Prostatic urethral lift is a minimally invasive procedure used to improve the symptoms of benign prostatic enlargement. It utilizes the UroLift device to insert small implants through occlusive ...lateral lobes of the prostate, thereby creating an open anterior channel through the prostate. We describe a previously unreported complication of UroLift whereby a patient presented with loin pain post-procedure and was found to have a UroLift clip across the vesico-ureteric junction , leading to ureteric obstruction, hydronephrosis and calyceal rupture.
A binning scheme is proposed for D→K+π−π−π+ phase space that will improve the sensitivity of a B−→DK− analysis to the angle γ of the Cabibbo-Kobayashi-Maskawa Unitarity Triangle. The scheme makes use ...of amplitude models recently reported by the LHCb collaboration. Assuming that a four-bin scheme optimised on the models retains a similar sensitivity when applied in data, it is estimated that the statistical uncertainty on γ from the B-meson sample so far collected by the LHCb experiment will be as low as 5 degrees. This will be one of the most precise results available for any single decay mode in a B−→DK− measurement. Quantum-correlated DD¯ data accumulated by the CLEO-c experiment are analysed to provide first constraints on the coherence factors and average strong-phase differences in the four bins, which are necessary inputs for the measurement. These constraints are compared with the predictions of the model, and consequences for the measurement of γ are discussed.
Motivation: To compare entire genomes from different species, biologists increasingly need alignment methods that are efficient enough to handle long sequences, and accurate enough to correctly align ...the conserved biological features between distant species. The two main classes of pairwise alignments are global alignment, where one string is transformed into the other, and local alignment, where all locations of similarity between the two strings are returned. Global alignments are less prone to demonstrating false homology as each letter of one sequence is constrained to being aligned to only one letter of the other. Local alignments, on the other hand, can cope with rearrangements between non-syntenic, orthologous sequences by identifying similar regions in sequences; this, however, comes at the expense of a higher false positive rate due to the inability of local aligners to take into account overall conservation maps. Results: In this paper we introduce the notion of glocal alignment, a combination of global and local methods, where one creates a map that transforms one sequence into the other while allowing for rearrangement events. We present Shuffle-LAGAN, a glocal alignment algorithm that is based on the CHAOS local alignment algorithm and the LAGAN global aligner, and is able to align long genomic sequences. To test Shuffle-LAGAN we split the mouse genome into BAC-sized pieces, and aligned these pieces to the human genome. We demonstrate that Shuffle-LAGAN compares favorably in terms of sensitivity and specificity with standard local and global aligners. From the alignments we conclude that about 9% of human/mouse homology may be attributed to small rearrangements, 63% of which are duplications. Availability: Our systems, supplemental information, and the alignment of the human and mouse genomes using Shuffle-LAGAN are available at http://lagan.stanford.edu/glocal Contact: serafim@cs.stanford.edu * To whom correspondence should be addressed. † These authors contributed equally to the work.
Purpose
To report the etiology, presenting symptoms and outcomes of the different treatments performed in female patients with recurrent urethral stricture.
Materials and methods
Twenty-six patients ...with refractory LUTS were diagnosed with a urethral stricture. The symptoms, the treatment performed and the outcomes were prospectively recorded. Sixteen patients were treated with a urethroplasty using a buccal mucosal graft (BMG) in 14 cases (54 %) and a vaginal flap in 2 (8 %). Urethral dilatation, optical urethrotomy and meatoplasty were performed in 8 (31 %), 1 (3.8 %) and 1 (3.8 %) patients, respectively.
Results
Strictures were idiopathic in 11 patients (42 %). Previous urethral instrumentation and traumatic vaginal delivery were the commonest causes of urethral stricture (42 and 15 %, respectively). The most frequent symptoms were reduced flow (93 %), detrusor overactivity (50 %) and UTIs (42 %). The stricture was cured in 93 % of patients treated with a BMG urethroplasty and in all the patients in which a vaginal flap urethroplasty was performed. In the same group, the improvement in urethral pain was observed in the 67 and the 88 % of patients were cured from recurrent UTIs. All the patients treated with urethral dilatation needed further dilatations; hence, the cure of the stricture was achieved in none of them. Improvement in urethral pain, UTIs and detrusor activity was not recorded in the latter group.
Conclusion
Urethroplasty in its various forms has demonstrated in the present series the highest cure rate for the treatment of recurrent urethral stricture.
As measurements of the CKM angle γ in decays of b-hadrons become increasingly precise, it is important to consider the impact of processes that affect secondary and tertiary decay products and can ...contribute to the observed CP violation. The golden decay mode used to measure γ is B → DK, where D → Ks0π+π−. Due to the presence of a Ks0 meson in the final state, γ measurements based on this mode are affected by neutral kaon CP violation and matter regeneration, and this study examines the potential size of the impact. Previous studies determine the impact of kaon CP violation to be a few degrees in size, but make simplifying assumptions about how experimental measurements are implemented. These assumptions are lifted in the present study, and the matter regeneration effect is included for the first time. The results are presented within the context of γ measurements to be made using the LHCb and Belle II detectors. It is found that the expected biases due to ignoring the effects of CP violation and matter regeneration in neutral kaons is small and less than 0.5° degrees in all experimental scenarios considered.
Quantum-correlated ψ(3770)→DD¯ decays collected by the CLEO-c experiment are used to perform first measurements of F+, the fractional CP-even content of the self-conjugate decays D→π+π−π0 and ...D→K+K−π0. Values of 0.968±0.017±0.006 and 0.731±0.058±0.021 are obtained for π+π−π0 and K+K−π0, respectively. It is demonstrated how modes of this sort can be cleanly included in measurements of the unitarity triangle angle γ using B∓→DK∓ decays. The high CP-even content of D→π+π−π0, in particular, makes this a promising mode for improving the precision on γ.
PDF
