Diversity is the fuel of innovation. Global diversity—geographical or international diversification—is indispensable for developing a true psychological science of human beings but remains poorly ...understood. We surveyed 68 top psychology journals in 10 subdisciplines and examined the global diversity of authors, editors (i.e., members of academic editorial teams), and journal ownership. Results show that (a) the global diversity of authorship, editorship, and ownership is low in top psychology journals, with the United States boasting outsized influences; (b) disparity intensifies along the hierarchy of authors, editors, and journal ownership and substantially differs between subdisciplines and journal types; (c) removing the United States markedly increases global diversity and eliminates differences in diversity between subdisciplines and between authorship and editorship; and (d) more authors and editors are from the journal’s home country (vs. a foreign journal) and from the editor-in-chief’s home country (vs. a journal with a foreign editor-in-chief), and the home-country biases are most pronounced in the United States—journals from the United States or with U.S. editors-in-chief have the lowest global diversity in authorship and editorship. These results provide substantial novel insights into the global diversity of psychology journals, with implications for a new diversity policy to stimulate the generation of variety and, by extension, innovation.
Discourse on gender diversity tends to overlook differences across levels of hierarchy (e.g., students, faculty, and editors) and critical dimensions (e.g., subdisciplines and geographical ...locations). Further ignored is its intersection with global diversity—representation from different countries. Here we document and contextualize gender disparity from perspectives of equal versus expected representation in journal editorship, by analyzing 68 top psychology journals in 10 subdisciplines. First, relative to ratios as students and faculty, women are underrepresented as editorial-board members (41%) and—unlike previous results based on one subfield—as editors-in-chief (34%) as well. Second, female ratios in editorship vary substantially across subdisciplines, genres of scholarship (higher in empirical and review journals than in method journals), continents/countries/regions (e.g., higher in North America than in Europe), and journal countries of origin (e.g., higher in American journals than in European journals). Third, under female (vs. male) editors-in-chief, women are much better represented as editorial-board members (47% vs. 36%), but the geographical diversity of editorial-board members and authorship decreases. These results reveal new local and broad contexts of gender diversity in editorship in psychology, with policy implications. Our approach also offers a methodological guideline for similar disparity research in other fields.
By analyzing the structural background, petroleum geological conditions, and typical regional (paleo) oil and gas reservoirs in marine ultra-deep oil and gas regions in China, this paper reveals the ...evolution processes of the marine ultra-deep oil and gas reservoirs and the key controlling factors of accumulation. The marine ultra-deep oil and gas resources in China are buried at depth of greater than 6000 m, and are mainly distributed in the Precambrian and Lower Paleozoic strata in the Sichuan, Tarim and Ordos cratonic basins. The development of marine ultra-deep source rocks in China is controlled by cratonic rifts and cratonic depressions with the background of global supercontinent breakup-convergence cycles. The source rocks in Sichuan Basin have the most developed strata, followed by Tarim Basin, and the development strata and scale of Ordos Basin needs to be further confirmed. The marine ultra-deep reservoir in China is dominated by carbonate rocks, and the reservoir performance is controlled by high-energy sedimentary environment in the early stage, superimposed corrosion and fracture in the later stage. The regional caprocks are dominated by gypsum salt rocks, shale, and tight carbonate rock. The ultra-deep oil and gas fields in China have generally experienced two stages of oil-reservoir forming, cracking (or partial cracking) of paleo-oil reservoirs, and late finalization of cracked gas (or highly mature to over mature oil and gas). The oil and gas accumulation is controlled by static and dynamic geological elements jointly. Major hydrocarbon generation center, high quality and large-scale reservoir resulted from karstification of high energy facies belt, thick gypsum rock or shale caprock, and stable trapping and preservation conditions are the key factors for accumulation of ultra-deep oil and gas. We propose three favorable exploration directions, i.e. the areas around intracratonic rift and intracratonic depression, and craton margin.
The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by the immunosuppressive tumor ...microenvironment (TME). Here, we reported a tumor acidity-responsive nanovaccine to remodel the immunosuppressive TME and expand the recruitment of tumor infiltrating lymphocytes (TILs) using hybrid micelles (HM), which encapsulated colony stimulating factor 1 receptor (CSF1-R) inhibitor BLZ-945 and indoleamine 2,3-dioxygenase (IDO) inhibitor NLG-919 in its core and displayed a model antigen ovalbumin (OVA) on its surface (denoted as BN@HM-OVA). The bioactive nanovaccine is coated with a polyethylene glycol (PEG) shell for extending nanoparticle circulation. The shell can be shed in response to the weakly acidic tumor microenvironment. The decrease in size and the increase in positive charge may cause the deep tumor penetration of drugs. We demonstrated that the bioactive nanovaccine dramatically enhance antigen presentation by dendritic cells (DCs) and drugs transportation into M1-like tumor-associated macrophages (TAMs) and tumor cells via size reduction and increasing positive charge caused by the weakly acidic TME. Such bioactive nanovaccine could remodel the immunosuppressive TME into an effector T cells favorable environment, leading to tumor growth inhibition in prophylactic and therapeutic E.G7-OVA tumor models. Furthermore, combining the bioactive nanovaccine with simultaneous anti-PD-1 antibody treatment leads to a long-term tumor inhibition, based on the optimal timing and sequence of PD-1 blockade against T cell receptor. This research provides a new strategy for the development of efficient cancer immunotherapy.
A tumor acidity-responsive nanovaccine to remodel the immunosuppressive tumor microenvironment and expand the recruitment of tumor infiltrating lymphocytes using bioactive micelles, which encapsulated colony stimulating factor 1 receptor (CSF1-R) inhibitor of BLZ-945 and indoleamine 2,3-dioxygenase (IDO) inhibitor of NLG-919 in their cores and displayed a model antigen of ovalbumin (OVA) on its surface (denoted as BN@HM-OVA). This BN@HM-OVA nanovaccine could remodel the immunosuppressive tumor microenvironment into an effector T cells favorable environment, which in turn enhanced dendritic cells recruitment, differentiation, antigen presentation and T-cells response, leading to inhibition of tumor growth in both prophylactic and therapeutic E.G7-OVA tumor models. Display omitted
•A bioactive nanovaccine (BN@HM-OVA) was adopted for synergistic immunotherapy of E.G7-OVA tumors.•BN@HM-OVA exhibited superior ability to induce DCs maturation and robust antigen-specific T cell responses.•BN@HM-OVA contributed to a homeostasis in the tumor microenvironment ideal for antitumor vaccination.•The combination treatment of BN@HM-OVA and αPD-1 achieved maximum therapeutic benefits.
A newly developed based on PEG-PLGA co-delivery nanoparticles for chemo-gene combined therapy to suppress colorectal carcinoma
Display omitted
•The design for a combination therapy for sorafenib and ...PEDF in a nano-formulation aimed to increase anti-tumor effect on CRC was the first time.•Sora@PEDF-NPs showed better inhibition effect on CRC compared with single loaded nanoparticles in vitro and in vivo.•Sora@PEDF-NPs could decrease the acute toxicity comparing with free Sora on Bal b/c mice.•The PEDF would not increase the toxicity of Sora@PEDF-NPs verified by acute toxicity analysis.
Combination treatment through simultaneous delivery of anticancer drugs and gene with nano-formulation has been demonstrated to be an elegant and efficient approach for colorectal cancer therapy. Recently, sorafenib being studied in combination therapy in colorectal cancer (CRC) attracted attention of researchers. On the basis of our previous study, pigment epithelium-derived factor (PEDF) loaded nanoparticles showed good effect on CRC in vitro and in vivo. Herein, we designed a combination therapy for sorafenib (Sora), a multi-kinase inhibitor and PEDF, a powerful antiangiogenic gene, in a nano-formulation aimed to increase anti-tumor effect on CRC for the first time. Sora and PEDF were simultaneously encapsulated in PEG-PLGA based nanoparticles by a modified double-emulsion solvent evaporation method. The obtained co-encapsulated nanoparticles (Sora@PEDF-NPs) showed high entrapment efficiency of both Sora and PEDF — and exhibited a uniform spherical morphology. The release profiles of Sora and PEDF were in a sustained manner. The most effective tumor growth inhibition in the C26 cells and C26-bearing mice was observed in the Sora@PEDF-NPs in comparison with none-drug nanoparticles, free Sora, mono-drug nanoparticles (Sora-NPs and PEDF-NPs) and the mixture of Sora-NPs and equivalent PEDF-NPs (Mix-NPs). More importantly, Sora@PEDF-NPs showed lower toxicity than free Sora in mice according to the acute toxicity test. The serologic biochemical analysis and mice body weight during therapeutic period revealed that Sora@PEDF-NPs had no obvious toxicity. All the data demonstrated that the simultaneously loaded nanoparticles with multi-kinase inhibitor and anti-angiogenic gene might be one of the most potential formulations in the treatment of colorectal carcinoma in clinic and worthy of further investigation.
Based on drilling cores, well logging and seismic data, source rocks and reservoirs are evaluated; and the natural gas genesis is identified through the analysis of natural gas isotopes, components ...and fluid inclusions, to study the gas accumulation conditions of the gypsum salt rock related strata of the Ordovician lower assemblage in Ordos Basin. (1) The natural gas from Ordovician lower assemblage is high thermal evolution dry gas from marine source rock, characterized by relatively light δ13C value of methane and heavy δ13C value of ethane. The natural gas is identified as gas cracking from crude oil according to component analysis. Thermochemical sulfate reduction (TSR) reaction has happened between the hydrocarbon fluid and sulfate as sulfur crystals are found in the cores, hydrogen sulfide is found in the natural gas, and hydrocarbon and hydrogen sulfide fluid inclusions are widespread in secondary minerals. (2) Around the gypsum-salt lows, argillaceous rocks are extensive in the Ordovician lower assemblage, reaching a cumulative thickness of 20–80 m. The effective source rocks include argillaceous rock rich in organic laminae, algal clump and algal dolomite. Analysis shows that the source rocks have a dominant TOC of 0.1%–0.5%, 0.31% on average and 3.24% at maximum. The source rocks have an average TOC of 0.58% after recovered through organic acid salt method, indicating the source rocks have high hydrocarbon supply potential. (3) In the sedimentary period, the palaeo-uplift controlled the distribution of reservoirs. The inherited secondary palaeo-uplift in Wushenqi–Jingbian east of the central palaeo-uplift and the low uplift formed by thick salt rocks near Shenmu–Zizhou area controlled the distribution of penecontemporaneous grain shoal dolomite reservoirs. The salinization sedimentary environment of gypsum salt rock can promote the development of reservoir. There are three types of dolomite reservoirs, the one with intercrystalline pore, with dissolution pore, and with fracture; intercrystalline and dissolution pores are main reservoir spaces. (4) There are two types of cap rocks, namely tight carbonate rock and gypsum-salt rock, constituting two types of source-reservoir-cap assemblages respectively. The general accumulation model is characterized by marine source rock supplying hydrocarbon, beach facies limy dolomite reservoir, small fractures acting as migration pathways, and structural-lithologic traps as accumulation zones. (5) The third and fourth members of Majiagou Formation are major target layers in the lower assemblage. The Wushengqi–Jingbian secondary paleo-uplift area and Shenmu–Zizhou low uplift are dolomite and limestone transition zone, there develops tight limestone to the east of the uplift zone, which is conducive to the formation of gas reservoir sealed by lithology in the updip. Two risk exploration wells drilled recently have encouraging results, indicating that the two uplift zones are important prospects.
Therapeutic approaches of combining conventional photodynamic therapy (PDT) with other adjuvant treatments to sensitize PDT represent an appealing strategy. Herein, a novel synergetic “nanobomb” ...strategy based on glutathione (GSH)-responsive biodegradation was proposed to effectively destroy tumors expeditiously and accurately. This “nanobomb” was rationally constructed via the simultaneous encapsulation of methylene blue (MB) and l-arginine (L-Arg) into polyethylene glycol (PEG) modified mesoporous organosilicon nanoparticles (MON). The resulting L-Arg/MB@MP initially exhibited prolonged blood circulation, improved bioavailability, and enhanced tumor accumulation in mice after tail vein injection according to the pharmacokinetic investigations, before the nanoparticles were entirely excreted. Under laser irradiation, L-Arg/MB@MP produced remarkable reactive oxygen species (ROS) directly for PDT therapy, while a portion of ROS may oxidize L-Arg to generate nitric oxide (NO) not only for gas therapy (GT) but also serve as a biological messenger to regulate vasodilation to alleviate the tumor hypoxia. Subsequently, the rapidly released NO was further oxidized to reactive nitrogen species, which together with ROS promote immunogenic cell death by inducing G2/M cell-cycle arrest and apoptosis in cancer cells, and eventually resulting in enhanced anti-tumor immune responses. Moreover, the GSH depletion in tumor tissues induced by L-Arg/MB@MP biodegradation can cooperate with GT to amplify the therapeutic effect of PDT. These results demonstrate that this “nanobomb” provides new ideas for clinical translation to treat tumor patients in terms of synergistic PDT-GT nanotherapy in hypoxic-solid tumors.
Display omitted
•Here, a novel GSH-responsive nanoplatform (L-Arg/MB@MP) was developed to combine nitric oxide (NO)-based gas therapy (GT) to amplify PDT.•The GSH-responsive property of L-Arg/MB@MP leaded to rapid biodegradation of the nanoparticles and controlled drug release.•L-Arg/MB@MP generated considerable ROS and NO for PDT-GT to relieve the tumor hypoxia, consequently activating antitumor immunity.
In this study, a facile but effective nanoplatform of hyaluronic acid nanomicelles baring with prodrug tirapazamine (TPZ) and photosensitizer (chlorin e6, Ce6) was demonstrated for the targeted and ...highly efficient photo-bioreductive cascading oncotherapy.
Display omitted
Currently, architecting a rational and efficient nanoplatform combing with multi-therapeutic modalities is highly obligatory for advanced cancer treatment. In order to remedy the self-limiting hypoxic dilemma of photodynamic therapy (PDT), herein, a facile photosensitizer (i.e., chlorin e6, Ce6) and bioreductive prodrug (i.e., tirapazamine, TPZ)-coloaded hyaluronic acid (HA) nanomicelles (denoted as TPZ@HA-Ce6) was developed for the cascading mode of photo-bioreductive cancer therapy. Taking the typical advantage of Ce6 coupled HA conjugate, TPZ was easily and successfully accommodated into the hydrophobic core of HA-Ce6 nanomicelles, yielding TPZ@HA-Ce6. It showed good dispersibility and stability with the hydrodynamic size of ca. 170 nm. It targeted the CD44 overexpressed cancer cells by receptor-mediated endocytosis way and killed them effectively with singlet oxygen and the subsequent TPZ radicals resulting from the oxygen depletion of PDT. The later was further verified by the hypoxia probe in vivo. Using murine mammary carcinoma 4T1 model, TPZ@HA-Ce6 nanomicelles exhibited cascading and synergistic anticancer effect of PDT and TPZ bioreductive therapy compared with each monotherapy. This work suggests the promising prospect of the hybrid hyaluronic nanomicelles for highly efficient cancer combination treatment.
Bovine herpesvirus 1 (BoHV-1), an important bovine viral pathogen, causes severe disease in the upper respiratory tract and reproductive system. Tonicity-responsive enhancer-binding protein (TonEBP), ...also known as nuclear factor of activated T cells 5 (NFAT5), is a pleiotropic stress protein involved in a range of cellular processes. In this study, we showed that the knockdown of NFAT5 by siRNA increased BoHV-1 productive infection and overexpression of NFAT5 via plasmid transfection decreased virus production in bovine kidney (MDBK) cells. Virus productive infection at later stages significantly increased transcription of NFAT5 but not appreciably alter measurable NFAT5 protein levels. Virus infection relocalized NFAT5 protein and decreased the cytosol accumulation. Importantly, we found a subset of NFAT5 resides in mitochondria, and virus infection led to the depletion of mitochondrial NFAT5. In addition to full-length NFAT5, another two isoforms with distinct molecular weights were exclusively detected in the nucleus, where the accumulation was differentially affected following virus infection. In addition, virus infection differentially altered mRNA levels of PGK1, SMIT, and BGT-1, the canonical downstream targets regulated by NFAT5. Taken together, NFAT5 is a potential host factor that restricts BoHV-1 productive infection, and virus infection hijacks NFAT5 signaling transduction by relocalization of NFAT5 molecules in cytoplasm, nucleus, and mitochondria, as well as altered expression of its downstream targets.
Accumulating studies have revealed that NFAT5 regulates disease development due to infection of numerous viruses, underlying the importance of the host factor in virus pathogenesis. Here, we report that NFAT5 has capacity to restrict BoHV-1 productive infection
. And virus productive infection at later stages may alter NFAT5 signaling pathway as observed by relocalization of NFAT5 protein, reduced accumulation of NFAT5 in cytosol, and differential expression of NFAT5 downstream targets. Importantly, for the first time, we found that a subset of NFAT5 resides in mitochondria, implying that NFAT5 may regulate mitochondrial functions, which will extend our knowledge on NFAT5 biological activities. Moreover, we found two NFAT5 isoforms with distinct molecular weights were exclusively detected in the nucleus, where the accumulation was differentially affected following virus infection, representing a novel regulation mechanism on NFAT5 function in response to BoHV-1infection.
The dolomitization of carbonate rocks has always been a hot topic in the study of the dolomite reservoir. In this study, the genesis of Cambrian dolomite in the Bachu area, Tarim Basin, was assessed ...through petrographic examinations, isotope compositions (C, O, and Sr), trace and rare earth elements, and fluid inclusion microthermometry. Microscopic analysis revealed three types of dolomites: very fine-crystalline, nonplanar dolomite (D1); fine-crystalline, nonplanar to planar-s dolomite (D2); and medium- to coarse-crystalline, planar-e to planar-s dolomite (D3). D1 dolomite exhibits well-preserved original sedimentary features, such as algal laminae, stromatolite, and evaporite streak, and is characterized by the 87Sr/86Sr value and δ18O value in equilibrium with the coeval seawater, its high Sr and Na content, and its low Mn content. This indicates that D1 dolomite is primarily a penecontemporaneous dolomite in tidal flat or lagoon environments, and its dolomitizing fluid is mainly evaporated mesosaline to penesaline seawater. D2 dolomite shows ghosts of precursor particles; features δ13C values in equilibrium with the coeval seawater, high 87Sr/86Sr values, low Sr content, and positive Eu anomaly; and is widely distributed close to stylolite. This illustrates that D2 dolomite was principally formed by seepage–reflux dolomitization, and is closely related to hydrothermal activity and pressure dissolution. D3 dolomite displays a crystal texture with a cloudy core and compositional zoning, and the original sedimentary fabrics cannot be identified. It has similar δ13C values and REE patterns to the calcite precipitated from coeval seawater, high 87Sr/86Sr values, low Sr contents and high Mn/Sr ratios, which suggests that D3 dolomite is chiefly related to the recrystallization of the precursor dolomite during the deep burial stage, and the deep circular brine provides Mg ions through the fluid–rock reaction. This study shows that the Cambrian dolomite in the Bachu area is mainly formed in the coeval seawater environment during the penecontemporaneous and shallow burial stages, and has extensively suffered from recrystallization and burial diagenesis due to long-term deep burial, which was further strengthened in the fracture-enriched area.
PDF
