We measured the triple coincidence A(e,e^{'}np) and A(e,e^{'}pp) reactions on carbon, aluminum, iron, and lead targets at Q^{2}>1.5 (GeV/c)^{2}, x_{B}>1.1 and missing momentum >400 MeV/c. This was ...the first direct measurement of both proton-proton (pp) and neutron-proton (np) short-range correlated (SRC) pair knockout from heavy asymmetric nuclei. For all measured nuclei, the average proton-proton (pp) to neutron-proton (np) reduced cross-section ratio is about 6%, in agreement with previous indirect measurements. Correcting for single-charge exchange effects decreased the SRC pairs ratio to ∼3%, which is lower than previous results. Comparisons to theoretical generalized contact formalism (GCF) cross-section calculations show good agreement using both phenomenological and chiral nucleon-nucleon potentials, favoring a lower pp to np pair ratio. The ability of the GCF calculation to describe the experimental data using either phenomenological or chiral potentials suggests possible reduction of scale and scheme dependence in cross-section ratios. Our results also support the high-resolution description of high-momentum states being predominantly due to nucleons in SRC pairs.
Per- and polyfluoroalkyl substances (PFASs) are a large class of compounds used in a variety of processes and consumer products. Their unique chemical properties make them ubiquitous and persistent ...environmental contaminants while also making them economically viable and socially convenient. To date, several reviews have been published to synthesize information regarding the immunotoxic effects of PFASs on the adaptive immune system. However, these reviews often do not include data on the impact of these compounds on innate immunity. Here, current literature is reviewed to identify and incorporate data regarding the effects of PFASs on innate immunity in humans, experimental models, and wildlife. Known mechanisms by which PFASs modulate innate immune function are also reviewed, including disruption of cell signaling, metabolism, and tissue-level effects. For PFASs where innate immune data are available, results are equivocal, raising additional questions about common mechanisms or pathways of toxicity, but highlighting that the innate immune system within several species can be perturbed by exposure to PFASs. Recommendations are provided for future research to inform hazard identification, risk assessment, and risk management practices for PFASs to protect the immune systems of exposed organisms as well as environmental health.
Per- and polyfluoroalkyl substances (PFASs) are used in a multitude of processes and products, including nonstick coatings, food wrappers, and fire-fighting foams. These chemicals are ...environmentally-persistent, ubiquitous, and can be detected in the serum of 98% of Americans. Despite evidence that PFASs alter adaptive immunity, few studies have investigated their effects on innate immunity. The report here presents results of studies that investigated the impact of nine environmentally-relevant PFASs e.g. perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid potassium salt (PFOS-K), perfluorononanoic acid (PFNA), perfluorohexanoic acid (PFHxA), perfluorohexane sulfonic acid (PFHxS), perfluorobutane sulfonic acid (PFBS), ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX), 7H-perfluoro-4-methyl-3,6-dioxa-octane sulfonic acid (Nafion byproduct 2), and perfluoromethoxyacetic acid sodium salt (PFMOAA-Na) on one component of the innate immune response, the neutrophil respiratory burst. The respiratory burst is a key innate immune process by which microbicidal reactive oxygen species (ROS) are rapidly induced by neutrophils in response to pathogens; defects in the respiratory burst can increase susceptibility to infection. The study here utilized larval zebrafish, a human neutrophil-like cell line, and primary human neutrophils to ascertain whether PFAS exposure inhibits ROS production in the respiratory burst. It was observed that exposure to PFHxA and GenX suppresses the respiratory burst in zebrafish larvae and a human neutrophil-like cell line. GenX also suppressed the respiratory burst in primary human neutrophils. This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function.
A multidimensional extraction of the structure function ratio σLT′/σ0 from the hard exclusive e→p→e′nπ+ reaction above the resonance region has been performed. The study was done based on beam-spin ...asymmetry measurements using a 10.6 GeV incident electron beam on a liquid-hydrogen target and the CLAS12 spectrometer at Jefferson Lab. The measurements focus on the very forward regime (t/Q2 ≪ 1) with a wide kinematic range of xB in the valence regime (0.17 <xB < 0.55), and virtualities Q2 ranging from 1.5 GeV2 up to 6 GeV2. The results and their comparison to theoretical models based on Generalized Parton Distributions demonstrate the sensitivity to chiral-odd GPDs and the directly related tensor charge of the nucleon. In addition, the data is compared to an extension of a Regge formalism at high photon virtualities. It was found that the Regge model provides a better description at low Q2, while the GPD model is more appropriate at high Q2.
The CLAS12 Geant4 simulation Ungaro, M.; Angelini, G.; Battaglieri, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2020, Volume:
959, Issue:
C
Journal Article
Peer reviewed
Open access
The Geant4 Monte-Carlo (GEMC) package is used to simulate the passage of particles through the various CLAS12 detectors. The geometry is implemented through a database of Geant4 volumes created ...either through the GEMC native API, by the CLAS12 geometry service, or imported from the CAD engineering model. The truth information is digitized with a plugin mechanism by routines specific to each detector and includes the use of the CLAS12 calibration database constants to produce both ADC and TDC response functions. Theoretical models that produce the generated events interface with GEMC through the LUND data format. The merging of simulated data with real random trigger data provides a mechanism to include both beam and electronic background into the simulation of generated events to accurately model beam data from the CLAS12 detector. The performance of simulation is demonstrated by comparison with the experimental data.
Measurements of the linearly-polarized photon beam asymmetry Σ for photoproduction from the proton of η and η′ mesons are reported. A linearly-polarized tagged photon beam produced by coherent ...bremsstrahlung was incident on a cryogenic hydrogen target within the CEBAF Large Acceptance Spectrometer. Results are presented for the γp→ηp reaction for incident photon energies from 1.070 to 1.876 GeV, and from 1.516 to 1.836 GeV for the γp→η′p reaction. For γp→ηp, the data reported here considerably extend the range of measurements to higher energies, and are consistent with the few previously published measurements for this observable near threshold. For γp→η′p, the results obtained are consistent with the few previously published measurements for this observable near threshold, but also greatly expand the incident photon energy coverage for that reaction. Initial analysis of the data reported here with the Bonn–Gatchina model strengthens the evidence for four nucleon resonances – the N(1895)1/2−, N(1900)3/2+, N(2100)1/2+ and N(2120)3/2− resonances – which presently lack the “four-star” status in the current Particle Data Group compilation, providing examples of how these new measurements help refine models of the photoproduction process.
The Electron Ion Collider (EIC) is the next generation of precision QCD facility to be built at Brookhaven National Laboratory in conjunction with Thomas Jefferson National Laboratory. There are a ...significant number of software and computing challenges that need to be overcome at the EIC. During the EIC detector proposal development period, the ECCE consortium began identifying and addressing these challenges in the process of producing a complete detector proposal based upon detailed detector and physics simulations. In this document, the software and computing efforts to produce this proposal are discussed; furthermore, the computing and software model and resources required for the future of ECCE are described.
This study presents the improvement in ice edge error within the US Navy's operational sea ice forecast systems gained by assimilating high horizontal resolution satellite-derived ice concentration ...products. Since the late 1980's, the ice forecast systems have assimilated near real-time sea ice concentration derived from the Defense Meteorological Satellite Program (DMSP) Special Sensor Microwave/Imager (SSMI and then SSMIS). The resolution of the satellite-derived product was approximately the same as the previous operational ice forecast system (25 km). As the sea ice forecast model resolution increased over time, the need for higher horizontal resolution observational data grew. In 2013, a new Navy sea ice forecast system (Arctic Cap Nowcast/Forecast System – ACNFS) went into operations with a horizontal resolution of ~ 3.5 km at the North Pole. A method of blending ice concentration observations from the Advanced Microwave Scanning Radiometer (AMSR2) along with a sea ice mask produced by the National Ice Center (NIC) has been developed, resulting in an ice concentration product with very high spatial resolution. In this study, ACNFS was initialized with this newly developed high resolution blended ice concentration product. The daily ice edge locations from model hindcast simulations were compared against independent observed ice edge locations. ACNFS initialized using the high resolution blended ice concentration data product decreased predicted ice edge location error compared to the operational system that only assimilated SSMIS data. A second evaluation assimilating the new blended sea ice concentration product into the pre-operational Navy Global Ocean Forecast System 3.1 also showed a substantial improvement in ice edge location over a system using the SSMIS sea ice concentration product alone. This paper describes the technique used to create the blended sea ice concentration product and the significant improvements in ice edge forecasting in both of the Navy's sea ice forecasting systems.
The US Navy's operational global ocean nowcast/forecast system is presently comprised of the 0.08° HYbrid Coordinate Ocean Model (HYCOM) and the Navy Coupled Ocean Data Assimilation (NCODA). Its high ...horizontal resolution and adaptive vertical coordinate system make it capable of producing nowcasts (current state) and forecasts of oceanic "weather," which includes three-dimensional ocean temperature, salinity, and current structure; surface mixed layer depth; and the location of mesoscale features such as eddies, meandering currents, and fronts. It runs daily at the Naval Oceanographic Office and provides seven-day forecasts that support fleet operations, provide boundary conditions to higher resolution regional models, and are available to the community. Using a data-assimilative hindcast and series of 14-day forecasts for 2012, the system is shown to have forecast skill of the oceanic mesoscale out to about 10 days for the Gulf Stream region and to 14+ days for the global ocean and other selected subregions. Forecast skill is sensitive to the type of atmospheric forcing (i.e., operational vs. analysis quality). Subsurface temperature bias is small (< 0.25°C) and root mean square error peaks at the depth range of the mixed layer and thermocline. Coupled to the Community Ice CodE (CICE) on the same grid, the HYCOM/CICE/NCODA system (initially restricted to the Arctic) provides sea ice nowcasts and forecasts. Ice edge location errors are improved from the previous sea ice prediction system but are limited in part by the accuracy of the satellite observations it assimilates.
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