In the current study the ability of copper complex to exert multiple biological activities is combined with the pharmacological action of sertraline (SerH2Cl, antidepressant drug). The hydrated and ...anhydrous forms of the tetrachlorocuprate(II) salts, namely (SerH2)2CuCl4·½H2O and (SerH2)2CuCl4, were synthesized and characterized by physicochemical methods. The crystal structures were determined by X-ray diffraction methods. The hydrate complex crystallizes in the monoclinic P21 space group with a=8.0807(2) Å, b=36.2781(8) Å, c=12.6576(3) Å, β=95.665(2)°, and Z=4 molecules per unit cell and the un-hydrate in P21 with a=13.8727(6) Å, b=7.5090(3) Å, c=18.618(1) Å, β=104.563(6)°, and Z=2. It has been suggested that Cu(II) ions might be critical in the development of mood disorders, showed potent biocidal activity, and also acted as analgesic adjuvant. To improve sertraline efficiency, the antidepressant and analgesic activities of the complex have been assessed in rats denoting a marked synergistic effect. Antithyroid and antimicrobial activities were also evaluated. Because depressive disorders and hyperthyroidism diseases led to an oxidative stress state, antioxidant capability has also been tested. The complex behaved as a good superoxide radical scavenger (IC50=6.3×10−6M). The ability of the complex to act as bromoperoxidase mimic was assessed. A pseudo-first order constant of k=0.157±0.007min−1 has been determined. The complex evidences promising biological-pharmacological activities and the albumin binding studies showed a Kb of 2.90×103M−1 showing an improvement in the uptake of sertraline by albumin at 8h incubation (time required for effective interaction of sertraline with the protein).
Cu(II) based sertraline compound capable of display combined benefits of sertraline and an essential element in order to get better pharmacological and biological activities: antidepressant, analgesic, antioxidant, catalytic behavior. Display omitted
•Sertralonium tetrachlorocuprate(II) complex with multiple biological activities•Antidepressant activity including an antianorexigenic effect•Analgesic and antioxidant behavior•Bromoperoxidase mimic activity
Zika virus (ZIKV) is a mosquito-borne pathogen, and Aedes aegypti has been identified as the main vector of the disease. Other mosquito species in the Aedes and Culex genera have been suggested to ...have the potential for being competent vectors based on experimental exposition of mosquitoes to an infectious blood meal containing ZIKV. Here, we report the isolation in cell culture of ZIKV obtained from different body parts of wild-caught female mosquitoes (Ae. aegypti, Ae. vexans, Cx. quinquefasciatus, Cx. coronator, and Cx. tarsalis) and whole male mosquitoes (Ae. aegypti and Cx. quinquefasciatus) in Mexico. Importantly, this is the first report that shows the presence of the virus in the salivary glands of the wild-caught female mosquitoes species, Cx. coronator, Cx. tarsalis, and Ae. vexans. Our findings strongly suggest that all the species reported herein are potential vectors for ZIKV.
Root architecture is important in nutrient uptake and avoidance of toxic compounds within the soil. Arabidopsis lyrata spp. lyrata has widespread distribution in disjunct environments that encounter ...unique stressors starting at germination. Five populations of A. lyrata spp. lyrata show local adaptation to Nickel (Ni) but cross-tolerance to variations in Calcium (Ca) concentration within the soil. Differentiation among the populations begins early in development and appears to impact timing of lateral root formation; therefore the purpose of the study was to understand changes in root architecture and root exploration in response to Ca and Ni within the first three weeks of growth. Lateral root formation was first characterized under one concentration of Ca and Ni. Lateral root formation and tap root length were reduced in all five populations in response to Ni compared to Ca, with the least reduction in the three serpentine populations. When the populations were exposed to a gradient (either Ca or Ni) there were differences in population response based on the nature of the gradient. Start side was the greatest determinant of root exploration and lateral root formation under a Ca gradient, while population was the greatest determinant of root exploration and lateral root formation under a Ni gradient. All populations exhibited about the same frequency of root exploration under a Ca gradient, while the serpentine populations exhibited much higher levels of root exploration under a Ni gradient compared to the two non-serpentine populations. Differences among populations in response to Ca and Ni demonstrate the importance of stress responses early in development, particularly in species that have widespread distribution among disparate habitats.
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Antioxidants undergo molecular association with dietary fibers in plant foods, and the actual nutritional functions depend on the conditions of association. As an approach to ...quantitative interpretation of the association effects, the present study proposes a method to evaluate association capacity, based on fluorometric titration of ferulic and p-coumaric acids with pectin and algin. The titration curve is formulated on the model that active sites on a fiber chain consist of segments each capable of binding to a single antioxidant molecule. The average segment sizes NS determined from observed curves range from 5 to 12 monomer units, and the mean association constant KA from 5 × 104 to 18 × 104 M−1 per segment, depending on fiber–antioxidant combinations. These parameters suggest that, although individual monomer units have weak binding forces, each segment involves multiple binding sites so that accumulating forces lead to the high thermodynamic stability of the molecular associates; the association capacity is presented by the half association concentration of antioxidant CG1/2 = 2Cm/NS – 2/KA at a monomer-based fiber concentration Cm. The extended application of the method to selected fiber–nutrient combinations would help to describe the association at molecular levels and to design better nutritional agents.
•Sexual minority college students are at higher risk for suicide and self-harm.•Heterosexual students with same-gender attraction are also at a higher risk.•Perceived life stress partially mediated ...suicide and self-injurious behaviors.•Asexual students did not differ from heterosexuals with no same-sex attraction.
Sexual minority college students are at a higher risk for suicidal thoughts and self-injurious behaviors compared to heterosexual students. Minority stress theory proposes sexual minority individuals experience higher stress due to stigma. Using a sample of Mexican college students, this study tested perceived life stress as a mediator of suicide and self-injury outcomes across various sexual orientation groups.
The sample of college students (N=7882) was recruited from nine Mexican universities as part of the WHO World Mental Health International College Student (WMH-ICS) initiative. Participants completed an online survey including demographic questions, measure of perceived life stress, suicide outcomes, and non-suicidal self-injury (NSSI) in the past 12 months.
Logistic regression analyses revealed identifying as a sexual minority significantly predicted a higher likelihood of suicide ideation (ORs 2.05-3.00), suicide attempts (ORs 2.48-8.73), and NSSI (ORs 2.92-4.18) compared to heterosexual students reporting no same-gender attraction. Significant indirect effects from mediation path analyses showed perceived life stress mediated the relationship between a sexual minority identity and suicide ideation (range of proportion mediated 10.48-31.48%), attempts (10.48-31.48%), and NSSI (7.69-20.09%) across each group except among asexual students.
The cross-sectional nature of the survey design precludes drawing causal inferences.
Findings from this study contribute to minority stress theory by elucidating the role of perceived life stress as a mediator of suicide ideation and attempts and NSSI among sexual minority college students. Clinical interventions may benefit in focusing on experiences of stress across various life areas when supporting sexual minority college students.
To estimate psychopathology and self-harm behavior of incoming first-year college students, sociodemographic correlates, service use and willingness to seek treatment.
4 189 male and female incoming ...first-year students of six universities in four different states of Mexico responded to an online survey with a 79.3% response rate.
Almost one in three incoming students has experienced some type of psychopathology; however, only one in five has received treatment. Female, students who are older, whose parents are not married or deceased, and who have a non-heterosexual orientation, no religion or a non-Catholic/Christian religion have greater odds (1.18 - 1.99), whereas those who attend a private university and have a parent with some college education have lower odds (0.68 - 0.75) of experiencing any probable disorder.
Substantial unmet need for mental health services combined with reported willingness to use university services suggests an opportunity for the detection, referral, and treatment of incoming students to promote a successful transition.
The presence of older volunteers in third-sector organisations has increased in recent years. In this sense, it is important to know what institutions can do in order to retain these volunteers. The ...present study analyses organisational support to volunteers and their satisfaction with the tasks they perform as explanatory factors of satisfaction with organisational management and the relationship between the organisation and volunteers' intention of remaining in service.
The sample was made up of 172 volunteers over 60, living in the Region of Murcia.
The analysis of structural equations revealed the relationship between degree of satisfaction with the management and the intention of remaining in service. The influence of organisational support and task satisfaction on the degree of satisfaction with management was also examined.
The degree of satisfaction with management has shown to be an important predictor of older volunteers' intention of remaining in service. These findings have important implications on how organisations manage volunteerism and the relationship between paid staff and volunteers.
Key message
Hypoxia promoted distinct changes in the levels of hormones, amino acids and organic acids in the roots and shoots of a seedling from 2
Eucalyptus
clones. These results indicate that ...modulation of hormone production, as well as specific chemical constituents associated with primary metabolism, contributes to the regulation of growth of
Eucalyptus
seedlings under hypoxic conditions.
Context
Although floods in areas under
Eucalyptus
cultivation in Brazil negatively affect plant growth, chemical markers and/or indicators of hypoxia contributes to the regulation.s
Aims
This study aimed to evaluate the hormonal and metabolic alterations induced by hypoxia on seedling growth.
Methods
Seedlings of
Eucalyptus urograndis
clones VCC 975 and 1004 were grown in liquid solution and submitted to bubbling with air or with nitrogen. Levels of indol-3-acetic acid (IAA), abscisic acid (ABA), ethylene, 1-aminocyclopropane-1-carboxylic acid (ACC), primary metabolite profile and photosynthetic parameters were evaluated after fourteen days.
Results
Hypoxia did not affect shoot dry mass of the seedlings. However, it decreased stomatal conductance and photosynthetic CO
2
assimilation rate, and increased levels of ABA in the shoot. Hypoxia greatly reduced the dry mass and volume of roots, concomitantly with higher ACC and ethylene production. Moreover, hypoxia promoted distinct changes in IAA levels, and in amino acid and organic acid metabolism in roots and shoots.
Conclusion
The biosynthesis of ABA, ethylene and IAA and its quantity in root tissues indicates the regulation of metabolism in response to hypoxia in
Eucalyptus
clones.
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