The complete characterization of the pressure profile of high-redshift galaxy clusters, from their core to their outskirts, is a major issue for the study of the formation of large-scale structures. ...It is essential to constrain a potential redshift evolution of both the slope and scatter of the mass-observable scaling relations used in cosmology studies based on cluster statistics. In this paper, we present the first thermal Sunyaev–Zel’dovich (tSZ) mapping of a cluster from the sample of the New IRAM Kids Arrays (NIKA2) SZ large program that aims at constraining the redshift evolution of cluster pressure profiles and the tSZ-mass scaling relation. We observed the galaxy cluster PSZ2 G144.83+25.11 at redshift z = 0.58 with the NIKA2 camera, a dual-band (150 and 260 GHz) instrument operated at the Institut de Radioastronomie Millimtrique (IRAM) 30-m telescope. We identify a thermal pressure excess in the south-west region of PSZ2 G144.83+25.11 and a high-redshift sub-millimeter point source that affect the intracluster medium (ICM) morphology of the cluster. The NIKA2 data are used jointly with tSZ data acquired by the Multiplexed SQUID/TES Array at Ninety Gigahertz (MUSTANG), Bolocam, and Planck experiments in order to non-parametrically set the best constraints on the electronic pressure distribution from the cluster core (R ~ 0.02R500) to its outskirts (R ~ 3R500). We investigate the impact of the over-pressure region on the shape of the pressure profile and on the constraints on the integrated Compton parameter Y500. A hydrostatic mass analysis is also performed by combining the tSZ-constrained pressure profile with the deprojected electronic density profile from XMM-Newton. This allows us to conclude that the estimates of Y500 and M500 obtained from the analysis with and without masking the disturbed ICM region differ by 65% and 79%, respectively. This work highlights that NIKA2 will have a crucial impact on the characterization of the scatter of the Y500−M500 scaling relation due to its high potential to constrain the thermodynamic and morphological properties of the ICM when used in synergy with X-ray observations of similar angular resolution. This study also presents the typical products that will be delivered to the community for all clusters included in the NIKA2 tSZ Large Program.
Astrometric accuracy of complex modern VLBI arrays cannot be calculated analytically. We study the astrometric accuracy of phase-referenced VLBI observations for the VLBA, EVN and global VLBI array ...by simulating VLBI data for targets at declinations $-25\degr$, $0\degr$, $25\degr$, $50\degr$, $75\degr$ and $85\degr$. The systematic error components considered in this study are calibrator position, station coordinate, Earth orientation and troposphere parameter uncertainties. We provide complete tables of the astrometric accuracies of these arrays for a source separation of $1 \degr$ either along the right ascension axis or along the declination axis. Astrometric accuracy is $50~\mu$as at mid declination and is $300~\mu$as at low ($-25 \degr$) and high ($85 \degr$) declinations for the VLBA and EVN. In extending our simulations to source separations of $0.5 \degr$ and $2 \degr$, we establish the formula for the astrometric accuracy of the VLBA: $\Delta_{\alpha\cos\delta ,\delta} = (\Delta_{\alpha\cos\delta, \delta}^{1^{\circ}}-14) \times d+ 14$ (μas) where $\Delta_{\alpha\cos\delta, \delta}^{1^{\circ}}$ is the astrometric accuracy for a separation $d=1\degr$ provided in our tables for various declinations and conditions of the wet troposphere. We argue that this formula is also valid for the astrometric accuracy of the EVN and global VLBI array.
Context. Millimetre-wave continuum astronomy is today an indispensable tool for both general astrophysics studies (e.g. star formation, nearby galaxies) and cosmology (e.g. cosmic microwave ...background and high-redshift galaxies). General purpose, large-field-of-view instruments are needed to map the sky at intermediate angular scales not accessible by the high-resolution interferometers (e.g. ALMA in Chile, NOEMA in the French Alps) and by the coarse angular resolution space-borne or ground-based surveys (e.g. Planck, ACT, SPT). These instruments have to be installed at the focal plane of the largest single-dish telescopes, which are placed at high altitude on selected dry observing sites. In this context, we have constructed and deployed a three-thousand-pixel dual-band (150 GHz and 260 GHz, respectively 2 mm and 1.15 mm wavelengths) camera to image an instantaneous circular field-of-view of 6.5 arcmin in diameter, and configurable to map the linear polarisation at 260 GHz. Aims. First, we are providing a detailed description of this instrument, named NIKA2 (New IRAM KID Arrays 2), in particular focussing on the cryogenics, optics, focal plane arrays based on Kinetic Inductance Detectors, and the readout electronics. The focal planes and part of the optics are cooled down to the nominal 150 mK operating temperature by means of an adhoc dilution refrigerator. Secondly, we are presenting the performance measured on the sky during the commissioning runs that took place between October 2015 and April 2017 at the 30-m IRAM telescope at Pico Veleta, near Granada (Spain). Methods. We have targeted a number of astronomical sources. Starting from beam-maps on primary and secondary calibrators we have then gone to extended sources and faint objects. Both internal (electronic) and on-the-sky calibrations are applied. The general methods are described in the present paper. Results. NIKA2 has been successfully deployed and commissioned, performing in-line with expectations. In particular, NIKA2 exhibits full width at half maximum angular resolutions of around 11 and 17.5 arcsec at respectively 260 and 150 GHz. The noise equivalent flux densities are, at these two respective frequencies, 33±2 and 8±1 mJy s1/2. A first successful science verification run was achieved in April 2017. The instrument is currently offered to the astronomy community and will remain available for at least the following ten years.
Triazole resistance in Aspergillus fumigatus is widespread and threatens first-line triazole therapy in patients with Aspergillus diseases.
To give an overview of the microbiology, epidemiology and ...clinical significance of triazole resistance in aspergillosis.
PubMed search for articles on resistance in Aspergillus species.
Triazoles are not mutagenic but select resistance when spontaneous mutations occur that are better able to proliferate in the triazole-containing environment. The major target for resistance mutations involves the Cyp51A gene, encoding an enzyme involved in cell wall synthesis. Triazole-resistance selection environments include patient treatment and organic matter containing triazole fungicide residues. Reported resistance frequencies vary widely between countries and hospitals, and resistance significantly complicates the diagnosis and treatment of Aspergillus diseases. Cultures may harbour various resistance phenotypes and multiple colonies must be analysed to detect resistance. PCR tests have become available for resistance detection in culture-negative patients, but show limited sensitivity. Individuals with triazole-resistant invasive aspergillosis have a 21% higher day-42 mortality compared with triazole-susceptible infection, and to prevent excess mortality resistant cases require first-line therapy that covers resistance. The recent ESCMID-ECMM-ERS Aspergillus guideline recommends resistance testing in A. fumigatus and local resistance surveillance. If resistance rates exceed 10% liposomal amphotericin B or triazole and echinocandin first-line therapy should be considered.
Triazole resistance significantly complicates the management of aspergillosis and multidisciplinary research from a ‘One-health’ perspective is required to retain the triazole class for medical use.
Abstract
This paper presents a study of circumstellar debris around Sun-like stars using data from the Herschel DEBRIS Key Programme. DEBRIS is an unbiased survey comprising the nearest ∼90 stars of ...each spectral type A-M. Analysis of the 275 F-K stars shows that excess emission from a debris disc was detected around 47 stars, giving a detection rate of 17.1$^{+2.6}_{-2.3}$ per cent, with lower rates for later spectral types. For each target a blackbody spectrum was fitted to the dust emission to determine its fractional luminosity and temperature. The derived underlying distribution of fractional luminosity versus blackbody radius in the population showed that most detected discs are concentrated at f ∼ 10−5 and at temperatures corresponding to blackbody radii 7–40 au, which scales to ∼40 au for realistic dust properties (similar to the current Kuiper belt). Two outlying populations are also evident; five stars have exceptionally bright emission ( f > 5 × 10−5), and one has unusually hot dust <4 au. The excess emission distributions at all wavelengths were fitted with a steady-state evolution model, showing that these are compatible with all stars being born with a narrow belt that then undergoes collisional grinding. However, the model cannot explain the hot dust systems – likely originating in transient events – and bright emission systems – arising potentially from atypically massive discs or recent stirring. The emission from the present-day Kuiper belt is predicted to be close to the median of the population, suggesting that half of stars have either depleted their Kuiper belts (similar to the Solar system) or had a lower planetesimal formation efficiency.
Context.
NIKA2 is a dual-band millimetre continuum camera of 2 900 kinetic inductance detectors, operating at 150 and 260 GHz, installed at the IRAM 30-m telescope in Spain. Open to the scientific ...community since October 2017, NIKA2 will provide key observations for the next decade to address a wide range of open questions in astrophysics and cosmology.
Aims.
Our aim is to present the calibration method and the performance assessment of NIKA2 after one year of observation.
Methods.
We used a large data set acquired between January 2017 and February 2018 including observations of primary and secondary calibrators and faint sources that span the whole range of observing elevations and atmospheric conditions encountered by the IRAM 30-m telescope. This allowed us to test the stability of the performance parameters against time evolution and observing conditions. We describe a standard calibration method, referred to as the “Baseline” method, to translate raw data into flux density measurements. This includes the determination of the detector positions in the sky, the selection of the detectors, the measurement of the beam pattern, the estimation of the atmospheric opacity, the calibration of absolute flux density scale, the flat fielding, and the photometry. We assessed the robustness of the performance results using the Baseline method against systematic effects by comparing results using alternative methods.
Results.
We report an instantaneous field of view of 6.5′ in diameter, filled with an average fraction of 84%, and 90% of valid detectors at 150 and 260 GHz, respectively. The beam pattern is characterised by a FWHM of 17.6″ ± 0.1″ and 11.1″ ± 0.2″, and a main-beam efficiency of 47%±3%, and 64%±3% at 150 and 260 GHz, respectively. The point-source rms calibration uncertainties are about 3% at 150 GHz and 6% at 260 GHz. This demonstrates the accuracy of the methods that we deployed to correct for atmospheric attenuation. The absolute calibration uncertainties are of 5%, and the systematic calibration uncertainties evaluated at the IRAM 30-m reference Winter observing conditions are below 1% in both channels. The noise equivalent flux density at 150 and 260 GHz are of 9 ± 1 mJy s
1/2
and 30 ± 3 mJy s
1/2
. This state-of-the-art performance confers NIKA2 with mapping speeds of 1388 ± 174 and 111 ± 11 arcmin
2
mJy
−2
h
−1
at 150 and 260 GHz.
Conclusions.
With these unique capabilities of fast dual-band mapping at high (better that 18″) angular resolution, NIKA2 is providing an unprecedented view of the millimetre Universe.
ABSTRACT The study of the planet-debris disk connection can shed light on the formation and evolution of planetary systems and may help "predict" the presence of planets around stars with certain ...disk characteristics. In preliminary analyses of subsamples of the Herschel DEBRIS and DUNES surveys, Wyatt et al. and Marshall et al. identified a tentative correlation between debris and the presence of low-mass planets. Here we use the cleanest possible sample out of these Herschel surveys to assess the presence of such a correlation, discarding stars without known ages, with ages Gyr, and with binary companions AU to rule out possible correlations due to effects other than planet presence. In our resulting subsample of 204 FGK stars, we do not find evidence that debris disks are more common or more dusty around stars harboring high-mass or low-mass planets compared to a control sample without identified planets. There is no evidence either that the characteristic dust temperature of the debris disks around planet-bearing stars is any different from that in debris disks without identified planets, nor that debris disks are more or less common (or more or less dusty) around stars harboring multiple planets compared to single-planet systems. Diverse dynamical histories may account for the lack of correlations. The data show a correlation between the presence of high-mass planets and stellar metallicity, but no correlation between the presence of low-mass planets or debris and stellar metallicity. Comparing the observed cumulative distribution of fractional luminosity to those expected from a Gaussian distribution in logarithmic scale, we find that a distribution centered on the solar system's value fits the data well, while one centered at 10 times this value can be rejected. This is of interest in the context of future terrestrial planet detection and characterization because it indicates that there are good prospects for finding a large number of debris disk systems (i.e., with evidence of harboring planetesimals, the building blocks of planets) with exozodiacal emission low enough to be appropriate targets for an ATLAST-type mission to search for biosignatures.
Context. In the past decade, sensitive, resolved Sunyaev-Zel’dovich (SZ) studies of galaxy clusters have become common. Whereas many previous SZ studies have parameterized the pressure profiles of ...galaxy clusters, non-parametric reconstructions will provide insights into the thermodynamic state of the intracluster medium. Aim. We seek to recover the non-parametric pressure profiles of the high redshift (z = 0.89) galaxy cluster CLJ 1226.9+3332 as inferred from SZ data from the MUSTANG, NIKA, Bolocam, and Planck instruments, which all probe different angular scales. Methods. Our non-parametric algorithm makes use of logarithmic interpolation, which under the assumption of ellipsoidal symmetry is analytically integrable. For MUSTANG, NIKA, and Bolocam we derive a non-parametric pressure profile independently and find good agreement among the instruments. In particular, we find that the non-parametric profiles are consistent with a fitted generalized Navaro-Frenk-White (gNFW) profile. Given the ability of Planck to constrain the total signal, we include a prior on the integrated Compton Y parameter as determined by Planck. Results. For a given instrument, constraints on the pressure profile diminish rapidly beyond the field of view. The overlap in spatial scales probed by these four datasets is therefore critical in checking for consistency between instruments. By using multiple instruments, our analysis of CLJ 1226.9+3332 covers a large radial range, from the central regions to the cluster outskirts: 0.05 R500 < r < 1.1 R500. This is a wider range of spatial scales than is typically recovered by SZ instruments. Similar analyses will be possible with the new generation of SZ instruments such as NIKA2 and MUSTANG2.
Abstract
Background
Triazole resistance is an increasing problem in invasive aspergillosis (IA). Small case series show mortality rates of 50%–100% in patients infected with a triazole-resistant ...Aspergillus fumigatus, but a direct comparison with triazole-susceptible IA is lacking.
Methods
A 5-year retrospective cohort study (2011–2015) was conducted to compare mortality in patients with voriconazole-susceptible and voriconazole-resistant IA. Aspergillus fumigatus culture-positive patients were investigated to identify patients with proven, probable, and putative IA. Clinical characteristics, day 42 and day 90 mortality, triazole-resistance profiles, and antifungal treatments were investigated.
Results
Of 196 patients with IA, 37 (19%) harbored a voriconazole-resistant infection. Hematological malignancy was the underlying disease in 103 (53%) patients, and 154 (79%) patients were started on voriconazole. Compared with voriconazole-susceptible cases, voriconazole resistance was associated with an increase in overall mortality of 21% on day 42 (49% vs 28%; P = .017) and 25% on day 90 (62% vs 37%; P = .0038). In non-intensive care unit patients, a 19% lower survival rate was observed in voriconazole-resistant cases at day 42 (P = .045). The mortality in patients who received appropriate initial voriconazole therapy was 24% compared with 47% in those who received inappropriate therapy (P = .016), despite switching to appropriate antifungal therapy after a median of 10 days.
Conclusions
Voriconazole resistance was associated with an excess overall mortality of 21% at day 42 and 25% at day 90 in patients with IA. A delay in the initiation of appropriate antifungal therapy was associated with increased overall mortality.
A multicenter, retrospective, cohort study showed a 21% higher day 42 mortality in voriconazole-resistant invasive aspergillosis compared with voriconazole-susceptible cases. In resistant cases, switch to appropriate antifungal therapy was associated with increased mortality compared with patients who directly received appropriate antifungal therapy.
The Crab nebula is a supernova remnant exhibiting a highly polarized synchrotron radiation at radio and millimetre wavelengths. It is the brightest source in the microwave sky with an extension of 7 ...by 5 arcmin, and is commonly used as a standard candle for any experiment which aims to measure the polarization of the sky. Though its spectral energy distribution has been well characterized in total intensity, polarization data are still lacking at millimetre wavelengths. We report in this paper high resolution observations (18′′ FWHM) of the Crab nebula in total intensity and linear polarization at 150 GHz with the NIKA camera. NIKA, operated at the IRAM 30 m telescope from 2012 to 2015, is a camera made of Lumped Element Kinetic Inductance Detectors (LEKIDs) observing the sky at 150 and 260 GHz. From these observations we are able to reconstruct the spatial distribution of the polarization degree and angle of the Crab nebula, which is found to be compatible with previous observations at lower and higher frequencies. Averaging across the source and using other existing data sets we find that the Crab nebula polarization angle is consistent with being constant over a wide range of frequencies with a value of − 87.7° ± 0.3 in Galactic coordinates. We also present the first estimation of the Crab nebula spectral energy distribution polarized flux in a wide frequency range: 30–353 GHz. Assuming a single power law emission model we find that the polarization spectral index βpol = – 0.347 ± 0.026 is compatible with the intensity spectral index β = – 0.323 ± 0.001.
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