The most recent version of the European Society for Medical Oncology (ESMO) consensus guidelines for the treatment of patients with metastatic colorectal cancer (mCRC) was published in 2016, ...identifying both a more strategic approach to the administration of the available systemic therapy choices, and a greater emphasis on the use of ablative techniques, including surgery. At the 2016 ESMO Asia Meeting, in December 2016, it was decided by both ESMO and the Japanese Society of Medical Oncology (JSMO) to convene a special guidelines meeting, endorsed by both ESMO and JSMO, immediately after the JSMO 2017 Annual Meeting. The aim was to adapt the ESMO consensus guidelines to take into account the ethnic differences relating to the toxicity as well as other aspects of certain systemic treatments in patients of Asian ethnicity. These guidelines represent the consensus opinions reached by experts in the treatment of patients with mCRC identified by the Presidents of the oncological societies of Japan (JSMO), China (Chinese Society of Clinical Oncology), Korea (Korean Association for Clinical Oncology), Malaysia (Malaysian Oncological Society), Singapore (Singapore Society of Oncology) and Taiwan (Taiwan Oncology Society). The voting was based on scientific evidence and was independent of both the current treatment practices and the drug availability and reimbursement situations in the individual participating Asian countries.
In view of the planned new edition of the most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of primary ...breast cancer published in 2015, it was decided at the ESMO Asia Meeting in November 2018, by both the ESMO and the Korean Society of Medical Oncology (KSMO), to convene a special face-to-face guidelines meeting in 2019 in Seoul. The aim was to adapt the latest ESMO 2019 guidelines to take into account the ethnic and geographical differences associated with the treatment of early breast cancer in Asian patients. These guidelines represent the consensus opinions reached by experts in the treatment of patients with early breast cancer representing the oncology societies of Korea (KSMO), China (CSCO), India (ISMPO) Japan (JSMO), Malaysia (MOS), Singapore (SSO) and Taiwan (TOS). The voting was based on scientific evidence, and was independent of both the current treatment practices, and the drug availability and reimbursement situations, in the individual participating Asian countries.
•The purpose of the article is to take into account the ethnic and geographical differences in Asian BC patients.•A decision was taken by the ESMO and the KSMO to use these latest ESMO guidelines for the treatment of Asian ethnicity.•80% or more than 80% of Asian experts have voted to accept completely or accept with reservation a specific recommendation.
Material selection is an important stage in the development of products from composites process of automotive component application. Numerious different Multi-Criteria Decision-Making tools have ...their own strenghts and limitations. This paper presents a framework for material selection of natural fibre reinforced polymer composites by using statistical approach. The framework is developed using statistical methods which are simple, multiple and stepwise regression for the material selection process. The performance of potential material is investigated by a statistical analysis such as coefficient of correlation, coefficient of determination and analysis of variance. A case study to select the best composite of parking brake lever is applied to this framework. End results revealed that kenaf reinforced polypropylene is the best candidate for construction of automotive parking brake lever component. The best possible of statistical model for material selection of the composite can be referred by design engineer in composite industry for a multiple application. Moreover, the proposed framework is an aid to help engineers and designers to choose most suitable material.
In the development of packaging products, the considerations are not limited to the food shelf-life, safety, and practicality, but also environmental sustainability. This paper reports a life cycle ...assessment (LCA) analysis of a proposed natural fiber-reinforced biopolymer composite takeout food container. The study focuses on the damage assessment of the whole product system, including disposal scenarios of the thermoformed sugar palm fiber (SPF)-reinforced sago starch composite takeout food container. The analysis performed was to anticipate the environmental impact of the cradle-to-grave approach. The results exhibited the total human health damage of 2.63 × 10−5 DALY and ecosystem damage of 9.46 × 10−8 species.year per kg of containers. The main contributor was the carbon dioxide emission from fossil fuel combustion for energy generation that contributed to climate change and caused human health and the ecosystem damages with low-level metrics of 1.3 × 10−5 DALY and 7.39 × 10−8 species.yr per kg of containers, respectively. The most contributed substances in the ‘Particulate matter formation’ impact categories that caused respiratory diseases were from air/nitrogen oxides, air/particulates, <2.5 µm, and air/sulphur dioxide with the metrics of 2.93 × 10−6 DALY, 2.75 × 10−6 DALY, and 1.9 × 10−6 DALY per kg containers, correspondingly. Whereas, for the ‘Agricultural land occupation’, which contributed to ecosystem damage, almost the total contributions came from raw/occupation, forest, intensive with the metric of 1.93 × 10−9 species.yr per kg of containers. Nevertheless, from the results, all impact categories impacted below than 0.0001 DALY for the Human Health damage category and below 0.00001 species.yr for the ecosystem damage category. These results would provide important insights to companies and manufacturers in commercializing the fully biobased takeout food containers.
The biodegradability of a material has been an important measure in packaging design. Green biocomposites, which are made of natural fiber and biopolymer matrix, are promising alternative materials ...in single-use packaging to replace conventional materials. Selection of the most suitable natural fiber for reinforcement in green biocomposites is an initial attempt towards reducing resources depletion and packaging waste dumping. A selection system of analytic hierarchy process (AHP)-based method is proposed. Food packaging materials’ requirements and production factors are the basis of selecting 13 vital characteristics of natural fibers as the selection criteria. Nine natural fibers were assessed based on data gathered from recent literature. From the results, ijuk obtained the highest priority score (14%). Whilst, sisal had the lowest rank with a score of 8.8%. Sensitivity analysis was then performed to further validate the results, and ijuk remained at the top rank in four out of the six scenarios tested. It was concluded that ijuk is the most suitable natural fiber for reinforcement in green biocomposites for food packaging design. Nonetheless, for future development, more comprehensive selection criteria, such as fiber specific properties, fiber processing, and fibre treatment, are suggested to be included in the framework for more comprehensive results.
The most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, staging and treatment of patients with metastatic breast cancer (MBC) was ...published in 2021. A special, hybrid guidelines meeting was convened by ESMO and the Korean Society of Medical Oncology (KSMO) in collaboration with nine other Asian national oncology societies in May 2022 in order to adapt the ESMO 2021 guidelines to take into account the differences associated with the treatment of MBC in Asia. These guidelines represent the consensus opinions reached by a panel of Asian experts in the treatment of patients with MBC representing the oncological societies of China (CSCO), India (ISMPO), Indonesia (ISHMO), Japan (JSMO), Korea (KSMO), Malaysia (MOS), the Philippines (PSMO), Singapore (SSO), Taiwan (TOS) and Thailand (TSCO). The voting was based on the best available scientific evidence and was independent of drug access or practice restrictions in the different Asian countries. The latter were discussed when appropriate. The aim of these guidelines is to provide guidance for the harmonisation of the management of patients with MBC across the different regions of Asia, drawing from data provided by global and Asian trials whilst at the same time integrating the differences in genetics, demographics and scientific evidence, together with restricted access to certain therapeutic strategies.
•This article provides ESMO recommendations adapted for the treatment of MBC in Asian patients.•Evidence-based medicine and the availability to molecular diagnostic tests and treatments in Asian countries are discussed.•The aim is to encourage harmonisation of the management of MBC patients and to facilitate drug registration, across Asia.
Emphasizing the green technology in manufacturing process with proper materials selection of natural fibre reinforced composite (NFRC) can save our future generation. There is multiple consideration ...of the criteria from the reseacher for material selection process since the database of NFRC is not completely available. Product design specification (PDS) of automotive component is studied from past researcher with the summarized of the elements considered. Literature from year 2000 until year 2016 were collected which is focused on related automotive component design. In this study, it is found that the most commonly used elements of PDS of automotive component was consider from the previous researcher were cost, density, tensile strength, Young's modulus and elongation at break. Generally, the mentioned elements are recommended to be considered by other researchers in automotive component design in material selection process.
Starch is a natural polymer and eligible for short-term, single-use food packaging applications. Nevertheless, different starches have different features and properties determined by their botanical ...plant origins. This paper presents an approach that combines Shannon’s entropy and the Analytic Hierarchy Process method to aid the selection process of starch as matrix in green biocomposites for takeout food packaging design. The proposed selection system ranks alternative starches in terms of the key design elements, i.e. strength, barrier property, weight, and cost. Shannon’s entropy established corresponding weight values for the indicators selected. Six starches: wheat, maize, potato, cassava, sago, and rice were appraised using gathered data from the literature to determine their suitability as a more sustainable option. This study found that sago starch obtained the highest priority score of 26.8%, followed by rice starch (20.2%). Sensitivity analysis was then carried out to further verify the results; sago starch was at the top rank for five of six different scenarios tested. The results showed that sago starch is the starch that can best satisfy the design requirements. Despite the results attained, the selection framework used could be enhanced with a more comprehensive attributes assessment and extensive dataset.
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