Computed tomography (CT) was a widely used diagnostic technique for COVID-19 during the pandemic. High-Resolution Computed Tomography (HRCT), is a type of computed tomography that enhances image ...resolution through the utilization of advanced methods. Due to privacy concerns, publicly available COVID-19 CT image datasets are incredibly tough to come by, leading to it being challenging to research and create AI-powered COVID-19 diagnostic algorithms based on CT images.
To address this issue, we created HRCTCov19, a new COVID-19 high-resolution chest CT scan image collection that includes not only COVID-19 cases of Ground Glass Opacity (GGO), Crazy Paving, and Air Space Consolidation but also CT images of cases with negative COVID-19. The HRCTCov19 dataset, which includes slice-level and patient-level labeling, has the potential to assist in COVID-19 research, in particular for diagnosis and a distinction using AI algorithms, machine learning, and deep learning methods. This dataset, which can be accessed through the web at http://databiox.com , includes 181,106 chest HRCT images from 395 patients labeled as GGO, Crazy Paving, Air Space Consolidation, and Negative.
Abstract
Background
We focused on Differentiated pseudoprogression (PPN) of progression (PN) and the response to radiotherapy (RT) or chemoradiotherapy (CRT) using diffusion and metabolic imaging.
...Methods
Seventy-five patients with glioma were included in this prospective study (approved by the Iranian Registry of Clinical Trials (IRCT) (IRCT20230904059352N1) in September 2023). Contrast-enhanced lesion volume (CELV), non-enhanced lesion volume (NELV), necrotic tumor volume (NTV), and quantitative values of apparent diffusion coefficient (ADC) and magnetic resonance spectroscopy (Cho/Cr, Cho/NAA and NAA/Cr) were calculated by a neuroradiologist using a semi-automatic method. All patients were followed at one and six months after CRT.
Results
The results of the study showed statistically significant changes before and six months after RT-CRT for M-CELV in all glioma types ( < 0.05). In glioma cell types, the changes in M-ADC, M-Cho/Cr, and Cho/NAA indices for PN were incremental and greater for PPN patients. M-NAA/Cr ratio decreased after six months which was significant only on PN for GBM, and Epn ( < 0.05). A significant difference was observed between diffusion indices, metabolic ratios, and CELV changes after six months in all types ( < 0.05). None of the patients were suspected PPN one month after treatment. The DWI/ADC indices had higher sensitivity and specificity (98.25% and 96.57%, respectively).
Conclusion
The results of the present study showed that ADC values and Cho/Cr and Cho/NAA ratios can be used to differentiate between patients with PPN and PN, although ADC is more sensitive and specific.
This report presents iatrogenic arteriovenous fistula of superficial temporal vessels after thread brow lift, which emphasizes on consideration of such rare complications during the procedure. A ...young woman presented with pulsatile mass of scalp after tread brow lift. Color Doppler and duplex sonography of the mass revealed an AVF (arteriovenous fistula) of superficial temporal vessels, a complication that in a few articles has been mentioned. Patient had received conservative treatment and the mass became very small and about to be disappeared. physicians must be aware of possible vascular injury during thread face lift and should be trained enough to avoid it.
Previous studies have demonstrated that vascular endothelial growth factor (VEGF) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and ...inflammatory cells. We aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of VEGF and the soluble form of its receptor-1 (sVEGFR1) to the severity of multiple sclerosis (MS). This case-control study was done on 102 cases of MS lacking any other inflammatory or pathologic conditions and 75 healthy volunteer subjects. The severity of MS was examined by expanded disability status scale (EDSS). The serum levels of VEGF and sVEGFR1 were measured by ELISA, and the circulatory frequency of VEGFR1 expressing cells was counted by flowcytometry. Then, the correlation of these variables was evaluated by pearson's correlation coefficient and spearman's test. We also investigated the influence of sex, age, treatment duration, and the number of recurrences on such association through linear multivariate regression method. We found an increase in circulatory level of VEGFR1 expressing cells and the serum level of VEGF as well as sVEGFR1 in MS patients compared to healthy controls (p<0.001). The greater severity of MS, the higher VEGFR1 expressing cells (ρ=0.47; p<0.001), serum level of VEGF (ρ=0.44; p<0.001), and sVEGFR1 (ρ=0.76; p<0.001). Having adjusted the effects of VEGF on sVEGFR1, we found a significant association between the EDSS score and sVEGFR1 (β=0.007; p<0.001). Our findings revealed that circulatory membranous as well as soluble expression of VEGFR1 increases during angiogenic and inflammatory phenomena of MS. Such increase may exacerbate the symptoms and cause more disability.
Previous studies have demonstrated that vascular endothelial growth factor (VEGF) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and ...inflammatory cells. We aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of VEGF and the soluble form of its receptor-1 (sVEGFR1) to the severity of multiple sclerosis (MS). This case-control study was done on 102 cases of MS lacking any other inflammatory or pathologic conditions and 75 healthy volunteer subjects. The severity of MS was examined by expanded disability status scale (EDSS). The serum levels of VEGF and sVEGFR1 were measured by ELISA, and the circulatory frequency of VEGFR1 expressing cells was counted by flowcytometry. Then, the correlation of these variables was evaluated by pearson's correlation coefficient and spearman's test. We also investigated the influence of sex, age, treatment duration, and the number of recurrences on such association through linear multivariate regression method. We found an increase in circulatory level of VEGFR1 expressing cells and the serum level of VEGF as well as sVEGFR1 in MS patients compared to healthy controls (p<0.001). The greater severity of MS, the higher VEGFR1 expressing cells (ρ=0.47; p<0.001), serum level of VEGF (ρ=0.44; p<0.001), and sVEGFR1 (ρ=0.76; p<0.001). Having adjusted the effects of VEGF on sVEGFR1, we found a significant association between the EDSS score and sVEGFR1 (β=0.007; p<0.001). Our findings revealed that circulatory membranous as well as soluble expression of VEGFR1 increases during angiogenic and inflammatory phenomena of MS. Such increase may exacerbate the symptoms and cause more disability.
Introduction: During the COVID-19 pandemic, computed tomography (CT) was a popular method for diagnosing COVID-19 patients. HRCT (High-Resolution Computed Tomography) is a form of computed tomography ...that uses advanced methods to improve image resolution. Publicly accessible COVID-19 CT image datasets are very difficult to come by due to privacy concerns, which impedes the study and development of AI-powered COVID-19 diagnostic algorithms based on CT images. Data description: To address this problem, we have introduced HRCTCov19, a new COVID-19 high-resolution chest CT scan image dataset that includes not only COVID-19 cases of Ground Glass Opacity (GGO), Crazy Paving, and Air Space Consolidation but also CT images of cases with negative COVID-19. The HRCTCov19 dataset, which includes slice-level, and patient-level labels, has the potential to aid COVID-19 research, especially for diagnosis and differentiation using artificial intelligence algorithms, machine learning, and deep learning methods. This dataset is accessible through the web at: http://databiox.com and includes 181,106 chest HRCT images from 395 patients with four labels: GGO, Crazy Paving, Air Space Consolidation, and Negative. Keywords: COVID-19, CT scan, Computed Tomography, Chest Image, Dataset, Medical Imaging
Current assessment tools of autosomal dominant polycystic kidney disease (ADPKD) diagnosis are challenging. This study evaluated the possible application of assessment of interleukin (IL)-17-related ...cytokines and the circulatory T helper 17 cells in the diagnosis of ADPKD.
Enrolling 54 ADPKD patients and 54 healthy individuals, we measured serum and urine levels of IL-6, IL-17, IL-23, and transforming growth factor-β and the peripheral blood frequency of T helper 17 cells through flowcytometry. We computed sensitivity and specificity of each inflammatory marker as well as their different combinations using the receiver operating characteristic curve and discriminant function analysis.
The mean serum and urine levels of IL-17 and IL-23 as well as urine levels of IL-6 were higher in ADPKD patients compared to the healthy controls (P < .001). There was no significant difference in the number of T helper 17 cells between the two groups. Among different combinations of the inflammatory markers, the serum IL-17 was the best factor in the diagnosis of ADPKD with a sensitivity as well as specificity of 100%.
It is likely that T helper 17 pathway is involved in the pathogenesis of ADPKD; therefore, it may be beneficial if such a pathway be considered in its diagnosis.
