Hallucinations, a central symptom of psychotic disorders, are attributed to excessive dopamine in the brain. However, the neural circuit mechanisms by which dopamine produces hallucinations remain ...elusive, largely because hallucinations have been challenging to study in model organisms. We developed a task to quantify hallucination-like perception in mice. Hallucination-like percepts, defined as high-confidence false detections, increased after hallucination-related manipulations in mice and correlated with self-reported hallucinations in humans. Hallucination-like percepts were preceded by elevated striatal dopamine levels, could be induced by optogenetic stimulation of mesostriatal dopamine neurons, and could be reversed by the antipsychotic drug haloperidol. These findings reveal a causal role for dopamine-dependent striatal circuits in hallucination-like perception and open new avenues to develop circuit-based treatments for psychotic disorders.
Using 25 years of data from uninterrupted monitoring of stellar orbits in the Galactic Center, we present an update of the main results from this unique data set: a measurement of mass and distance ...to Sgr A*. Our progress is not only due to the eight-year increase in time base, but also to the improved definition of the coordinate system. The star S2 continues to yield the best constraints on the mass of and distance to Sgr A*; the statistical errors of 0.13 × 10 6 M and 0.12 kpc have halved compared to the previous study. The S2 orbit fit is robust and does not need any prior information. Using coordinate system priors, the star S1 also yields tight constraints on mass and distance. For a combined orbit fit, we use 17 stars, which yields our current best estimates for mass and distance: M = 4.28 0.10 stat . 0.21 sys × 10 6 M and R 0 = 8.32 0.07 stat . 0.14 sys kpc . These numbers are in agreement with the recent determination of R0 from the statistical cluster parallax. The positions of the mass, of the near-infrared flares from Sgr A*, and of the radio source Sgr A* agree to within 1 mas. In total, we have determined orbits for 40 stars so far, a sample which consists of 32 stars with randomly oriented orbits and a thermal eccentricity distribution, plus eight stars that we can explicitly show are members of the clockwise disk of young stars, and which have lower-eccentricity orbits.
(ProQuest: ... denotes formulae and/or non-USASCII text omitted)We obtain the basic properties of the nuclear cluster of the Milky Way. First, we investigate the structural properties by constructing ...a stellar density map of the central 1000'' using extinction-corrected old star counts from VISTA, WFC3/IR, and VLT/NACO data. We describe the data using two components. The inner, slightly flattened (axis ratio of q= 0.80 + or - 0.04) 7 component is the nuclear cluster, while the outer component corresponds to the stellar component of the circumnuclear zone. For the nuclear cluster, we measure a half-light radius of 178 + or - 0.04 51" thickapproximate + or - 2 pc and a luminosity of M sub(ks)= - 16.0 + or - 0.5. Second, we measure detailed dynamics out to 4 pc. We obtain 10,351 proper motions from AO data, and 2513 radial velocities from VLT/SINFONI data. We determine the cluster mass by means of isotropic spherical Jeans modeling. We fix the distance to the Galactic Center and the mass of the supermassive black hole. We model the cluster either with a constant M/L or with a power law. For the latter case, we obtain a slope of 1.18 + or - 0.06. We get a cluster mass within 100'' of ... for both modeling approaches. A model which includes the observed flattening gives a 47% larger mass (see Chatzopoulos et al.). Our results slightly favor a core over a cusp in the mass profile. By minimizing the number of unbound stars within 8'', we obtain a distance of ... kpc when using an R sub(0) supermassive black hole mass relation from stellar orbits. Combining our results, we obtain ... , which is roughly consistent with a Chabrier IMF.
Assessing the global threat from Zika virus Lessler, Justin; Chaisson, Lelia H.; Kucirka, Lauren M. ...
Science (American Association for the Advancement of Science),
08/2016, Volume:
353, Issue:
6300
Journal Article
Peer reviewed
Open access
First discovered in 1947, Zika virus (ZIKV) infection remained a little-known tropical disease until 2015, when its apparent association with a considerable increase in the incidence of microcephaly ...in Brazil raised alarms worldwide. There is limited information on the key factors that determine the extent of the global threat from ZIKV infection and resulting complications. Here, we review what is known about the epidemiology, natural history, and public health effects of ZIKV infection, the empirical basis for this knowledge, and the critical knowledge gaps that need to be filled.
Two recent papers (Ghez et al. 2008; Gillessen et al. 2009) have estimated the mass of and the distance to the massive black hole (MBH) in the center of the Milky Way using stellar orbits. The two ...astrometric data sets are independent and yielded consistent results, even though the measured positions do not match when simply overplotting the two sets. In this Letter, we show that the two sets can be brought to excellent agreement with each other when we allow for a small offset in the definition of the reference frame of the two data sets. The required offsets in the coordinates and velocities of the origin of the reference frames are consistent with the uncertainties given in Ghez et al. The so-combined data set allows for a moderate improvement of the statistical errors of the mass of and the distance to Sgr A*, but the overall accuracies of these numbers are dominated by systematic errors and the long-term calibration of the reference frame. We obtain R{sub 0} = 8.28 +- 0.15|{sub stat} +- 0.29|{sub sys} kpc and M{sub MBH} = 4.30 +- 0.20|{sub stat} +- 0.30|{sub sys} x 10{sup 6} M{sub sun} as best estimates from a multi-star fit.
Abstract
We present the first fully simultaneous fits to the near-infrared (NIR) and X-ray spectral slope (and its evolution) during a very bright flare from Sgr A*, the supermassive black hole at ...the Milky Way's centre. Our study arises from ambitious multiwavelength monitoring campaigns with XMM–Newton, NuSTAR and SINFONI. The average multiwavelength spectrum is well reproduced by a broken power law with ΓNIR = 1.7 ± 0.1 and ΓX = 2.27 ± 0.12. The difference in spectral slopes (ΔΓ = 0.57 ± 0.09) strongly supports synchrotron emission with a cooling break. The flare starts first in the NIR with a flat and bright NIR spectrum, while X-ray radiation is detected only after about 103 s, when a very steep X-ray spectrum (ΔΓ = 1.8 ± 0.4) is observed. These measurements are consistent with synchrotron emission with a cooling break and they suggest that the high-energy cut-off in the electron distribution (γmax) induces an initial cut-off in the optical–UV band that evolves slowly into the X-ray band. The temporal and spectral evolution observed in all bright X-ray flares are also in line with a slow evolution of γmax. We also observe hints for a variation of the cooling break that might be induced by an evolution of the magnetic field (from B ∼ 30 ± 8 G to B ∼ 4.8 ± 1.7 G at the X-ray peak). Such drop of the magnetic field at the flare peak would be expected if the acceleration mechanism is tapping energy from the magnetic field, such as in magnetic reconnection. We conclude that synchrotron emission with a cooling break is a viable process for Sgr A*'s flaring emission.
A first-principles study of diffusion in a strongly coupled one-component plasma in a magnetic field B is presented. As in a weakly coupled plasma, the diffusion coefficient perpendicular to the ...field exhibits a Bohm-like 1/B behavior in the strong-field limit but its overall scaling is substantially different. The diffusion coefficient parallel to the field is strongly affected by the field as well and also approaches a 1/B scaling, in striking contrast to earlier predictions.
The GRAVITY fringe tracker Lacour, S.; Dembet, R.; Abuter, R. ...
Astronomy and astrophysics (Berlin),
04/2019, Volume:
624
Journal Article
Peer reviewed
Open access
Context. The GRAVITY instrument was commissioned on the VLTI in 2016 and is now available to the astronomical community. It is the first optical interferometer capable of observing sources as faint ...as magnitude 19 in K band. This is possible through the fringe tracker, which compensates the differential piston based on measurements of a brighter off-axis astronomical reference source. Aims. The goal of this paper is to describe the main developments made in the context of the GRAVITY fringe tracker. This could serve as basis for future fringe-tracking systems. Methods. The paper therefore covers all aspects of the fringe tracker, from hardware to control software and on-sky observations. Special emphasis is placed on the interaction between the group-delay controller and the phase-delay controller. The group-delay control loop is a simple but robust integrator. The phase-delay controller is a state-space control loop based on an auto-regressive representation of the atmospheric and vibrational perturbations. A Kalman filter provides the best possible determination of the state of the system. Results. The fringe tracker shows good tracking performance on sources with coherent K magnitudes of 11 on the Unit Telescopes (UTs) and 9.5 on the Auxiliary Telescopes (ATs). It can track fringes with a signal-to-noise ratio of 1.5 per detector integration time, limited by photon and background noises. During good seeing conditions, the optical path delay residuals on the ATs can be as low as 75 nm root mean square. The performance is limited to around 250 nm on the UTs because of structural vibrations.
The Galactic Center black hole Sgr A* is the archetypical example of an underfed massive black hole. The extremely low accretion rate can be understood in radiatively inefficient accretion flow ...models. Testing those models has proven to be difficult due to the lack of suitable probes. Radio and submillimeter polarization measurements constrain the flow very close to the event horizon. X-ray observations resolving the Bondi radius yield an estimate roughly four orders of magnitude further out. Here, we present a new, indirect measurement of the accretion flow density at intermediate radii. We use the dynamics of the gas cloud G2 to probe the ambient density. We detect the presence of a drag force slowing down G2 with a statistical significance of 9 . This probes the accretion flow density at around 1000 Schwarzschild radii and yields a number density of 4 × 103 cm−3. Self-similar accretion models where the density follows a power-law radial profile between the inner zone and the Bondi radius have predicted similar values.
PDF
