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  • A TIM-3/Gal-9 Autocrine Sti... A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression
    Kikushige, Yoshikane; Miyamoto, Toshihiro; Yuda, Junichiro ... Cell stem cell, 09/2015, Volume: 17, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Signaling mechanisms underlying self-renewal of leukemic stem cells (LSCs) are poorly understood, and identifying pathways specifically active in LSCs could provide opportunities for therapeutic ...
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  • Defucosylated anti-CCR4 mon... Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study
    Ishida, Takashi; Joh, Tatsuro; Uike, Naokuni ... Journal of clinical oncology, 03/2012, Volume: 30, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Adult T-cell leukemia-lymphoma (ATL) is usually resistant to conventional chemotherapies, and there are few other treatment options. Because CC chemokine receptor 4 (CCR4) is expressed on tumor cells ...
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  • Identification of TIM-3 as a Leukemic Stem Cell Surface Molecule in Primary Acute Myeloid Leukemia
    Kikushige, Yoshikane; Miyamoto, Toshihiro Oncology, 01/2015, Volume: 89 Suppl 1
    Journal Article
    Peer reviewed

    Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target in AML. Eradication of LSCs should be a critical and efficient therapeutic ...
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  • Maintenance therapy after a... Maintenance therapy after allogeneic hematopoietic stem cell transplantation
    Yoshimoto, Goichi; Miyamoto, Toshihiro Rinshō ketsueki, 2023, Volume: 64, Issue: 6
    Journal Article

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival for patients with hematological malignancy, especially for those highly at risk of relapse. However, disease ...
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  • TIM-3 Is a Promising Target... TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells
    Kikushige, Yoshikane; Shima, Takahiro; Takayanagi, Shin-ichiro ... Cell stem cell, 12/2010, Volume: 7, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target for AML. Here we identified T cell immunoglobulin mucin-3 (TIM-3) as a surface ...
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  • Peripheral helper-T-cell-de... Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease
    Harada, Takuya; Kikushige, Yoshikane; Miyamoto, Toshihiro ... Nature communications, 10/2023, Volume: 14, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Abstract Castleman disease (CD) is a rare lymphoproliferative disorder. Among subtypes of CD, idiopathic multicentric CD-not otherwise specified (iMCD-NOS) has a poor prognosis and its pathogenesis ...
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  • Self-Renewing Hematopoietic... Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia
    Kikushige, Yoshikane; Ishikawa, Fumihiko; Miyamoto, Toshihiro ... Cancer cell, 08/2011, Volume: 20, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    We report here that in chronic lymphocytic leukemia (CLL), the propensity to generate clonal B cells has been acquired already at the hematopoietic stem cell (HSC) stage. HSCs purified from patients ...
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  • Myeloablative and reduced-i... Myeloablative and reduced-intensity conditioning in HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide
    Sugita, Junichi; Kagaya, Yusuke; Miyamoto, Toshihiro ... Bone marrow transplantation, 03/2019, Volume: 54, Issue: 3
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    Peer reviewed
    Open access

    We conducted two parallel prospective, multicenter, phase II studies to evaluate the safety and efficacy of HLA-haploidentical peripheral blood stem cell transplantation using post-transplant ...
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  • Risk factors for late cytom... Risk factors for late cytomegalovirus infection after completing letermovir prophylaxis
    Mori, Yasuo; Harada, Takuya; Yoshimoto, Goichi ... International journal of hematology, 08/2022, Volume: 116, Issue: 2
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    Peer reviewed

    Prophylactic use of letermovir (LMV) markedly reduces the incidence of early clinically significant cytomegalovirus (csCMV) infection within the first 100 days after allogeneic hematopoietic cell ...
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  • Outcomes of third allogeneic hematopoietic stem cell transplantation in relapsed/refractory acute leukemia after a second transplantation
    Kobayashi, Shinichi; Kanda, Yoshinobu; Konuma, Takaaki ... Bone marrow transplantation (Basingstoke), 01/2022, Volume: 57, Issue: 1
    Journal Article
    Peer reviewed

    Relapsed acute leukemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with poor prognosis. In a subset of patients, durable remissions can be achieved with a ...
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