Se presenta el caso de una niña con diagnóstico de urticaria autoinmunitaria y su evolución terapéutica con omalizumab. Caso clínico. Paciente de sexo femenino de 12 años de edad con un cuadro de ...urticaria crónica grave y angioedema de 14 meses de evolución, escasa respuesta a dosis máximas de 3 antihistamínicos combinados, antileucotrienos y corticoides, y gran afectación de su calidad de vida. Se realizó una prueba de suero autólogo, que fue positiva hasta la dilución 1:100, llegándose al diagnóstico de urticaria crónica autoinmunitaria. La falta de respuesta al tratamiento lleva a indicar terapia con omalizumab, con una reducción notable de los síntomas hacia la tercera dosis y ausencia de ellos tras 12 meses de tratamiento. Conclusión. El omalizumab podría ser una opción terapéutica para pacientes con urticaria autoinmunitaria que no responden a otros tratamientos.
We report the case of a child with diagnosis of chronic urticaria/angioedema and its evolution upon omalizumab treatment.
Our patient is a 12-years-old female who suffered for 14 months severe ...chronic urticaria/angioedema. She had a poor response to the highest doses of combined therapy with 3 antihistamines, steroids and anti-leukotrienes and great impairment of her quality of life. An autologous serum skin test was positive until 1:100 dilutions, leading to the diagnosis of chronic autoimmune urticaria. Due to the lack of response to treatment, therapy with omalizumab was administered. A notable reduction in symptoms toward the third dose was observed. After 12 months of this treatment, the patient is asymptomatic and has a negative autologous serum test.
Omalizumab could be a therapeutic option for patients with autoimmune urticaria unresponsive to other treatments.
...in the last two decades, this topic has been revisited and experienced a surge of academic interest as evidenced by numerous studies in the literature (Gearhardt et al., 2009a; Brewerton, 2017; ...Cassin et al., 2019; Munguía et al., 2022). Sena et al. examined two genetically similar substrains of BALB/c mice to investigate escalated food consumption, compulsive-like food consumption in an aversive context, and incubation of craving after a no-food training period. In their research, Ghobadi-Azbari et al. studied the neural dynamics underlying food cue-reactivity in overweight/obese participants who reported frequent food cravings. In a well-conducted study, they showed that OSN dysfunction decreased food intake, increased resistance to starvation by modulating lipid metabolism, and reduced cold stress.
Entrevista realizada com Diana Costa no primeiro semestre de 2023, presencialmente no estúdio privado da artista, em Lisboa, Portugal, por ocasião de Cooperação internacional entre o Estúdio de ...Pintura Apotheke e a Faculdade de Belas-Artes da Universidade de Lisboa, via Edital CNPq nº 26/2021, coordenada pela Professora Titular Dra. Jociele Lampert (UDESC).
Entrevista realizada com Rui Serra no primeiro semestre de 2023, presencialmente no estúdio privado do artista, em Lisboa, Portugal, por ocasião de Cooperação internacional entre o Estúdio de Pintura ...Apotheke e a Faculdade de Belas-Artes da Universidade de Lisboa, via Edital CNPq nº 26/2021, coordenada pela Professora Titular Dra. Jociele Lampert (UDESC).
