Over the past decades, transport researchers and policy-makers have devoted increasing attention to questions about justice and equity. Nonetheless, there is still little engagement with theories in ...political philosophy to frame what justice means in the context of transport policies. This paper reviews key theories of justice (utilitarianism, libertarianism, intuitionism, Rawls' egalitarianism, and Capability Approaches (CAs)) and critically evaluates the insights they generate when applied to transport. Based on a combination of Rawlsian and CAs, we propose that distributive justice concerns over transport disadvantage and social exclusion should focus primarily on accessibility as a human capability. This means that, in policy evaluation, a detailed analysis of the distributional effects of transport policies should take account of the setting of minimum standards of accessibility to key destinations and the extent to which these policies respect individuals' rights and prioritise disadvantaged groups, reduce inequalities of opportunities, and mitigate transport externalities. A full account of justice in transportation requires a more complete understanding of accessibility than traditional approaches have been able to deliver to date.
Introduction
Sexual minority individuals consistently report higher rates of mental disorders and suicidal behavior than heterosexuals. However, much of this research is limited to Anglo-Saxon ...studies and no information on Portuguese reality is available.
Objectives
The purpose of this study is to compare levels of mental functioning and suicidal behavior among heterosexual, bisexual, and homosexual individuals in Portugal.
Methods
Using online surveys, 1140 individuals (62.40% women, Mage = 36.83, SDage = 13.39, 76.4% heterosexual, 9.4% bisexual, and 14.2% gay or lesbian) completed the BSI subscales for depression and anxiety symptoms, as well as the Suicide Behaviors Questionnaire-Revised.
Results
Self-identified bisexual participants presented higher levels of depressive and anxiety symptoms and higher levels of suicidal ideation and likelihood of suicidal behavior than homosexual and heterosexual participants (who scored the lowest); yet, homosexual participants showed higher levels of suicide attempts. Also, depression and anxiety symptoms were strongly and positively correlated with all dimensions of suicidal behavior. Finally, hierarchical multiple regression analysis showed that higher levels of depression and non-heterosexual sexual orientations were significant predictors of suicidal ideation and the likelihood of suicidal behavior.
Conclusions
The present study adds to the evidence that sexual minority individuals are at risk of increased mental health problems and suicidal behavior, compared to heterosexuals, and reiterates the need for local political and legislative efforts to normalize LGB identities, fighting continued institutional heterosexism, interpersonal intolerance. Mental health providers and mental health policymakers need to consider these results if they want to address inequalities in mental health and in suicidality among these minority groups.
Introduction
With the growing recognition of overweightness and obesity as significant, international public health concerns, the body of research investigating the relationship between body mass ...index (BMI), sexual health and sexual functioning in sexual minority men is still scarce.
Objectives
The purpose of this study is to assess sexual health determinants (sexual behavior and sexual functioning) in relation to normal weight, overweightness and obesity among gay and bisexual men.
Methods
The survey included four categories of questions/measurements, encompassing sociodemographic information, protected/unprotected sexual behaviors, sexual functioning, and BMI. The survey was conducted online, and recruitment consisted of online notifications (emails and electronic messages), and advertisements sent to LGBT community organizations, mailing lists, and social networks.
Results
The study sample was composed of 741 gay and bisexual men, ranging in age from 21 to 75 years old (M
age
=43.30, SD
age
=11.37), 62.5% of men self-identified as gay and 37.5% as bisexual. Prevalence of normal weight was 50.3%, of overweight 33.3% and of obesity 16.4%. Hierarchical multiple regression analysis to assess the effects of BMI on sexual health showed that being younger in age, self-identifying as gay, being in a relationship, having longer penises, adopting insertive position in sex and being normal weight were significant predictors of anal receptive sex without condoms, explaining 24.2% of the total variance. Yet, BMI was not predictive of sexual functioning.
Conclusions
These findings highlight the importance of including BMI in sexual behavior models of sexual minority men to better understand BMI’s role in influencing sexual risk.
Cities worldwide are pursuing policies to reduce car use and prioritise public transit (PT) as a means to tackle congestion, air pollution, and greenhouse gas emissions. The increase of PT ridership ...is constrained by many aspects; among them, travel time and the built environment are considered the most critical factors in the choice of travel mode. We propose a data fusion framework including real-time traffic data, transit data, and travel demand estimated using Twitter data to compare the travel time by car and PT in four cities (São Paulo, Brazil; Stockholm, Sweden; Sydney, Australia; and Amsterdam, the Netherlands) at high spatial and temporal resolutions. We use real-world data to make realistic estimates of travel time by car and by PT and compare their performance by time of day and by travel distance across cities. Our results suggest that using PT takes on average 1.4-2.6 times longer than driving a car. The share of area where travel time favours PT over car use is very small: 0.62% (0.65%), 0.44% (0.48%), 1.10% (1.22%) and 1.16% (1.19%) for the daily average (and during peak hours) for São Paulo, Sydney, Stockholm, and Amsterdam, respectively. The travel time disparity, as quantified by the travel time ratio Formula: see text (PT travel time divided by the car travel time), varies widely during an average weekday, by location and time of day. A systematic comparison between these two modes shows that the average travel time disparity is surprisingly similar across cities: Formula: see text for travel distances less than 3 km, then increases rapidly but quickly stabilises at around 2. This study contributes to providing a more realistic performance evaluation that helps future studies further explore what city characteristics as well as urban and transport policies make public transport more attractive, and to create a more sustainable future for cities.
Neutrophils are the innate immune system's first line of defense. Neutrophils play a critical role in protecting the host against infectious pathogens, resolving sterile injuries, and mediating ...inflammatory responses. The granules of neutrophils and their constituent proteins are central to these functions. Although neutrophils may exert a protective role upon acute inflammatory conditions or insults, continued activity of neutrophils in chronic inflammatory diseases can contribute to tissue damage. Neutrophil granule proteins are involved in a number of chronic inflammatory conditions and diseases. However, the functions of these proteins in neuroinflammation and chronic neuroinflammatory diseases, including Alzheimer's disease (AD), remain to be elucidated. In this review, we discuss recent findings from our lab and others that suggest possible functions for neutrophils and the neutrophil granule proteins, CAP37, neutrophil elastase, and cathepsin G, in neuroinflammation, with an emphasis on AD. These findings reveal that neutrophil granule proteins may exert both neuroprotective and neurotoxic effects. Further research should determine whether neutrophil granule proteins are valid targets for therapeutic interventions in chronic neuroinflammatory diseases.
Governments have set the ambitious target of reducing biodiversity loss by the year 2010. The scientific community now faces the challenge of assessing the progress made towards this target and ...beyond. Here, we review current monitoring efforts and propose a global biodiversity monitoring network to complement and enhance these efforts. The network would develop a global sampling programme for indicator taxa (we suggest birds and vascular plants) and would integrate regional sampling programmes for taxa that are locally relevant to the monitoring of biodiversity change. The network would also promote the development of comparable maps of global land cover at regular time intervals. The extent and condition of specific habitat types, such as wetlands and coral reefs, would be monitored based on regional programmes. The data would then be integrated with other environmental and socioeconomic indicators to design responses to reduce biodiversity loss.
The rapid spread of COVID-19 across the world has raised concerns about the responsiveness of cities and healthcare systems during pandemics. Recent studies try to model how the number of COVID-19 ...infections will likely grow and impact the demand for hospitalization services at national and regional levels. However, less attention has been paid to the geographic access to COVID-19 healthcare services and to hospitals’ response capacity at the local level, particularly in urban areas in the Global South. This paper shows how transport accessibility analysis can provide actionable information to help improve healthcare coverage and responsiveness. It analyzes accessibility to COVID-19 healthcare at high spatial resolution in the 20 largest cities of Brazil. Using network-distance metrics, we estimate the vulnerable population living in areas with poor access to healthcare facilities that could either screen or hospitalize COVID-19 patients. We then use a new balanced floating catchment area (BFCA) indicator to estimate spatial, income, and racial inequalities in access to hospitals with intensive care unit (ICU) beds and mechanical ventilators while taking into account congestion effects. Based on this analysis, we identify substantial social and spatial inequalities in access to health services during the pandemic. The availability of ICU equipment varies considerably between cities, and it is substantially lower among black and poor communities. The study maps territorial inequalities in healthcare access and reflects on different policy lessons that can be learned for other countries based on the Brazilian case.
•Use of a Balanced Floating Catchment Area to calculate accessibility to healthcare.•Estimates access to healthcare in the 20 largest Brazilian cities during COVID-19.•Over 1.6 million people have poor access to healthcare for severe cases of COVID-19.•41% of vulnerable population have poor access to ICU beds and mechanical ventilators.•Low income and black communities in urban periphery have less healthcare access.
The objectives of these experiments were as follows: (1) to determine the association between circulating concentrations of pregnancy-associated glycoproteins (PAG) and late embryonic mortality (EM) ...in lactating dairy cattle following fixed-time artificial insemination (TAI) on d 0 or timed embryo transfer (TET) on d 7, (2) to identify a circulating concentration of PAG on d 31 below which late EM would be likely to occur, and (3) to identify when during gestation (d 31–59) late EM is occurring. Cows were diagnosed pregnant on d 31 of gestation based on presence of a fetal heartbeat and reconfirmed to be pregnant on d 59 of gestation. Late EM occurred when a cow had a viable embryo on d 31 of gestation but not on d 59 following TAI or TET. Only pregnant cows on d 31 were included in the analysis (TAI-maintained, n=413; TAI-EM, n=77; TET-maintained, n=238; TET-EM, n=47). Cows that were pregnant at d 31 of gestation and maintained the pregnancy until d 59 had significantly higher circulating concentrations of PAG at d 31 of gestation compared with cows that experienced late EM between d 31 and 59 of gestation in both TAI and TET. To conduct a more stringent test of the effectiveness of a single circulating PAG concentration (d 31) to predict EM, a receiver-operating characteristic curve was generated to identify a PAG concentration on d 31 that would predict EM with ≥95% accuracy in cows that received TAI or TET. Based on positive and negative predicative value analysis, a circulating concentration of PAG below 1.4ng/mL (TAI; minimal detectable level 0.28ng/mL) and 1.85ng/mL (TET) was 95% accurate in predicting EM (between d 31 and 59) at d 31 of gestation, respectively. Following TET, embryonic loss was tracked by Doppler ultrasound, progesterone, and PAG from d 24 to 59 of gestation, with more than 50% of the loss occurring between d 31 and 38 of gestation. In summary, circulating concentrations of PAG on d 31 of gestation may provide a good marker for predicting EM between d 31 and 59 of gestation, and the data suggest that this model could help predict which cows will undergo late EM.
A viable model for inflation driven by a torsion function in a Friedmann background is presented. The scalar spectral index in the interval
0.92
≲
n
s
≲
0.97
is obtained in order to satisfy the ...initial conditions for inflation. The post inflationary phase is also studied, and the analytical solutions obtained for scale factor and energy density generalizes that ones for a matter dominated universe, indicating just a small deviation from the standard model evolution. The same kind of torsion function used also describes satisfactorily the recent acceleration of the universe, which could indicate a possible unification of different phases, apart form specific constants
Copper nanoparticles (CuNPs) are attractive as a low-cost alternative to their gold and silver analogues for numerous applications, although their potential has hardly been explored due to their ...higher susceptibility to oxidation in air. Here we show the unexpected findings of an investigation into the correlation between the air-stability of CuNPs and the structure of the thiolate capping ligand; of the eight different ligands screened, those with the shortest alkyl chain, -(CH
)
-, and a hydrophilic carboxylic acid end group are found to be the most effective at retarding oxidation in air. We also show that CuNPs are not etched by thiol solutions as previously reported, and address the important fundamental question of how the work function of small supported metal particles scales with particle size. Together these findings set the stage for greater utility of CuNPs for emerging electronic applications.
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