We report measurements of the branching fractions of the decays Λ c+ → Σ +π-π+ , Λ c+ → Σ 0π+π0 and Λ c+ → Σ +π0π0 relative to the reference channel Λ c+ → pK-π+ . The analysis is based on the full ...data sample collected at and near the Υ ( 4S ) resonance by the Belle detector at the KEKB asymmetric-energy e+e- collider, corresponding to an integrated luminosity of 711fb-1 . We measure B ( Λ c+ → Σ +π-π+ ) / B ( Λ c+ → pK-π+ ) =0.719±0.003±0.024 , B ( Λ c+ → Σ 0π+π0 ) / B ( Λ c+ → pK-π+ ) =0.575±0.005±0.036 and B ( Λ c+ → Σ +π0π0 ) / B ( Λ c+ → pK-π+ ) =0.247±0.006±0.019 . The listed uncertainties are statistical and systematic, respectively.
Aims
Carboplatin dosage is calculated by using the estimated glomerular filtration rate (GFR) to achieve a target plasma area under the plasma concentration–time curve (AUC). The aims of the present ...study were to investigate factors that influence the pharmacokinetics of carboplatin in children with high‐risk neuroblastoma, and whether target exposures for carboplatin were achieved using current treatment protocols.
Methods
Data on children receiving high‐dose carboplatin, etoposide and melphalan for neuroblastoma were obtained from two study sites European International Society for Paediatric Oncology (SIOP) Neuroblastoma study, Children's Hospital at Westmead; n = 51. A population pharmacokinetic model was built for carboplatin to evaluate various dosing formulas. The pharmacokinetics of etoposide and melphalan was also investigated. The final model was used to simulate whether target carboplatin AUC (16.4 mg ml–1·min) would be achieved using the paediatric Newell formula, modified Calvert formula and weight‐based dosing.
Results
Allometric weight was the only significant, independent covariate for the pharmacokinetic parameters of carboplatin, etoposide and melphalan. The paediatric Newell formula and modified Calvert formula were suitable for achieving the target AUC of carboplatin for children with a GFR <100 ml min–1 1.73 m–2 but not for those with a GFR ≥100 ml min–1 1.73 m–2. A weight‐based dosing regimen of 50 mg kg–1 achieved the target AUC more consistently than the other formulas, regardless of renal function.
Conclusions
GFR did not appear to influence the pharmacokinetics of carboplatin after adjusting pharmacokinetic parameters for weight. This model‐based approach validates the use of weight‐based dosing as an appropriate alternative for carboplatin in children with either mild renal impairment or normal renal function.
We report the measurement of γγ → ηc ( 1S ) ,ηc ( 2S ) → η'π+π- with η' decays to γρ and ηπ+π- using 941fb-1 of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. The ...ηc ( 1S ) mass and width are measured to be M= 2984.6±0.7 ( stat ) ±2.2 ( syst ) ±0.3 ( model ) MeV/c2 and Γ = 30.8-2.2+2.3 ( stat ) ±2.5 ( syst ) ±1.4 ( model ) MeV , respectively. First observation of ηc ( 2S ) → η'π+π- with a significance of 5.5σ including systematic error is obtained, and the ηc ( 2S ) mass is measured to be M= 3635.1±3.7 ( stat ) ±2.9 ( syst ) ±0.4 ( model ) MeV/c2 . The products of the two-photon decay width and branching fraction ( B ) of decays to η'π+π- are determined to be Γ γγ Γ γγ B = 65.4±2.6 ( stat ) ±7.8 ( syst ) eV for ηc ( 1S ) and 5.6-1.1+1.2 ( stat ) ±1.1 ( syst ) eV for ηc ( 2S ) . The cross sections for γγ → η'π+π- and η'f2 ( 1270 ) are measured for the first time.
We report a search for a dark vector gauge boson U′ that couples to quarks in the decay chain D*+→D0π+,D0→KS0η,η→U′γ, U′→π+π−. No signal is found and we set a mass-dependent limit on the baryonic ...fine structure constant of 10−3−10−2 in the U′ mass range of 290 to 520 MeV/c2. This analysis is based on a data sample of 976 fb−1 collected by the Belle experiment at the KEKB asymmetric-energy e+e− collider.
A search for the decays B+ → hcK+ and B0 → hcKS0 is performed. Evidence for the decay B+ → hcK+ is found; its significance is 4.8σ . No evidence is found for B0 → hcKS0 . The branching fraction for ...B+ → hcK+ is measured to be ( 3.7-0.9+1.0 -0.8+0.8 ) ×10-5 ; the upper limit for the B0 → hcKS0 branching fraction is 1.4×10-5 at 90% C.L. In addition, a study of the p p ¯ π+π- invariant mass distribution in the channel B+ → ( p p ¯ π+π- ) K+ results in the first observation of the decay ηc ( 2S ) → p p ¯ π+π- with 12.1σ significance. The analysis is based on the 711 fb-1 data sample collected by the Belle detector at the asymmetric-energy e+e- collider KEKB at the γ ( 4S ) resonance.
We report a new measurement of the exclusive e+e−→D(*)±D*∓ cross sections as a function of the center-of-mass energy from the D(*)±D*∓ threshold through s=6.0 GeV, using the initial-state radiation ...technique. The analysis is based on a data sample collected with the Belle detector with an integrated luminosity of 951 fb−1. The accuracy of the cross section measurement is increased by a factor of 2 over the first Belle study. We perform the first angular analysis of the e+e−→D*±D*∓ process and decompose this exclusive cross section into three components corresponding to the D* helicities.
We have searched for the lepton-flavor-violating decay B0 → K*0µ±e∓ using a data sample of 711 fb-1 that contains 772 × 106 $B\bar{B}$ pairs. The data were collected near the Υ(4S) resonance with the ...Belle detector at the KEKB asymmetric-energy e+e- collider. No signals were observed, and we set 90% confidence level upper limits on the branching fractions of B(B0 → K*0µ+e-) < 1.2 × 10-7, B(B0 → K*0µ-e+) < 1.6 × 10-7, and, for both decays combined, B(B0 → K*0µ±e∓) < 1.8 × 10-7. These are the most stringent limits on these decays to date.
We report a search for X ( 3872 ) and X ( 3915 ) in B+ → χc1π0K+ decays. We set an upper limit of B ( B+ → X ( 3872 ) K+ ) × B ( X ( 3872 ) → χc1π0 ) <8.1×10-6 and B ( B+ → X ( 3915 ) K+ ) × B ( X ( ...3915 ) → χc1π0 ) <3.8×10-5 at 90% confidence level. We also measure B ( X ( 3872 ) → χc1π0 ) / B ( X ( 3872 ) → J / ψπ+π- ) <0.97 at 90% confidence level. The results reported here are obtained from 772×106 B B ¯ events collected at the Υ ( 4S ) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider.
We have proposed and validated an ansatz as effective potential for confining electron/hole within a spherical quantum dot in order to understand quantum confinement and its consequences associated ...with energy states and band gap of Spherical Quantum Dots. Within effective mass approximation formalism, we have considered an ansatz incorporating a conjoined harmonic oscillator and Coulomb interaction as the effective potential for confining an electron or a hole within a spherical quantum dot and by employing appropriate boundary conditions, we have calculated the shifts in energy of minimum of conduction band (CBM) and maximum of valence band (VBM) with respect to size of spherical quantum dots. We have also determined the quantum confinement induced shift in band gap energy of spherical quantum dots. In order to verify our theoretical predictions as well as to validate our ansatz, we have performed phenomenological analysis in comparison with available experimental results for quantum dots made of CdSe and observe a very good agreement in this regard. Our experimentally consistent theoretical results also help in mapping the probability density of electron and hole inside a spherical quantum dot. The consistency of our results with available experimental data signifies the capability as well as applicability of the ansatz for the effective confining potential to have reasonable information in the study of real nano-structured spherical systems.
•Proposed and validated a confining potemtial model for Quantum Dot (QD).•Quantum confinement induced shifts in band edges and band gap of QD are presented.•A prediction of Electron and hole probability density distribution inside quantum dot.
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