The rotation curve (RC) of the Milky Way out to ~100 kpc has been constructed using ~16,000 primary red clump giants (PRCGs) in the outer disc selected from the LAMOST Spectroscopic Survey of the ...Galactic Anti-centre (LSS-GAC) and the Sloan Digital Sky Survey (SDSS)-III/APOGEE survey, combined with ~5700 halo K giants (HKGs) selected from the SDSS/SEGUE survey. To derive the RC, the PRCG sample of the warm disc population and the HKG sample of halo stellar population are, respectively, analysed using a kinematical model allowing for the asymmetric drift corrections and re-analysed using the spherical Jeans equation along with measurements of the anisotropic parameter beta currently available. The typical uncertainties of RC derived from the PRCG and HKG samples are, respectively, 5-7 km s super( -1) and several tens km s super( -1). We determine a circular velocity at the solar position, ... and an azimuthal peculiar speed of the Sun, ..., both in good agreement with the previous determinations. The newly constructed RC has a generally flat value of 240 km s super( -1) within a Galactocentric distance rof 25 kpc and then decreases steadily to 150 km s super( -1) at r ~ 100 kpc. On top of this overall trend, the RC exhibits two prominent localized dips, one at r ~ 11 kpc and another at r ~ 19 kpc. From the newly constructed RC, combined with other constraints, we have built a parametrized mass model for the Galaxy, yielding a virial mass of the Milky Way's dark matter halo of ... and a local dark matter density, ... (ProQuest: ... denotes formulae/symbols omitted.)
miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma (ATC), and is believed to be an important event in thyroid cell transformation. In this study, we ...found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin, a commonly used chemotherapeutic drug for treatment of this neoplasm. Using a mimic of miR-30d, we demonstrated that miR-30d could negatively regulate the expression of beclin 1, a key autophagy gene, leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis. A reporter gene assay demonstrated that the binding sequences of miR-30d in the beclin 1-3′ UTR was the region required for the inhibition of beclin 1 expression by this miRNA. We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro (cell culture) and in vivo (animal xenograft model). These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival. Thus, miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC.
Abstract
We present a three-dimensional (3D) extinction analysis in the region towards the supernova remnant (SNR) S147 (G180.0–1.7) using multiband photometric data from the Xuyi Schmidt Telescope ...Photometric Survey of the Galactic Anticentre (XSTPS-GAC), 2MASS and WISE. We isolate a previously unrecognized dust structure likely to be associated with SNR S147. The structure, which we term as ‘S147 dust cloud’, is estimated to have a distance d = 1.22 ± 0.21 kpc, consistent with the conjecture that S147 is associated with pulsar PSR J0538 + 2817. The cloud includes several dense clumps of relatively high extinction that locate on the radio shell of S147 and coincide spatially with the CO and gamma-ray emission features. We conclude that the usage of CO measurements to trace the SNR associated MCs is unavoidably limited by the detection threshold, dust depletion and the difficulty of distance estimates in the outer Galaxy. 3D dust extinction mapping may provide a better way to identify and study SNR–MC interactions.
The new Scientific Decade 2013–2022 of IAHS, entitled “Panta Rhei—Everything Flows”, is dedicated to research activities on change in hydrology and society. The purpose of Panta Rhei is to reach an ...improved interpretation of the processes governing the water cycle by focusing on their changing dynamics in connection with rapidly changing human systems. The practical aim is to improve our capability to make predictions of water resources dynamics to support sustainable societal development in a changing environment. The concept implies a focus on hydrological systems as a changing interface between environment and society, whose dynamics are essential to determine water security, human safety and development, and to set priorities for environmental management. The Scientific Decade 2013–2022 will devise innovative theoretical blueprints for the representation of processes including change and will focus on advanced monitoring and data analysis techniques. Interdisciplinarity will be sought by increased efforts to connect with the socio-economic sciences and geosciences in general. This paper presents a summary of the Science Plan of Panta Rhei, its targets, research questions and expected outcomes. Editor Z.W. Kundzewicz Citation Montanari, A., Young, G., Savenije, H.H.G., Hughes, D., Wagener, T., Ren, L.L., Koutsoyiannis, D., Cudennec, C., Toth, E., Grimaldi, S., Blöschl, G., Sivapalan, M., Beven, K., Gupta, H., Hipsey, M., Schaefli, B., Arheimer, B., Boegh, E., Schymanski, S.J., Di Baldassarre, G., Yu, B., Hubert, P., Huang, Y., Schumann, A., Post, D., Srinivasan, V., Harman, C., Thompson, S., Rogger, M., Viglione, A., McMillan, H., Characklis, G., Pang, Z., and Belyaev, V., 2013. “Panta Rhei—Everything Flows”: Change in hydrology and society—The IAHS Scientific Decade 2013–2022. Hydrological Sciences Journal . 58 (6) 1256–1275.
SFTS virus (SFTSV) is a novel bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease that occurred in China in recent years, with an average case ...fatality rate of 10–12%. Intervention in the early clinical stage is the most effective measure to reduce the mortality rate of disease. To elucidate the natural course of and immune mechanisms associated with the pathogenesis of SFTSV, 59 laboratory-confirmed SFTS patients in the acute phase, who were hospitalized between October 2010 and September 2011, were enrolled in this study, and the patients sera were dynamically collected and tested for SFTSV viral RNA load, 34 cytokines or chemokines and other related laboratory parameters. All clinical diagnostic factors in the acute phase of SFTS were evaluated and assessed. The study showed that the severity of the disease in 11 (18.6%) patients was associated with abdominal pain (p 0.007; OR = 21.95; 95% CI, 2.32–208.11) and gingival bleeding (p 0.001; OR = 122.11; 95% CI, 6.41–2328). The IP-10, TNF-α, IL-6, IL-10, granzyme B and HSP70 levels were higher over the 7–8 days in severe cases, accompanied by altered AST, CK and LDH levels. HSP70 (p 0.012; OR = 8.29; 95% CI, 1.58–43.40) was independently correlated with the severity of the early acute phase of SFTSV infection. The severity of SFTS can be predicted based on the presence of symptoms such as abdominal pain and gingival bleeding and on the level of HSP70 in the acute phase of the disease.
Abstract Although the study of X-ray binaries has led to major breakthroughs in high-energy astrophysics, their circumbinary environment at scales of ∼100–10,000 au has not been thoroughly ...investigated. In this paper, we undertake a novel and exploratory study by employing direct and high-contrast imaging techniques on a sample of X-ray binaries, using adaptive optics and the vortex coronagraph on Keck/NIRC2. High-contrast imaging opens up the possibility to search for exoplanets, brown dwarfs, circumbinary companion stars, and protoplanetary disks in these extreme systems. Here we present the first near-infrared high-contrast images of 13 high-mass X-ray binaries located within ∼2–3 kpc. The key results of this campaign involve the discovery of several candidate circumbinary companions ranging from substellar (brown dwarf) to stellar masses. By conducting an analysis based on Galactic population models, we discriminate sources that are likely background/foreground stars and isolate those that have a high probability (≳60%–99%) of being gravitationally bound to the X-ray binary. This paper seeks to establish a preliminary catalog for future analyses of proper motion and subsequent observations. With our preliminary results, we calculate the first estimate of the companion frequency and the multiplicity frequency for X-ray binaries: ≈0.6 and 1.8 ± 0.9, respectively, considering only the sources that are most likely bound to the X-ray binary. In addition to extending our comprehension of how brown dwarfs and stars can form and survive in such extreme systems, our study opens a new window to our understanding of the formation of X-ray binaries.
We present a catalog of 5290 RR Lyrae stars (RRLs) with metallicities estimated from spectra of the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) and the Sloan Extension for ...Galactic Understanding and Exploration (SEGUE) surveys. Nearly 70% of them (3642 objects) also have systemic radial velocities measured. Given the pulsating nature of RRLs, metallicity estimates are based on spectra of individual exposures that have been matched with their synthetic templates. The systemic radial velocities are measured by fitting the observed velocity as a function of phase assuming an empirical pulsating velocity template curve. Various tests show that our analyses yield metallicities with a typical precision of 0.20 dex and systemic radial velocities with uncertainties ranging from 5 to 21 km s−1 (depending on the number of radial-velocity measurements available for a given star). Based on the well-calibrated near-infrared PMW1Z or , and MV-Fe/H relations, precise distances are derived for these RRLs. Finally, we include Gaia DR2 proper motions in our catalog. The catalog should be very useful for various Galactic studies, especially of the Galactic halo.
The aim of this study was to develop a self-administered scale based on the special features of smartphone. The reliability and validity of the Smartphone Addiction Inventory (SPAI) was demonstrated.
...A total of 283 participants were recruited from Dec. 2012 to Jul. 2013 to complete a set of questionnaires, including a 26-item SPAI modified from the Chinese Internet Addiction Scale and phantom vibration and ringing syndrome questionnaire. There were 260 males and 23 females, with ages 22.9 ± 2.0 years. Exploratory factor analysis, internal-consistency test, test-retest, and correlation analysis were conducted to verify the reliability and validity of the SPAI. Correlations between each subscale and phantom vibration and ringing were also explored.
Exploratory factor analysis yielded four factors: compulsive behavior, functional impairment, withdrawal and tolerance. Test-retest reliabilities (intraclass correlations = 0.74-0.91) and internal consistency (Cronbach's α = 0.94) were all satisfactory. The four subscales had moderate to high correlations (0.56-0.78), but had no or very low correlation to phantom vibration/ringing syndrome.
This study provides evidence that the SPAI is a valid and reliable, self-administered screening tool to investigate smartphone addiction. Phantom vibration and ringing might be independent entities of smartphone addiction.
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18-21 and are established driver mutations in non-small cell lung cancer (NSCLC)
. Targeted therapies are approved for ...patients with 'classical' mutations and a small number of other mutations
. However, effective therapies have not been identified for additional EGFR mutations. Furthermore, the frequency and effects of atypical EGFR mutations on drug sensitivity are unknown
. Here we characterize the mutational landscape in 16,715 patients with EGFR-mutant NSCLC, and establish the structure-function relationship of EGFR mutations on drug sensitivity. We found that EGFR mutations can be separated into four distinct subgroups on the basis of sensitivity and structural changes that retrospectively predict patient outcomes following treatment with EGFR inhibitors better than traditional exon-based groups. Together, these data delineate a structure-based approach for defining functional groups of EGFR mutations that can effectively guide treatment and clinical trial choices for patients with EGFR-mutant NSCLC and suggest that a structure-function-based approach may improve the prediction of drug sensitivity to targeted therapies in oncogenes with diverse mutations.
Accurate determination of stellar atmospheric parameters and elemental abundances is crucial for Galactic archaeology via large-scale spectroscopic surveys. In this paper, we estimate stellar ...atmospheric parameters -- effective temperature T sub( eff), surface gravity log g and metallicity Fe/H, absolute magnitudes M sub( V) and M sub( Ks), ...-element to metal (and iron) abundance ratio .../M (and .../Fe), as well as carbon and nitrogen abundances C/H and N/H from the Large Sky Area Multi-Object Fibre Spectroscopic Telescope (LAMOST) spectra with a multivariate regression method based on kernel-based principal component analysis, using stars in common with other surveys (Hipparcos, Kepler, Apache Point Observatory Galactic Evolution Experiment) as training data sets. Both internal and external examinations indicate that given a spectral signal-to-noise ratio (SNR) better than 50, our method is capable of delivering stellar parameters with a precision of ~100 K for T sub( eff), ~0.1 dex for log g, 0.3-0.4 mag for M sub( V) and M sub( Ks), 0.1 dex for Fe/H, C/H and N/H, and better than 0.05 dex for .../M (.../Fe). The results are satisfactory even for a spectral SNR of 20. The work presents first determinations of C/H and N/H abundances from a vast data set of LAMOST, and, to our knowledge, the first reported implementation of absolute magnitude estimation directly based on a vast data set of observed spectra. The derived stellar parameters for millions of stars from the LAMOST surveys will be publicly available in the form of value-added catalogues. (ProQuest: ... denotes formulae/symbols omitted.)
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