During a 21/2-year period, studies were done on 14 patients with chronic renal failure to evaluate pleural effusions which we believe were secondary to the uremic process. The patients with uremic ...pleural effusions closely resembled those in the group with chronic renal failure as a whole with respect to diagnosis and clinical features. Fever and pericarditis were noted in half the patients. The pleural fluid appeared serosanguineous or hemorrhagic in 10 of 14 patients and contained a predominance of lymphocytes more often than of neutrophils. Elevated protein and lactic dehydrogenase (LDH) levels gave the effusion characteristics of an exudate. Pleural tissue obtained by pleural biopsy or autopsy showed chronic fibrinous pleuritis in every patient. With continued dialysis the effusions resolved in 4 to 6 weeks after thoracentesis in 11 patients and recurred in 3 patients.
1 in Environmental Toxicology and Chemistry questioning the validity of our work on the toxicity of petroleum-derived polycyclic aromatic hydrocarbons (PAHs) to the early life stages of fish.
A wearable artificial glomerulus Neff, M S; Sadjadi, S; Slifkin, R
Transactions - American Society for Artificial Internal Organs,
1979, Volume:
25
Journal Article
Peer reviewed
We have shown that hemofiltration can be conducted for 16 hrs/day for more than 3 continuous days by connecting an Amicon 0.2 M2 hemofilter to an arteriovenous shunt. We can produce over 8 ml/min of ...ultrafiltrate with no external pump, and this ultrafiltrate can be replaced by having the patient drink an electrolyte-glucose solution. Anticoagulation can be attained with heparin, warfarin and cyproheptadine. Each filter can be expected to function at least 48 hrs before it must be replaced.
Plants perceive subtle changes in light quality and quantity through a set of photoreceptors, including phytochromes and cryptochromes. Upon perception, these photoreceptors initiate signal ...transduction pathways leading to photomorphogenic changes in development. Using activation-tagging mutagenesis to identify novel light-signaling components, we have isolated a gain-of-function mutant,
sob1-D
(suppressor of
phytochrome B-4
phyB-4
dominant), which suppresses the long-hypocotyl phenotype of the
phyB
missense allele,
phyB-4
. The
sob1-D
mutant phenotype is caused by the overexpression of a Dof (DNA binding with one finger) transcription factor,
OBF4 Binding Protein 3
(
OBP3
). A translational fusion between OBP3 and green fluorescent protein is nuclear localized in onion (
Allium cepa
) cells. Tissue-specific accumulation of an OBP3:OBP3-β-glucuronidase translational fusion is regulated by light in
Arabidopsis thaliana
. Hypocotyls of transgenic lines with reduced
OBP3
expression are less responsive to red light. This aberrant phenotype in red light requires functional phyB, suggesting that OBP3 is a positive regulator of phyB-mediated inhibition of hypocotyl elongation. Furthermore, these partial-loss-of-function lines have larger cotyledons. This light-dependent cotyledon phenotype is most dramatic in blue light and requires functional cryptochrome 1 (cry1), indicating that OBP3 is a negative regulator of cry1-mediated cotyledon expansion. These results suggest a model where OBP3 is a component in both phyB and cry1 signaling pathways, acting as a positive and negative regulator, respectively. An alternate, though not mutually exclusive, model places OBP3 as a general inhibitor of tissue expansion with phyB and cry1, differentially modulating OBP3's role in this response.
Thirty autogenous saphenous vein grafts, 91 modified bovine heterografts and 96 PTFE grafts were used in the construction of vascular access for hemodialysis. The indication for the use of an ...arterial substitute was the unavailability of suitable artery or vein for the construction of a standard subcutaneous arteriovenous fistula. Ten of these grafts were placed in the lower extremity while the rest were placed in either the forearm or upper arm. All three types of grafts provided an immediate satisfactory solution to a difficult problem. When compared in terms of longterm patency, the autogenous saphenous vein proved to be inferior to either the modified bovine heterograft or the PTFE graft. Comparing all three grafts, the PTFE graft is currently our vascular substitute of choice for patients requiring grafts for arteriovenous fistulas for hemodialysis.
Larval mud crabs Rhithropanopeus harrisii were exposed continuously from hatching through the first crab stage to sublethal concentrations of naphthalene (0, 75, 150 or 300 μg l⁻¹) at several ...combinations of salinity and temperature (5, 15, or 25 ‰ S and 20°, 25° or 30 °C, respectively), the experimental design consisting of a complete 3 × 3 × 4 factorial. Respiration rates were determined under all treatment combinations for the second and fourth zoeal stage, megalops and first crab. In addition to a steady-state respiratory response at the rearing salinity, an osmotic-shock respiratory response was also assessed by respirometry immediately after transfer of larvae reared at 15 ‰ S to either 5 ‰ S (hypoosmotic shock) or 25 ‰ S (hyperosmotic shock). Respiratory rates increased with temperature for all stages. Increases in the respiration rate of larval stages, especially zoeal stages, also occurred in low salinities. The increase due to low environmental salinity was least in the juvenile crab, probably because of development of the osmoregulatory capacity of the gill. Respiratory response to hypoosmotic shock was similar to that observed for steady-state trials at 5 ‰ S, but the pattern for hyperosmotic shock was intermediate between the steady-state response at 15 and 25 ‰ S. Naphthalene exposure usually resulted in an increase in respiration rate (of the zoeal stages) in low salinities. However, when physical conditions were not stressful, naphthalene effects generally were not obvious. The weight of megalops from the various trials (environmental factor combinations) was determined as an indication of growth during zoeal development. Growth was affected substantially by higher temperatures and lower salinities, and slightly by lower salinity-higher naphthalene combinations. At optimal salinity, 15 ‰ S, no consistent effect of naphthalene on growth was apparent. This partial energy budget approach is seen as a useful method for assessing long-term sublethal stress in marine invertebrates.
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