The RIDART I study found a 13.6% prevalence of anemia in Italian patients with inflammatory bowel disease (IBD); most cases were due to iron-deficiency anemia (IDA).
To evaluate changes in hemoglobin ...concentration during a 24-week follow-up of anemic patients with IBD.
Follow-up laboratory and clinical data were obtained from RIDART I study patients with anemia. Factors affecting hemoglobin concentration, the impact of anemia on fatigue and quality of life (QoL), and its relationship with treatment, disease activity and disease complications were investigated.
Hemoglobin was 108 g/L at baseline, increased to 121 g/L at follow-up week 12 (p < 0.001) and then stabilized until week 24, but most patients remained anemic, with IDA, throughout the study. Hemoglobin improvement was greater in patients receiving either oral or parenteral iron supplementation. Following hemoglobin normalization, anemia relapse rate during follow-up was 30%. Oral iron did not cause disease reactivation. Lower follow-up hemoglobin was associated with a higher probability of having active disease, clinical complications, increased fatigue and reduced QoL.
In anemic patients with IBD, anemia represents a long-lasting problem, in most cases persisting for up to 24 weeks, with high relapse rate and a negative impact on fatigue and QoL.
Virtual biologics clinics are often used to review patients with inflammatory bowel disease receiving biological therapy, with decisions whether to continue, switch, or stop therapy made based on ...review of symptoms, disease history, and investigations. We aimed to investigate whether therapeutic drug monitoring of infliximab (IFX) trough levels and anti-drug antibodies influences decision making within a virtual biologics clinic.
For all patients with inflammatory bowel disease receiving IFX maintenance therapy, 2 decisions were recorded in a preset format. The first decision was based on assessment of clinical details, with clinicians blinded to IFX trough levels and anti-drug antibodies. The second decision was made after unblinding of these data.
Among 191 patients (mean age 40 years; 106 (55.5%) male), IFX trough levels were sub-therapeutic in 53 (27.7%) (<2 mg/L), therapeutic in 100 (52.4%), and supra-therapeutic in 38 (19.9%) (>6 mg/L). Anti-drug antibodies were detected in 58 (30.4%), and were >50 AU/mL in 26 (13.6%). Blinded treatment decisions were changed on unblinding these data in 56 cases (29.3%; P < 0.0001). Knowledge of these data led to 7 (3.7%) patients receiving intensified IFX, whereas 33 (17.3%) patients were able to either dose de-escalate or stop IFX.
Basing decisions on therapeutic drug monitoring, rather than clinical acumen alone, led to a change in almost one-third of decisions made, offering considerable cost savings and reducing exposure to potentially toxic therapies. Routine therapeutic drug monitoring should be considered an integral part of annual biologics assessment (see Video Abstract, Supplemental Digital Content 1, http://links.lww.com/IBD/B629).
Photons produced in pp interactions at 450 GeV/c were detected by reconstructing the e+e− pairs of photon conversions in a 1 mm thick lead sheet placed in front of the MWPCs of the OMEGA spectrometer ...at CERN. A soft photon signal 4.1±0.8 times the inner bremsstrahlung prediction was observed in the forward rapidity region (yc.m.s.⩾1.2), thus extending the domain of the anomalous soft photon effect seen already in K+p, π+p and π−p interactions.
The reaction pp -> pf (eta eta) ps has been studied at 450 GeV/c. For the first time a partial wave analysis of the centrally produced eta eta system has been performed. Signals for the f0(1500), ...f0(1710) and f2(2150) are observed and the decay branching fractions of these states are determined.
The reactions
pp→
p
f
(
X
0)
p
s
, where
X
0 is observed decaying to
π
0
π
0
π
0
π
0 ,
π
+
π
−
π
+
π
− and
π
+
π
−
π
0
π
0 , have been studied at 450 GeV/
c. There is evidence for an
a
2(1320)
π ...decay mode of the
η
2(1645) and
η
2(1870) in the
π
+
π
−
π
0
π
0 and
π
+
π
−
π
+
π
− final states. The
f
2(1950) is consistent with being a single resonance with a dominant
f
2(1270)
ππ decay mode. The
f
0(1370) is found to decay dominantly to
ρρ while the
f
0(1500) is found to decay to
ρρ and
σσ.
In this Letter we present additional experimental characteristics of anomalous soft photon radiation observed in π−p interactions at 280 GeV/c in the CERN experiment WA91, together with a ...re-calculated ratio of the observed direct soft photon signal to the expected level of the hadronic inner bremsstrahlung, which is found to be 5.3±1.0. The other presented characteristics, energy dependence and angular distributions of direct soft photons, show the similarity of the observed signal to the expected hadronic bremsstrahlung behaviour.
The ALICE Silicon Pixel Detector: System, components and test procedures Riedler, P.; Anelli, G.; Antinori, F. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
11/2006, Volume:
568, Issue:
1
Journal Article
Peer reviewed
The ALICE Silicon Pixel Detector consists of two barrel layers of hybrid silicon pixel detectors. In total
9.8
×
10
6
pixel cells with
50
μ
m
×
425
μ
m
will provide precision tracking information in ...the high multiplicity environment expected in heavy ion collisions. This paper gives an overview of the system, its components and the test procedures that have been developed.
The production and decay properties of the
f
0(1370),
f
0(1500),
f
0(2000) and
f
2(1950) have been studied in central pp interactions at 450 GeV/c. The
dP
T
,
φ and |
t| distributions of these ...resonances are presented. For the
J=0 states, the
f
0(1370) and
f
0(2000) have similar
dP
T
and
φ dependences. These are different to the
dP
T
and
φ dependences of the
f
0(980),
f
0(1500) and
f
0(1710). For the
J=2 states the
f
2(1950) has different dependences to the
f
2(1270) and
f
2
′(1520). This shows that the
dP
T
and
φ dependences are not just
J phenomena.
First results from the ALICE silicon pixel detector prototype Riedler, P; Anelli, G; Antinori, F ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
03/2003, Volume:
501, Issue:
1
Journal Article
Peer reviewed
System prototyping of the ALICE silicon pixel detector (SPD) is well underway. The ALICE SPD consists of two barrel layers with 9.83 million channels in total. These are read out by the ALICE1LHCb ...pixel chip, which has been developed in a commercial
0.25
μm
process with radiation hardening by design layout. The readout chip contains 8192 pixel cells each with a fast analog preamplifier and shaper followed by a discriminator and digital delay lines. Test results show a pixel cell noise of about 110 electrons rms and a mean minimum threshold of about 1000 electrons rms before threshold fine tuning. Several readout chips have been flip-chip bonded to detectors using two different bump-bonding techniques (solder, indium). Results of radioactive source measurements of these assemblies are presented for
90
Sr
and
55
Fe
sources. Several chip-detector assemblies have been tested in a
150
GeV/
c
pion beam at CERN where an online efficiency of about 99% across a wide range of detector bias and threshold settings was observed. All preliminary investigations confirm the functionality of the chip and the chip-detector assemblies for the ALICE experiment.
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