In refractory and relapsing multiple, myeloma good complete response rates may be achieved by Vincristine, Melphalan, Cyclophosphamide and Prednisolone (VMCP) like regimen which is effective ...alternative and less expensive in developing country like Bangladesh. The study was conducted to see the response of VMCP as an alternative in relapsing or refractory multiple myeloma. The study has been carried out in the department of Haematology, Bangabandhu Sheikh Mujib Medical University from July 2004 to June, 2005. This study was conducted on refractory case of multiple myeloma, having aged between 45 to 70 years. A total of ten patients had been taken for this study group. Newly diagnosed multiple myeloma is not included in this study. All of the 10 patients were treated according to the following VMCP protocol, Vincristine 1mg IV, d1, Melphalan 6mg/m2/d p.o. d1-d7, Cyclophosphamide 120mg/m2/d p.o. d1-d7 Prednisolone 60mg/m2/d p.o. d1-d7. Cycles were repeated every 28 days for 6 cycle. Six out of ten patients with refractory multiple myeloma displayed minimal response (60%) after treatment with 6 cycle of VMCP protocol, three patients entered partial remission (30%), and one (10%) showed complete response.
Objective: To ascertain that antibiotics have no role in the management of bronchiolitis.
Design: Multicentre randomized control trial (RCT).
Setting: Five purposively selected teaching hospitals ...in Bangladesh.
Patient: Children under 24 months old with bronchiolitis.
Interventions: Children were randomized into three groups of therapeutic interventions: parenteral ampicillin (P‐Ab), oral erythromycin (O‐Ab) and no antibiotic (N‐Ab) in adjunct to supportive measures.
Main outcome measures: Clinical improvement was assessed using 18 symptoms/signs which were graded on a two‐point recovery scale of ‘rapid’ and ‘gradual’, indicating improvement within ‘four days’ and ‘beyond four days’, respectively.
Results: Each intervention group consisted of 98 ± 1 children having comparable clinico‐epidemiological characteristics at the baseline. The trial revealed that most chesty features (features appearing to arise from chest, i.e. cough, breathing difficulty, wheeze, chest indrawing, tachypnoea, tachycardia, rhonchi and crepitation) demonstrated a gradual recovery, beyond 4th admission day and, not differing among the three intervention groups (p > 0.23, p < 0.62, p = 0.54, p < 0.27, p = 0.75, p = 0.76, p = 0.81, p > 0.98, respectively). Most non‐chesty features (features appearing to arise away from chest, i.e. feeding/sleeping difficulties, social smile, restlessness, inconsolable crying, nasal flaring, fever and hypoxaemia) demonstrated a rapid recovery, within 4 days, remaining comparable among the three intervention groups (p < 0.07, p = 0.65, p = 0.24, p < 0.61, p = 0.22, p = 0.84, p = 0.29 and p = 0.96, respectively). However, nasal symptoms (runny nose and nasal blockage) also showed no difference among groups (p = 0.36 and p = 0.66, respectively). Thus, the dynamics of clinical outcome obviates that children not receiving antibiotics had similar clinical outcome than those who did.
Conclusion: In hospital settings, managing bronchiolitis with only supportive measures but without antibiotics remains preferable.
To assess the relationship between placental weight and birth weight, two hundred forty six pregnant mothers, who were otherwise healthy, were prospectively followed in a city hospital during ...antenatal period until delivery and immediate post-partum period. Height of mothers was measured initially and weight measured at each visit during the antenatal check-up. Placental weight and birth weight of babies were measured by one of the authors immediately after delivery by a weighing scale. Eighty one percent of the mothers were between the age group of 20-29 years. The BMI of 92% mothers was 18.5 and above. Most of the mothers came both with primigravida (42%) or second gravida (33%) and in 25% cases 3rd or onwards. In 49% cases the placental weight was between 401-500 gm, in 30% cases >500 gm and in 21% cases 400 gm or less. There was delivery of appropriate-birth-weight babies in 85% cases and low-birth-weight babies in 15% cases. It was observed that a very strong correlation existed between placental weight and birth weight (r = 0.391, p<0.001). Even this correlation was stronger in small for gestational age babies. However, there was no correlation between placental weight and APGAR score at one minute. It is concluded that increment of birth weight occurs with increase of placental weight. If placental weight can be measured by ultrasonography in second or early third trimester of pregnancy birth weight is possible to be assessed and appropriate measure can be taken to increase the birth weight.
Here, the doubly-strange Ξ baryons provide an effective way to study a puzzle called the missing-baryons problem, where both quark models and lattice gauge theory predict more baryon excited states ...than are seen experimentally. However, few of these excited states have been observed with any certainty. Here, high-mass Ξ states have been searched for in photoproduction with the CLAS detector, and upper limits for the total cross sections have been established from threshold to W = 3.3 GeV. In addition, the total cross sections of the ground state Ξ¯(1320) and first excited state Ξ¯(1530) are presented, extending significantly the center-of-mass energy range of previous data.
The exclusive reaction γp→pK+K− was studied in the photon energy range 3.0–3.8 GeV and momentum transfer range 0.6<−t<1.3 GeV2. Data were collected with the CLAS detector at the Thomas Jefferson ...National Accelerator Facility. In this kinematic range the integrated luminosity was approximately 20 pb−1. The reaction was isolated by detecting the K+ and the proton in CLAS, and reconstructing the K− via the missing-mass technique. Moments of the dikaon decay angular distributions were extracted from the experimental data. Besides the dominant contribution of the ϕ meson in the P wave, evidence for S−P interference was found. The differential production cross sections dσ/dt for individual waves in the mass range of the ϕ resonance were extracted and compared to predictions of a Regge-inspired model. This is the first time the t-dependent cross section of the S-wave contribution to the elastic K+K− photoproduction has been measured.
Despite decades of studies of the photoproduction of hyperons, both their production mechanisms and their spectra of excited states are still largely unknown. While the parity-violating weak decay of ...hyperons offers a means of measuring their polarization, which could help discern their production mechanisms and identify their excitation spectra, no such study has been possible for doubly strange baryons in photoproduction, due to low production cross sections. However, by making use of the reaction γp→K+K+Ξ−, we have measured, for the first time, the induced polarization, P, and the transferred polarization from circularly polarized real photons, characterized by Cx and Cz, to recoiling Ξ−s. The data were obtained using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab for photon energies from just over threshold (2.4 GeV) to 5.45 GeV. These first-time measurements are compared, and are shown to broadly agree, with model predictions in which cascade photoproduction proceeds through the decay of intermediate hyperon resonances that are produced via relativistic meson exchange, offering a new step forward in the understanding of the production and polarization of doubly-strange baryons.
We report the first measurements of the E beam-target helicity asymmetry for the →γ→n→K0Λ and K0Σ0 channels in the energy range 1.70≤W≤2.34 GeV. The CLAS system at Jefferson Lab uses a circularly ...polarized photon beam and a target consisting of longitudinally polarized solid molecular hydrogen deuteride with low background contamination for the measurements. The multivariate analysis method boosted decision trees is used to isolate the reactions of interest. Comparisons with predictions from the KaonMAID, SAID, and Bonn-Gatchina models are presented. These results will help separate the isospin I=0 and I=1 photocoupling transition amplitudes in pseudoscalar meson photoproduction.
The cross section for coherent omega-meson photoproduction off the deuteron has been measured for the first time as a function of the momentum transfer t=(P-gamma - P-omega)(2) and photon energy ...E-gamma using the CLAS detector at the Thomas Jefferson National Accelerator Facility. The cross sections are measured in the energy range 1.4 < E-gamma < 3.4GeV. A model based on omega- N rescattering is consistent with the data at low and intermediate momentum transfer, vertical bar t vertical bar. For 2.8 < E-gamma < 3.4GeV, the total cross-section of omega - N scattering, based on fits within the framework of the Vector Meson Dominance model, is in the range of 30-40 mb.
We report on the first measurement of cross sections for exclusive deeply virtual pion electroproduction off the proton, ep -> e'n pi(+), above the resonance region at backward pion center-of-mass ...angles. The phi(pi)*-dependent cross sections were measured, from which we extracted three combinations of structure functions of the proton. Our results are compatible with calculations based on nucleon-to-pion transition distribution amplitudes (TDAs). These non-perturbative objects are defined as matrix elements of three-quark-light-cone-operators and characterize partonic correlations with a particular emphasis on baryon charge distribution inside a nucleon
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