FLAG Review 2021 Aoki, Y.; Blum, T.; Colangelo, G. ...
The European physical journal. C, Particles and fields,
10/2022, Volume:
82, Issue:
10
Journal Article
Peer reviewed
Open access
We review lattice results related to pion, kaon,
D
-meson,
B
-meson, and nucleon physics with the aim of making them easily accessible to the nuclear and particle physics communities. More ...specifically, we report on the determination of the light-quark masses, the form factor
f
+
(
0
)
arising in the semileptonic
K
→
π
transition at zero momentum transfer, as well as the decay constant ratio
f
K
/
f
π
and its consequences for the CKM matrix elements
V
us
and
V
ud
. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of
S
U
(
2
)
L
×
S
U
(
2
)
R
and
S
U
(
3
)
L
×
S
U
(
3
)
R
Chiral Perturbation Theory. We review the determination of the
B
K
parameter of neutral kaon mixing as well as the additional four
B
parameters that arise in theories of physics beyond the Standard Model. For the heavy-quark sector, we provide results for
m
c
and
m
b
as well as those for the decay constants, form factors, and mixing parameters of charmed and bottom mesons and baryons. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. We review the status of lattice determinations of the strong coupling constant
α
s
. We consider nucleon matrix elements, and review the determinations of the axial, scalar and tensor bilinears, both isovector and flavor diagonal. Finally, in this review we have added a new section reviewing determinations of scale-setting quantities.
FLAG Review 2019 Aoki, S; Aoki, Y; Bečirević, D ...
The European physical journal. C, Particles and fields,
02/2020, Volume:
80, Issue:
2
Journal Article
Peer reviewed
Open access
We review lattice results related to pion, kaon, D-meson, B-meson, and nucleon physics with the aim of making them easily accessible to the nuclear and particle physics communities. More ...specifically, we report on the determination of the light-quark masses, the form factor f+(0) arising in the semileptonic K→π transition at zero momentum transfer, as well as the decay constant ratio fK/fπ and its consequences for the CKM matrix elements Vus and Vud. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of SU(2)L×SU(2)R and SU(3)L×SU(3)R Chiral Perturbation Theory. We review the determination of the BK parameter of neutral kaon mixing as well as the additional four B parameters that arise in theories of physics beyond the Standard Model. For the heavy-quark sector, we provide results for mc and mb as well as those for D- and B-meson decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. We review the status of lattice determinations of the strong coupling constant αs. Finally, in this review we have added a new section reviewing results for nucleon matrix elements of the axial, scalar and tensor bilinears, both isovector and flavor diagonal.
Patients with brain metastases (BM) from human epidermal growth factor receptor 2 (HER2)-positive breast cancer represent a difficult-to-treat population. Trastuzumab emtansine (T-DM1) has shown ...potential activity in this subset of patients in small clinical series.
KAMILLA is an ongoing, phase IIIb study of T-DM1 in patients with HER2-positive locally advanced/metastatic breast cancer with prior HER2-targeted therapy and chemotherapy. Patients received T-DM1 3.6 mg/kg every 3 weeks (intravenously) until unacceptable toxicity, withdrawal of consent, or disease progression. Tumor response and clinical outcomes in patients with baseline BM were evaluated in this post hoc, exploratory analysis. The main outcome measures were best overall response rate (complete response + partial response) and clinical benefit rate (complete response + partial response + stable disease lasting ≥6 months) by RECIST v1.1 criteria, progression-free survival, overall survival, and safety.
Of 2002 treated patients, 398 had baseline BM. In 126 patients with measurable BM, the best overall response rate and clinical benefit rate were 21.4% 95% confidence interval (CI) 14.6–29.6 and 42.9% (95% CI 34.1–52.0), respectively. A reduction in the sum of the major diameters of BM ≥30% occurred in 42.9% (95% CI 34.1–52.0), including 49.3% (95% CI 36.9–61.8) of 67 patients without prior radiotherapy to BM. In the 398 patients with baseline BM, median progression-free survival and overall survival were 5.5 (95% CI 5.3–5.6) months and 18.9 (95% CI 17.1–21.3) months, respectively. The adverse event profile was broadly similar in patients with and without baseline BM, although nervous system adverse events were more common in patients with 208 (52.3%) versus without 701 (43.7%) baseline BM.
This exploratory analysis of patients with HER2-positive metastatic breast cancer and BM enrolled in a prospective clinical trial shows that T-DM1 is active and well-tolerated in this population. T-DM1 should be explored further in this setting.
ClinicalTrials.gov identifier: NCT01702571.
•KAMILLA exploratory analysis suggests T-DM1 is active and well tolerated in HER2-positive MBC with brain metastases (BM).•Overall response rate was 21.4% (27/126) across all organs in patients with HER2-positive MBC and measurable BM.•Brain target lesion responses were observed in patients with and without prior radiotherapy.•In 398 patients with baseline BM treated with T-DM1, median progression-free survival was 5.5 (95% CI, 5.3–5.6) months.•Safety was generally similar in patients with versus without baseline BM, except for nervous system adverse events.
We review lattice results related to pion, kaon, D- and B-meson physics with the aim of making them easily accessible to the particle-physics community. More specifically, we report on the ...determination of the light-quark masses, the form factor \f_+(0)\, arising in the semileptonic \K \rightarrow \pi \ transition at zero momentum transfer, as well as the decay constant ratio \f_K/f_\pi \ and its consequences for the CKM matrix elements \V_{us}\ and \V_{ud}\. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of \SU(2)_L\times SU(2)_R\ and \SU(3)_L\times SU(3)_R\ Chiral Perturbation Theory. We review the determination of the \B_K\ parameter of neutral kaon mixing as well as the additional four B parameters that arise in theories of physics beyond the Standard Model. The latter quantities are an addition compared to the previous review. For the heavy-quark sector, we provide results for \m_c\ and \m_b\ (also new compared to the previous review), as well as those for D- and B-meson-decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. Finally, we review the status of lattice determinations of the strong coupling constant \\alpha _s\.
We review lattice results related to pion, kaon,
D
- and
B
-meson physics with the aim of making them easily accessible to the particle-physics community. More specifically, we report on the ...determination of the light-quark masses, the form factor
f
+
(
0
)
, arising in semileptonic
K
→
π
transition at zero momentum transfer, as well as the decay-constant ratio
f
K
/
f
π
of decay constants and its consequences for the CKM matrix elements
V
u
s
and
V
u
d
. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of
SU
(
2
)
L
×
SU
(
2
)
R
and
SU
(
3
)
L
×
SU
(
3
)
R
Chiral Perturbation Theory and review the determination of the
B
K
parameter of neutral kaon mixing. The inclusion of heavy-quark quantities significantly expands the FLAG scope with respect to the previous review. Therefore, we focus here on
D
- and
B
-meson decay constants, form factors, and mixing parameters, since these are most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. In addition we review the status of lattice determinations of the strong coupling constant
α
s
.
Copanlisib is a pan-class I phosphatidylinositol 3-kinase inhibitor with predominant activity against the α- and δ-isoforms.
This phase II study evaluated the response rate of copanlisib administered ...intravenously on days 1, 8, and 15 of a 28-day cycle, in patients with indolent or aggressive malignant lymphoma. Archival tumor tissues were used for immunohistochemistry, gene-expression profiling, and mutation analysis.
Thirty-three patients with indolent lymphoma and 51 with aggressive lymphoma received copanlisib. Follicular lymphoma (48.5%) and peripheral T-cell lymphoma (33.3%) were the most common histologic subtypes. Most patients (78.6%) had received prior rituximab and 54.8% were rituximab-refractory. Median duration of treatment was 23 and 8 weeks in the indolent and aggressive cohorts, respectively (overall range 2–138). Eighty patients were evaluated for efficacy. The objective response rate was 43.7% (14/32) in the indolent cohort and 27.1% (13/48) in the aggressive cohort; median progression-free survival was 294 days (range 0–874) and 70 days (range 0–897), respectively; median duration of response was 390 days (range 0–825) and 166 days (range 0–786), respectively. Common adverse events included hyperglycemia (57.1%; grade ≥3, 23.8%), hypertension (54.8%; grade ≥3, 40.5%), and diarrhea (40.5%; grade ≥3, 4.8%), all generally manageable. Neutropenia occurred in 28.6% of patients (grade 4, 11.9%). Molecular analyses showed enhanced antitumor activity in tumors with upregulated phosphatidylinositol 3-kinase pathway gene expression.
Intravenous copanlisib demonstrated promising efficacy and manageable toxicity in heavily pretreated patients with various subtypes of indolent and aggressive malignant lymphoma. Subtype-specific studies of copanlisib in patients with follicular, peripheral T-cell, and mantle cell lymphomas are ongoing.
This trial is registered with ClinicalTrials.gov number NCT01660451 (Part A).
We present the discovery of 816 high-amplitude infrared variable stars (...K sub( s) > 1 mag) in 119 deg super( 2) of the Galactic mid-plane covered by the VISTA Variables in the Via Lactea (VVV) ...survey. Almost all are new discoveries and about 50 per cent are young stellar objects (YSOs). This provides further evidence that YSOs are the commonest high-amplitude infrared variable stars in the Galactic plane. In the 2010-2014 time series of likely YSOs, we find that the amplitude of variability increases towards younger evolutionary classes (class I and flat-spectrum sources) except on short time-scales (<25 d) where this trend is reversed. Dividing the likely YSOs by light-curve morphology, we find 106 with eruptive light curves, 45 dippers, 39 faders, 24 eclipsing binaries, 65 long-term periodic variables (P > 100 d) and 162 short-term variables. Eruptive YSOs and faders tend to have the highest amplitudes and eruptive systems have the reddest spectral energy distribution (SEDs). Follow-up spectroscopy in a companion paper verifies high accretion rates in the eruptive systems. Variable extinction is disfavoured by the two epochs of colour data. These discoveries increase the number of eruptive variable YSOs by a factor of at least 5, most being at earlier stages of evolution than the known FUor and EXor types. We find that eruptive variability is at least an order of magnitude more common in class I YSOs than class II YSOs. Typical outburst durations are 1-4 yr, between those of EXors and FUors. They occur in 3-6 per cent of class I YSOs over a 4 yr time span. (ProQuest: ... denotes formulae/symbols omitted.)
In a companion work (Paper I), we detected a large population of highly variable Young Stellar Objects (YSOs) in the Vista Variables in the Via Lactea (VVV) survey, typically with class I or flat ...spectrum spectral energy distributions and diverse light-curve types. Here we present infrared spectra (0.9-2.5 ...m) of 37 of these variables, many of them observed in a bright state. The spectra confirm that 15/18 sources with eruptive light curves have signatures of a high accretion rate, either showing EXor-like emission features (... = 2 CO, Br...) and/or FUor-like features (... = 2 CO and H sub( 2)O strongly in absorption). Similar features were seen in some long-term periodic YSOs and faders but not in dippers or short-term variables. The sample includes some dusty Mira variables (typically distinguished by smooth Mira-like light curves), two cataclysmic variables and a carbon star. In total, we have added 19 new objects to the broad class of eruptive variable YSOs with episodic accretion. Eruptive variable YSOs in our sample that were observed at bright states show higher accretion luminosities than the rest of the sample. Most of the eruptive variables differ from the established FUor and EXor subclasses, showing intermediate outburst durations and a mixture of their spectroscopic characteristics. This is in line with a small number of other recent discoveries. Since these previously atypical objects are now the majority amongst embedded members of the class, we propose a new classification for them as MNors. This term (pronounced emnor) follows V1647 Ori, the illuminating star of McNeil's Nebula. (ProQuest: ... denotes formulae/symbols omitted.)
A
bstract
We study the impact of precision timing detection systems on the LHC experiments’ long-lived particle search program during the HL-LHC era. We develop algorithms that allow us to ...reconstruct the mass of such charged particles and perform particle identification using the time-of-flight measurement. We investigate the reach for benchmark scenarios as a function of the timing resolution, and find sensitivity improvement of up to a factor of ten over searches that use ionization energy loss information, depending on the particle’s mass.
We review lattice results related to pion, kaon,
D
- and
B
-meson physics with the aim of making them easily accessible to the particle-physics community. More specifically, we report on the ...determination of the light-quark masses, the form factor
f
+
(
0
)
, arising in the semileptonic
K
→
π
transition at zero momentum transfer, as well as the decay constant ratio
f
K
/
f
π
and its consequences for the CKM matrix elements
V
u
s
and
V
u
d
. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of
S
U
(
2
)
L
×
S
U
(
2
)
R
and
S
U
(
3
)
L
×
S
U
(
3
)
R
Chiral Perturbation Theory. We review the determination of the
B
K
parameter of neutral kaon mixing as well as the additional four
B
parameters that arise in theories of physics beyond the Standard Model. The latter quantities are an addition compared to the previous review. For the heavy-quark sector, we provide results for
m
c
and
m
b
(also new compared to the previous review), as well as those for
D
- and
B
-meson-decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. Finally, we review the status of lattice determinations of the strong coupling constant
α
s
.
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