Objectif Rapporter la première expérience française d’utilisation, en vie réelle, d’une nouvelle patch-pompe (Cellnovo) prochainement commercialisée en France. Patients et méthodes Cinq patients (3♀, ...2♂) diabétiques de type 1 (43,4 ± 4,5 ans, diabétiques depuis 20,6 ± 14,7 ans, mis sous pompe depuis 4,2 ± 1,3 ans) bien équilibrés (HbA1c 6,8 ± 0,6 %), sans antécédents d’hypoglycémies graves et peu compliqués (1 rétinopathie débutante, 1 artérite distale) ont mis en place, après une matinée de formation, le nouveau système mobile de gestion du diabète Cellnovo composé d’une patch-pompe unique et d’une tablette tactile envoyant, automatiquement et continuellement, par le réseau téléphonique mobile, toutes les données du patient sur un site web sécurisé. Ces données (glycémies, débits de base, boli, changement de cathéter, diététique et score d’activité physique) ont été suivies, en temps réel, durant 2 semaines sur le site web dédié par le médecin responsable. À l’issue de cette période, un questionnaire a été adressé à chaque patient et une interview réalisée. Résultats Les cinq questionnaires ont pu être analysés. Sur une échelle de 1-7 (1 = pas d’accord, 7 complètement d’accord), ont été cotées les caractéristiques et facilité d’utilisation : pompe : 4,5, mesure de la glycémie : 4,2, tablette tactile : 4,1, définition des débits d’insuline : 3,6, site web sécurisé : 4,6, base alimentaire et activité physique : 5,7, jugement global : 5. Tous les patients souhaitent garder ce système et le préfèrent au précédent. Ont été unanimement appréciés, confort et discrétion du système, tablette tactile, disponibilité en temps réel des données sur le site web et accès des données au médecin. Aucun incident, n’a été rapporté durant cette période d’observation. Conclusion Cette première expérience met en évidence l’intérêt des patients et la sécurité du système pour les professionnels de santé. Déclaration d’intérêt Les auteurs déclarent avoir un intérêt avec un organisme privé, industriel ou commercial en relation avec le sujet présenté. CellNovo.
The Physics Beyond Colliders initiative is an exploratory study aimed at exploiting the full scientific potential of the CERN's accelerator complex and scientific infrastructures through projects ...complementary to the LHC and other possible future colliders. These projects will target fundamental physics questions in modern particle physics. This document presents the status of the proposals presented in the framework of the Beyond Standard Model physics working group, and explore their physics reach and the impact that CERN could have in the next 10-20 years on the international landscape.
Permanent electric dipole moments (EDMs) of fundamental particles provide powerful probes for physics beyond the Standard Model. We propose to search for the EDM of strange and charm baryons at LHC, ...extending the ongoing experimental program on the neutron, muon, atoms, molecules and light nuclei. The EDM of strange
Λ
baryons, selected from weak decays of charm baryons produced in
p
p
collisions at LHC, can be determined by studying the spin precession in the magnetic field of the detector tracking system. A test of
C
P
T
symmetry can be performed by measuring the magnetic dipole moment of
Λ
and
Λ
¯
baryons. For short-lived
Λ
c
+
and
Ξ
c
+
baryons, to be produced in a fixed-target experiment using the 7
TeV
LHC beam and channeled in a bent crystal, the spin precession is induced by the intense electromagnetic field between crystal atomic planes. The experimental layout based on the LHCb detector and the expected sensitivities in the coming years are discussed.
We propose a unique program of measurements of electric and magnetic dipole moments of charm, beauty and strange charged baryons at the LHC, based on the phenomenon of spin precession of channeled ...particles in bent crystals. Studies of crystal channeling and spin precession of positively- and negatively-charged particles are presented, along with feasibility studies and expected sensitivities for the proposed experiment using a layout based on the LHCb detector.
Throughout the ages, hair has had psychological and sociological importance in framing the personality and general appearance of an individual. Despite efforts to solve this problem, no ...groundbreaking measures have been proposed. Glycosaminoglycans (GAGs) and associated proteoglycans have important functions in homeostatic maintenance and regenerative processes of the skin. However, little is known about the role of these molecules in the regulation of the hair follicle cycle. Three fractions (F1, F2 and F3) were obtained after separation and purification of GAGs from ascidian tunics. F1 was observed to contain a small amount of amino sugar while high contents of galactose and N-acetylglucosamine were noted in F2 and F3. 2-acetamido-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose (∆Di-6S) and 2-acetamido-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose (∆Di-4S) were the main disaccharide components. F3 exhibited the highest proliferation activity on human follicle dermal papilla (HFDP) cells. In addition, mixed samples (FFM) of F2 and F3 at different concentrations showed peak activities for five days. After cell culture at a concentration of 10 mg/mL and dihydrotestosterone (DHT), the inhibition effect was higher than that for Minoxidil. Application of 10 mg of FFM to the hair of mice for 28 days resulted in a hair growth effect similar to that of Minoxidil, a positive control.
Electromagnetic dipole moments of short-lived particles are sensitive to physics within and beyond the Standard Model of particle physics but have not been accessible experimentally to date. To ...perform such measurements it has been proposed to exploit the spin precession of channeled particles in bent crystals at the LHC. Progress that enables the first measurement of charm baryon dipole moments is reported. In particular, the design and characterization on beam of silicon and germanium bent crystal prototypes, the optimization of the experimental setup, and advanced analysis techniques are discussed. Sensitivity studies show that first measurements of Λc+ and Ξc+ baryon dipole moments can be performed in two years of data taking with an experimental setup positioned upstream of the LHCb detector.
A novel method for the direct measurement of the elusive magnetic and electric dipole moments of the τ lepton is presented. The experimental approach relies on the production of τ^{+} leptons from ...D_{s}^{+}→τ^{+}ν_{τ} decays, originating in fixed-target collisions at the LHC. A sample of polarized τ^{+} leptons is kinematically selected and subsequently channeled in a bent crystal. The magnetic and electric dipole moments of the τ^{+} lepton are measured by determining the rotation of the spin-polarization vector induced by the intense electromagnetic field between crystal atomic planes. The experimental technique is discussed along with the expected sensitivities.
Background. In inflammatory bowel disease (IBD) patients there are reports of the occurrence of hepatobiliary manifestations, so the aim of this study was to evaluate the hepatobiliary manifestations ...in patients with Crohn’s disease (CD) and ulcerative colitis (UC) from an IBD reference center. Methods. Cross-sectional study in an IBD reference center, with interviews and review of medical charts, between July 2015 and August 2016. A questionnaire addressing epidemiological and clinical characteristics was used. Results. We interviewed 306 patients, and the majority had UC (53.9%) and were female (61.8%). Hepatobiliary manifestations were observed in 60 (19.6%) patients with IBD. In the greater part of the patients (56.7%) hepatobiliary disorders were detected after the diagnosis of IBD. In UC (18.2%) patients, the hepatobiliary disorders identified were 11 (6.7%) non-alcoholic fatty liver disease, 9 (5.5%) cholelithiasis, 6 (3.6%) primary sclerosing cholangitis (PSC), 3 (1.8%) hepatotoxicity associated with azathioprine, 1 (0.6%) hepatitis B, and 1 (0.6%) hepatic fibrosis. In CD (21.3%) patients, 11 (7.8%) had cholelithiasis, 11 (7.8%) non-alcoholic fatty liver disease, 4 (2.8%) PSC, 3 (2.1%) hepatotoxicity, 1 (0.7%) hepatitis B, (0.7%) hepatitis C, 1 (0.7%) alcoholic liver disease, and 1 (0.7%) autoimmune hepatitis (AIH). There was one case of PSC/AIH overlap syndrome. Conclusion. The frequency of hepatobiliary disorders was similar in both forms of IBD in patients evaluated. The most common nonspecific hepatobiliary manifestations in IBD patients were non-alcoholic liver disease and cholelithiasis. The most common specific hepatobiliary disorder was PSC in patients with extensive UC or ileocolonic CD involvement; this was seen more frequently in male patients.
In this Erratum, an improved simulation of the channeling efficiency of protons and antiprotons as a function of the particle momentum is shown in for different configurations
Purpose
Patients with diagnosis of diffuse large B-cell lymphoma, who relapse after stem cell transplant (SCT) or are no candidates to SCT, have a poor prognosis and no current treatment is ...available. Thus, we conduct a rotatory chemotherapy schedule that employed low doses of chemotherapy agents to assess efficacy and toxicity in this setting of patients; the end point was the improved outcome.
Methods
Retrospectively we revised an analysis of 461 patients who were treated with a low-doses regimen of cytotoxic agents, who were treated in a single institution, all patients has been treated with at least two salvage regimens, including SCT, > 18 years, performance status < 3, and that were informed about the possibility of severe toxicities,, were considered candidates to the study. They received a weekly rotatory scheme including low doses of cytotoxic agents during 2 years.
Results
Overall response rate was achieved in 314 patients (68%, 95% Confidence interval (CI) 59–76%) and complete response was achieved in 151 cases (32%, 95% CI 25–38%); actuarial curves at 10 years show that progression-free survival was 58% (95% CI 51–66%) and OS was 50% (95% CI 43–57%). Dose reduction was not necessary; toxicity was minimal and well controlled. No death related to acute or late toxicities has been observed.
Conclusion
Low doses of cytotoxic agents for continuous, prolonged periods, with minimal drug-free intervals, represent a novel, active, and easily tolerated approach to management of patients with DLBCL in a terminal phase and improved outcome.
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