The functional role of the uncinate fasciculus is still a matter of debate. We examined 44 patients submitted to awake surgery for removal of a left frontal or temporal glioma. In 18 patients, the ...removal included the uncinate fasciculus. We compared patients with or without removal on a series of neuropsychological tasks, performed at different time intervals: pre-surgery, in the first week after surgery and 3 months after surgery. Functional magnetic resonance and diffusion tensor imaging, fibre-tracking techniques were performed before surgery. At the last examination, patients with uncinate removal were significantly impaired in naming of famous faces and objects as compared with patients without removal. We further divided patients according to the site of the tumour (either frontal or temporal). At the follow-up, patients with a temporal glioma who underwent uncinate removal had the worst loss of performance in famous face naming. In addition, on the same task, the group with a frontal glioma that underwent resection of the frontal part of the uncinate performed significantly worse than the group with a frontal glioma but without uncinate removal. In conclusion, the resection of the uncinate fasciculus, in its frontal or temporal part, has long-lasting consequences for famous face naming. We suggest that this fibre tract is part of a circuitry involved in the retrieval of word form for proper names. Retrieval of conceptual knowledge was intact.
A method for the simultaneous determination of pesticides, biopesticides and mycotoxins from organic products was developed. Extraction of more than 90 compounds was evaluated and performed by using ...a modified QuEChERS-based (acronym of Quick, Easy, Cheap, Effective, Rugged, and Safe) sample preparation procedure. The method was based on a single extraction with acidified acetonitrile, followed by partitioning with salts, avoiding any clean-up step prior the determination by ultra-high performance liquid chromatography/tandem quadrupole mass spectrometry (UHPLC–MS/MS). Validation studies were carried out in wheat, cucumber and red wine as representative matrixes. Recoveries of the spiked samples were in the range between 70 and 120% (with intra-day precision, expressed as relative standard deviation, lower than 20%) for most of the analysed compounds, except picloram and quinmerac. Inter-day precision, expressed as relative standard deviation, was lower than 24%. Limits of quantification were lower than 10
μg
kg
−1 and the developed method was successfully applied to the analysis of organic food products, detecting analytes belonging to the three types of compounds.
•Rietveld refinement results show a decreased in volume due to the decrease in c lattice parameter as iron is introduced.•The deconvolution process of the high resolution XPS spectra of Fe 3d shows ...that the Fe3+ ion is present in the samples.•Theoretical calculations by DFT reveal that the Bi2Te3 compound is a semiconductor with a narrow energy band gap in agreement with experimental results.•Magnetic susceptibility measurements on Bi2Te3 do not show a magnetic behavior; however, for the doped sample with x = 0.2, a weak ferromagnetic behavior (WFM) below 14 K is observed.
The crystal structure and magnetic properties of Fe doped Bi2Te3 are presented. The samples were studied by X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and magnetization measurements. Rietveld refinement results show a decrease in volume due to the decrease in c lattice parameter as iron is introduced. By XPS measurements, the Te 3d, Bi 4f, Bi 5d, Te 4d, and Fe 3d core levels were identified, and the XPS valence band (VB) was measured. The deconvolution process of high resolution XPS spectra in Fe 3d orbital shows that the Fe3+ ion is present in the samples. Theoretical calculations by DFT reveal that the Bi2Te3 compound is a semiconductor with a narrow energy band gap in agreement with experimental results. DOS analysis shows that the main contributions to the valence band are the Te 5p, Bi 6p, and Fe 3d states. XPS VB shows a decrease in the intensity at zero eV due to increased Fe 3d states and good correspondence with DOS calculated for Bi2Te3. Finally, magnetic susceptibility measurements on Bi2Te3 do not show a magnetic behavior; however, for the doped sample with x = 0.2, a weak ferromagnetic behavior (WFM) below 14 K is observed.
Summary
A 65‐year‐old pluripathological woman attended our hospital with a cutaneous eruption of sudden appearance after vancomycin treatment. She presented targetoid lesions affecting approximately ...25–30% of her body surface, large erosions with mucosal lesions and positive Nikolsky sign. Under the initial clinical suspicion of toxic epidermal necrolysis (TEN), and considering the recent literature of successful use of etanercept in these cases, she was treated with a single dose of this antitumour necrosis factor (anti‐TNF) agent. Subsequently, the exanthema progression stopped and resolution of the lesions happened in a few days. Later on, histopathology revealed a subepidermal blister with dense neutrophilic infiltrate and linear deposits of immunoglobulin A (IgA) on the dermoepidermal junction, allowing us to establish the diagnosis of drug‐induced linear IgA dermatosis mimicking TEN. Linear IgA dermatosis can have severe clinical manifestations, even mimicking TEN, and can have high mortality, especially in drug‐induced cases. We have not found any other report of linear IgA dermatosis treated with etanercept in the English literature. Anti‐TNF medications could represent useful therapeutic alternatives in this dermatosis.
What's already known about this topic?
Linear IgA dermatosis is an autoimmune bullous dermatosis that can have multiple clinical presentations including a severe one that mimics toxic epidermal necrolysis.
Drug‐induced cases are frequently more serious.
Apart from drug suspension no medication has been proven to modify its natural course.
What does this study add?
We could not find any previous report of linear IgA dermatosis treated with etanercept.
We report a more rapid than expected improvement of this disease, which we believe was due to this therapy.
This could point to a more important role of tumour necrosis factor (TNF)‐α in this dermatosis.
Anti‐TNF agents could represent alternative therapies.
Octopus vulgaris (Cuvier, 1797) is a cephalopod species with great economic value. In western Asturias (northwest of Spain), O. vulgaris artisanal fisheries are relatively well monitored and ...conditionally eco-labeled by the Marine Stewardship Council (MSC). Despite this, the Asturian octopus stocks have not been genetically assessed so far. In order to improve the current fishery plan and contrast the octopus eco-label validity in Asturias, 539 individuals from five regions of the O. vulgaris geographic distribution, including temporal samplings in Asturias, were collected and genotyped at thirteen microsatellite loci. All the samples under analysis were in agreement with Hardy-Weinberg expectations. Spatial levels of genetic differentiation were estimated using F-statistics, multidimensional scaling, and Bayesian analyses. Results suggested that the O. vulgaris consists of at least four genetically different stocks coming from two ancestral lineages. In addition, temporal analyses showed stability in terms of genetic variation and high N
(> 50) for several generations in different localities within Asturias, pointing out to indeed sustainable fishery exploitation levels. Even though, the current Asturias fishery plan shows no significant genetic damages to the stocks, the regional-specific management plans need systematic genetic monitoring schemes as part of an efficient and preventive regional fishery regulation strategy.
Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some patients exposed to certain drugs (antiresorptives such as bisphosphonates or denosumab, and ...antiangiogenic drugs). From a review of the literature it appears that there is no uniform criterion when selecting preventive measures; these vary according to author. Likewise, the measures recommended are usually general, so that in few cases they result in specific actions to be applied depending on the different variables involved such as the type of drug used, the duration of its application, the underlying pathology, the presence or absence of risk factors, etc. The aim of this study has been to design a preventive protocol which can be easily applied in any clinic or by any dental care service.
We undertook an exhaustive literature review to find any articles related to the topic of study, namely, preventive measures for medication-related osteonecrosis of the jaw, on the one hand generically and on the other focusing on dental implant treatment. The most part the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. From 3946 items, we selected a total of 21 items.
From the analysis of the selected articles, several protocols have been developed that are easy to apply in a dental clinic.: Protocol 1. Before starting treatment with antiresorptives (Patients who are going to be treated for osteoporosis / Patients who are going to be treated for cancer). Protocol 2. Once treatment is initiated with antiresorptives (Patients being treated for osteoporosis / Patients being treated for cancer).
The application of these protocols requires an interdisciplinary team which can handle the various treatments and apply the measures contained in them. Along with a team of well-educated and trained dentists, it is equally important to maintain contact with the medical team involved in the treatment of the underlying pathology, especially rheumatologists, oncologists, internists and gynaecologists. All the above requires a great staff learning and organization effort, continuous training and coordination of the whole team involved in the preventive management of these patients.
Context.
Nearly a dozen star-forming galaxies have been detected in
γ
-rays by the
Fermi
observatory in the last decade. A remarkable property of this sample is the quasi-linear relation between the
...γ
-ray luminosity and the star formation rate, which was obtained assuming that the latter is well traced by the infrared luminosity of the galaxies. The non-linearity of this relation has not been fully explained yet.
Aims.
We aim to determine the biases derived from the use of the infrared luminosity as a proxy for the star formation rate and to shed light on the more fundamental relation between the latter and the
γ
-ray luminosity. We expect to quantify and explain some trends observed in this relation.
Methods.
We compiled a near-homogeneous set of distances, ultraviolet, optical, infrared, and
γ
-ray fluxes from the literature for all known
γ
-ray emitting, star-forming galaxies. From these data, we computed the infrared and
γ
-ray luminosities, and star formation rates. We determined the best-fitting relation between the latter two, and we describe the trend using simple, population-orientated models for cosmic-ray transport and cooling.
Results.
We find that the
γ
-ray luminosity–star formation rate relation obtained from infrared luminosities is biased to shallower slopes. The actual relation is steeper than previous estimates, having a power-law index of 1.35 ± 0.05, in contrast to 1.23 ± 0.06.
Conclusions.
The unbiased
γ
-ray luminosity–star formation rate relation can be explained at high star formation rates by assuming that the cosmic-ray cooling region is kiloparsec-sized and pervaded by mild to fast winds. Combined with previous results about the scaling of wind velocity with star formation rate, our work provides support to advection as the dominant cosmic-ray escape mechanism in galaxies with low star formation rates.
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