Tumor cells adapt to excessive oxidative stress by actuating reactive oxygen species (ROS)‐defensing system, leading to a resistance to oxidation therapy. In this work, self‐delivery photodynamic ...synergists (designated as PhotoSyn) are developed for oxidative damage amplified tumor therapy. Specifically, PhotoSyn are fabricated by the self‐assembly of chlorine e6 (Ce6) and TH588 through π–π stacking and hydrophobic interactions. Without additional carriers, nanoscale PhotoSyn possess an extremely high drug loading rate (up to 100%) and they are found to be fairly stable in aqueous phase with a uniform size distribution. Intravenously injected PhotoSyn prefer to accumulate at tumor sites for effective cellular uptake. More importantly, TH588‐mediated MTH1 inhibition could destroy the ROS‐defensing system of tumor cells by preventing the elimination of 8‐oxo‐2′‐deoxyguanosine triphosphate (8‐oxo‐dG), thereby exacerbating the oxidative DNA damage induced by the photodynamic therapy (PDT) of Ce6 under light irradiation. As a consequence, PhotoSyn exhibit enhanced photo toxicity and a significant antitumor effect. This amplified oxidative damage strategy improves the PDT efficiency with a reduced side effect by increasing the lethality of ROS without generating superabundant ROS, which would provide a new insight for developing self‐delivery nanoplatforms in photodynamic tumor therapy in clinic.
Carrier free photodynamic synergists are developed for oxidative damage amplified tumor therapy by destroying the reactive oxygen species (ROS)‐defensing system without generating excessive ROS, which shed light on the development of self‐delivery nanoplatforms for efficient photodynamic therapy by utilizing the limited oxygen in hypoxic tumors.
Abstract
In this paper, we report 591 high-velocity star candidates (HiVelSCs) selected from over 10 million spectra of Data Release 7 (DR7) of the Large Sky Area Multi-object Fiber Spectroscopic ...Telescope and the second Gaia data release, with three-dimensional velocities in the Galactic rest frame larger than 445 km s
−1
. We show that at least 43 HiVelSCs are unbound to the Galaxy with escape probabilities larger than 50%, and this number decreases to eight if the possible parallax zero-point error is corrected. Most of these HiVelSCs are metal-poor and slightly
α
-enhanced inner halo stars. Only 14% of them have Fe/H > −1, which may be the metal-rich “in situ” stars in the halo formed in the initial collapse of the Milky Way or metal-rich stars formed in the disk or bulge but kinematically heated. The low ratio of 14% implies that the bulk of the stellar halo was formed from the accretion and tidal disruption of satellite galaxies. In addition, HiVelSCs on retrograde orbits have slightly lower metallicities on average compared with those on prograde orbits; meanwhile, metal-poor HiVelSCs with Fe/H < −1 have an even faster mean retrograde velocity compared with metal-rich HiVelSCs. To investigate the origins of HiVelSCs, we perform orbit integrations and divide them into four types, i.e., hypervelocity stars, hyper-runaway stars, runaway stars and fast halo stars. A catalog for these 591 HiVelSCs, including radial velocities, atmospheric parameters, Gaia astrometric parameters, spatial positions, and velocities, etc., is available in the China-VO PaperData Repository at doi:
10.12149/101038
.
Most networked systems of scientific interest are characterized by temporal links, meaning the network’s structure changes over time. Link temporality has been shown to hinder many dynamical ...processes, from information spreading to accessibility, by disrupting network paths. Considering the ubiquity of temporal networks in nature, we ask: Are there any advantages of the networks’ temporality? We use an analytical framework to show that temporal networks can, compared to their static counterparts, reach controllability faster, demand orders of magnitude less control energy, and have control trajectories, that are considerably more compact than those characterizing static networks. Thus, temporality ensures a degree of flexibility that would be unattainable in static networks, enhancing our ability to control them.
Abstract
To understand the parameter degeneracy of M subdwarf spectra at low resolution, we assemble a large number of spectral features in the wavelength range 0.6–2.5
μ
m with band strength ...quantified by narrowband indices. Based on the index trends of BT-Settl model sequences, we illustrate how the main atmospheric parameters (
T
eff
, log
g
, M/H, and
α
/Fe) affect each spectral feature differently. Furthermore, we propose a four-step process to determine the four parameters sequentially, which extends the basic idea proposed by Jao et al. Each step contains several spectral features that break the degeneracy effect when determining a specific stellar parameter. Finally, the feasibility of each spectroscopic diagnostic with different spectral quality is investigated. The result is resolution-independent down to
R
∼ 200.
Carbapenem-resistant
(CRE) have been responsible for nosocomial outbreaks worldwide and have become endemic in several countries.
To better understand the epidemiological trends and characteristics ...of CRE in the Henan province.
We assessed the molecular epidemiological characteristics of 305 CRE strains isolated from patients in 19 secondary or tertiary hospitals in ten areas of the Henan province in China.
A total of 305 CRE isolates were subjected to multiple tests, including
antimicrobial susceptibility testing, PCR for carbapenemase genes
,
,
,
,
-
. Tigecycline-resistant genes
,
,
,
A,
,
X,
M,
L were analysed in five tigecycline non-susceptible carbapenem-resistant
isolates (TNSCRKP). Additionally, multilocus sequence typing (MLST) was performed for carbapenem-resistant
(CRKP).
The most common CRE species were
(234, 77 %),
(36, 12 %) and
(13, 4 %). All strains exhibited multi-drug resistance. Overall, 97 % (295/305) and 97 % (297/305) of the isolates were susceptible to polymyxin B and tigecycline, respectively. A total of 89 % (271/305) of the CRE isolates were carbapenemase gene-positive, including 70 %
, 13 %
, 6 %
, and 1 % combined
/
genes.
carbapenemase (KPC) was the predominant carbapenemase in
(87 %), whereas NDM and IMP were frequent in
(53 %) and
(69 %), respectively. Mutations in the
,
and
genes were detected in five TNSCRKP. Moreover, 15 unique sequence types were detected, with ST11 (74 %), ST15 (9 %) and ST2237 (5 %) being dominant among
strains.
A high proportion of CRE strains were carbapenemase-positive, and five carbapenem-resistant
isolates were tigecycline non-susceptible, indicating a need for the ongoing surveillance of CRE and effective measures for the prevention of CRE infections.
Abstract
We first derive the stellar population properties: age and metallicity for ∼43,000 low redshift galaxies in the DR7 of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) ...survey, which have no spectroscopic observations in the Sloan Digital Sky Survey (SDSS). We employ a fitting procedure based on the small-scale features of galaxy spectra so as to avoid possible biases from the uncertain flux calibration of the LAMOST spectroscopy. We show that our algorithm can successfully recover the average age and metallicity of the stellar populations of galaxies down to signal-to-noise ratio ≥5 through testing on both mock galaxies and real galaxies comprising LAMOST and their SDSS counterparts. We provide a catalog of the age and metallicity for ∼43,000 LAMOST galaxies online. As a demonstration of the scientific application of this catalog, we present the Holmberg effect on both age and metallicity of a sample of galaxies in galaxy pairs.
(
) is a conserved microRNA family that targets growth-regulating factors (GRFs), which play significant roles in plant growth and stress responses. Available evidence justifies the idea that
...-targeted GRFs have important functions in many plant species; however, no genome-wide analysis of the pitaya (
)
gene has yet been reported. Further, its biological functions remain elusive. To uncover the regulatory roles of
and its targets, the hairpin sequence of pitaya
and the open reading frame (ORF) of its target,
, were isolated from pitaya. Phylogenetic analysis showed that the precursor
(
) gene of plants might be clustered into three major groups, and, generally, a more recent evolutionary relationship in the intra-family has been demonstrated. The sequence analysis indicated that the binding site of
in
is located at the conserved motif which codes the conserved "RSRKPVE" amino acid in the Trp-Arg-Cys (WRC) region. In addition, degradome sequencing analysis confirmed that four GRFs (
, c56908.graph_c0;
, c52862.graph_c0;
, c39378.graph_c0 and
, c54658.graph_c0) are
targets that are regulated by specific cleavage at the binding site between the 10th and 11th nucleotides from the 5' terminus of
. Furthermore, quantitative real-time polymerase chain reaction (qRT-PCR) analysis showed that
is down-regulated when confronted with drought stress (15% polyethylene glycol, PEG), and its expression fluctuates under other abiotic stresses, i.e., low temperature (4 ± 1 °C), high temperature (42 ± 1 °C), NaCl (100 mM), and abscisic acid (ABA; 0.38 mM). Conversely, the expression of
showed the opposite trend to exposure to these abiotic stresses. Taken together,
plays a regulatory role in the control of
, which might influence the abiotic stress response of pitaya. This is the first documentation of this role in pitaya and improves the understanding of the molecular mechanisms underlying the tolerance to drought stress in this fruit.
Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved ...in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived mainly from cancer-associated fibroblasts played the most important role in chemoresistance by upregulating C-X-C motif chemokine receptor 7 (CXCR7) expression through signal transducer and activator of transcription 3/nuclear factor-κB pathway. CXCR7 knockdown resulted in the inhibition of IL6-induced proliferation and chemoresistance. In addition, CXCR7 silencing significantly decreased gene expression associated with stemness, chemoresistance and epithelial-mesenchymal transition and suppressed the proliferation ability of ESCC cells in three-dimensional culture systems and angiogenesis assay. In clinical samples, ESCC patients with high expression of CXCR7 and IL6 presented a significantly worse overall survival and progression-free survival upon receiving cisplatin after operation. These results suggest that the IL6-CXCR7 axis may provide a promising target for the treatment of ESCC.
With the rapid development in perovskite solar cell (PSC), high efficiency has been achieved, but the long‐term operational stability is still the most important challenges for the commercialization ...of this emerging photovoltaic technology. So far, bi‐dopants lithium bis(trifluoromethylsulfonyl)‐imide (Li‐TFSI)/4‐tert‐butylpyridine (t‐BP)‐doped hole‐transporting materials (HTM) have led to state‐of‐the art efficiency in PSCs. However, such dopants have several drawbacks in terms of stability, including the complex oxidation process, undesirable ion migration and ultra‐hygroscopic nature. Herein, a fluorine‐containing organic Lewis acid dopant bis(pentafluorophenyl)zinc (Zn‐FP) with hydrophobic property and high migration barrier has been employed as a potential alternative to widely employed bi‐dopants Li‐TFSI/t‐BP for polybis(4‐phenyl)(2,4,6‐trimethylphenyl)amine (PTAA). The resulting Zn‐FP‐based PSCs achieve a maximum PCE of 20.34 % with hysteresis‐free current density‐voltage (J‐V) scans. Specifically, the unencapsulated device exhibits a significantly advanced of operational stability under the International Summit on Organic Photovoltaic Stability protocols (ISOS−L‐1), maintaining over 90 % of the original efficiency after operation for 1000 h under continuous 1‐sun equivalent illumination in N2 atmosphere in both forward and reverse J‐V scan.
Superiorly operational stability: A fluorine‐containing hydrophobic Lewis acid dopant Zn‐FP as a potential alternative to widely employed bi‐dopant Li‐TFSI/t‐BP for PTAA, the resulting perovskite solar cells achieve high efficiency and superiorly operational stability.
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