We analyzed the research data on antitumor effects of a wide range of ferrocene compounds and discussed possible mechanisms of their bioactivities. Current trends in the study of anticancer effects ...of ferrocene derivatives were considered. Promising ways in the design of low-toxicity anticancer ferrocene-based drugs of new generation were outlined.
The influence of a REM-containing Insteel 7 complex modifier on the structure and the contents of dissolved gases and sulfur in Fe–Al alloys with an increased aluminum content (11–15 wt %) melted in ...an open induction furnace is studied.
We report a comprehensive study of physical properties of the binary superconductor compound SnAs. The electronic band structure of SnAs was investigated using both angle-resolved photoemission ...spectroscopy (ARPES) in a wide binding energy range and density functional theory (DFT) within generalized gradient approximation (GGA). The DFT/GGA calculations were done including spin-orbit coupling for both bulk and (111) slab crystal structures. Comparison of the DFT/GGA band dispersions with ARPES data shows that the spectrum for the (111) slab much better describes ARPES data than that for the bulk. In addition, we studied experimentally superconducting properties of SnAs by specific heat, magnetic susceptibility, magnetotransport measurements, and Andreev reflection spectroscopy. Temperature dependencies of the superconducting gap and of the specific heat were found to be well consistent with those expected for the single band BCS superconductors with an isotropic s-wave order parameter. Despite spin-orbit coupling present in SnAs, our data show no signatures of a potential unconventional superconductivity, and the characteristic BCS ratio 2Δ/Tc=3.48–3.73 is very close to the BCS value in the weak coupling limit.
Data on the antitumor activities of ferrocene compounds and the results concerning the mechanisms of their action published between 1995 and 2010 are discussed. The biomedical aspects of the study of ...ferrocene derivatives are briefly analyzed.
The composition of fluids used in “electronic cigarettes” was studied without preliminary preparation procedures using one- and two-dimensional homo- and heteronuclear 1H and 13C NMR spectroscopy in ...addition to electrospray ionization mass spectrometry (ESI-MS). It was shown that the main components of the mixtures were non-tobacco products.
A new asymptotic method for solving Cauchy problems with localized initial data (perturbation) for the linearized shallow-water equation is suggested. The solution is decomposed into two parts: waves ...and vortices. Metamorphosis of the profile takes place for the wave part: it is localized in the neighborhood of the initial point and later on it is localized in the neighborhood of the front (1-D curve on the plane). Initially, the front is a smooth curve, but as the time increases turning (focal) and self-intersection points might appear. The vortical part is localized in the neighborhood of a point moving along the trajectory of the basic velocity vector field. Both parts are described by very simple formulae taking into account the form of the initial perturbation. These formulae are expressed by means of elementary functions for some special choice of the initial data. Due to the profile-metamorphosis phenomenon the method leading to the final formulae is not elementary. It makes use of semiclassical approximations and ray expansions. It is based on the generalization of the construction known as the Maslov canonical operator and boundary-layer expansions.
The structures, electrochemical properties, enantiomeric separation of ferrocenyl-(alkyl)pyrimidines and ferrocenyl(ethyl)adenine and their effects on the DNA synthesis in tumor cells were studied. ...Enantiomeric mixtures were separated by HPLC on modified cellulose as the chiral selector. The electrochemical properties of compounds were studied by cyclic voltammetry. All compounds have reversible single-electron redox transition in the region of 0.52–0.60 V, which belongs to ferrocene—ferrocenium with a positive shift compared to ferrocene (0.52 V). The molecular structure of 1-
N
-(ferrocenylbenzyl)-5-iodocytosine was studied by X-ray diffraction. 1-
N
-(Ferrocenylethyl)adenine was studied for ability to inhibit the DNA synthesis in the human ovarian cancer cell culture by the
3
H-thymidine test.
We have studied the behavior of ferrocene CpFeCp (FcH), ferrocenium triiodide FcH
+
I
3
−
, dimethylaminomethylferrocene FcCH
2
NMe
2
and its trimethylammonium salt FcCH
2
NMe
3
+
I
−
under the ...conventional conditions of electrospray ionization (ESI), when the substance solution is subjected to spraying, and in two versions of desorption electrospray ionization (DESI), when the sprayed solvent bombards the surface of solid or liquid samples. In addition to these techniques, the behavior of neutral compounds under conditions of electrospray ionization of vapors of the studied compounds in a gas phase (ESI_V) has been investigated. It has been shown using the examples of ferrocene and its dimethylaminomethyl derivative that the detection limits for these compounds occurring in a gas phase are comparable within an order of magnitude with their detection limits under the ESI and DESI conditions of solid and liquid samples. The high effectiveness of ionization of analyte vapors makes it possible to use the ESI method not only in combination with liquid (conventional ESI technology) and thin layer chromatography (DESI), but also with gas liquid chromatography (ESI_V). Thus, the electrospray ionization becomes a universal method allowing studies of a compound under the natural conditions in any state of aggregation, that is, solid, liquid, and gas. With the help of statistical methods for designing experiments (complete factorial experiment), quantitative evaluation of the influence of experimental parameters on the ion-formation processes under different ESI conditions has been carried out, which makes it possible to purposefully select the optimal conditions to record the ESI mass spectra with a minimum number of experiments. Moreover, analysis of the dependences of the mass spectra on the experimental parameters can serve as an instrument for studying the details of the ion-formation mechanisms depending upon different ways of ionization.
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