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  • Circulating extracellular v... Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma
    Serratì, Simona; Guida, Michele; Di Fonte, Roberta ... Molecular cancer, 01/2022, Volume: 21, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    The immunotherapy with immune checkpoints inhibitors (ICI) has changed the life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients do not respond hence, the ...
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  • Hepatic stellate cells indu... Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin‐332/α3 integrin axis recovery of focal adhesion kinase ubiquitination
    Azzariti, Amalia; Mancarella, Serena; Porcelli, Letizia ... Hepatology (Baltimore, Md.), December 2016, Volume: 64, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    In patients with hepatocellular carcinoma (HCC) receiving sorafenib, drug resistance is common. HCC develops in a microenvironment enriched with extracellular matrix proteins including laminin ...
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  • The β-adrenergic receptor a... The β-adrenergic receptor antagonist propranolol offsets resistance mechanisms to chemotherapeutics in diverse sarcoma subtypes: a pilot study
    Porcelli, Letizia; Garofoli, Marianna; Di Fonte, Roberta ... Scientific reports, 06/2020, Volume: 10, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Standard chemotherapy for soft tissue sarcomas has shown limited efficacy. Here, we sought to evaluate whether β-adrenergic receptor (β-AR) signalling contributed to the progression of sarcomas and ...
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  • Targeting human liver cance... Targeting human liver cancer cells with lactobionic acid-G(4)-PAMAM-FITC sorafenib loaded dendrimers
    Iacobazzi, Rosa Maria; Porcelli, Letizia; Lopedota, Angela Assunta ... International journal of pharmaceutics, 08/2017, Volume: 528, Issue: 1-2
    Journal Article
    Peer reviewed

    Display omitted Reported here is the synthesis and biological evaluation of the asialoglycoprotein receptor (ASGP-R) targeted fourth generation poliamidoamine dendrimer (G(4)-PAMAM) loaded with ...
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  • The Role of Non-Coding RNAs... The Role of Non-Coding RNAs as Prognostic Factor, Predictor of Drug Response or Resistance and Pharmacological Targets, in the Cutaneous Squamous Cell Carcinoma
    Garofoli, Marianna; Volpicella, Mariateresa; Guida, Michele ... Cancers, 09/2020, Volume: 12, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Cutaneous squamous cell carcinoma (CSCC) is the most common keratinocyte-derived skin cancer in the Caucasian population. Exposure to UV radiations (UVRs) represents the main risk carcinogenesis, ...
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  • CAFs and TGF-β Signaling Ac... CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer
    Porcelli, Letizia; Iacobazzi, Rosa Maria; Di Fonte, Roberta ... Cancers, 03/2019, Volume: 11, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Tumor⁻stroma interactions are of key importance for pancreatic ductal adenocarcinoma (PDAC) progression. Our aim was to investigate whether cancer associated fibroblasts (CAFs) and mast cells (MC) ...
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  • Gene Expression Comparison ... Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study
    Argentiero, Antonella; De Summa, Simona; Di Fonte, Roberta ... Cancers, 07/2019, Volume: 11, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Over the past several years there has been much debate with regards to the prognostic and clinical significance of pancreatic ductal adenocarcinoma (PDAC) with lymph nodes metastasis. The PDAC gene ...
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  • Active notch protects MAPK ... Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib
    Porcelli, Letizia; Mazzotta, Annalisa; Garofoli, Marianna ... Biomedicine & pharmacotherapy, January 2021, 2021-Jan, 2021-01-00, 20210101, 2021-01-01, Volume: 133
    Journal Article
    Peer reviewed
    Open access

    Display omitted •Notch boosts MAPK signaling in mutated uveal and cutaneous melanoma.•Notch inhibition counteracts GNAQ-induced MAPK activation.•Galunisertib prolongs the efficacy of cobimetinib in ...
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  • Behind the Scene: Exploitin... Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention
    Manganelli, Michele; Guida, Stefania; Ferretta, Anna ... Genes, 07/2021, Volume: 12, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Melanoma and non-melanoma skin cancers (NMSCs) are the most frequent cancers of the skin in white populations. An increased risk in the development of skin cancers has been associated with the ...
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  • Tomatine Displays Antitumor... Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma
    Serratì, Simona; Porcelli, Letizia; Guida, Stefania ... International journal of molecular sciences, 07/2020, Volume: 21, Issue: 15
    Journal Article
    Peer reviewed
    Open access

    There is a growing interest in the cytotoxic effects of bioactive glycoalkaloids, such as α-tomatine on tumor cells. Here, for the first time, we determine the antitumor potential of tomatine, a ...
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