The past few years witnessed the rapid development of bottom-up synthesis strategies for preparing various nanostructures (i.e., nanoparticles, nanorods, nanowires, etc.) with distinct ...morphology-dependent properties. In this study, we reported a facile and efficient synthesis method for preparing anatase titanium dioxide (TiO2) nanorings based on multiarm, starlike amphiphilic polystyrene-b-poly(acrylic acid) (PS-b-PAA) diblock copolymers as nanoreactors which were prepared via a sequential atom-transfer radical polymerization (ATRP) technique followed by the conversion of polystyrene-b-poly(tert-butyl acrylate) (PS-b-PtBA) to PS-b-PAA. The outer PAA block of nanoreactors possessed carboxylic acid groups which could coordinate with a titanium precursor followed by high-temperature calcination to form crystalline TiO2 nanorings. The living nature of ATRP enabled the precise preparation of starlike diblock copolymer nanoreactors with a controlled length of each block (i.e., PtBA and PS), thereby tailoring the inner diameter and wall thickness of the resulting TiO2 nanorings, which were inaccessible to conventional routes.
The past few years witnessed the rapid development of bottom-up synthesis strategies for preparing various nanostructures (i.e., nanoparticles, nanorods, nanowires, etc.) with distinct ...morphology-dependent properties. In this study, we reported a facile and efficient synthesis method for preparing anatase titanium dioxide (TiO
) nanorings based on multiarm, starlike amphiphilic polystyrene-
-poly(acrylic acid) (PS-
-PAA) diblock copolymers as nanoreactors which were prepared via a sequential atom-transfer radical polymerization (ATRP) technique followed by the conversion of polystyrene-
-poly(
-butyl acrylate) (PS-
-P
BA) to PS-
-PAA. The outer PAA block of nanoreactors possessed carboxylic acid groups which could coordinate with a titanium precursor followed by high-temperature calcination to form crystalline TiO
nanorings. The living nature of ATRP enabled the precise preparation of starlike diblock copolymer nanoreactors with a controlled length of each block (i.e., P
BA and PS), thereby tailoring the inner diameter and wall thickness of the resulting TiO
nanorings, which were inaccessible to conventional routes.
Puerarin is the main isoflavone extracted from Radix Puerariae lobata (Willd.) and exerts a strong protective effect on endothelial cells. This isoflavone also exerts proven angiogenic effects; ...however, the potential underlying mechanism has not been fully explored. Here in this work, we aimed to determine the proangiogenesis effect of a puerarin-attached lignin nanoparticle-incorporated hydrogel and explore the underlying mechanism.PurposePuerarin is the main isoflavone extracted from Radix Puerariae lobata (Willd.) and exerts a strong protective effect on endothelial cells. This isoflavone also exerts proven angiogenic effects; however, the potential underlying mechanism has not been fully explored. Here in this work, we aimed to determine the proangiogenesis effect of a puerarin-attached lignin nanoparticle-incorporated hydrogel and explore the underlying mechanism.Puerarin-attached lignin nanoparticles were fabricated and mixed with the GelMA hydrogel. After the hydrogel was characterized, the angiogenic effect was evaluated in a mouse hind-limb ischemia model. To further explore the mechanism of angiogenesis, human endothelial cell line EA.hy926 was exposure to different concentrations of puerarin. Wound healing assays and tube formation assays were used to investigate the effects of puerarin on cell migration and angiogenesis. qPCR and Western blotting were performed to determine the changes in the levels of angiogenesis indicators, autophagy indicators and PPARβ/δ. 3-MA was used to assess the role of autophagy in the puerarin-mediated angiogenesis effect in vivo and in vitro.Materials and MethodsPuerarin-attached lignin nanoparticles were fabricated and mixed with the GelMA hydrogel. After the hydrogel was characterized, the angiogenic effect was evaluated in a mouse hind-limb ischemia model. To further explore the mechanism of angiogenesis, human endothelial cell line EA.hy926 was exposure to different concentrations of puerarin. Wound healing assays and tube formation assays were used to investigate the effects of puerarin on cell migration and angiogenesis. qPCR and Western blotting were performed to determine the changes in the levels of angiogenesis indicators, autophagy indicators and PPARβ/δ. 3-MA was used to assess the role of autophagy in the puerarin-mediated angiogenesis effect in vivo and in vitro.The hydrogel significantly improved blood flow restoration in mice with hind-limb ischemia. This effect was mainly due to puerarin-mediated increases in the angiogenic capacity of endothelial cells and the promotion of autophagy activation. A potential underlying mechanism might be that puerarin-mediated activation of autophagy could induce an increase in PPARβ/δ expression.ResultsThe hydrogel significantly improved blood flow restoration in mice with hind-limb ischemia. This effect was mainly due to puerarin-mediated increases in the angiogenic capacity of endothelial cells and the promotion of autophagy activation. A potential underlying mechanism might be that puerarin-mediated activation of autophagy could induce an increase in PPARβ/δ expression.The puerarin-attached lignin nanoparticle-incorporated hydrogel effectively alleviated blood perfusion in mice with hind-limb ischemia. Puerarin has a prominent proangiogenic effect. The potential mechanisms might be that puerarin-mediated autophagy activation and increase in PPARβ/δ.ConclusionThe puerarin-attached lignin nanoparticle-incorporated hydrogel effectively alleviated blood perfusion in mice with hind-limb ischemia. Puerarin has a prominent proangiogenic effect. The potential mechanisms might be that puerarin-mediated autophagy activation and increase in PPARβ/δ.
Electric shovel is a large-scale excavation equipment, which often suffer from discontinuous and inefficient excavation due to complicated mine condition. To address these challenges, a ...multi-objective optimization strategy for electric shovel is proposed to achieve an efficient, stable and intelligent operation. Firstly, the dynamical model of the electric shovel system is established based on Lagrange method. Then, the minimum energy consumption per volume and minimum relief angle difference are regarded as the optimization formulation considering multiple system constraints. Finally, the strategy is applied to the ROS-based intelligent prototype of shovel to verify the effectiveness. The results show that the multi-objective optimization strategy of the excavation trajectory has great guiding significance for the design of the intelligent electric shovel.
The development of green energy conversion devices such as metal air battery relies on the use of efficient reversible oxygen electrocatalyst. Commonly used precious metal catalyst could not support ...the large scale application of these devices due to their high cost and limited stability. In this paper, we report the synthesis of a coordination polymer and its use for the preparation of oxygen electrocatalyst. Our results show that the use of the coordination polymer as catalyst precursor could results in a homogeneous catalyst with both high activity and good stability, which is close to that of commercial Pt/C catalyst. Our results show that the nitrogen doped carbon wrapped Fe3O4 could function as a promising oxygen catalyst in a variety of applications.
Syphilis, a sexually transmitted disease, is commonly referred to as the "great imitator" because of its wide-ranging clinical presentations. Recently, we noticed that patients with neurosyphilis ...(NS) seemed to be more susceptible to complications of diabetes mellitus (DM). This is an interesting phenomenon, but it also puzzles clinicians because of scant knowledge about this situation.
A case-control study was conducted to explore the association between NS and DM. Clinical data and the prevalence of DM among NS patients, patients with syphilis but not NS (syphilis/non-NS), non-syphilis patients, and healthy controls were analyzed. In addition, we explored the time of occurrence of NS and DM.
Fasting plasma glucose and HbA1c levels in NS patients were significantly higher than in syphilis/non-NS patients, non-syphilis patients, and healthy controls (P < 0.05). In all, 45 of 149 NS patients (30.2%) were diagnosed with DM. The prevalence of DM in NS patients was significantly higher than in the other three groups (P < 0.05). There was no relationship between the prevalence of DM and the type of NS (e.g. asymptomatic NS, syphilitic meningitis, meningovascular NS, general paresis, and tabes dosalis). In the study population, 57.8% of NS patients were diagnosed with DM at the same time, whereas 80.0% were diagnosed with DM within 5 years of their diagnosis of NS.
Based on the results of the present study, DM is not merely an occasional chance occurrence in NS patients. There is an association between NS and DM.
Background
Syphilis, a sexually transmitted disease, is commonly referred to as the “great imitator” because of its wide‐ranging clinical presentations. Recently, we noticed that patients with ...neurosyphilis (NS) seemed to be more susceptible to complications of diabetes mellitus (DM). This is an interesting phenomenon, but it also puzzles clinicians because of scant knowledge about this situation.
Methods
A case‐control study was conducted to explore the association between NS and DM. Clinical data and the prevalence of DM among NS patients, patients with syphilis but not NS (syphilis/non‐NS), non‐syphilis patients, and healthy controls were analyzed. In addition, we explored the time of occurrence of NS and DM.
Results
Fasting plasma glucose and HbA1c levels in NS patients were significantly higher than in syphilis/non‐NS patients, non‐syphilis patients, and healthy controls (P < 0.05). In all, 45 of 149 NS patients (30.2%) were diagnosed with DM. The prevalence of DM in NS patients was significantly higher than in the other three groups (P < 0.05). There was no relationship between the prevalence of DM and the type of NS (e.g. asymptomatic NS, syphilitic meningitis, meningovascular NS, general paresis, and tabes dosalis). In the study population, 57.8% of NS patients were diagnosed with DM at the same time, whereas 80.0% were diagnosed with DM within 5 years of their diagnosis of NS.
Conclusions
Based on the results of the present study, DM is not merely an occasional chance occurrence in NS patients. There is an association between NS and DM.
摘要
背景：梅毒，作为一种性传播性疾病，具有多种的临床特征，常常被人称为“伟大的魔术师”。最近，我们的研究发现神经梅毒患者似乎更加容易并发糖尿病。这一直是个很有意思的问题，但是由于我们对此现象的原因所知甚少，因此它困扰着很多临床医生。
方法：我们采用病例对照研究方法，探讨神经梅毒与糖尿病的关系。对神经梅毒组、非神经梅毒组、非梅毒组、健康对照组患者的糖尿病发病率以及相关临床数据进行了分析。另外，我们也对神经梅毒与糖尿病的前后发病诊断时间顺序进行了探讨。
结果：神经梅毒组的空腹血糖和糖化血红蛋白明显高于非神经梅毒组、梅毒组和健康对照组（P < 0.05）。此次研究的149例神经梅毒患者中，有45例（30.2%）同时患有糖尿病。神经梅毒组的糖尿病患病率明显高于其它三组（P < 0.05）。进一步的研究发现不同类型的神经梅毒（无症状神经梅毒、梅毒性脑膜炎、脑膜血管神经梅毒、麻痹性痴呆、脊髓痨）与糖尿病的患病率无关。在此研究中，我们发现57.8%的神经梅毒患者在诊断神经梅毒时即发现患有糖尿病，80.0%的患者是在诊断神经梅毒的5年内发现患有糖尿病的。
结论：神经梅毒患者并发糖尿病不是偶然事件，它们之间应该存在着某种联系。
Reliability is extremely important for large-scale cloud systems like Microsoft 365. Cloud failures such as disk failure, node failure, etc. threaten service reliability, resulting in online service ...interruptions and economic loss. Existing works focus on predicting cloud failures and proactively taking action before failures happen. However, they suffer from poor data quality like data missing in model training and prediction, which limits the performance. In this paper, we focus on enhancing data quality through data imputation by the proposed Diffusion+, a sample-efficient diffusion model, to impute the missing data efficiently based on the observed data. Our experiments and application practice show that our model contributes to improving the performance of the downstream failure prediction task.
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