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  • Brain Oxygen Optimization i... Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial
    Okonkwo, David O; Shutter, Lori A; Moore, Carol ... Critical care medicine 45, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    A relationship between reduced brain tissue oxygenation and poor outcome following severe traumatic brain injury has been reported in observational studies. We designed a Phase II trial to assess ...
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  • The molecular genetics of c... The molecular genetics of coenzyme Q biosynthesis in health and disease
    Laredj, Leila N; Licitra, Floriana; Puccio, Hélène M Biochimie, 05/2014, Volume: 100
    Journal Article
    Peer reviewed

    Coenzyme Q, or ubiquinone, is an endogenously synthesized lipid-soluble antioxidant that plays a major role in the mitochondrial respiratory chain. Although extensively studied for decades, recent ...
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  • Mammalian Fe-S cluster biog... Mammalian Fe-S cluster biogenesis and its implication in disease
    Beilschmidt, Lena K; Puccio, Hélène M Biochimie, 05/2014, Volume: 100
    Journal Article
    Peer reviewed

    Iron-sulfur (Fe-S) clusters are inorganic cofactors that are ubiquitous and essential. Due to their chemical versatility, Fe-S clusters are implicated in a wide range of protein functions including ...
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  • Spreading depolarisations a... Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study
    Hartings, Jed A, Dr; Bullock, M Ross, MD; Okonkwo, David O, MD ... Lancet neurology, 12/2011, Volume: 10, Issue: 12
    Journal Article
    Peer reviewed

    Summary Background Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50–60% of patients after traumatic brain ...
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  • Drug repurposing for COVID-... Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium
    Gupta, Rajaneesh K; Nwachuku, Enyinna L; Zusman, Benjamin E ... PloS one, 09/2021, Volume: 16, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Drug repurposing has the potential to bring existing de-risked drugs for effective intervention in an ongoing pandemic—COVID-19 that has infected over 131 million, with 2.8 million people succumbing ...
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  • Cis P-tau is induced in cli... Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
    Albayram, Onder; Kondo, Asami; Mannix, Rebekah ... Nature communications, 10/2017, Volume: 8, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) and Alzheimer's disease. We previously ...
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  • Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: a TRACK-TBI study
    Yuh, Esther L; Cooper, Shelly R; Mukherjee, Pratik ... Journal of neurotrauma, 2014-Sep-01, Volume: 31, Issue: 17
    Journal Article
    Peer reviewed
    Open access

    We evaluated 3T diffusion tensor imaging (DTI) for white matter injury in 76 adult mild traumatic brain injury (mTBI) patients at the semiacute stage (11.2±3.3 days), employing both whole-brain ...
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  • Circulating Brain-Derived N... Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury
    Korley, Frederick K; Diaz-Arrastia, Ramon; Wu, Alan H B ... Journal of neurotrauma, 2016-Jan-15, Volume: 33, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Brain-derived neurotrophic factor (BDNF) is important for neuronal survival and regeneration. We investigated the diagnostic and prognostic values of serum BDNF in traumatic brain injury (TBI). We ...
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  • Interaction of obesity and ... Interaction of obesity and proteins associated with the NLRP3 inflammasome following mild traumatic brain injury
    Eagle, Shawn R; Basantani, Mahesh K; Preszler, Jonathan ... Scientific reports, 05/2024, Volume: 14, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome has been associated with worse outcomes from severe traumatic brain injury (TBI). The NLRP3 inflammasome is also strongly ...
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