Abstract
We present Atacama Large Millimeter Array C i(1 − 0) (rest frequency 492 GHz) observations for a sample of 13 strongly lensed dusty star-forming galaxies (DSFGs) originally discovered at ...1.4 mm in a blank-field survey by the South Pole Telescope (SPT). We compare these new data with available C i observations from the literature, allowing a study of the interstellar medium (ISM) properties of ∼30 extreme DSFGs spanning a redshift range 2 < z < 5. Using the C i line as a tracer of the molecular ISM, we find a mean molecular gas mass for SPT-DSFGs of 6.6 × 1010 M⊙. This is in tension with gas masses derived via low-J
12CO and dust masses; bringing the estimates into accordance requires either (a) an elevated CO-to-H2 conversion factor for our sample of αCO ∼ 2.5 and a gas-to-dust ratio ∼200, or (b) an high carbon abundance
$X_{\rm C\,\small {I}} \sim 7\times 10^{-5}$
. Using observations of a range of additional atomic and molecular lines (including C i, C iiand multiple transitions of CO), we use a modern photodissociation region code (3d-pdr) to assess the physical conditions (including the density, UV radiation field strength and gas temperature) within the ISM of the DSFGs in our sample. We find that the ISM within our DSFGs is characterized by dense gas permeated by strong UV fields. We note that previous efforts to characterize photodissociation region regions in DSFGs may have significantly under-estimated the density of the ISM. Combined, our analysis suggests that the ISM of extreme dusty starbursts at high redshift consists of dense, carbon-rich gas not directly comparable to the ISM of starbursts in the local Universe.
We present C ii observations of 20 strongly lensed dusty star-forming galaxies at 2.1 < z < 5.7 using Atacama Pathfinder EXperiment and Herschel. The sources were selected on their 1.4 mm flux (S
1.4 ...mm > 20 mJy) from the South Pole Telescope (SPT) survey, with far-infrared (FIR) luminosities determined from extensive photometric data. The C ii line is robustly detected in 17 sources, all but one being spectrally resolved. 11 out of 20 sources observed in C ii also have low-J CO detections from Australia Telescope Compact Array. A comparison with mid- and high-J CO lines from Atacama Large Millimeter/submillimeter Array reveals consistent C ii and CO velocity profiles, suggesting that there is little differential lensing between these species. The C ii, low-J CO and FIR data allow us to constrain the properties of the interstellar medium. We find C ii to CO(1–0) luminosity ratios in the SPT sample of 5200 ± 1800, with significantly less scatter than in other samples. This line ratio can be best described by a medium of C ii and CO emitting gas with a higher C ii than CO excitation temperature, high CO optical depth τCO(1–0) ≫ 1, and low to moderate C ii optical depth
$\tau _{{\rm C\,\small {II}}}$
≲ 1. The geometric structure of photodissociation regions allows for such conditions.
Within living cells, mitochondria are considered relevant sources of reactive oxygen species (ROS) and are exposed to reactive nitrogen species (RNS). During the last decade, accumulating evidence ...suggests that mitochondrial (dys)function, ROS/RNS levels, and aberrations in mitochondrial morphology are interconnected, albeit in a cell- and context-dependent manner. Here it is hypothesized that ROS and RNS are involved in the short-term regulation of mitochondrial morphology and function via non-transcriptional pathways. We review the evidence for such a mechanism and propose that it allows homeostatic control of mitochondrial function and morphology by redox signaling.
Willems et al. explore the links between cellular and mitochondrial redox homeostasis and the non-transcriptional regulation of mitochondrial fission and fusion. Proper understanding of this rheostatic system is crucial to unravel how disturbed redox homeostasis, mitochondrial function, and mitochondrial structure are linked to pathology in human disorders.
GOALS: The Great Observatories All-Sky LIRG Survey Armus, L.; Mazzarella, J. M.; Evans, A. S. ...
Publications of the Astronomical Society of the Pacific,
06/2009, Volume:
121, Issue:
880
Journal Article
Peer reviewed
Open access
The Great Observatories All-Sky LIRG Survey (GOALS20) combines data from NASA’sSpitzer Space Telescope,
Chandra X-Ray Observatory,
Hubble Space Telescope(HST), andGalaxy Evolution Explorer(GALEX) ...observatories, together with ground-based data, into a comprehensive imaging and spectroscopic survey of over 200 low-redshift (
z < 0.088
z
<
0.088
), Luminous Infrared Galaxies (LIRGs). The LIRGs are a complete subset of theIRASRevised Bright Galaxy Sample (RBGS), which comprises 629 extragalactic objects with 60 μm flux densities above 5.24 Jy, and Galactic latitudes above five degrees. The LIRGs targeted in GOALS span the full range of nuclear spectral types defined via traditional optical line-ratio diagrams (type-1 and type-2 AGN, LINERs, and starbursts) as well as interaction stages (major mergers, minor mergers, and isolated galaxies). They provide an unbiased picture of the processes responsible for enhanced infrared emission in galaxies in the local Universe. As an example of the analytic power of the multiwavelength GOALS data set, we presentSpitzer, Chandra, HST,andGALEXimages and spectra for the interacting system VV 340 (IRAS
F14547 + 2449
F
14547
+
2449
). TheSpitzerMIPS imaging data indicates that between 80–95% of the total far-infrared emission (or about5 × 1011 L
⊙
5
×
10
11
L
⊙
) originates in VV 340 north. While theSpitzerIRAC colors of VV 340 north and south are consistent with star-forming galaxies, both theSpitzerIRS andChandraACIS data indicate the presence of an AGN in VV 340 north. The observed line fluxes, without correction for extinction, imply that the AGN accounts for less than 10%–20% of the observed infrared emission. The X-ray data are consistent with a heavily absorbed (
N
H
≥1024 cm-2
N
H
≥
10
24
cm
-
2
) AGN. The GALEX far and near-UV fluxes imply a extremely large infrared “excess” (IRX) for the system (FIR/Ffuv ∼ 81
F
IR
/
F
fuv
∼
81
) which is well above the correlation seen in starburst galaxies. Most of this excess is driven by VV 340 N, which has an IR excess of nearly 400. The VV 340 system seems to be comprised of two very different galaxies: an infrared luminous edge-on galaxy (VV 340 north) that dominates the long-wavelength emission from the system, which hosts a buried AGN; and a face-on starburst (VV 340 south) that dominates the short-wavelength emission.
ABSTRACT We use the Atacama Large Millimeter/submillimeter Array (ALMA) in Cycle 1 to determine spectroscopic redshifts of high-redshift dusty star-forming galaxies (DSFGs) selected by their 1.4 mm ...continuum emission in the South Pole Telescope (SPT) survey. We present ALMA 3 mm spectral scans between 84 and 114 GHz for 15 galaxies and targeted ALMA 1 mm observations for an additional eight sources. Our observations yield 30 new line detections from CO, C i, N ii, H2O and NH3. We further present Atacama Pathfinder Experiment C ii and CO mid-J observations for seven sources for which only a single line was detected in spectral-scan data from ALMA Cycle 0 or Cycle 1. We combine the new observations with previously published and new millimeter/submillimeter line and photometric data of the SPT-selected DSFGs to study their redshift distribution. The combined data yield 39 spectroscopic redshifts from molecular lines, a success rate of >85%. Our sample represents the largest data set of its kind today and has the highest spectroscopic completeness among all redshift surveys of high-z DSFGs. The median of the redshift distribution is z = 3.9 0.4, and the highest-redshift source in our sample is at z = 5.8. We discuss how the selection of our sources affects the redshift distribution, focusing on source brightness, selection wavelength, and strong gravitational lensing. We correct for the effect of gravitational lensing and find the redshift distribution for 1.4 mm selected sources with a median redshift of z = 3.1 0.3. Comparing to redshift distributions selected at shorter wavelengths from the literature, we show that selection wavelength affects the shape of the redshift distribution.
We present the average rest-frame spectrum of high-redshift dusty, star-forming galaxies from 250 to 770 GHz. This spectrum was constructed by stacking Atacama Large Millimeter/submillimeter Array ...(ALMA) 3 mm spectra of 22 such sources discovered by the South Pole Telescope and spanning z = 2.0-5.7. In addition to multiple bright spectral features of super(12)CO, CI, and H sub(2)O, we also detect several faint transitions of super(13)CO, HCN, HNC, HCO super(+), and CN, and use the observed line strengths to characterize the typical properties of the interstellar medium of these high-redshift starburst galaxies. We find that the super(13)CO brightness in these objects is comparable to that of the only other z > 2 star-forming galaxy in which super(13)CO has been observed. We show that the emission from the high-critical density molecules HCN, HNC, HCO super(+), and CN is consistent with a warm, dense medium with T sub(kin) ~ 55 K and n sub(H2), gap 10 super(5.5) cm super(-3). High molecular hydrogen densities are required to reproduce the observed line ratios, and we demonstrate that alternatives to purely collisional excitation are unlikely to be significant for the bulk of these systems. We quantify the average emission from several species with no individually detected transitions, and find emission from the hydride CH and the linear molecule CCH for the first time at high redshift, indicating that these molecules may be powerful probes of interstellar chemistry in high-redshift systems. These observations represent the first constraints on many molecular species with rest-frame transitions from 0.4 to 1.2 mm in star-forming systems at high redshift, and will be invaluable in making effective use of ALMA in full science operations.
We identify stellar structures in the PHANGS sample of 74 nearby galaxies and construct morphological masks of sub-galactic environments based on
Spitzer
3.6
μ
m images. At the simplest level, we ...distinguish five environments: centres, bars, spiral arms, interarm regions, and discs without strong spirals. Slightly more sophisticated masks include rings and lenses, which are publicly released but not explicitly used in this paper. We examine trends with environment in the molecular gas content, star formation rate, and depletion time using PHANGS–ALMA CO(2–1) intensity maps and tracers of star formation. The interarm regions and discs without strong spirals clearly dominate in area, whereas molecular gas and star formation are quite evenly distributed among the five basic environments. We reproduce the molecular Kennicutt–Schmidt relation with a slope compatible with unity within the uncertainties and without significant slope differences among environments. In contrast to what has been suggested by early studies, we find that bars are not always deserts devoid of gas and star formation, but instead they show large diversity. Similarly, spiral arms do not account for most of the gas and star formation in disc galaxies, and they do not have shorter depletion times than the interarm regions. Spiral arms accumulate gas and star formation, without systematically boosting the star formation efficiency. Centres harbour remarkably high surface densities and on average shorter depletion times than other environments. Centres of barred galaxies show higher surface densities and wider distributions compared to the outer disc; yet, depletion times are similar to unbarred galaxies, suggesting highly intermittent periods of star formation when bars episodically drive gas inflow, without enhancing the central star formation efficiency permanently. In conclusion, we provide quantitative evidence that stellar structures in galaxies strongly affect the organisation of molecular gas and star formation, but their impact on star formation efficiency is more subtle.
Current data suggest that platinum-based combination therapy is the standard first-line treatment for biliary tract cancer. EGFR inhibition has proven beneficial across a number of gastrointestinal ...malignancies; and has shown specific advantages among KRAS wild-type genetic subtypes of colon cancer. We report the combination of panitumumab with gemcitabine (GEM) and oxaliplatin (OX) as first-line therapy for KRAS wild-type biliary tract cancer.
Patients with histologically confirmed, previously untreated, unresectable or metastatic KRAS wild-type biliary tract or gallbladder adenocarcinoma with ECOG performance status 0-2 were treated with panitumumab 6 mg kg(-1), GEM 1000 mg m(-2) (10 mg m(-2) min(-1)) and OX 85 mg m(-2) on days 1 and 15 of each 28-day cycle. The primary objective was to determine the objective response rate by RECIST criteria v.1.1. Secondary objectives were to evaluate toxicity, progression-free survival (PFS), and overall survival.
Thirty-one patients received at least one cycle of treatment across three institutions, 28 had measurable disease. Response rate was 45% and disease control rate was 90%. Median PFS was 10.6 months (95% CI 5-24 months) and median overall survival 20.3 months (95% CI 9-25 months). The most common grade 3/4 adverse events were anaemia 26%, leukopenia 23%, fatigue 23%, neuropathy 16% and rash 10%.
The combination of gemcitabine, oxaliplatin and panitumumab in KRAS wild type metastatic biliary tract cancer showed encouraging efficacy, additional efforts of genetic stratification and targeted therapy is warranted in biliary tract cancer.
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