Losses from environmental hazards have escalated in the past decade, prompting a reorientation of emergency management systems away from simple postevent response. There is a noticeable change in ...policy, with more emphasis on loss reduction through mitigation, preparedness, and recovery programs. Effective mitigation of losses from hazards requires hazard identification, an assessment of all the hazards likely to affect a given place, and risk-reduction measures that are compatible across a multitude of hazards. The degree to which populations are vulnerable to hazards, however, is not solely dependent upon proximity to the source of the threat or the physical nature of the hazard -social factors also play a significant role in determining vulnerability. This paper presents a method for assessing vulnerability in spatial terms using both biophysical and social indicators. A geographic information system was utilized to establish areas of vulnerability based upon twelve environmental threats and eight social characteristics for our study area, Georgetown County, South Carolina. Our results suggest that the most biophysically vulnerable places do not always spatially intersect with the most vulnerable populations. This is an important finding because it reflects the likely 'social costs' of hazards on the region. While economic losses might be large in areas of high biophysical risk, the resident population also may have greater safety nets (insurance, additional financial resources) to absorb and recover from the loss quickly. Conversely, it would take only a moderate hazard event to disrupt the well-being of the majority of county residents (who are more socially vulnerable, but perhaps do not reside in the highest areas of biophysical risks) and retard their longer-term recovery from disasters. This paper advances our theoretical and conceptual understanding of the spatial dimensions of vulnerability. It further highlights the merger of conceptualizations of human environment relationships with geographical techniques in understanding contemporary public policy issues.
Background:
Platelet-rich plasma (PRP) has been used extensively in clinical practice to treat patients with symptomatic knee osteoarthritis (OA). Leukocyte-poor PRP (LP-PRP) has been clinically ...preferred over leukocyte-rich PRP (LR-PRP); however, it is unclear which cytokine mediators of pain and inflammation are present in LR-PRP and LP-PRP from patients with mild to moderate knee OA in order to rationalize a specific formulation.
Hypothesis:
LP-PRP would be predominantly anti-inflammatory and have reduced nociceptive pain mediators compared with LR-PRP from the same individual with mild to moderate knee OA.
Study Design:
Controlled laboratory study.
Methods:
A total of 24 unique samples of PRP were prepared in order to assess 48 samples of LR-PRP and LP-PRP taken from 12 patients (6 male and 6 female) with symptomatic knee OA of Kellgren-Lawrence grade 2 to 3. Patients underwent blood collection for LR-PRP and LP-PRP preparation through a double-spin protocol to obtain baseline whole blood, platelet concentration, and white blood cell subtypes. LR-PRP and LP-PRP from the same patient were produced at the same time and underwent a comprehensive panel through Luminex (multicytokine profiling) to assess key mediators of inflammation: interleukin 1 receptor antagonist (IL-1Ra), interleukin 4, 6, 8, and 10 (IL-4, IL-6, IL-8, and IL-10), IL-1β, tissue necrosis factor α (TNF-α), and matrix metalloproteinase 9 (MMP-9). To assess mediators of nociceptive pain, nerve growth factor (NGF) and tartrate resistant acid phosphatase 5 (TRAP5) were also assessed.
Results:
LR-PRP from patients with mild to moderate knee OA expressed significantly more IL-1Ra, IL-4, IL-8, and MMP-9 compared with LP-PRP formulations from the same patients. No significant differences were found between LR-PRP and LP-PRP in mediators of nociceptive pain—namely, NGF and TRAP5. Other mediators including TNF-α, IL-1β, IL-6, and IL-10 were also found to have no significant expression differences between LR-PRP and LP-PRP.
Conclusion:
LR-PRP expressed significantly more IL-1Ra, IL-4, and IL-8, suggesting that LR-PRP may be more anti-inflammatory than LP-PRP. MMP-9 was expressed in higher concentrations in LR-PRP, suggesting that LR-PRP may be more chondrotoxic than LP-PRP.
Clinical Relevance:
LR-PRP was found to have a robust expression of anti-inflammatory mediators compared with LP-PRP and may be beneficial to patients with long-term knee OA where chronic low-grade inflammation is present. Mechanistic clinical trials are needed to elucidate the key mediators in both LR-PRP and LP-PRP to assess their effect on long-term progression of knee OA.
Hurricane Katrina slammed into the Gulf Coast in August 2005 with devastating consequences. Almost all analyses of the disaster have been dedicated to the way the hurricane affected New Orleans. This ...volume examines the impact of Katrina on southern Mississippi. While communities along Mississippi's Gulf Coast shared the impact, their socioeconomic and demographic compositions varied widely, leading to different types and rates of recovery. This volume furthers our understanding of the pace of recovery and its geographic extent, and explores the role of inequalities in the recovery process and those antecedent conditions that could give rise to a 'recovery divide'. It will be especially appealing to researchers and advanced students of natural disasters and policy makers dealing with disaster consequences and recovery.
The anisotropy parameter (v(2)), the second harmonic of the azimuthal particle distribution, has been measured with the PHENIX detector in Au+Au collisions at roots(NN)=200 GeV for identified and ...inclusive charged particle production at central rapidities (eta<0.35) with respect to the reaction plane defined at high rapidities (eta=3-4 ). We observe that the v(2) of mesons falls below that of (anti)baryons for p(T)>2 GeV/c, in marked contrast to the predictions of a hydrodynamical model. A quark-coalescence model is also investigated.
The PHENIX experiment has measured midrapidity transverse momentum spectra (0.4<p(T)<4.0 GeV/c) of single electrons as a function of centrality in Au+Au collisions at roots(NN) = 200 GeV. ...Contributions from photon conversions and Dalitz decays of light neutral mesons are measured by introducing a thin (1.7% X-0) converter into the PHENIX acceptance and are statistically removed. The subtracted nonphotonic electron spectra are primarily due to the semileptonic decays of hadrons containing heavy quarks, mainly charm at lower p(T). For all centralities, the charm production cross section is found to scale with the nuclear overlap function, T-AA. For minimum-bias collisions the charm cross section per binary collision is N-c (c) over bar/T-AA=622+/-57(stat)+/-160(syst) mub.
Transverse momentum spectra of neutral pions in the range 1<p(T)<10 GeV/c have been measured at midrapidity by the PHENIX experiment at BNL RHIC in Au+Au collisions at roots(NN)=200 GeV. The pi(0) ...multiplicity in central reactions is significantly below the yields measured at the same roots(NN) in peripheral Au+Au and p+p reactions scaled by the number of nucleon-nucleon collisions. For the most central bin, the suppression factor is similar to2.5 at p(T)=2 GeV/c and increases to similar to4-5 at p(T)approximate to4 GeV/c. At larger p(T), the suppression remains constant within errors. The deficit is already apparent in semiperipheral reactions and increases smoothly with centrality.
Transverse momentum spectra for charged hadrons and for neutral pions in the range 1 Gev/c < P-T < 5 GeV/c have been measured by the PHENIX experiment at RHIC in Au + Au collisions at rootS(NN) = 130 ...GeV. At high p(T) the spectra from peripheral nuclear collisions are consistent with scaling the spectra from p + p collisions by the average number of binary nucleon-nucleon collisions. The spectra from central collisions are significantly suppressed when compared to the binary-scaled p + p expectation, and also when compared to similarly binary-scaled peripheral collisions, indicating a novel nuclear-medium effect in central nuclear collisions at RHIC energies.
Hurricane Katrina was not the strongest of the three storms that reached Category Five intensity in terms of wind speeds or central pressures, but converging factors--primarily its strength and ...landfall location along the Gulf Coast--made it the most devastating and costly hurricane in US history. Here, Cutter et al highlight the challenging tasks of recovery and the implications of the reconstruction process of the region.
Disinhibition has received considerable recognition as a primary deficit in Attention-Deficit/Hyperactivity Disorder (AD/HD). The goal of the present study was to investigate claims that Gray’s ...Behavioral Approach System (BAS) is linked to a disinhibitory deficit and can account for hyperactive-impulsive AD/HD behaviors. A sample of 184 undergraduates responded to measures of Gray’s and other personality dimensions. BAS scores were positively related to and were significant predictors of hyperactive-impulsive symptoms, and also appeared to be related to inattentive AD/HD symptoms in females. Behavioral Inhibition System (BIS) scores did not predict hyperactive-impulsive symptoms, suggesting that it is not a primary deficit for hyperactive-impulsive behaviors. Other disinhibitory pathways along Gray’s model, such as a response modulation deficit, were supported. Overactive BAS functioning is offered as a contributor to hyperactive-impulsive symptoms in adults.
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