The mechanisms responsible for cyclosporin-induced encephalopathy remain controversial. Herein we present a case of cyclosporin-induced encephalopathy with unusually prolonged vasospasm, which might ...have contributed to the slow recovery of the patient.
ArrayFusion annotates conventional CGH results and various types of microarray data from a range of platforms (cDNA, expression, exon, SNP, array-CGH and ChIP-on-chip) and converts them into standard ...formats which can be visualized in genome browsers (Affymetrix™ Integrated Genome Browser and GBrowse in the HapMap Project). Converted files can then be imported simultaneously into a single genome browser to benefit a collective interpretation between different array results. ArrayFusion therefore provides a new type of tool facilitating the integration of CGH and array results to provide new experimental directions. Availability: Contact:hwwang@ym.edu.tw
Time‐sampling measurements are used in this paper to build time dependent LTPS TFT current model. The device model that considers bias and time dependent threshold voltage (Vth) shift and mobility ...degradation is implemented in Eldo through GUDM for simulating a pixel circuit as an indicator of panel performance.
The photo leakage current (
I
PLC) characteristic of a-Si:H TFTs under different bending strains has been studied. The larger
I
PLC of a-Si:H TFTs under the outward bending strain is due to larger ...conductivity of a-Si:H, stemmed from the shift up of Fermi level (
E
F). Experimental results show the
I
PLC of a-Si:H TFTs under the outward bending strain is larger than that of flattened and inward bending a-Si:H TFTs in the density of states (DOS) limited region, stemmed from the lower recombination centers present in outward bending a-Si:H material. Furthermore, the extracted smaller activity energy (
E
a) of a-Si:H TFTs under the outward bending strain also confirmed the shift of
E
F.
Thermal stability of a porous low-
k film is a critical issue for application consideration in the back-end-of-line. In this study, thermal stability of the porous silicate has been investigated by ...changing the thermal processing temperatures. Experimental results have shown that the dielectric constant of the porous silicate still remains below 2.0 after thermal processing at 500 °C for 1 h. A series of material analysis techniques and electrical characteristics have been used to verify the physical and chemical characteristics of the porous silicate film.
Oxidative stress has been associated with degenerative diseases such as cardiovascular and neurodegenerative diseases. Acute myocardial infarction (AMI) is the major cause of death among ...cardiovascular diseases. Inflammation, major risk factor of AMI, is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and subsequent oxidant generation. It has been hypothesized that oxidative stress is a risk factor for AMI. To test this hypothesis, we studied profiles of oxidative damage and antioxidants in patients with AMI. The levels of MPO, 8‐OHdG, and 3‐Cl‐Tyr were higher in blood specimens from AMI patients than in those of controls. Antioxidant levels, such as vitamin E and glutathione peroxidase, were significantly lower in these patients. The GSH/GSSG ratio, indicative of redox status, was also lower in AMI patients. Such findings suggest that these AMI patients experience increased oxidative stress. Moreover, markers in combination are better for evaluating antioxidant status and monitoring cardiac events than the same markers used separately.
This study was performed to investigate the clinical factors, tumor characteristics, treatment approach, and prognosis of patients with Stage IV thymic carcinoma (WHO type C).
The records of 20 ...patients with histologically confirmed thymic carcinoma treated between 1988 and 2002 at the Division of Oncology at Taipei Veterans General Hospital were reviewed.
Therapy consisted of surgical debulking, adjuvant radiotherapy, and chemotherapy in six patients (30%), surgical debulking with adjuvant chemotherapy in two patients (10%), surgical debulking with adjuvant radiotherapy in one patient (5%), radiotherapy with adjuvant chemotherapy in eight patients (40%), and chemotherapy alone in three patients (15%). After a median follow-up of 22 months (range, 5-72 months), three patients (15%) were alive. Eighteen patients (90%) experienced disease recurrence after a median of 9 months (range, 2-41 months); 12 (66%) of these patients initially had stage IVa disease, and 6 (33%) had stage IV b disease. Five patients had an undifferentiated type of histology. The median time to progression was 5 months. However, none of these patients was able to receive salvage therapy due to their poor performance status. For those patients with a lymphoepithelioma-like histology, the median survival was 36 months; there was tumor recurrence in five patients and they all received salvage chemotherapy. The median survival time for these five patients was 51 months. For patients with squamous cell type, the median time to progression was 10 months. Five patients received salvage chemotherapy and the median survival was 28 months. There was a significant difference (P < 0.0001) in the median survival between those who received chemotherapy (18 months) after tumor relapse and those who did not (1 month).
Our results indicate that multidisciplinary treatment, including surgery, radiotherapy, and chemotherapy, is beneficial in treating primary thymic carcinoma. Chemotherapy plays an important role in both primary and relapsed stage IV thymic carcinoma in terms of prolonging the disease-free survival and median survival of patients with lymphoepithelioma-like or squamous cell histology types. For patients with an undifferentiated histology, multidisciplinary treatment or chemotherapy might not be helpful in either primary or relapsed stage IV thymic carcinoma.
The impact of stress effect to the performance of an IGZO panel is discussed in this paper. Depart from conventional method of observing the threshold voltage (V
th
) shift, the time dependency of ...serial I
D
‐V
G
test is included in building an accurate V
th
shift model. The model can be used to simulate the IGZO TFT current change under fixed bias for aiding the circuit design and optimization.
The impact of stress effect to the performance of an IGZO panel is discussed in this paper. Depart from conventional method of observing the threshold voltage (V sub(th)) shift, the time dependency ...of serial I sub(D)-V sub(G) test is included in building an accurate V sub(th) shift model. The model can be used to simulate the IGZO TFT current change under fixed bias for aiding the circuit design and optimization.
The infiltrative nature of lesions is a significant feature of malignant breast lesion on ultrasound image. Characterizing the infiltrative nature of lesions with computationally inexpensive and ...highly efficacious features is crucial for the realization of a computer-aided diagnosis system. In this study, the infiltrative nature is regarded as an energy that produces irregularly and considerably local variances in a 1-D signal. The local variances can be characterized by a few high octave energies (i.e., the channel energies close to low-frequency bands) in a 1-D discrete periodic wavelet transform. For computational cost reduction, high octave decomposition is performed by a reversible round-off 1-D nonrecursive discrete periodic wavelet transform. A test dataset of breast sonograms with the lesion contour delineated by an experienced physician and two inexperienced persons is built for feature efficacy evaluation. High individual performance results imply that the proposed feature is well correlated with the diagnosis of the experienced physician. Experimental results also reveal that with a great performance improvement, the proposed feature is suitable for the combination with some morphometric parameters.
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