The field of dark matter detection is a highly visible and highly competitive one. In this paper, we propose recommendations for presenting dark matter direct detection results particularly suited ...for weak-scale dark matter searches, although we believe the spirit of the recommendations can apply more broadly to searches for other dark matter candidates, such as very light dark matter or axions. To translate experimental data into a final published result, direct detection collaborations must make a series of choices in their analysis, ranging from how to model astrophysical parameters to how to make statistical inferences based on observed data. While many collaborations follow a standard set of recommendations in some areas, for example the expected flux of dark matter particles (to a large degree based on a paper from Lewin and Smith in 1995), in other areas, particularly in statistical inference, they have taken different approaches, often from result to result by the same collaboration. We set out a number of recommendations on how to apply the now commonly used Profile Likelihood Ratio method to direct detection data. In addition, updated recommendations for the Standard Halo Model astrophysical parameters and relevant neutrino fluxes are provided. The authors of this note include members of the DAMIC, DarkSide, DARWIN, DEAP, LZ, NEWS-G, PandaX, PICO, SBC, SENSEI, SuperCDMS, and XENON collaborations, and these collaborations provided input to the recommendations laid out here. Wide-spread adoption of these recommendations will make it easier to compare and combine future dark matter results.
The physics reach of a low threshold (100 eV) scintillating argon bubble chamber sensitive to coherent elastic neutrino-nucleus scattering (CE ν NS) from reactor neutrinos is studied. The sensitivity ...to the weak mixing angle, neutrino magnetic moment, and a light Z′ gauge boson mediator are analyzed. A Monte Carlo simulation of the backgrounds is performed to assess their contribution to the signal. The analysis shows that world-leading sensitivities are achieved with a one-year exposure for a 10 kg chamber at 3 m from a 1 MWth research reactor or a 100 kg chamber at 30 m from a 2000 MWthpower reactor. Such a detector has the potential to become the leading technology to study CE ν NS using nuclear reactors.
Abstract
Cosmic-ray muons detected by deep underground and underwater detectors have served as an information source on the high-energy cosmic-ray spectrum and hadronic interactions in air showers ...for almost a century. The theoretical interest in underground muons has nearly faded away because space-borne experiments probe the cosmic-ray spectrum more directly, and accelerators provide precise measurements of hadron yields. However, underground muons probe unique hadron interaction energies and phase space, which are still inaccessible to present accelerator experiments. The cosmic-ray nucleon energies reach the hundred-TeV and PeV ranges, which are barely accessible with space-borne experiments. Our new calculation combines two modern computational tools:
mceq
for surface muon fluxes and
proposal
for underground transport. We demonstrate excellent agreement with measurements of cosmic-ray muon intensities underground within estimated errors. Beyond that, the precision of historical data turns out to be significantly smaller than our error estimates. This result shows that the sources of high-energy atmospheric lepton flux uncertainties at the surface or underground can be significantly constrained without taking more data or building new detectors. The reduction of uncertainties can be expected to impact data analyses at large-volume neutrino telescopes and be used for the design of future ton-scale direct dark matter detectors.
We report on a dark matter search for a Weakly Interacting Massive Particle (WIMP) in the mass range
m
χ
∈
4
,
30
GeV
/
c
2
with the EDELWEISS-III experiment. A 2D profile likelihood analysis is ...performed on data from eight selected detectors with the lowest energy thresholds leading to a combined fiducial exposure of 496 kg-days. External backgrounds from
γ
- and
β
-radiation, recoils from
206
Pb
and neutrons as well as detector intrinsic backgrounds were modelled from data outside the region of interest and constrained in the analysis. The basic data selection and most of the background models are the same as those used in a previously published analysis based on boosted decision trees (BDT)
1
. For the likelihood approach applied in the analysis presented here, a larger signal efficiency and a subtraction of the expected background lead to a higher sensitivity, especially for the lowest WIMP masses probed. No statistically significant signal was found and upper limits on the spin-independent WIMP-nucleon scattering cross section can be set with a hypothesis test based on the profile likelihood test statistics. The 90 % C.L. exclusion limit set for WIMPs with
m
χ
=
4
GeV
/
c
2
is
1.6
×
10
-
39
cm
2
, which is an improvement of a factor of seven with respect to the BDT-based analysis. For WIMP masses above
15
GeV
/
c
2
the exclusion limits found with both analyses are in good agreement.
DEAP-3600 is a single-phase liquid argon (LAr) direct-detection dark matter experiment, operating 2 km underground at SNOLAB (Sudbury, Canada). The detector consists of 3279 kg of LAr contained in a ...spherical acrylic vessel. This paper reports on the analysis of a 758 tonne·day exposure taken over a period of 231 live-days during the first year of operation. No candidate signal events are observed in the WIMP-search region of interest, which results in the leading limit on the WIMP-nucleon spin-independent cross section on a LAr target of 3.9×10−45 cm2 (1.5×10−44 cm2) for a 100 GeV/c2 (1 TeV/c2) WIMP mass at 90% C.L. In addition to a detailed background model, this analysis demonstrates the best pulse-shape discrimination in LAr at threshold, employs a Bayesian photoelectron-counting technique to improve the energy resolution and discrimination efficiency, and utilizes two position reconstruction algorithms based on the charge and photon detection time distributions observed in each photomultiplier tube.
We report on WIMP search results of the XENON100 experiment, combining three runs summing up to 477 live days from January 2010 to January 2014. Data from the first two runs were already published. A ...blind analysis was applied to the last run recorded between April 2013 and January 2014 prior to combining the results. The ultralow electromagnetic background of the experiment, ∼5×10−3 events/(keVee×kg×day)) before electronic recoil rejection, together with the increased exposure of 48 kg×yr, improves the sensitivity. A profile likelihood analysis using an energy range of (6.6–43.3) keVnr sets a limit on the elastic, spin-independent WIMP-nucleon scattering cross section for WIMP masses above 8 GeV/c2, with a minimum of 1.1×10−45 cm2 at 50 GeV/c2 and 90% confidence level. We also report updated constraints on the elastic, spin-dependent WIMP-nucleon cross sections obtained with the same data. We set upper limits on the WIMP-neutron (proton) cross section with a minimum of 2.0×10−40 cm2 (52×10−40 cm2) at a WIMP mass of 50 GeV/c2, at 90% confidence level.
The NEWS-G collaboration uses spherical proportional counters (SPCs) to search for weakly interacting massive particles (WIMPs). Here, in this paper, we report the first measurements of the nuclear ...quenching factor in neon gas at 2 bar using an SPC deployed in a neutron beam at the TUNL facility. The energy-dependence of the nuclear quenching factor is modeled using a simple power law: $αE^{β}_{nr}$; we determine its parameters by simultaneously fitting the data collected with the detector over a range of energies. We measured the following parameters in Ne : CH4 at 2 bar: α= 0.2801±0.0050 (fit) ±0.0045 (sys) and β=0.0867±0.020 (fit) ±0.006 (sys). Our measurements do not agree with expected values from SRIM or Lindhard theory. We demonstrated the feasibility of performing quenching factor measurements at sub-keV energies in gases using SPCs and a neutron beam.
Targeting new molecular pathways leading to Osteoporosis (OP) and Osteoarthritis (OA) is a hot topic for drug discovery. Clusterin (CLU) is a glycoprotein involved in inflammation, proliferation, ...cell death, neoplastic disease, Alzheimer disease and aging. The present study focuses on the expression and the role of CLU in influencing the decrease of muscle mass and fiber senescence in OP-OA condition.
Vastus lateralis muscle biopsies were collected from 20 women with OP undergoing surgery for fragility hip fracture and 20 women undergoing arthroplasty for hip osteoarthritis.
We found an overexpression of CLU in degenerated fibers in OP closely correlated with interleukin 6 (IL6) and histone H4 acetylation level. Conversely, in OA muscle tissues we observed a weak expression of CLU but no nuclear histone H4 acetylation. Ex vivo studies on isolated human myoblasts confirmed CLU overexpression in OP as compared to OA (p < 0.001). CLU treatment of isolated OP and OA myoblasts showed: modulation of proliferation, morphological changes, increase of histone H4 acetylation and induction of myogenin (MYOG) activation in OP myoblast only. In OP condition, functional knockdown of CLU by siRNA restores proliferative myoblasts capability and tissue damage repair, carried out by an evident upregulation of Transglutaminase 2 (TGM2). We also observed downmodulation of CX3CR1 expression with consequent impairing of the inflammatory infiltrate recruitment.
Results obtained suggest a potential role of CLU in OP by influencing myoblasts terminal differentiation, epigenetic regulation of muscle cell differentiation and senescence. Moreover, CLU silencing points out its role in the modulation of tissue damage repair and inflammation, proposing it as a new diagnostic marker for muscle degeneration and a potential target for specific therapeutic intervention in OP related sarcopenia.
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