ABSTRACT
We present a sample of galaxies with the Dark Energy Survey (DES) photometry that replicates the properties of the BOSS CMASS sample. The CMASS galaxy sample has been well characterized by ...the Sloan Digital Sky Survey (SDSS) collaboration and was used to obtain the most powerful redshift-space galaxy clustering measurements to date. A joint analysis of redshift-space distortions (such as those probed by CMASS from SDSS) and a galaxy–galaxy lensing measurement for an equivalent sample from DES can provide powerful cosmological constraints. Unfortunately, the DES and SDSS-BOSS footprints have only minimal overlap, primarily on the celestial equator near the SDSS Stripe 82 region. Using this overlap, we build a robust Bayesian model to select CMASS-like galaxies in the remainder of the DES footprint. The newly defined DES-CMASS (DMASS) sample consists of 117 293 effective galaxies covering $1244\,\deg ^2$. Through various validation tests, we show that the DMASS sample selected by this model matches well with the BOSS CMASS sample, specifically in the South Galactic cap (SGC) region that includes Stripe 82. Combining measurements of the angular correlation function and the clustering-z distribution of DMASS, we constrain the difference in mean galaxy bias and mean redshift between the BOSS CMASS and DMASS samples to be $\Delta b = 0.010^{+0.045}_{-0.052}$ and $\Delta z = \left(3.46^{+5.48}_{-5.55} \right) \times 10^{-3}$ for the SGC portion of CMASS, and $\Delta b = 0.044^{+0.044}_{-0.043}$ and $\Delta z= (3.51^{+4.93}_{-5.91}) \times 10^{-3}$ for the full CMASS sample. These values indicate that the mean bias of galaxies and mean redshift in the DMASS sample are consistent with both CMASS samples within 1σ.
We conducted paleoseismic studies along the Montereale fault system (MFS; central Italy). The MFS shows geomorphological evidence of Late Quaternary activity and falls within the highest seismic ...hazard zone of central Apennines, between the epicentral areas of two recent earthquake sequences: 2009 L'Aquila and 2016–2017 central Italy. We excavated two trenches along the San Giovanni fault splay of the system, one intercepting the N140° striking bedrock main fault plane and the other cutting two subparallel fault scarps on the colluvial/alluvial deposits on the fault hanging wall. Excavations revealed repeated fault reactivation with surface faulting in prehistorical and historical times. We recognized and dated seven events in the last 26 kyr. The most recent ground‐rupturing event (evb1) possibly occurred 650–1,820 AD, consistent with one of the three main shocks that struck the area in 1,703 AD. A previous event (evb2) occurred between 5,330 bc and 730 bc, while older events occurred at 6,590–5,440 bc (evb3), 9,770–6,630 bc (evb4), and 16,860–13,480 bc (evb5). We documented two older displacement events (evb7 and evb6) between 23,780 bc and 16,850 bc. The minimum vertical slip rate at the trench site in the last 28–24 kyr is 0.3–0.4 mm/year. The inferred average recurrence interval for surface‐faulting events along the MFS is no longer than ~4 kyr. Based on the surface fault length ranging between 12 and 20 km, earthquakes with ≥M 6.0 are possible for the MFS. The MFS is an independent earthquake source, and its paleoseismic data are fully comparable with those known for faults in central Apennines.
Key Points
Seven earthquakes ruptured the Montereale fault system (central Italy) since 26 kyr
First estimates of the Montereale fault parameters: length, earthquake recurrence, and slip rate
The Montereale fault system is an individual earthquake source within the central Apennines seismogenic belt (Italy)
The REMIX project is focused on the cyclotron-based production of 47Sc, 149Tb, 152Tb, 155Tb and 161Tb radionuclides, whose decay characteristics make them suitable for medical applications. This work ...will outline the main results achieved withing the REMIX collaboration, that is organized in the following Work Packages (WP): WP1. Target manufacturing (49Ti, 50Ti and 155Gd2O3) and characterization; WP2. Nuclear cross section (XS) measurements with 49Ti and 50Ti targets for 47Sc production; WP3. Nuclear XS measurements with natDy, 159Tb and natEu targets for xxTb production; WP4. Nuclear XS modeling for 47Sc and 155Tb production; WP5. Dosimetric calculations for 47Sc- and xxTb-labelled radiopharmaceuticals; WP6. 155Tb Thick Target Yield (TTY) measurements; WP7. Apparatus design and realization for irradiation tests with the LARAMED beamline. Since the LARAMED bunkers and ancillary laboratories are currently under completion at the INFN-LNL, the nuclear XS experiments are carried out in collaboration with the GIP ARRONAX facility (Saint-Herblain, France) and the Thick Target Yield (TTY) measurements are performed at the Sacro Cuore Don Calabria hospital (SCDCh, Negrar, Verona, Italy).
We performed paleoseismological investigations at four sites across the normal Paganica fault (PF) (source of the 2009 Mw 6.3 L'Aquila earthquake), with the goal of reconstructing the rupture history ...and of contributing to the evaluation of the maximum event expected along the PF. We recognized five distinct surface faulting earthquakes (including the 2009) in the trenches. The age of the penultimate event is consistent with the 1461 earthquake; the third event back occurred around 1000 AD. The two oldest events have larger uncertainties and occurred in the interval 760 BC–670 AD and 2900–760 BC, respectively. The along‐strike vertical displacement for each paleoevent has a limited variability consistently with the fairly homogeneous slip observed in 2009 along the northern part of the rupture. Conversely, the throws change between distinct events and range between 0.15 m in 2009 (maximum estimate) and close to 0.4 (lower bound estimate) in earlier events. These paleorecords and the high fault escarpments imply that earthquakes larger than 2009 occurred on the PF, with implications for the level of hazard. Recurrence intervals also reflect a change with time, the average interval before ∼1000 AD is longer compared to that after this date. Two events occurred in the 2000–4000 years preceding ∼1000 AD, while three events occurred since ∼1000 AD. The age uncertainties affecting the interpreted events prevent the evaluation of a unique value for interevent interval; the older events appear closely spaced in time or far apart depending on the upper or lower boundary of the age interval. We tentatively assign an average interevent time of ∼500 years for the three youngest events, whereas the time elapsed between the previous ones could be larger, in the order of 1000–2000 years. We calculate a late Pleistocene dip‐slip rate for the PF of 0.2–0.4 mm/yr, consistent with 0.25–0.5 mm/yr for the early Pleistocene. Using age and throw of individual events, we calculate a similar late Holocene average dip‐slip rate of ∼0.3–0.4 mm/yr. This suggests that the portion of the PF where the 2009 continuous surface faulting occurred has fairly a constant average slip release since late Pleistocene. Finally, we discuss different rupture scenarios and alternative models of occurrence compatible with our data and their variability.
Key Points
The 2009 Paganica surface rupture coincides with normal fault at depth
Four distinct paleoevents were recognized in the trenches
The pre‐2009 event is the 1461 earthquake
The Large Magellanic Cloud (LMC) harbours a rich and diverse system of star clusters, whose ages, chemical abundances and positions provide information about the LMC history of star formation. We use ...Science Verification imaging data from the Dark Energy Survey (DES) to increase the census of known star clusters in the outer LMC and to derive physical parameters for a large sample of such objects using a spatially and photometrically homogeneous data set. Our sample contains 255 visually identified cluster candidates, of which 109 were not listed in any previous catalogue. We quantify the crowding effect for the stellar sample produced by the DES Data Management pipeline and conclude that the stellar completeness is <10 per cent inside typical LMC cluster cores. We therefore reanalysed the DES co-add images around each candidate cluster and remeasured positions and magnitudes for their stars. We also implement a maximum-likelihood method to fit individual density profiles and colour–magnitude diagrams. For 117 (from a total of 255) of the cluster candidates (28 uncatalogued clusters), we obtain reliable ages, metallicities, distance moduli and structural parameters, confirming their nature as physical systems. The distribution of cluster metallicities shows a radial dependence, with no clusters more metal rich than Fe/H ≃ −0.7 beyond 8 kpc from the LMC centre. The age distribution has two peaks at ≃1.2 and ≃2.7 Gyr.
Estrogen receptor beta (ERbeta) plays a protective role against uncontrolled cell proliferation. ERbeta is lost during prostate cancer (CaP) progression suggesting its direct involvement in ...contrasting tumor proliferation in this disease; however, the molecular mechanism at the basis of this effect has not been clearly defined yet. Possible molecular targets of ERbeta were assessed in DU145 cells, a CaP cell line expressing only ERbeta. Cells treated from 1 to 9 days with different doses of estradiol or diarylpropionitrile (DPN, an ERbeta-selective agonist) show a time-dependent decrease in cell proliferation. The reduced proliferation rate is accompanied by the stimulation of ERbeta expression and the increase of cyclin-dependent kinase inhibitor p21. We demonstrate that the endogenous ERbeta is one of the mediator of the antiproliferative action of estrogens enhancing the synthesis of molecules such as p21 that control cell cycle, an effect amplified by the autoregulation of ERbeta expression. Our observations suggest that CaP, when expressing a functional ERbeta, might be sensitive to the antiproliferative action of estrogens; therefore, ERbeta specific agonists might be valid candidates for new pharmacological approaches to this disease.
Despite overwhelming evidence for a negative effect of inbreeding on fitness in plants and nonhuman animals, the exact nature of its effect in humans remains subject to debate. To obtain a better ...understanding of the effects of inbreeding on reproductive success in humans, we reconstructed the genealogies of the current inhabitants of a small and isolated Swiss village and used these to estimate the level of inbreeding of both members of all married couples, as well as their relatedness (i.e. the level of inbreeding of their offspring). Although there was no effect of parental relatedness on the number of children a couple had, we found that inbred mothers, but not inbred fathers, had significantly fewer children. Thus, although related couples did not have fewer children themselves, their inbred daughters did leave them with fewer grandchildren. Thereby, we provide evidence for the existence of inbreeding depression in human fertility, also in relatively outbred and egalitarian communities.
Background
Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in ...patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer.
Methods
Data of patients operated between 2015 and 2018 were retrospectively analysed. Propensity Score Matching was performed to balance baseline characteristics of patients undergoing laparoscopic and open gastrectomy. The primary endpoint was 3-year overall survival. Secondary endpoints were 3-year disease-free survival and short-term outcomes. Multivariable regression analyses for survival were conducted.
Results
Data were retrieved from 20 centres. Of the 717 patients included, 438 patients were correctly matched, 219 per group. The 3-year overall survival was 73.6% and 68.7% in the laparoscopic and open group, respectively (
p
= 0.40). When compared with open gastrectomy, laparoscopic gastrectomy showed comparable 3-year disease-free survival (62.8%, vs 58.9%,
p
= 0.40), higher rate of return to intended oncologic treatment (56.9% vs 40.2%,
p
= 0.001), similar 30-day morbidity/mortality. Prognostic factors for survival were ASA Score ≥ 3, age-adjusted Charlson Comorbidity Index ≥ 5, lymph node ratio ≥ 0.15, p/ypTNM Stage III and return to intended oncologic treatment.
Conclusions
Laparoscopic gastrectomy for advanced gastric cancer offers similar rates of survival when compared to open gastrectomy, with higher rates of return to intended oncologic treatment. ASA score, age-adjusted Charlson Comorbidity Index, lymph node ratio, return to intended oncologic treatment and p/ypTNM Stage, but not surgical approach, are prognostic factors for survival.
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