Primary sebaceous carcinoma of the tongue Oshiro, Hisashi; Iwai, Toshinori; Hirota, Makoto ...
Medical molecular morphology,
12/2010, Volume:
43, Issue:
4
Journal Article
Peer reviewed
Sebaceous carcinoma is the rarest type of oral malignancies. We report a case of primary sebaceous carcinoma of the tongue. Systemic imaging studies revealed that the patient had a T2N2cM0 ...(International Union Against Cancer guidelines) primary lingual tumor. Histopathological examination revealed neoplastic sebocytic and basaloid cells, and Sudan III staining and electron microscopy revealed intracytoplasmic lipid droplets. The neoplastic cells stained positive for adipophilin; epithelial membrane antigen; epithelial antigen; and cytokeratins 7, 8, and 15, but negative for cytokeratins 5/6, 18, 19, and 20; the androgen receptor; and carcinoembryonic antigen. Superselective intraarterial chemotherapy was administered via the superficial temporal artery concurrent with daily radiotherapy. Multiple biopsies confirmed a complete response of the primary lesion. The patient then underwent neck dissection followed by pathological examination, which revealed lymph nodes metastases. After postoperative radiotherapy to the neck, distant metastases were identified in the mediastinal lymph nodes and the lung. The patient died 17 months after completing the initial course of chemoradiotherapy. Our case demonstrates that superselective intraarterial chemotherapy combined with concurrent radiotherapy can be effective in treating the primary lesion of patients with a sebaceous carcinoma of the tongue. However, an effective strategy to eradicate metastases has yet to be established.
•A robust and incremental stroke order evaluation for Kanji written on a tablet.•Matching partially written Kanji patterns rather than matching strokes.•Shape context features are taken around each ...feature point.•Stroke order evaluation is 98.5% correct with up to 0.12 sec. /character on a PC.•Very low false positive and acceptable false negative for incremental detection.
Writing Kanji characters of Chinese origin in the correct stroke order and direction is still one of the important subjects in Japanese elementary education. So far, the stroke order evaluation was made by stroke-to-stroke matching without stroke context so that it was unrobust to Kanji characters having multiple similar strokes. Here, we employ shape context features around each feature point in not only conventional fan-shaped bins but also in square bins with applying a Gaussian function. We also propose simple incremental context and augmented context from future strokes. Our approach can judge whether the stroke order and direction are correct or not every time a new stroke is written on a tablet by matching a partially written Kanji pattern with the reference pattern written to the same number of strokes. Evaluation shows that the best-tuned method with square bins and the Gaussian function records the highest performance and correctly evaluates stroke order by 98.5% with the maximum time of 0.12 sec. /character for Kanji patterns after all strokes are written using an average desktop PC. The method is also shown to possess high reliability to detect wrong stroke order and direction incrementally every time after each stroke is written.
The existence of chaotic motion in a simple single-degree or two-degree-of-freedom gear model has already been verified numerically by the authors. In this study, the chaotic motion and the influence ...of a random component on chaos are invesigated using the Poincare map and the power spectrum analysis, since characterizing the chaotic motion in the gear system is an important and interesting problem from the practical viewpoint of estimating the dynamic load or gear noise as well as from an academic perspective of contributing to nonlinear mechanics.
The osteoarthritic (OA) knee demonstrated reduced tibial internal rotation during squat (Saari 2005) and a knee exercise with tibial internal rotation was effective on immediately improving symptoms ...(Yoshida 2013). A comparison between OA and healthy knees is necessary to determine the mechanism of the reason of the clinical effects. The aim of this study was to determine if a leg press exercise with tibial internal rotation is effective on plantar pressure distribution during gait and knee rotational range of motion in healthy females. Twenty healthy, young females were randomly allocated to internal or external rotation groups, who performed a leg press exercise with either tibial internal or external rotation, respectively, for two weeks. Knee rotational range and plantar pressure distribution during gait were measured. The internal rotation group demonstrated increased internal rotation and total rotation ranges as well as medial shift of the center of plantar pressure during gait. To conclude, the leg press exercise with tibial internal rotation induced a kinematic chain of combined tibial internal rotation and hindfoot pronation during gait. Future studies will include a similar study for patients with knee OA.
There are few descriptions of the cytologic features of subependymoma because this neoplasm is rare and most commonly encountered incidentally at autopsy. Here we report a surgical case of ...subependymoma occurring in the lateral ventricle and provide the first documentation of the crush cytologic features of this tumor.
A 34-year-old woman was found to have a tumorous lesion in the right lateral ventricle. At surgery, a 2-cm-diameter tumor was detected in the anterior horn. Histologic examination during surgery revealed that the mass was composed of loose,fibrillary networks and clusters of nuclei showing mild pleomorphism. A number of microcystic formations were evident. Histologically, the neoplasm was considered benign--specifically, a subependymoma. Papanicolaou- or Giemsa-stained crush specimens and imprint smears were also prepared. The cytologic morphology was fundamentally the same as the histologic. In the crush specimens, microcystic formations were readily visible. Moreover, details of the cellular morphology were more easily recognized in the cytologic slides than in the frozen sections.
Cytologic examination, particularly crush cytology, appears to be useful for the rapid diagnosis of subependymoma during surgery in combination with the examination of frozen histologic sections.
Exercise has numerous health-promoting effects in humans; however, individual responsiveness to exercise with regard to endurance or metabolic health differs markedly. This 'exercise resistance' is ...considered to be congenital, with no evident acquired causative factors. Here we show that the anti-oxidative hepatokine selenoprotein P (SeP) causes exercise resistance through its muscle receptor low-density lipoprotein receptor-related protein 1 (LRP1). SeP-deficient mice showed a 'super-endurance' phenotype after exercise training, as well as enhanced reactive oxygen species (ROS) production, AMP-activated protein kinase (AMPK) phosphorylation and peroxisome proliferative activated receptor γ coactivator (Ppargc)-1α (also known as PGC-1α; encoded by Ppargc1a) expression in skeletal muscle. Supplementation with the anti-oxidant N-acetylcysteine (NAC) reduced ROS production and the endurance capacity in SeP-deficient mice. SeP treatment impaired hydrogen-peroxide-induced adaptations through LRP1 in cultured myotubes and suppressed exercise-induced AMPK phosphorylation and Ppargc1a gene expression in mouse skeletal muscle-effects which were blunted in mice with a muscle-specific LRP1 deficiency. Furthermore, we found that increased amounts of circulating SeP predicted the ineffectiveness of training on endurance capacity in humans. Our study suggests that inhibitors of the SeP-LRP1 axis may function as exercise-enhancing drugs to treat diseases associated with a sedentary lifestyle.
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