Use of nanoparticles is among the most promising strategies to overcome microbial drug resistance. This review article consists of three parts. The first part discusses the epidemiology of microbial ...drug resistance. The second part describes mechanisms of drug resistance used by microbes. The third part explains how nanoparticles can overcome this resistance, including the following: Nitric oxide-releasing nanoparticles (NO NPs), chitosan-containing nanoparticles (chitosan NPs), and metal-containing nanoparticles all use multiple mechanisms simultaneously to combat microbes, thereby making development of resistance to these nanoparticles unlikely. Packaging multiple antimicrobial agents within the same nanoparticle also makes development of resistance unlikely. Nanoparticles can overcome existing drug resistance mechanisms, including decreased uptake and increased efflux of drug from the microbial cell, biofilm formation, and intracellular bacteria. Finally, nanoparticles can target antimicrobial agents to the site of infection, so that higher doses of drug are given at the infected site, thereby overcoming resistance.
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The Touch And Go Camera System (TAGCAMS) is a three-camera-head instrument onboard NASA’s OSIRIS-REx asteroid sample return mission spacecraft. The purpose of TAGCAMS is to facilitate navigation to ...the target asteroid, (101955) Bennu; confirm acquisition of the asteroid sample; document asteroid sample stowage; and provide supplementary imaging for OSIRIS-REx science investigations.
During the almost two-year OSIRIS-REx outbound cruise phase we pursued nine TAGCAMS imaging campaigns to check, calibrate and characterize the camera system’s performance before asteroid arrival and proximity operations began in late 2018. The TAGCAMS in-flight calibration dataset provides the relevant information to enable the three cameras to complete their primary observation goals during asteroid operations. The key performance parameters that we investigated in flight included: linearity, responsivity (both point source and extended body), dark current, hot pixels, pointing, image geometry transformation, image quality and stray light. Analyses of the in-flight performance either confirmed the continued applicability of the TAGCAMS ground test results or substantially improved upon the ground test knowledge. In addition, the TAGCAMS calibration observations identified the source of a spacecraft outgassing feature that guided successful remediation efforts prior to asteroid arrival.
Near‐Earth asteroid (101955) Bennu is an active asteroid experiencing mass loss in the form of ejection events emitting up to hundreds of millimeter‐ to centimeter‐scale particles. The close ...proximity of the Origins, Spectral Interpretations, Resource Identification, and Security–Regolith Explorer spacecraft enabled monitoring of particles for a 10‐month period encompassing Bennu's perihelion and aphelion. We found 18 multiparticle ejection events, with masses ranging from near zero to hundreds of grams (or thousands with uncertainties) and translational kinetic energies ranging from near zero to tens of millijoules (or hundreds with uncertainties). We estimate that Bennu ejects ~104 g per orbit. The largest event took place on 6 January 2019 and consisted of ~200 particles. The observed mass and translational kinetic energy of the event were between 459 and 528 g and 62 and 77 mJ, respectively. Hundreds of particles not associated with the multiparticle ejections were also observed. Photometry of the best‐observed particles, measured at phase angles between ~70° and 120°, was used to derive a linear phase coefficient of 0.013 ± 0.005 magnitudes per degree of phase angle. Ground‐based data back to 1999 show no evidence of past activity for Bennu; however, the currently observed activity is orders of magnitude lower than observed at other active asteroids and too low be observed remotely. There appears to be a gentle decrease in activity with distance from the Sun, suggestive of ejection processes such as meteoroid impacts and thermal fracturing, although observational bias may be a factor.
Plain Language Summary
We measured the brightness of pebble‐sized particles in the vicinity of near‐Earth asteroid Bennu to better understand their physical characteristics and the events that launched them from Bennu's surface. Our measurements spanned 10 months, encompassing Bennu's closest and farthest distances from the Sun, so that we could assess how the level of ejection activity changes with solar distance. We observed 18 multiparticle ejection events containing anywhere from a few to 200+ particles. Individual particles ranged from millimeters to centimeters in diameter. The energy of the events and a possible decrease in activity with larger distances from the Sun suggest that meteoroid impacts, fracturing of surface boulders due to solar heating, or both may be responsible for ejecting the particles. We estimate that Bennu releases ~10,000 g of material over one orbit or 1.2 years. Although mass loss has been remotely observed for other asteroids, the comparatively low level of particle ejection activity at Bennu was only observable thanks to the close proximity of the Origins, Spectral Interpretations, Resource Identification, and Security–Regolith Explorer spacecraft.
Key Points
Asteroid (101955) Bennu is active from perihelion through aphelion with a possible decrease in activity further from the Sun
Bennu's activity is less than that detected by telescope for other active asteroids and is only observable up close
The particles' shallow phase functions resemble those of similarly sized individual rocks rather than those of ensemble asteroid surfaces
The OSIRIS‐REx mission has observed multiple instances of particles being ejected from the surface of near‐Earth asteroid (101955) Bennu. The ability to quickly identify the particle trajectories and ...origins is necessary following a particle ejection event. Using proven initial orbit determination techniques, we can rapidly estimate particle trajectories and ejection locations. We present current results pertaining to the identification of particle tracks, an evaluation of the estimated orbits and the excess velocity necessary to induce the particle ejection from the surface, and the uncertainty quantification of the ejection location. We estimate energies per particle ranging from 0.03 to 11.03 mJ for the largest analyzed events and velocities ranging from 5 to 90 cm/s, though we exclude the highest‐velocity particles in this technique. We estimate ejection times for eight events and constrain six of the analyzed ejection events to have occurred between about 16:30 and 19:00 local solar time, with the largest events occurring between 16:30 and 18:05.
Key Points
We present orbit determination techniques used to reconstruct particle ejections from near‐Earth asteroid Bennu
We estimate energies per particle ranging from 0.03 to 11.03 mJ and velocities ranging from 5 to 90 cm/s for the largest analyzed events
We find ejection times between about 16:30 and 19:00 local solar time for most events analyzed
Reconstruction of Bennu Particle Events From Sparse Data Pelgrift, John Y.; Lessac‐Chenen, Erik J.; Adam, Coralie D. ...
Earth and space science (Hoboken, N.J.),
August 2020, 2020-Aug, 2020-08-00, 20200801, 2020-08-01, Volume:
7, Issue:
8
Journal Article
Peer reviewed
Open access
OSIRIS‐REx began observing particle ejection events shortly after entering orbit around near‐Earth asteroid (101955) Bennu in January 2019. For some of these events, the only observations of the ...ejected particles come from the first two images taken immediately after the event by OSIRIS‐REx's NavCam 1 imager. Without three or more observations of each particle, traditional orbit determination is not possible. However, by assuming that the particles all ejected at the same time and location for a given event, and approximating that their velocities remained constant after ejection (a reasonable approximation for fast‐moving particles, i.e., with velocities on the order of 10 cm/s or greater, given Bennu's weak gravity), we show that it is possible to estimate the particles' states from only two observations each. We applied this newly developed technique to reconstruct the particle ejection events observed by the OSIRIS‐REx spacecraft during orbit about Bennu. Particles were estimated to have ejected with inertial velocities ranging from 7 cm/s to 3.3 m/s, leading to a variety of trajectory types. Most (>80%) of the analyzed events were estimated to have originated from midlatitude regions and to have occurred after noon (local solar time), between 12:44 and 18:52. Comparison with higher‐fidelity orbit determination solutions for the events with sufficient observations demonstrates the validity of our approach and also sheds light on its biases. Our technique offers the capacity to meaningfully constrain the properties of particle ejection events from limited data.
Key Points
We show how Bennu's particle ejection events can be reconstructed using only two observations
For each event, we estimate the particle velocities and ejection location
Velocities ranged from 7 cm/s to 3.3 m/s, and most observed events took place after noon
The
New Horizons
mission performed a successful flyby of Arrokoth, a distant Kuiper-Belt Object, on January 1, 2019, representing the farthest planetary encounter to date. The navigation strategy and ...performance required to deliver the spacecraft to the desired flyby target were driven by a number of challenges including those related to Arrokoth’s viewing angle and relatively recent discovery in June 2014. These and other challenges required the
New Horizons
science and navigation teams to devise a strategy in close collaboration that would substantially reduce the flyby navigation errors. Earth-based astrometry and occultation measurements of Arrokoth were collected and used to estimate Arrokoth’s orbit and its associated uncertainties, which were in turn used to inform and reduce navigation approach and flyby uncertainties. The
New Horizons
navigation effort used these a priori orbits along with radio metric and optical navigation measurements to first predict the navigation performance in support of the flyby design, and then estimate
New Horizons
’ trajectory, maneuvers and other filter state parameters during navigation operations. An overview of the Arrokoth orbit estimation and navigation strategy and predicted performance, as well as the operational results from the initial target search campaign in 2004 through Arrokoth’s successful flyby in 2019 are presented, along with the principal challenges and most important lessons learned along the way.
When optical navigation images acquired by the OSIRIS‐REx (Origins, Spectral Interpretation, Resource Identification, and Security‐Regolith Explorer) mission revealed the periodic ejection of ...particles from asteroid (101955) Bennu, it became a mission priority to quickly identify and track these objects for both spacecraft safety and scientific purposes. The large number of particles and the mission criticality rendered time‐intensive manual inspection impractical. We present autonomous techniques for particle detection and tracking that were developed in response to the Bennu phenomenon but that have the capacity for general application to particles in motion about a celestial body. In an example OSIRIS‐REx data set, our autonomous techniques identified 93.6% of real particle tracks and nearly doubled the number of tracks detected versus manual inspection alone.
Key Points
We describe autonomous techniques for the identification and tracking of particles in motion about a celestial body
We demonstrate these techniques using images from the OSIRIS‐REx mission to the active asteroid (101955) Bennu
In the OSIRIS‐REx dataset, our autonomous algorithms detected 93.6% of real particle tracks, including 244 tracks not identified by manual inspection
Acquiring and processing astrometric measurements of a spacecraft’s target using on-board images, generically referred to as optical navigation, is an integral function of the orbit determination and ...navigation of NASA’s New Horizons spacecraft. Since New Horizons’ reconnaissance of the Pluto system in July 2015, many preparations have been completed to further enhance the optical navigation system and prepare for the reconnaissance of New Horizons’ next target, Kuiper Belt Object (486958) 2014 MU
69
(unofficially nicknamed Ultima Thule). Due to its low relative brightness compared to most planetary exploration targets, Ultima Thule presents several unique challenges to the optical navigation system. The optical navigation system design, imaging schedule, and technical algorithms that were developed and tailored to these challenges are explored in detail. Additionally, several operational readiness tests, simulation methods, and test results are presented and analyzed to assess the optical navigation system performance and implications to flight operations. Lastly, a first look at Ultima as viewed from the New Horizons LORRI imager is presented.
We analyze the trajectories of 313 particles seen in the near‐Bennu environment between December 2018 and September 2019. Of these, 65% follow suborbital trajectories, 20% undergo more than one ...orbital revolution around the asteroid, and 15% directly escape on hyperbolic trajectories. The median lifetime of these particles is ∼6 hr. The trajectories are sensitive to Bennu's gravitational field, which allows us to reliably estimate the spherical harmonic coefficients through degree 8 and to resolve nonuniform mass distribution through degree 3. The particles are perturbed by solar radiation pressure, enabling effective area‐to‐mass ratios to be estimated. By assuming that particles are oblate ellipsoids of revolution, and incorporating photometric measurements, we find a median axis ratio of 0.27 and diameters for equivalent‐volume spheres ranging from 0.22–6.1 cm, with median 0.74 cm. Our size distribution agrees well with that predicted for fragmentation due to diurnal thermal cycling. Detailed models of known accelerations do not produce a match to the observed trajectories, so we also estimate empirical accelerations. These accelerations appear to be related to mismodeling of radiation pressure, but we cannot rule out contributions from mass loss. Most ejections take place at local solar times in the afternoon and evening (12:00–24:00), although they occur at any time of day. We independently identify ten ejection events, some of which have previously been reported. We document a case where a particle ricocheted off the surface, revealing a coefficient of restitution 0.57±0.01 and demonstrating that some apparent ejections are not related to surface processes.
Plain Language Summary
The Origins, Spectral Interpretation, Resource Identification, Security, Regolith Explorer (OSIRIS‐REx) mission discovered that near‐Earth asteroid (101955) Bennu is periodically ejecting small particles from its surface, placing it in the uncommon class of “active asteroids.” We linked together individual detections of ejected particles and used numerical models of the forces acting on them to ascertain their trajectories and fates. We found that most particles have suborbital trajectories, meaning they fall back to Bennu's surface shortly after being ejected, but some orbit Bennu for days at a time, and some escape directly into space. From the particle trajectories, we are able to estimate their sizes (comparable to pebbles, from a few millimeters to a few centimeters in diameter) and shapes (probably flake like). Their trajectories also make it possible to estimate Bennu's gravity field more precisely than spacecraft measurements and help shed light on the possible causes of the ejections.
Key Points
Most of the 313 particles we study have suborbital trajectories, but some orbit Bennu and others directly escape
The particles appear to have flake‐like shapes and have effective diameters 0.22–6.1 cm with median 0.74 cm
Ejections tend to take place in the local afternoon and evening but can occur anytime
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