The Neutrino Mass Ordering (NMO) remains one of the outstanding questions in the field of neutrino physics. One strategy to measure the NMO is to observe matter effects in the oscillation pattern of ...atmospheric neutrinos above
∼
1
GeV
, as proposed for several next-generation neutrino experiments. Moreover, the existing IceCube DeepCore detector can already explore this type of measurement. We present the development and application of two independent analyses to search for the signature of the NMO with three years of DeepCore data. These analyses include a full treatment of systematic uncertainties and a statistically-rigorous method to determine the significance for the NMO from a fit to the data. Both analyses show that the dataset is fully compatible with both mass orderings. For the more sensitive analysis, we observe a preference for normal ordering with a
p
-value of
p
IO
=
15.3
%
and
CL
s
=
53.3
%
for the inverted ordering hypothesis, while the experimental results from both analyses are consistent within their uncertainties. Since the result is independent of the value of
δ
CP
and obtained from energies
E
ν
≳
5
GeV
, it is complementary to recent results from long-baseline experiments. These analyses set the groundwork for the future of this measurement with more capable detectors, such as the IceCube Upgrade and the proposed PINGU detector.
IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The νμ energy unfolding described in this paper is based on data taken with IceCube in its 79-string ...configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of a multivariate classification process based on machine learning. The subsequent unfolding was performed using the software Truee. The resulting spectrum covers an Eν-range of more than four orders of magnitude from 125 GeV to 3.2 PeV. Compared to the Honda atmospheric neutrino flux model, the energy spectrum shows an excess of more than 1.9σ in four adjacent bins for neutrino energies Eν≥177.8TeV. The obtained spectrum is fully compatible with previous measurements of the atmospheric neutrino flux and recent IceCube measurements of a flux of high-energy astrophysical neutrinos.
IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The
energy unfolding described in this paper is based on data taken with IceCube in its 79-string ...configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of a multivariate classification process based on machine learning. The subsequent unfolding was performed using the software Truee. The resulting spectrum covers an E
-range of more than four orders of magnitude from 125 GeV to 3.2 PeV. Compared to the Honda atmospheric neutrino flux model, the energy spectrum shows an excess of more than
in four adjacent bins for neutrino energies
. The obtained spectrum is fully compatible with previous measurements of the atmospheric neutrino flux and recent IceCube measurements of a flux of high-energy astrophysical neutrinos.
Este trabalho objetivou avaliar a divergência genética entre nove acessos de mentrasto (Ageratum conyzoides) por métodos multivariados utilizando caracteres morfológicos, em quatro épocas de ...colheita. Os nove acessos de mentrasto foram obtidos de plantas que ocorrem naturalmente nas cinco regiões climáticas do Estado do Tocantins. Em cada época de colheita foram avaliadas as características como biomassa fresca da parte aérea, biomassa seca, área foliar, número de folhas, floração e altura. Pela análise de agrupamento (método de Tocher) foram formados dois grupos na primeira e quarta épocas de colheita, três grupos na segunda época e quatro grupos na terceira época de colheita. Observou-se variação na constituição dos grupos pelos acessos nas épocas de colheita. A divergência genética entre acessos de mentrasto, avaliada por caracteres morfológicos, foi influenciada pelo estádio de desenvolvimento da espécie. A existência de variabilidade entre os acessos coletados em diferentes localidades fornece subsídio para a coleta sistematizada de germoplasma em A. conyzoides no Estado do Tocantins.
Adverse drug reactions (ADRs) are recognised as a common cause of hospital admissions, and they constitute a significant economic burden for hospitals. Hospital-based ADR monitoring and reporting ...programmes aim to identify and quantify the risks associated with the use of drugs provided in a hospital setting. This information may be useful for identifying and minimising preventable ADRs and may enhance the ability of prescribers to manage ADRs more effectively. The main objectives of this study were to evaluate ADRs that occurred during inpatient stays at the Hospital Geral de Palmas (HGP) in Tocantins, Brazil, and to facilitate the development of a pharmacovigilance service.
A prospective study was conducted at HGP over a period of 8 months, from January 2009 to August 2009. This observational, cross-sectional, descriptive study was based on an analysis of medical records. Several parameters were utilised in the data evaluation, including patient demographics, drug and reaction characteristics, and reaction outcomes. The reaction severity and predisposing factors were also assessed.
The overall incidence of ADRs in the patient population was 3.1%, and gender was not found to be a risk factor. The highest ADR rate (75.8%) was found in the adult age group 15 to 50 years, and the lowest ADR rate was found in children aged 3 to 13 years (7.4%). Because of the high frequency of ADRs in orthopaedic (25%), general medicine (22%), and oncology (16%) patients, improved control of the drugs used in these specialties is required. Additionally, the nurse team (52.7%) registered the most ADRs in medical records, most likely due to the job responsibilities of nurses. As expected, the most noticeable ADRs occurred in skin tissues, with such ADRs are more obvious to medical staff, with rashes being the most common reactions. Metamizole, tramadol, and vancomycin were responsible for 21, 11.6, and 8.4% of ADRs, respectively. The majority of ADRs had moderate severity (58.9%), thus requiring intervention. Type A reactions were the most common (82.1%). At least one predisposing factor was present in 79.9% of the reports examined, and the most common predisposing factor was polypharmacy.
The results obtained will contribute to the development of strategies for the pharmacovigilance service at HGP and other hospitals throughout the country, which will improve the quality of ADR reporting and ensure safer drug use in Brazilian hospitals.
We present an all-sky search for muon neutrinos produced during the prompt \(\gamma\)-ray emission of 1172 gamma-ray bursts (GRBs) with the IceCube Neutrino Observatory. The detection of these ...neutrinos would constitute evidence for ultra-high energy cosmic ray (UHECR) production in GRBs, as interactions between accelerated protons and the prompt \(\gamma\)-ray field would yield charged pions, which decay to neutrinos. A previously reported search for muon neutrino tracks from Northern Hemisphere GRBs has been extended to include three additional years of IceCube data. A search for such tracks from Southern Hemisphere GRBs in five years of IceCube data has been introduced to enhance our sensitivity to the highest energy neutrinos. No significant correlation between neutrino events and observed GRBs is seen in the new data. Combining this result with previous muon neutrino track searches and a search for cascade signature events from all neutrino flavors, we obtain new constraints for single-zone fireball models of GRB neutrino and UHECR production.
We present a search for a neutrino signal from dark matter self-annihilations in the Milky Way using the IceCube Neutrino Observatory (IceCube). In 1005 days of data we found no significant excess of ...neutrinos over the background of neutrinos produced in atmospheric air showers from cosmic ray interactions. We derive upper limits on the velocity averaged product of the dark matter self-annihilation cross section and the relative velocity of the dark matter particles \(\langle\sigma_{\text{A}}v\rangle\). Upper limits are set for dark matter particle candidate masses ranging from 10 GeV up to 1 TeV while considering annihilation through multiple channels. This work sets the most stringent limit on a neutrino signal from dark matter with mass between 10 GeV and 100 GeV, with a limit of \(1.18\cdot10^{-23}\text{cm}^3\text{s}^{-1}\) for 100 GeV dark matter particles self-annihilating via \(\tau^+\tau^-\) to neutrinos (assuming the Navarro-Frenk-White dark matter halo profile).
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