGs put in RatDEGdb were annotated with equal changes in the expression of their human homologs in affected people. In its current release, RatDEGdb contains 94,873 such annotations for 321 human genes in 836 diseases based on 959 original scientific papers found in the current PubMed. RatDEGdb may be interesting first of all to human geneticists, molecular biologists, clinical physicians, genetic advisors as well as experts in biopharmaceutics, bioinformatics and personalized genomics. RatDEGdb is publicly available at https://www.sysbio.ru/RatDEGdb.
In the blood of male steppe lemmings, relatively low background levels of testosterone were detected, this is characteristic of a monogamous species. A significant increase in testosterone level, ...more expressed in sexually active males, was observed at the initial stage of formation of reproductive couples. Apparently, in the future, the couple will exist in a stable relationship, and, hence, the maintenance of a high testosterone level becomes excessive. The decrease in, and the relative “normalization” of, the hormone level during the existence of the pair, including raising of the young, promotes higher expression of the male paternal care of the offspring at the species level.
The issues related to the integration of functional elements of ReRAM memory based on resistive Pt/HfO
2
/TiN structures with transistors fabricated by CMOS technology (0.18 μm node) are discussed ...when placing the memory cells in metallization layers. It is shown that the formation of a ReRAM stack can be organized as the “back end of line” (BEOL) process. The possibility is demonstrated of writing information in fabricated 1T-1R cells at the given levels of current determined by the voltage on the transistor, which allows one to choose the required values of resistance for the ON and OFF states. The presence of a transistor makes it possible to limit the power that is scattered in a resistance-switchable structure, and makes its parameters virtually insensitive to changes in the voltage of writing. The latter circumstance makes it possible to use the same recording voltage for all devices, which makes the problem of reproducing the values for different cells in an array less acute.
The stresses faced by animals in nature are reflected in the adrenal cortex functional activity. It is possible to expect that the basal concentrations of glucocorticoid hormones will be increased in ...animals inhabiting unfavorable conditions (and correspondingly the value of the adrenocortical reaction to acute stress will be decreased). Since mobilization of the organism resources for the compensation of environmental challenges is the main function of the stress reaction, its weakening should result in a decrease in the reserve capabilities of metabolism. To check this assumption, the basal and maximal metabolic rates, body temperature, and corticosterone concentration in plasma measured before and after acute cooling in a helium–oxygen mixture were compared in northern red-backed voles (
Myodes rutilus
) from two populations differing in their relative abundance. It was found that, despite higher basal levels of corticosterone and decreased stress reaction values, individuals from the population of the forest park zone of Novosibirsk Science Center with a low relative abundance demonstrated a higher maximal metabolic rate than individuals from the mountain–taiga population with a high abundance. The results demonstrated that habitation in unfavorable conditions leads to elaboration of physiological adaptations that increase resistance to acute stress but increase the risk of the development of the chronic stress, which negatively influences adaptability.
Experimental data on sorption properties of a new material based on the basal fiber and functional cover from MnO
3
with respect to Mn
2+
in water have been obtained. Kinetic parameters of the ...chemical reaction on the surface of the material have been determined.
In animal populations inhabiting ecologically suboptimal environmental conditions, phenotypical shifts in physiological traits responsible for coping with environmental challenges can be expected. If ...such variations are of heritable origin, then they will manifest themselves even in individuals bred in captivity. In laboratory-born red-backed voles (Myodes rutilus (Pallas, 1779)) originating from a population with constantly low density, maximum cold-induced metabolic rates were higher than in voles from a high-density population, similar to the data obtained on wild-caught individuals from the same populations. However, unlike wild-caught voles, in laboratory-born individuals maintained under comfortable conditions, we revealed no interpopulation differences either in basal plasma corticosterone level or in corticosterone response to acute cooling. These data confirm the suggestion about the heritable origin of increased maximum cold-induced metabolic rate in a red-backed vole population with relatively low density.
Рассматривается процесс лазерной наплавки, как метод восстановления сложных криволинейных поверхностей деталей ГТД. Описан принцип работы данного метода, указаны режимы обработки и характеристики ...оборудования, изучен материал наплавки. Представлены выбранные поверхности для восстановления: торцы лопаток центробежного колеса (ЦБК) из никелевого сплава, торцы лопаток ЦБК из титанового сплава и поверхности лабиринтных гребешков диска уплотнительного заднего ТСД из никелевого сплава. Как результат, отображены исследования фрагмента ЦБК из сплава на никелевой основе, также отмечено, что диск уплотнительный задний после восстановления методом лазерной наплавки установлен в двигателе Д-18Т. dx.doi.org/10.29010/085.12
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