In this research, a new protocol for the one-pot multicomponent synthesis of diazepine derivatives using a 1,2-diamine, a linear or cyclic ketone, and an isocyanide in the presence of a catalytic ...amount of silica-supported iron oxide (Fe3O4/SiO2) nanoparticles at ambient temperature in excellent yields is described.
Display omitted
A new, efficient, one-pot multicomponent reaction for the synthesis of diazepine derivatives in excellent yields is described. The reactions of various 1,2-diamines, terminal alkynes, and an ...isocyanide take place in the presence of a catalytic amount of magnetically recoverable silica-supported superparamagnetic Fe3O4 nanoparticles in ethanol (as a green reaction medium) at ambient temperature.
A one‐pot multicomponent synthesis of imidazo1,2‐apyridine derivatives by using pyridin‐2‐amines, aldehydes, and terminal alkynes in the presence of a catalytic amount of silica‐supported iron oxide ...(Fe3O4@SiO2) nanoparticles in refluxing EtOH in good‐to‐excellent yields is reported.
Rapid growth in nanotechnology toward the development of nanomedicine agents holds massive promise to improve therapeutic approaches against cancer. Nanomedicine products represent an opportunity to ...achieve sophisticated targeting strategies and multifunctionality. Nowadays, nanoparticles (NPs) have multiple applications in different branches of science. In recent years, NPs have repetitively been reported to play a significant role in modern medicine. They have been analyzed for different clinical applications, such as drug carriers, gene delivery to tumors, and contrast agents in imaging. A wide range of nanomaterials based on organic, inorganic, lipid, or glycan compounds, as well as on synthetic polymers has been utilized for the development and improvement of new cancer therapeutics. In this study, we discuss the role of NPs in treating cancer among different drug delivery methods for cancer therapy.
In recent years, nanoparticles (NPs) have repetitively been reported to play a significant role in modern medicine. They have been analyzed for different clinical applications, such as drug carriers, gene delivery to tumors, and contrast agents in imaging.In this review, we discuss the role of NPs in treating cancer among different drug delivery methods for cancer therapy.
Among the main promising systems to triggering therapeutic antitumor immunity is the blockade of immune checkpoints. Immune checkpoint pathways regulate the control and eradication of infections, ...malignancies, and resistance against a host of autoantigens. Initiation point of the immune response is T cells, which have a critical role in this pathway. As several immune checkpoints are initiated by ligand–receptor interactions, they can be freely blocked by antibodies or modulated by recombinant forms of ligands or receptors. Antibodies against cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4) were the first immunotherapeutics that achieved the US Food and Drug Administration approval. Preliminary clinical results with the blockers of additional immune checkpoint proteins, such as programmed cell death protein 1 (PD‐1) indicate extensive and different chances to boost antitumor immunity with the objective of conferring permanent clinical effects. This study provides an overview of the immune checkpoint pathways, including CTLA‐4, PD‐1, lymphocyte activation gene 3, T‐cell immunoglobulin and mucin domain 3, B7‐H3, and diacylglycerol kinase α and implications of their inhibition in the cancer therapy.
Recent advances in the understating of tumor immunology suggest that cancer immunotherapy is an effective treatment against various types of cancer. In particular, the remarkable successes of immune checkpoint‐blocking antibodies in clinical settings have encouraged researchers to focus on developing other various immunologic strategies to combat cancer. Checkpoints are a kind of control mechanisms whose functions are important in survival, initiation, intensification, and termination of the immune system activities in the body. Their stimulation or inhibition occasionally leads to immune cell survival and/or in contrary, they identify the survival of their target. To avoid the excessive activity of the immune system there are reciprocal receptors of these ligands on various cells.
The aim of this review is providing an overview of the various representative literature procedures for the preparation of tetrazoles
via
isocyanide-based reactions. These reactions have been divided ...into four classes including two-component reactions (2CRs), Passerini-azide three-component reactions (PA-3CRs), Ugi-azide four-component reactions (UA-4CRs) and Ugi-azide three-component reactions (UA-3CRs).
This article provides an overview of the contributions and advances in the synthesis of tetrazoles
via
isocyanide-based reactions.
A cellulose-based nanocomposite with highly loaded Fe3O4 nanoparticles was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR) spectra, scanning electron microscopy (SEM) ...images, energy-dispersive X-ray spectroscopy (EDX) spectra and X-ray diffraction (XRD) measurements. Its catalytic activity was investigated in the condensation reaction between o-phenylenediamines and ketones that produced benzodiazepines in good to excellent yields under mild reaction conditions. A good correlation between the amount of surface acid sites and the morphology of the catalyst and its catalytic activity was observed. The nanocatalyst could be recycled and reused without significant loss of its catalytic activity.
Display omitted
•A cellulose-based nanocomposite with highly loaded Fe3O4 was prepared.•Its morphology was characterized by FT-IR, SEM, EDX and XRD analyses.•Its catalytic activity was excellent in the synthesis of benzodiazepines.•Work-up procedure was easy.
Display omitted
•Benzodiazepines were synthesized in high yields by a three-component reaction at room temperature.•An eco-friendly, stable, and magnetically reusable composite nanocatalyst is ...introduced.•The reaction was highly selective; and workup procedure was easy.•Precursors were simple and readily available.
This work describes the catalytic ability of Fe3O4@chitosan as an environmentally benign and stable composite nanocatalyst for the synthesis of benzodiazepine derivatives starting from o-phenylenediamine, dimedone, and different aldehydes via a one-pot, three-component reaction at room temperature. High-to-excellent yields, easy work-up, reusability of the nanocatalyst, and non-toxicity are some of the advantages of this protocol.
Greenhouse gases such as CO2 are considered effective materials in global warming due to their high absorptivity. So, lowering atmospheric CO2 is one of the most practical strategies. Utilizing ...carbon dioxide in chemical processes is an applicable method. In this study, Aspen HYSYS 10 was used to investigate how carbon dioxide can be added to the process of dimethyl carbonate production, and the affective parameters of the process, including temperature, residence time, feed ratio, and recycle ratio, were evaluated. It was observed that the production of DMC grew as temperature rose. The simulation results also revealed that a maximum conversion of roughly 8% was attained in the MeOH/EC. Additionally, boosting the recycle ratio is detrimental, and the impact of temperature and MeOH/EC has been enhanced by increasing the residence time. The interactions of the above parameters have been studied by Design Expert 12. The optimum value of effective parameters for the production of dimethyl carbonate has been obtained as follows: temperature of 164.7° C, recycle ratio of 0.2, residence time of 139.45 min, and feed ratio of 5.9%, leading to the conversion of 70%.
![Synthesis of Imidazo[1,2-a]...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/0018-019X/small "Synthesis of Imidazo[1,2-a]pyridines Using Fe3O4@SiO2 as an Efficient Nanomagnetic Catalyst via a One-Pot Multicomponent Reaction")
