Hospital effluents represent an important source for the release of antibiotics and antibiotic resistant bacteria into the environment. This study aims to determine concentrations of various ...antibiotics in wastewater before and after wastewater treatment in a rural hospital (60 km from the center of Hanoi) and in an urban hospital (in the center of Hanoi) in Vietnam, and it aims to explore the relationship between antibiotic concentrations in wastewater before wastewater treatment and quantities of antibiotics used in the rural hospital, over a period of one year in 2013. Water samples were collected using continuous sampling for 24 h in the last week of every month. The data on quantities of antibiotics delivered to all inpatient wards were collected from the Pharmacy department in the rural hospital. Solid-phase extraction and high performance liquid chromatography-tandem mass spectrometry were used for chemical analysis. Significant concentrations of antibiotics were present in the wastewater both before and after wastewater treatment of both the rural and the urban hospital. Ciprofloxacin was detected at the highest concentrations in the rural hospital's wastewater (before treatment: mean = 42.8 µg/L; after treatment: mean = 21.5 µg/L). Metronidazole was detected at the highest concentrations in the urban hospital's wastewater (before treatment: mean = 36.5 µg/L; after treatment: mean = 14.8 µg/L). A significant correlation between antibiotic concentrations in wastewater before treatment and quantities of antibiotics used in the rural hospital was found for ciprofloxacin (r = 0.78; p = 0.01) and metronidazole (r = 0.99; p < 0.001).
A simple design of a broadband multifunctional polarization converter using an anisotropic metasurface for X-band application is proposed. The proposed polarization converter consists of a periodic ...array of the two-corner-cut square patch resonators based on the FR-4 substrate that achieves both cross-polarization and linear-to-circular polarization conversions. The simulated results show that the polarization converter displays the linear cross-polarization conversion in the frequency range from 8 to 12 GHz with the polarization conversion efficiency above 90%. The efficiency is kept higher than 80% with wide incident angle up to 45°. Moreover, the proposed design achieves the linear-to-circular polarization conversion at two frequency bands of 7.42-7.6 GHz and 13-13.56 GHz. A prototype of the proposed polarization converter is fabricated and measured, showing a good agreement between the measured and simulated results. The proposed polarization converter exhibits excellent performances such as simple structure, multifunctional property, and large cost-efficient bandwidth and wide incident angle insensitivity in the linear cross polarization conversion, which can be useful for X-band applications. Furthermore, this structure can be extended to design broadband polarization converters in other frequency bands.
We report a numerical study on the design of a broadband metamaterial absorber (MMA) with a single layer of metal–dielectric–metal based on an FR-4 substrate for X-band applications. The MMA ...structure consists of a periodic array of a split circle ring and lumped resistors coupled within split segments. The MMA structure achieves a broadband absorption response in the frequency range of 7.8–12.6 GHz with an absorptivity of above 90% under normal incidence for all polarization angles. The absorptivity remains above 70% in the frequency range of 6.8–11.8 GHz at wide incident angles from 0° to 30° for both transverse electric and transverse magnetic polarizations. The physical mechanism of the absorber is explained by the electric and the surface current distributions that, in turn, are significantly affected by magnetic resonance.
Developing a simple structure using low-cost material that enables both large-scale fabrication and broadband absorption response is highly desirable but very challenging for achieving ...high-performance metamaterial absorber. Herein, we propose and numerically investigate an ultra-broadband and wide-angle insensitive perfect metamaterial absorber in the ultraviolet to near-infrared (UV–NIR) region based on a simple metal–dielectric–metal structure. The proposed absorber structure consists of a periodic array of a tungsten hexagonal prism and a tungsten ground plane separated by a silicon dioxide dielectric substrate. The proposed absorber achieves an ultra-broadband absorption response in the range of 275–1000 nm with an absorptivity above 90
%
and a relative bandwidth of 106.8
%
at normal incidence, which covers from the UV to NIR region. The absorption efficiency is maintained with the figure of merit
η
OBW
higher than 90
%
for a wide incident angle up to 40
o
for transverse electric (TE) polarization and 65
o
for transverse magnetic (TM) polarization. The effects of structural parameters and different metallic materials on the absorption performance are presented. In addition, the physical mechanism is analyzed using the surface density and distributions of electric and magnetic fields that are attributed to both localized surface plasmon (LSP) and propagating surface plasmon (PSP) resonances. Owing to outstanding merits of simple structure, low cost, and high absorption performance, the designed absorber can be suitable for many applications in the UV–NIR spectrum such as thermal emitters and solar cells.
The environmental spread of antibiotic-resistant bacteria has been recognised as a growing public health threat for which hospitals play a significant role. The aims of this study were to investigate ...the prevalence of antibiotic resistance and antibiotic resistance genes (ARGs) in
isolates from hospital wastewater in Vietnam. Wastewater samples before and after treatment were collected using continuous sampling every month over a year. Standard disk diffusion and E-test were used for antibiotic susceptibility testing. Extended-spectrum beta-lactamase (ESBL) production was tested using combined disk diffusion. ARGs were detected by polymerase chain reactions. Resistance to at least one antibiotic was detected in 83% of isolates; multidrug resistance was found in 32%. The highest resistance prevalence was found for co-trimoxazole (70%) and the lowest for imipenem (1%). Forty-three percent of isolates were ESBL-producing, with the
gene being more common than
Co-harbouring of the
,
and
genes was found in 46% of isolates resistant to ciprofloxacin. The large presence of antibiotic-resistant
isolates combined with ARGs in hospital wastewater, even post-treatment, poses a threat to public health. It highlights the need to develop effective processes for hospital wastewater treatment plants to eliminate antibiotic resistant bacteria and ARGs.
•New design of CE-C4D purpose-made system.•CE-C4D methods for analyses of β-lactam-based antibiotics.•Affordable tool for quality control and detection of counterfeiting of antibiotic formulations.
A ...simple and inexpensive approach for determination of various antimicrobial drugs using a purpose-made compact capillary electrophoresis (CE) instrument with capacitively coupled contactless conductivity detection (C4D) is reported. The objective of the work is to propose an affordable and easily-implemented tool for quality control and detection of counterfeiting of antibiotic formulations in resource constrained developing countries. The design of the purpose-made CE-C4D system was improved according to the feedback from over 10 years of use of our previous instrument. CE-C4D methods were for the first time developed to analyze β-lactam-based antibiotics commonly used in Vietnam, including single- β-lactam antibiotics (i.e. Cephalexin, Cefotaxime Sodium, Cefixime and Sulbactam) as well as β-lactams co-formulated with Sulbactam (i.e. Amoxicillin, Ampicillin, Cefoperazone and Sulbactam). Single β-lactam antibiotics were analyzed using a background electrolyte (BGE) composed of Tris/Ace (10 mM, pH 7.8) whereas β-lactam – Sulbactam combinations were simultaneously separated using a BGE containing Tris/Ace (10 mM, pH 7.5). The best achieved detection limits were 2.0 mg/L and 1.0 mg/L for these two groups, respectively. Good agreement between results obtained from CE-C4D and standard confirmation methods (LCMS) was achieved, with a coefficient of determination, r2, of 0.9991. The applicability of the developed CE-C4D method was demonstrated for quality control of 24 β-lactam-based antimicrobial drugs available in Vietnam.
Abstract
Reconfigurable metasurfaces (RMSs) that enable the switching function of absorption and polarization conversion have attracted increasing attention. However, the design of RMSs to achieve ...wideband and high efficiency for both absorption and polarization conversion functions simultaneously remains a great challenge. Here, we propose the design of a RMS structure with a high-efficiency cross-polarization conversion and nearly perfect absorption. The reconfiguration between different functions of polarization conversion and absorption is obtained based on the reversible insulator-to-metal phase transition of Vanadium dioxide (VO
$$_{2}$$
2
). When the VO
$$_{2}$$
2
is in insulator state, the RMS realizes the cross-polarization conversion function in the wideband of 1.04–3.75 THz with a relative bandwidth up to 113
$$\%$$
%
due to the multi-resonant modes of electric and magnetic resonances. Meanwhile, the nearly-perfect absorption is achieved in the range of 1.36–3.38 THz with the corresponding relative bandwidth up to 85
$$\%$$
%
for the VO
$$_{2}$$
2
in metallic state. Specially, the wideband and high-efficiency performance of these functionalities is maintained for a wide angle incidence. The capability of bi-functional switch and integration with polarization conversion and absorption in a single metasurface structure endowed with both wideband and high-efficiency characteristics for a wide incident angle is very promising for emerging RMS devices in the terahertz region.
We report a facile design of an ultra-thin broadband metamaterial absorber (MA) for C-band applications by utilizing a single layer of a metal-dielectric-metal structure of FR-4 substrate. The ...absorption performances are characterized using a numerical method. The proposed MA exhibits the broadband absorption response over the entire C-band spectrum range from 4.0 GHz to 8.0 GHz with absorptivity above 90% and the high absorptivity is remained over 80% for a large incident angle up to 40° under both transverse electric (TE) and transverse magnetic (TM) polarizations over the band. The origin of absorption mechanism is explained by the electric and surface current distributions, which is also supported by the retrieved constitutive electromagnetic parameters, significantly affected by magnetic resonance. In addition, compared with the previous reports, the proposed MA presents a greater practical feasibility in term of low-profile and wide incident angle insensitivity, suggesting that the proposed absorber is a promising candidate for C-band applications.
Microbial fuel cells are one of the alternative methods that generate green, renewable sources of energy from wastewater. In this study, a new bio-electrochemical system called the sulfide-oxidizing ...fuel cell (SOFC) is developed for the simultaneous removal of sulfide/sulfide and electricity generation. To improve the application capacity of the SOFC, a system combining sulfate-reducing and sulfide-oxidizing processes for sulfate/sulfide removal and electricity generation was designed. Key factors influencing the sulfide-removal efficiency and electricity-generation capacity of the SOFC are the anolytes and catholytes. The sulfide produced from the sulfate-reducing process is thought to play the key role of an electron mediator (anolyte), which transfers electrons to the electrode to produce electricity. Sulfide can be removed in the anodic chamber of the SOFC when it is oxidized to the element sulfur (S°) through the biochemical reaction at the anode. The performance of wastewater treatment for sulfate/sulfide removal and electricity generation was evaluated by using different catholytes (dissolved oxygen in deionized water, a phosphate buffer, and ferricyanide). The results showed that the sulfate-removal efficiency is 92 ± 1.2% during a 95-day operation. A high sulfide-removal efficiency of 93.5 ± 1.2 and 83.7 ± 2% and power density of 18.5 ± 1.1 and 15.2 ± 1.2 mW/m2 were obtained with ferricyanide and phosphate buffers as the catholyte, respectively, which is about 2.6 and 2.1 times higher than dissolved oxygen being used as a catholyte, respectively. These results indicated that cathode electron acceptors have a direct effect on the performance of the treatment system. The sulfide-removal efficiency and power density of the phosphate buffer SOFC were only slightly less than the ferricyanide SOFC. Therefore, a phosphate buffer could serve as a low-cost and effective pH buffer for practical applications, especially for wastewater treatment. The results presented in this study clearly revealed that the integrated treatment system can be effectively applied for sulfate/sulfide removal and electricity generation simultaneously.
A wastewater treatment system has been established based on sulfate-reducing and sulfide—oxidizing processes for treating organic wastewater containing high sulfate/sulfide. The influence of ...COD/SO42− ratio and hydraulic retention time (HRT) on removal efficiencies of sulfate, COD, sulfide and electricity generation was investigated. The continuous operation of the treatment system was carried out for 63 days with the optimum COD/SO42− ratio and HRT. The result showed that the COD and sulfate removal efficiencies were stable, reaching 94.8 ± 0.6 and 93.0 ± 1.3% during the operation. A power density level of 18.0 ± 1.6 mW/m2 was obtained with a sulfide removal efficiency of 93.0 ± 1.2%. However, the sulfide removal efficiency and power density decreased gradually after 45 days. The results from scanning electron microscopy (SEM) with an energy dispersive X-ray (EDX) show that sulfur accumulated on the anode, which could explain the decline in sulfide oxidation and electricity generation. This study provides a promising treatment system to scale up for its actual applications in this type of wastewater.
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