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  • Mutagenesis by AID: Being i... Mutagenesis by AID: Being in the Right Place at the Right Time
    Rada, Cristina PLOS genetics, 09/2015, Volume: 11, Issue: 9
    Journal Article
    Peer reviewed
    Open access

      ...loss of AID's C-terminal nuclear export signal, a mutation observed in immunodeficiency patients, leads to rapid degradation of the protein as it cannot be translocated back to the cytosol. ...
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  • Introduction of the circula... Introduction of the circular economy within developing regions: A comparative analysis of advantages and opportunities for waste valorization
    Ferronato, Navarro; Rada, Elena Cristina; Gorritty Portillo, Marcelo Antonio ... Journal of environmental management, 01/2019, Volume: 230
    Journal Article
    Peer reviewed

    The introduction of effective solid waste management strategies in developing countries should be considered for improving sustainability at global level. Many barriers should be overcome, concerning ...
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  • Germline ablation of SMUG1 ... Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice
    Kemmerich, Kristin; Dingler, Felix A; Rada, Cristina ... Nucleic acids research, 07/2012, Volume: 40, Issue: 13
    Journal Article
    Peer reviewed
    Open access

    Deamination of cytosine (C), 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) occurs spontaneously in mammalian DNA with several hundred deaminations occurring in each cell every day. The ...
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  • DNA deaminases induce break... DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis
    Taylor, Benjamin Jm; Nik-Zainal, Serena; Wu, Yee Ling ... eLife, 04/2013, Volume: 2
    Journal Article
    Peer reviewed
    Open access

    Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered ...
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  • Aicardi-Goutières Syndrome ... Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex
    Shapson-Coe, Alexander; Valeiras, Brenda; Wall, Christopher ... PloS one, 03/2019, Volume: 14, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    DNA-RNA hybrids arise in all cell types, and are removed by multiple enzymes, including the trimeric ribonuclease, RNase H2. Mutations in human RNase H2 result in Aicardi-Goutières syndrome (AGS), an ...
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  • Altering the spectrum of im... Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID
    Wang, Meng; Rada, Cristina; Neuberger, Michael S The Journal of experimental medicine, 01/2010, Volume: 207, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    High-affinity antibodies are generated by somatic hypermutation with nucleotide substitutions introduced into the IgV in a semirandom fashion, but with intrinsic mutational hotspots strategically ...
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  • A study on the carbon footp... A study on the carbon footprint contributions from a large wastewater treatment plant
    Riccardo, Boiocchi; Paolo, Viotti; Davide, Lancione ... Energy reports, September 2023, 2023-09-00, 2023-09-01, Volume: 9
    Journal Article
    Peer reviewed
    Open access

    The present work analyses aspects of the carbon footprint of a large wastewater treatment plant in central Italy. The plant mainly consists of a traditional activated sludge system along with an ...
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  • The in vivo pattern of AID ... The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice
    Xue, Kanmin; Rada, Cristina; Neuberger, Michael S The Journal of experimental medicine, 09/2006, Volume: 203, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Immunoglobulin (Ig) class switching is initiated by deamination of C-->U within the immunoglobulin heavy chain locus, catalyzed by activation-induced deaminase (AID). In the absence of uracil-DNA ...
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  • microRNA-155 Regulates the ... microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells
    Vigorito, Elena; Perks, Kerry L.; Abreu-Goodger, Cei ... Immunity, 12/2007, Volume: 27, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show ...
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  • Investigating the effective... Investigating the effectiveness of clothes recovery programs in promoting a circular economy: A review
    Lawrence, Jassica; Bettinetti, Roberta; Torretta, Vincenzo ... E3S web of conferences, 01/2023, Volume: 408
    Journal Article
    Peer reviewed
    Open access

    Textile plays a crucial role in a circular economy and its traditional use needs to be replaced with sustainable ways. A circular economy gives repurpose and value to a resource in a continuous loop ...
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