The replacement of directly connected synchronous generators with power electronics interfaced generation has led to a decrease in system's inertia posing a significant challenge on frequency ...dynamics. In isolated systems with reduced inertia predefined limits for renewable penetration and primary reserves are frequently set for dynamic security purposes. This approach might not ensure dynamic security or can prove conservative in certain conditions. Furthermore, these approaches rarely consider the capabilities of inverter based renewable generation to provide frequency services. In this paper, a data driven approach, based on optimal classification trees is proposed to extract, from a detailed dynamic model of the system, the constraints for a frequency dynamic unit commitment formulation. Hence, both dynamic security and optimal exploitation of renewable and conventional units for power production and frequency support can be achieved. The advantages of the proposed method compared to conventional and state of the art approaches in frequency security are validated through dynamic simulations on a realistic model of Rhodes island and IEEE 118. Uncertainties in load demand and renewable generation are dealt by a robust optimization method. Its economic performance, computational overhead and modelling complexity is compared to a stochastic approach.
Altered cell metabolism is inherently connected with pathological conditions including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's ...sarcoma (KS). KS tumour cells display features of lymphatic endothelial differentiation and in their vast majority are latently infected with KSHV, while a small number are lytically infected, producing virions. Latently infected cells express only a subset of viral genes, mainly located within the latency-associated region, among them 12 microRNAs. Notably, the metabolic properties of KSHV-infected cells closely resemble the metabolic hallmarks of cancer cells. However, how and why KSHV alters host cell metabolism remains poorly understood. Here, we investigated the effect of KSHV infection on the metabolic profile of primary dermal microvascular lymphatic endothelial cells (LEC) and the functional relevance of this effect. We found that the KSHV microRNAs within the oncogenic cluster collaborate to decrease mitochondria biogenesis and to induce aerobic glycolysis in infected cells. KSHV microRNAs expression decreases oxygen consumption, increase lactate secretion and glucose uptake, stabilize HIF1α and decreases mitochondria copy number. Importantly this metabolic shift is important for latency maintenance and provides a growth advantage. Mechanistically we show that KSHV alters host cell energy metabolism through microRNA-mediated down regulation of EGLN2 and HSPA9. Our data suggest that the KSHV microRNAs induce a metabolic transformation by concurrent regulation of two independent pathways; transcriptional reprograming via HIF1 activation and reduction of mitochondria biogenesis through down regulation of the mitochondrial import machinery. These findings implicate viral microRNAs in the regulation of the cellular metabolism and highlight new potential avenues to inhibit viral latency.
This document is a summary of a report prepared by the IEEE PES Task Force (TF) on Microgrid Stability Definitions, Analysis, and Modeling, IEEE Power and Energy Society, Piscataway, NJ, USA, Tech. ...Rep. PES-TR66, Apr. 2018, which defines concepts and identifies relevant issues related to stability in microgrids. In this paper, definitions and classification of microgrid stability are presented and discussed, considering pertinent microgrid features such as voltage-frequency dependence, unbalancing, low inertia, and generation intermittency. A few examples are also presented, highlighting some of the stability classes defined in this paper. Further examples, along with discussions on microgrid components modeling and stability analysis tools can be found in the TF report.
In this paper, a highly reliable back-to-back (BTB) power converter is proposed for doubly fed induction generator-based wind turbines (DFIG-WTs). When a power switch open-circuit fault is ...encountered in either the grid-side converter (GSC) or the rotor-side converter (RSC), a four-switch three-phase (FSTP) topology is formed to avoid using redundant bridge arms, which reduces the power circuit complexity and minimizes the conduction and switching losses. A simplified space vector pulsewidth modulation technique is used to eliminate sector identification and complex trigonometric calculations. In addition, the influence of dc-bus capacitor voltage unbalance on the electromagnetic torque is analyzed in detail. The offset current components are calculated, and they are deducted from the reference values in the modified control strategies to suppress the dc-bus voltage deviation. Moreover, the power loss model of a BTB converter is analyzed in detail, and the efficiency study is performed in various post-fault situations. Simulations in MATLAB/Simulink are carried out to verify the performance of a DFIG-WT based on a FSTP BTB converter. Furthermore, the control hardware-in-the-loop setup with RSC and GSC separately simulated in a digital real-time simulator is applied for experimental verification of the proposed control strategy.
The highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as the causative agent of coronavirus disease 2019 (COVID-19) in late 2019, igniting an unprecedented ...pandemic. A mechanistic picture characterising the acute immunopathological disease in severe COVID-19 is developing. Non-coding RNAs (ncRNAs) constitute the transcribed but un-translated portion of the genome and, until recent decades, have been undiscovered or overlooked. A growing body of research continues to demonstrate their interconnected involvement in the immune response to SARS-CoV-2 and COVID-19 development by regulating several of its pathological hallmarks: cytokine storm syndrome, haemostatic alterations, immune cell recruitment, and vascular dysregulation. There is also keen interest in exploring the possibility of host-virus RNA-RNA and RNA-RBP interactions. Here, we discuss and evaluate evidence demonstrating the involvement of short and long ncRNAs in COVID-19 and use this information to propose hypotheses for future mechanistic and clinical studies.
The role of flexible alternating current transmission systems (FACTSs) in the provision of grid services is becoming increasingly important, due to the massive integration of intermittent renewable ...energy sources, energy storage systems, and the decommissioning of thermal plants. A comprehensive literature review of grid services offered by FACTS is performed, focusing on the different grid services that they can provide, such as power flow control, reactive power control, voltage control, power quality improvement, harmonic mitigation, improvement of transient stability, and damping of inter-area and intra-area oscillations. These grid services need to be realistically and economically validated in suitable testing environments. A review of relevant standards, guides, and the literature is performed, which covers the entire range from functional specification and factory testing up to the field testing of FACTS. Advanced industry practices, such as controller hardware in the loop (CHIL) testing of FACTS controllers by the manufacturer, and recent trends, such as CHIL testing of replica controllers by the owner, are underlined. Limitations of conventional testing and CHIL testing are explained and the use of power hardware in the loop (PHIL) simulation for FACTS testing is discussed. CHIL and scaled-down PHIL tests on a transmission static synchronous compensator (STATCOM) are performed and a comparison of the results is presented.
In this paper, a seamless interchange method between interconnected and islanded operational mode of a DC Microgrid is presented. The DC Microgrid examined consists of photovoltaic generation, ...batteries, and loads. A novel islanding detection method is presented ensuring fast detection of the islanding condition. The proposed detection method is based on the insertion of a controllable load in parallel with the DC Microgrid central switch. To achieve seamless interconnection to the utility grid, a proportional-integral (PI) regulator is installed in the Microgrid central controller. The PI regulator sends to the voltage forming unit (batteries) the appropriate setpoint, in order to align the voltage of the DC Microgrid to the utility network voltage during reconnection. The performance of the proposed control strategy is evaluated through simulations and Control Hardware-in-the-loop experiments performed at the Electric Energy Systems Laboratory, National Technical University of Athens.
The Evolution of Research in Microgrids Control Vasilakis, Athanasios; Zafeiratou, Igyso; Lagos, Dimitris T. ...
IEEE open access journal of power and energy,
2020, Volume:
7
Journal Article
Peer reviewed
Open access
Microgrids (MGs), as novel paradigms of active Distribution Networks, have been gaining increasing interest by the research community in the last 20 years. Currently, they are considered as key ...components in power system decentralization, providing viable solutions for rural electrification, enhancing resilience and supporting local energy communities. Their main characteristic is the coordinated control of the interconnected distributed energy resources (DER), which can be realized by various methods, ranging from decentralized communication-free approaches to centralized ones, where decisions are taken at a central point. This paper provides an overview of this development focusing on the technical control solutions proposed by reseachers for the various levels of MG organization hierarchy. A critical assessment of selected, popular technologies is provided and open research questions regarding the trend to more decentralized power systems are discussed.
The complexity of a smart grid with a high share of renewable energy resources introduces several issues in testing power equipment and controls. In this context, real-time simulation and Hardware in ...the Loop (HIL) techniques can tackle these problems that are typical for power system testing. However, implementing a convoluted HIL setup in a single infrastructure can be physically impossible or can increase the time required to test a smart grid application in detail. This paper introduces the Joint Test Facility for Smart Energy Networks with Distributed Energy Resources (JaNDER) that allows users to exchange data in real-time between two or more infrastructures. This tool enables the integration of infrastructures, exploiting the synergies between them, and creating a virtual infrastructure that can perform more experiments using a combination of the resources installed in each infrastructure. In particular, JaNDER can extend a HIL setup. In order to validate this new testing concept, a coordinated voltage controller has been tested in a Controller HIL setup where JaNDER was used to interact with an actual On Load Tap Changer (OLTC) controller located in a remote infrastructure. The results show that the latency introduced by JaNDER is not critical; hence, under certain circumstances, it can be used to expand the real-time testing without affecting the stability of the experiment.
HIV TAR RNA‐binding protein (TRBP) and Protein Activator of PKR (PACT) are double‐stranded (ds) RNA‐binding proteins that participate in both small regulatory RNA biogenesis and the response to viral ...dsRNA. Despite considerable progress toward understanding the structure–function relationship of TRBP and PACT, their specific roles in these seemingly distinct cellular pathways remain unclear. Both proteins are composed of three copies of the double‐stranded RNA‐binding domain, two of which interact with dsRNA, while the C‐terminal copy mediates protein–protein interactions. PACT and TRBP are found in a complex with the endonuclease Dicer and facilitate processing of immature microRNAs. Their precise contribution to the Dicing step has not yet been defined: possibilities include precursor recruitment, rearrangement of dsRNA within the complex, loading the processed microRNA into the RNA‐induced silencing complex, and distinguishing different classes of small dsRNA. TRBP and PACT also interact with the viral dsRNA sensors retinoic acid‐inducible gene I (RIG‐I) and double‐stranded RNA‐activated protein kinase (PKR). Current models suggest that PACT enables RIG‐I to detect a wider range of viral dsRNAs, while TRBP and PACT exert opposing regulatory effects on PKR. Here, the evidence that implicates TRBP and PACT in regulatory RNA processing and viral dsRNA sensing is reviewed and discussed in the context of their molecular structure. The broader implications of a link between microRNA biogenesis and the innate antiviral response pathway are also considered. WIREs RNA 2015, 6:271–289. doi: 10.1002/wrna.1272
This article is categorized under:
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms
Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs
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