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  • Gastric microbiota: An emer... Gastric microbiota: An emerging player in Helicobacter pylori-induced gastric malignancies
    Espinoza, J. Luis; Matsumoto, Ayumi; Tanaka, Hirokazu ... Cancer letters, 02/2018, Volume: 414
    Journal Article
    Peer reviewed

    The complex diversity of nonpathogenic microbes that colonize the human body, known as microbiota, exert considerable effects on physiological homeostasis, and immune regulation. Helicobacter pylori ...
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  • KBTBD11, encoding a novel P... KBTBD11, encoding a novel PPARγ target gene, is involved in NFATc1 proteolysis by interacting with HSC70 and HSP60
    Watanabe, Kazuhisa; Matsumoto, Ayumi; Tsuda, Hidetoshi ... Scientific reports, 11/2022, Volume: 12, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    We previously revealed that Kbtbd11 mRNA levels increase during 3T3-L1 differentiation and Kbtbd11 knockdown suppresses whereas its overexpression promotes adipogenesis. However, how Kbtbd11 mRNA is ...
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  • Gene therapy improves motor... Gene therapy improves motor and mental function of aromatic l-amino acid decarboxylase deficiency
    Kojima, Karin; Nakajima, Takeshi; Taga, Naoyuki ... Brain, 02/2019, Volume: 142, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    AADC deficiency causes severe motor and intellectual disability as a result of reduced catecholamine levels. Kojima et al. report beneficial effects of gene therapy in six patients with heterogeneous ...
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  • A Randomized Trial of Magne... A Randomized Trial of Magnesium Oxide and Oral Carbon Adsorbent for Coronary Artery Calcification in Predialysis CKD
    Sakaguchi, Yusuke; Hamano, Takayuki; Obi, Yoshitsugu ... Journal of the American Society of Nephrology, 06/2019, Volume: 30, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Developing strategies for managing coronary artery calcification (CAC) in patients with CKD is an important clinical challenge. Experimental studies have demonstrated that magnesium inhibits vascular ...
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  • ILDR2 stabilization is regu... ILDR2 stabilization is regulated by its interaction with GRP78
    Watanabe, Kazuhisa; Nakayama, Kazuhiro; Ohta, Satoshi ... Scientific reports, 04/2021, Volume: 11, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Ildr2 was initially identified as a genetic modifier of diabetes susceptibility in B6.DBA Lep  congenic mice, and was associated with decreased β-cell replication rates, reduced β-cell mass, and ...
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  • Electrocardiogram findings at the initiation of hemodialysis and types of subsequent cardiovascular events
    Yamaguchi, Satoshi; Hamano, Takayuki; Oka, Tatsufumi ... Hypertension research, 05/2021, Volume: 44, Issue: 5
    Journal Article
    Peer reviewed

    The prognostic value of electrocardiograms (ECGs) has been reported in predialysis patients but not in incident hemodialysis patients with overhydration and electrolyte disturbances, both of which ...
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  • Hidden Hypocalcemia as a Ri... Hidden Hypocalcemia as a Risk Factor for Cardiovascular Events and All-Cause Mortality among Patients Undergoing Incident Hemodialysis
    Yamaguchi, Satoshi; Hamano, Takayuki; Doi, Yohei ... Scientific reports, 03/2020, Volume: 10, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Lower corrected calcium (cCa) levels are associated with a better prognosis among incident dialysis patients. However, cCa frequently overestimates ionized calcium (iCa) levels. The prognostic ...
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  • Lack of GPR180 ameliorates ... Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling
    Yoshida, Ken; Yokota, Kazuha; Watanabe, Kazuhisa ... Scientific reports, 02/2023, Volume: 13, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Our previous genome-wide association study to explore genetic loci associated with lean nonalcoholic fatty liver disease (NAFLD) in Japan suggested four candidate loci, which were mapped to chr6, ...
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  • N4BP2L1 interacts with dyna... N4BP2L1 interacts with dynactin and contributes to GLUT4 trafficking and glucose uptake in adipocytes
    Watanabe, Kazuhisa; Matsumoto, Ayumi; Tsuda, Hidetoshi ... Journal of diabetes investigation, November 2021, Volume: 12, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    ABSTRACT Aims/Introduction It was reported previously that N4bp2l1 expression increases in 3T3‐L1 cells in a differentiation‐dependent manner and N4bp2l1 knockdown suppresses adipocyte ...
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  • Clinical spectrum of early ... Clinical spectrum of early onset epileptic encephalopathies caused by KCNQ2 mutation
    Kato, Mitsuhiro; Yamagata, Takanori; Kubota, Masaya ... Epilepsia, July 2013, Volume: 54, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Summary Purpose KCNQ2 mutations have been found in patients with benign familial neonatal seizures, myokymia, or early onset epileptic encephalopathy (EOEE). In this study, we aimed to delineate the ...
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