We explored the evidence for a quantitative trait locus (QTL)-specific genotype x alcoholism interaction for an evoked electroencephalogram theta band oscillation (ERP) phenotype on a region of ...chromosome 7 in participants of the US Collaborative Study on the Genetics of Alcoholism. Among 901 participants with both genotype and phenotype data available, we performed variance component linkage analysis (SOLAR version 2.1.2) in the full sample and stratified by DSM-III-R and Feighner-definite alcoholism categories. The heritability of the ERP phenotype after adjusting for age and sex effects in the combined sample and in the alcoholism classification sub-groups ranged from 40% to 66%. Linkage on chromosome 7 was identified at 158 cM (LOD = 3.8) in the full sample and at 108 in the non-alcoholic subgroup (LOD = 3.1). Further, we detected QTL-specific genotype x alcoholism interaction at these loci. This work demonstrates the importance of considering the complexity of common complex traits in our search for genes that predispose to alcoholism.
In this, the first of six volumes, the main results of the excavations which the University of Oslo carried out at Kaupang 1998-2003 are presented. A completely new picture is put forward of the port ...that the adventurer Ohthere visited in c. 890. It is now clear that Kaupang was one of the four Scandinavian towns that were founded around the year 800. Kaupang is connected to the power centre of Skiringssal, to the Ynglings - the legendary Norwegian royal lineage, and to the King of the Danes - the dominant political actor in south-west Scandinavia. Kaupang is shown to have had several of the same features revealed in Birka, Hedeby and Ribe - i.e., a compact permanent settlement, divided into small plots, each with a dwelling. The town could have had 400-800 inhabitants. Substantial traces of trade and craftwork are proof of the main areas of occupation. Advanced geo- and environmental-archaeological analyses have played a large role in interpreting the finds. Documentary sources indicate that Skiringssal was an important royal seat in the 700s and 800s. In the book these sources are put together with the archaeological and toponymical sources which, united, show a centre of power with a clear likeness to similar places in Denmark and Sweden. A hall or sal building, presumably the Skirings-sal itself, was excavated at Huseby, near Kaupang. Nearby, a thing site is situated by a holy lake. In this, the Yngling kings' centre of power, to which many people came to attend thing meetings and sacrificial feasts, the town Kaupang was founded. In nine of the book's 20 chapters, the excavations' finds, analyses and results are presented. In three chapters, 200 years of research on Kaupang and Skiringssal are summarised, while in the remaining eight chapters an endeavour is made to re-establish the holistic approach to Skiringssal which dominated research during the first 100 years.
In order to identify regulatory genes, we determined the heritability of gene transcripts, performed linkage analysis to identify quantitative trait loci (QTLs), and evaluated the evidence for shared ...genetic effects among transcripts with co-localized QTLs in non-diseased participants from 14 CEPH (Centre d'Etude du Polymorphisme Humain) Utah families. Seventy-six percent of transcripts had a significant heritability and 54% of them had LOD score >or= 1.8. Bivariate genetic analysis of 15 transcripts that had co-localized QTLs on 4q28.2-q31.1 identified significant genetic correlation among some transcripts although no improvement in the magnitude of LOD scores in this region was noted. Similar results were found in analysis of 12 transcripts, that had co-localized QTLs in the 13q34 region. Principal-component analyses did not improve the ability to identify chromosomal regions of co-localized gene expressions.
The aims of the Strong Heart Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in American Indians and to map and identify genes for CVD susceptibility. The ...authors describe the design of the Strong Heart Family Study (conducted between 1998 and 1999) and evaluate the heritabilities of CVD risk factors in American Indians from this study. In the first phase of the study, approximately 950 individuals, aged 18 years or more, in 32 extended families, were examined. The examination consisted of a personal interview, physical examination, laboratory tests, and an ultrasound examination of the carotid arteries. The phenotypes measured during the physical examination included anthropometry, lipoproteins, blood pressure, glycemic status, and clotting factors. Heritabilities for CVD risk factor phenotypes were estimated using a variance component approach and the program SOLAR. After accounting for the effects of covariates, the authors detected significant heritabilities for many CVD risk factor phenotypes (e.g., high density lipoprotein cholesterol (heritability = 0.50) and diastolic blood pressure (heritability = 0.34)). These results suggest that heredity explains a substantial proportion of the variability of CVD risk factors and that these heritabilities are large enough to warrant a search for major risk factor genes.
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.
Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of ...Philosophy in the School of Public Health Epidemiology." Discipline: Epidemiology; Department/School: Public Health.
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